Publications by authors named "Minmin Chang"

18 Publications

  • Page 1 of 1

Effect of Osteoporosis on Adjacent Segmental Degeneration After Posterior Lumbar Interbody Fusion Under Whole Body Vibration.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

School of Chinese Medicine, Jinan University, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications after posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, to the best of our knowledge, no studies have investigated the effects of osteoporosis on ASD after PLIF under WBV.

Methods: In the present study, using one normal model, one PLIF model and one PLIF with osteoporosis model of the L1-S1 segment were developed. A 5-Hz, 40-N sinusoidal vertical load was imposed on the superior surface of L1 of each model to simulate WBV, and the dynamic responses and maximal values of intradiscal pressure, shear stress on annulus fibrosus, total deformation, and disc bulge were evaluated in the L1-L2, L2-L3, L3-L4, and L5-S1 segments.

Results: At the L1-L2, L2-L3, and L3-L4 levels, the differences in the dynamic responses and maximal values in intradiscal pressure, shear stress, total deformation, and disc bulge between the PLIF and PLIF with osteoporosis models were slight. However, at the L5-S1 level, the dynamic response curves and maximal intradiscal pressure, shear stress, and disc bulge values in the PLIF with osteoporosis model were significantly lower than those in the PLIF model.

Conclusions: Osteoporosis can mitigate the development of ASD in the lower adjacent segment but has no obvious influence on the upper adjacent segments during WBV.
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http://dx.doi.org/10.1016/j.wneu.2021.06.031DOI Listing
June 2021

Biomechanical effects of osteoporosis on adjacent segments after posterior lumbar interbody fusion: A finite element study.

Pak J Med Sci 2021 Mar-Apr;37(2):403-408

Shujie Tang, School of Chinese Medicine, Jinan University, Guangzhou, 510630, China.

Objective: To investigate the biomechanical effects of osteoporosis on adjacent segments after posterior lumbar interbody fusion (PLIF).

Methods: This study was designed and conducted in the Traumatology and Orthopedics Laboratory, School of Chinese Medicine, Jinan University, Guangzhou, China, between December 2019 and February 2020. A healthy finite element model of L3-S1 was developed along with one PLIF model and one PLIF with osteoporosis model. Based on a hybrid test method, the inferior surface of S1 was entirely fixed, and a preload of 400N combined with an adjusted moment was imposed on the superior surface of L3 in each model to simulate flexion, extension, lateral bending and axial rotation. The intradiscal pressure (IDP), shear stress on annulus fibrosus, and the range of motion (ROM) of L3-L4 and L5-S1 were calculated and compared.

Results: In each direction, the highest value of IDP and shear stress on annulus fibrosus at L3-L4 and L5-S1 was found in the PLIF model, and the lowest value in the healthy model. The largest ROM at L4-L5 appeared in the healthy model, and the smallest value in the PLIF model in each direction. At L3-L4 and L5-S1, the highest ROM in most directions was found in the PLIF model, followed by the PLIF with osteoporosis model, and the lowest value in the healthy model.

Conclusions: Osteoporosis can decrease IDP, shear stress on annulus fibrosus, and ROM at adjacent levels, and slow down the development of ASD after PLIF.
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http://dx.doi.org/10.12669/pjms.37.2.3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931299PMC
March 2021

A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application.

Curr Med Chem 2021 Feb 7. Epub 2021 Feb 7.

State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering, South China University of Technology, Guangzhou 510640. China.

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years.

Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized.

Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment.

Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.
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http://dx.doi.org/10.2174/0929867328666210208113354DOI Listing
February 2021

Does Osteoporosis Affect the Adjacent Segments Following Anterior Lumbar Interbody Fusion? A Finite Element Study.

World Neurosurg 2021 02 7;146:e739-e746. Epub 2020 Nov 7.

School of Chinese Medicine, Jinan University, Guangzhou, China. Electronic address:

Background: Adjacent segment degeneration is a common complication following anterior lumbar interbody fusion (ALIF). Osteoporosis is becoming increasingly prevalent in the elderly population and thus patients undergoing ALIF may experience osteoporosis with age. However, the influence of osteoporosis on adjacent segment degeneration after ALIF remains unclear.

Methods: Three finite element models of the L3-S1 segment, including a healthy model, an ALIF model, and an ALIF with osteoporosis model, were used for analysis. ALIF was simulated at the L4-L5 segment. Based on a hybrid test method, the models were imposed with a preload of 400 N and an adjusted moment in flexion, extension, lateral bending, and axial torsion. Intradiscal pressure, shear stress on anulus fibrosus, and range of motion at L3-L4 and L5-S1 were calculated and compared.

Results: In each direction, the maximal values of intradiscal pressure and shear stress on anulus fibrosus at L3-L4 and L5-S1 were found in the ALIF model, and the minimal values were found in the healthy model. At L3-L4 and L5-S1, the maximal values of range of motion in most directions were found in the ALIF model followed by the ALIF with osteoporosis model, and the minimal values were found in the healthy model. However, the maximal value of range of motion at L5-S1 in axial torsion was found in the ALIF with osteoporosis model.

Conclusions: Osteoporosis may mitigate the adverse influence of ALIF on adjacent segments.
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http://dx.doi.org/10.1016/j.wneu.2020.11.005DOI Listing
February 2021

Comparison Between 7 Osteoporotic Vertebral Compression Fractures Treatments: Systematic Review and Network Meta-analysis.

World Neurosurg 2021 01 3;145:462-470.e1. Epub 2020 Sep 3.

School of Chinese Medicine, Jinan University, Guangzhou, Guangdong Province, China. Electronic address:

Background: Vertebroplasty (VP), kyphoplasty (KP), SpineJack system (SJ), radiofrequency kyphoplasty (RFK), Kiva system (Kiva), Sky kyphoplasty system (SK), and conservative treatment are widely used in the treatment of osteoporotic vertebral compression fractures (OVCFs). However, it is still unknown which is the best intervention. The aim of the current study was to evaluate the effectiveness and safety of VP, KP, SJ, RFK, Kiva, SK, and CT in the treatment of OVCFs.

Methods: Randomized controlled trials and cohort studies comparing VP, KP, SJ, RFK, Kiva, SK, or CT for the treatment of OVCFs were identified on the basis of databases including PubMed, the Cochrane Library, Web of Science, and Springer Link. A network meta-analysis was performed using STATA 15.1.

Results: A total of 56 studies with 6974 patients and 7 interventions were included in this study. The results of the surface under the cumulative probability demonstrated that SK was the best intervention in decreasing VAS scores and recovering middle vertebral height, RFK was the best intervention in improving ODI scores and decreasing incidence of new fractures, SJ was the best intervention to restore kyphosis angle, and Kiva was the best intervention to reduce incidence of bone cement leakage. Cluster analysis showed that SK was the preferable intervention on the basis of the outcomes of VAS, ODI, middle vertebral height, and kyphotic angle, and RFK was the preferable treatment in decreasing the incidence of adverse events. In our network meta-analysis, node-splitting analysis and loop inconsistency analysis showed no significant inconsistencies.

Conclusions: SK may be the most effective treatment in relieving pain, improving the quality of life, and recovering vertebral body height and kyphotic angle, while RFK may be the safest intervention for OVCFs. However, considering the limitations of this study, more high-quality trials are needed in the future to confirm the current conclusion.
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http://dx.doi.org/10.1016/j.wneu.2020.08.216DOI Listing
January 2021

Neonicotinoid insecticide and their metabolite residues in fruit juices: Implications for dietary intake in China.

Chemosphere 2020 Dec 16;261:127682. Epub 2020 Jul 16.

Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, PR China. Electronic address:

Neonicotinoid insecticides (NEOs) have become the most widely used insecticides worldwide, and they are ubiquitous in food (i.e., fruit juices). In the present study, occurrence of seven NEOs and four metabolites (m-NEOs) in 400 fruit juice samples were investigated. NEOs and m-NEOs were frequently detected (65%-86%) in fruit juice samples. The median residues of NEOs and m-NEOs were ranged from 0.06 ng/mL to 0.94 ng/mL. Seasonal variations in NEOs and m-NEOs in fruit juices were found, indicating that the target analyte residues during the dry season were remarkably higher than those of residues during wet season. The relative potency factor (RPF) method was used to integrate individual NEOs into a single metric [imidacloprid (IMI)] representing the intakes of IMI equivalent to total NEOs for each fruit juice sample. The estimated daily intake (EDI) of total NEOs for the general Chinese population was obtained. The median IMI for total fruit juices was 13.4 ng/g, and the median EDI of NEOs was 18.2 ng/kg bw/day for the general population. Although the EDIs in this study were considerably lower than the acceptable daily intake (60 μg/kg bw/day, ADI), the dietary exposure risks for total NEOs should not be ignored because of the increasing usage of NEOs and their ubiquitous presence in fruit juices in China. To the best of our knowledge, this report was the first time to document residues of NEO and m-NEO in fruit juice samples collected from China.
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http://dx.doi.org/10.1016/j.chemosphere.2020.127682DOI Listing
December 2020

Fabrication of cellulose nanocrystal reinforced nanocomposite hydrogel with self-healing properties.

Carbohydr Polym 2020 Jul 22;240:116289. Epub 2020 Apr 22.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

High strength and self-healing properties of hydrogels are of great interest in tissue engineering and biomedical fields. In this paper, nanocomposite hydrogels were prepared by freeze-thaw cycle method via fabricating physical cross-links into chemical-crosslinked formed polymer network. The properties of nanocomposite hydrogels were characterized by FTIR, XRD, SEM, rheological analysis, swelling analysis and mechanical test. The results showed that the electrostatic interaction between CNC and QAX and the high amount of PVA (20 wt%) were favorable to improve the mechanical properties of nanocomposite hydrogels, in which the maximum compressive strength and elongation at break of nanocomposite hydrogels were 1.56 MPa and 771 %, respectively. Prepared hydrogels achieved self-healing without any external stimuli at room temperature with the help of hydrogen bonds and the entanglement of long polymer chains, the healing efficiency was 37.03 % within 48 h. These hydrogels with high strength and self-healing properties will offer new insights for xylan application.
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http://dx.doi.org/10.1016/j.carbpol.2020.116289DOI Listing
July 2020

Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review.

Curr Med Chem 2020 ;27(28):4593-4612

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.

Background: Biosensors are widely applied for the detection of bio-molecules in blood glucose , cholesterol, and gene. Cellulose as the most dominating natural polymer has attracted more and more interest, especially in the field of medicine such as advanced medical diagnosis. Cellulose could endow biosensors with improved biocompatibility, biodegradability and nontoxicity, which could help in medical diagnosis. This mini-review summarizes the current development of cellulose-based biosensors as well as their applications in medical diagnosis in recent years.

Methods: After reviewing recent years' publications we can say that, there are several kinds of cellulose used in biosensors including different cellulose derivatives, bacterial cellulose and nanocellulose. Different types of cellulose-based biosensors, such as membrane, nano-cellulose and others were briefly described in addition to the detection principle. Cellulose-based biosensors were summarized as in the previous papers. The description of various methods used for preparing cellulose-based biosensors was also provided.

Results: Cellulose and its derivatives with their unique chemical structure proved to be versatile materials providing a good platform for achieving immobilizing bioactive molecules in biosensors. These cellulose-based biosensors possess various desirable properties such as accuracy, sensitivity, convenience, low cost and fast response. Among them, cellulose paper-based biosensors have the advantages of low cost and easy operation. Nano-cellulose has unique properties such as a large aspect ratio, good dispersing ability and high absorption capacity.

Conclusion: Cellulose displays a promising application in biosensors which could be used to detect different bio-molecules such as glucose, lactate, urea, gene, cell, amino acid, cholesterol, protein and hydroquinone. In future, the attention will be focused on designing miniaturized, multifunctional, intelligent and integrated biosensors. Creation of low cost and environmentally friendly biosensors is also very important.
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http://dx.doi.org/10.2174/0929867327666200221145543DOI Listing
September 2020

Comparisons of the Effectiveness and Safety of Tuina, Acupuncture, Traction, and Chinese Herbs for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis.

Evid Based Complement Alternat Med 2019 20;2019:6821310. Epub 2019 Mar 20.

School of Chinese Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.

Background: Tuina, acupuncture, traction, and Chinese herbs play an important role in the treatment of lumbar disc herniation. However, the comparative effectiveness and safety of the four commonly utilized treatment modalities are still unclear.

Objective: To compare the effectiveness and safety of the four interventions for lumbar disc herniation.

Methods: Randomized controlled trials comparing any two of the four interventions in the treatment of lumbar disc herniation were identified using the following databases: PubMed, the Cochrane Library, Embase, Web of Science, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Wanfang data, and network meta-analysis was performed using STATA 14.0.

Results: One hundred and twenty-one studies involving a total of 13075 patients were included. In all the outcome measurements, traction demonstrated a worst effectiveness, and Tuina and acupuncture demonstrated a best effectiveness, but no significant differences were found between Tuina and acupuncture. Compared with Tuina or acupuncture, Chinese herbs showed a similar effectiveness in Visual Analogue Score and Japanese Orthopedic Association Scores, but an inferior effectiveness in invalid rate and cure rate.

Conclusions: In the treatment of lumbar disc herniation, Tuina and acupuncture were superior to traction or Chinese herbs, and the effectiveness of traction was the worst. However, considering the limitations of this review, more high-quality trials, especially those comparing Chinese herbs with the other three interventions, should be carried out in the future to further confirm the current findings.
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http://dx.doi.org/10.1155/2019/6821310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446119PMC
March 2019

Preparation of Xylan--/P(AA--AM)/GO Nanocomposite Hydrogel and its Adsorption for Heavy Metal Ions.

Polymers (Basel) 2019 Apr 4;11(4). Epub 2019 Apr 4.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.

Xylan--/P(AA--AM)/Graphene oxide (GO) hydrogels were prepared and used in the removal of heavy mental ions. Acrylamide (AM), acrylic acid (AA), and xylan were used as the raw materials to prepare the hydrogels with ammonium persulfate (APS) as the initiator. The prepared hydrogels were characterized by Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), and energy dispersive X-ray (EDX). Some important properties of nanocomposite hydrogels such as swelling behavior, mechanical property, and adsorption capacity were also examined as well as the regeneration of the hydrogels. The results showed that the prepared hydrogels reached the equilibrium state of swelling after 12 h, and the compressive strength of the hydrogel with 30 mg of GO could reach up to 203 kPa. Compared with traditional hydrogel, the mechanical properties of the hydrogels with GO were obviously improved. The maximum adsorption capacity of hydrogels for Pb, Cd, and Zn could reach up to 683 mg/g, 281 mg/g, and 135 mg/g, respectively. After five cycles of adsorption and desorption, the recovery rate of the hydrogels on Pb, Cd, and Zn was still up to 87%, 80%, and 80%, respectively-all above 80%.
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http://dx.doi.org/10.3390/polym11040621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523173PMC
April 2019

Effects of nano-ZnO and nano-SiO particles on properties of PVA/xylan composite films.

Int J Biol Macromol 2019 Jul 14;132:978-986. Epub 2019 Mar 14.

State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China. Electronic address:

The effects of nano-ZnO and nano-SiO on the properties of PVA/xylan composite films were investigated in this work. Results showed that nano-ZnO and nano-SiO could effectively improve the mechanical strength, moisture and oxygen barrier properties and surface hydrophobic property of the composite films. The results of FTIR and XRD indicated the interaction of hydrogen bonds between nanoparticles and PVA and xylan. When the contents of nano-ZnO and nano-SiO in the composite films were 3%, the tensile strength was increased to 20.4 MPa and 22.5 MPa, respectively, while water vapor permeability (3.14 and 3.03 × 10 g·m·s·Pa) and oxygen permeability (5.28 and 5.003 cm·m·24 h·0.1 MPa) reached the minima. With the increase of nano-ZnO and nano-SiO dosage, the solubility of composite films was increased. When the contents of nano-ZnO and nano-SiO were 3% and 4%, respectively, the contact angles of the films was increased up to 101° and 78°. Besides, the composite films with nano-ZnO exhibited UV shielding performance, whereas the ones with nano-SiO had similar UV light-transparency to the pure PVA/xylan composite films.
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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.088DOI Listing
July 2019

A new and highly efficient conservation treatment for deacidification and strengthening of aging paper by in-situ quaternization.

Carbohydr Polym 2019 Apr 11;209:250-257. Epub 2019 Jan 11.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, China. Electronic address:

Ancient papers, facing the threat of acidification, aging and microbial corrosion, need to be repaired due to their significance of history, art and culture research. In this work, a new and highly efficient approach was proposed to deacidify and strengthen aging paper by in-situ quaternization for the conservation, in which MgO nanoparticles dispersed in hexamethyldisiloxane was coated on the paper surface and the aqueous alkaline solution and the 2, 3-epoxypropyl trimethyl ammonium chloride/isopropyl alcohol/water mixture were sprayed in a closed reactor. Results showed that properties of ageing papers were improved after MSCE-8/2 treatment. The pH value was in the range of 7.5-9.0 and the maximum amount of alkali storage was 220 mmol/Kg. The tensile strength and folding endurance were increased by 28.05% and 80%, respectively. The fluctuation range of brightness and chromatic aberration was 0.14 and 1.27. Moreover, treated paper also had the great anti-bacteria and anti-aging effects.
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http://dx.doi.org/10.1016/j.carbpol.2019.01.034DOI Listing
April 2019

Xylan-Based Hydrogels as a Potential Carrier for Drug Delivery: Effect of Pore-Forming Agents.

Pharmaceutics 2018 Dec 5;10(4). Epub 2018 Dec 5.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, 510640 Guangzhou, China.

Pore-forming agents have a significant influence on the pore structure of hydrogels. In this study, a porogenic technique was employed to investigate the preparation of macroporous hydrogels which were synthesized by radical copolymerization of carboxymethyl xylan with acrylamide and -isopropylacrylamide under the function of a cross-linking agent. Six kinds of pore-forming agents were used: polyvinylpyrrolidone K30, polyethylene glycol 2000, carbamide, NaCl, CaCO₃, and NaHCO₃. The application of these hydrogels is also discussed. The results show that pore-forming agents had an important impact on the pore structure of the hydrogels and consequently affected properties of the hydrogels such as swelling ratio and mechanical strength, while little effect was noted on the thermal property of the hydrogels. 5-Fluorouracil was used as a model drug to study the drug release of the as-prepared hydrogels, and it was found that the drug release was substantially improved after using the NaHCO₃ pore-forming agent: a cumulative release rate of up to 71.05% was achieved.
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http://dx.doi.org/10.3390/pharmaceutics10040261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321516PMC
December 2018

A one-pot strategy for preparation of high-strength carboxymethyl xylan-g-poly(acrylic acid) hydrogels with shape memory property.

J Colloid Interface Sci 2019 Mar 6;538:507-518. Epub 2018 Dec 6.

Key Laboratory of Pulp & Paper Science and Technology Ministry of Education, Qilu University of Technology, Jinan, Shandong 250353, China.

High strength hydrogels open new possibilities in the fields of bioengineering and biomedical. In this paper, a highly efficient one-pot strategy was developed to prepare carboxymethyl xylan-g-poly (acrylic acid) (CMX-g-PAA) hydrogels with high compression strength, high elongation and high elasticity by using the metal coordination and the reinforcement of hydroxylate multi-walled carbon nanotubes (HCNTs). Prepared hydrogels were characterized by means of FTIR, XRD, SEM, rheological measurements as well as their swelling and mechanical properties. Results showed that the Fe-carboxyl coordination and HCNTs imparted hydrogels with high strength and good rapid recovery properties, in which the maximum high compressive strength and elongation at break were achieved to 10.4 MPa and 1032%, and the shape of hydrogels almost returned to the original shape after the external force was removed after 30 cycles of compression. These hydrogels also exhibited Fe-triggered shape memory properties. Therefore, as-prepared hydrogels possessing high strength, rapid recovery and shape memory properties, could broaden access for application in intelligent toys, electronic skin, biosensing, and tissue engineering.
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http://dx.doi.org/10.1016/j.jcis.2018.12.023DOI Listing
March 2019

Comparison of three fixation modalities for unilateral open-door cervical laminoplasty: a systematic review and network meta-analysis.

Neurosurg Rev 2020 Jun 27;43(3):813-823. Epub 2018 Sep 27.

School of Chinese Medicine, Jinan University, 601 Huangpu Dadao Road, Guangzhou, 510632, Guangdong Province, China.

Three fixation modalities including suture suspensory, anchor, and titanium plate are used extensively in unilateral open-door cervical laminoplasty. Nevertheless, up to now no systematic review and network meta-analysis have been published, and the differences in efficacy and safety of the three fixation modalities are still unclear. The purpose of this study is to compare the effectiveness and safety of the three fixation modalities including suture suspensory, anchor, and titanium plate in unilateral open-door cervical laminoplasty. Randomized controlled trials and cohort studies which compared the three interventions in unilateral open-door cervical laminoplasty were identified using the following databases: PubMed, Cochrane Library, Embase, Web of science, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Wanfang data. Network meta-analysis was performed using R 3.4.3 software and STATA version 14.0. The results revealed that compared with suture suspensory, titanium plate and anchor showed the same effects in Japanese Orthopedic Association Scores, operative time, and blood loss. However, titanium plate showed superiority in postoperative range of motion of cervical spine, incidence of axial symptoms, and C5 paralysis; in terms of cervical curvature, titanium plate also showed better effectiveness than suture suspensory, but similar as anchor. Our network meta-analysis suggests that titanium plate is preferable to suture suspensory or anchor with more range of motion and lower incidence of axial symptoms and C5 paralysis. However, considering the limitations of this research, high-quality trials are needed in the future to evaluate the outcomes.
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http://dx.doi.org/10.1007/s10143-018-1035-0DOI Listing
June 2020

Exercise therapy versus surgery for lumbar spinal stenosis: A systematic review and meta-analysis.

Pak J Med Sci 2018 Jul-Aug;34(4):879-885

Shujie Tang, School of Chinese Medicine, Jinan University, Guangzhou, Guangdong Province, 510632, China.

Objective: To compare the effectiveness of exercise therapy with surgery for lumbar spinal stenosis.

Methods: Five English databases PubMed, the Cochrane Library, Web of science, OVID and PEDro database were searched for randomized controlled trials comparing surgical procedures with exercise therapy for lumbar spinal stenosis. Information on patients, study design, inclusion criteria, intervention and follow-up, outcomes, treatment details and adverse events were extracted. Meta-analysis was performed using Review Manager Version 5.3.

Results: Two randomized controlled trials and one mixed design trial with a total of 897 patients were included. The pooled results showed a significant difference between exercise and surgery in Oswestry Disability Index at two years (MD= 3.85, 95%CI: 0.48 to 7.22; P=0.03), but no significant difference at six months (MD= 2.18, 95%CI: -2.80 to 7.17; P=0.39) and one year (MD= 4.26, 95%CI: -1.79 to 10.32; P=0.17). In terms of physical function of 36 Items Short Form Health Survey, there were no significant differences between exercise and surgery at six months (MD= -2.23, 95% CI: -7.46 to 2.99; P=0.40), one year (MD= -2.17, 95% CI: -7.44 to 3.10; P=0.42) and two years (MD= -0.67, 95% CI: -6.16 to 4.82; P=0.81).

Conclusion: In brief, the current evidence demonstrated a trend that exercise therapy had a similar effect for lumbar spinal stenosis compared with decompressive laminectomies. However, for the small sample size and low methodology quality of the included trials, some rigorously designed and large-scaled RCTs need to be performed to confirm the conclusion.
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http://dx.doi.org/10.12669/pjms.344.14349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115590PMC
September 2018

Comparative effectiveness and safety of posterior lumbar interbody fusion, Coflex, Wallis, and X-stop for lumbar degenerative diseases: A systematic review and network meta-analysis.

Clin Neurol Neurosurg 2018 09 30;172:74-81. Epub 2018 Jun 30.

School of Chinese Medicine, Jinan University, Guangzhou, Guangdong province, 510632, China. Electronic address:

Posterior lumbar interbody fusion and lumbar interspinous non-fusion technique are common surgical procedures for lumbar degenerative diseases, but the effectiveness and safety of these two techniques are still unclear. We performed this network meta-analysis to evaluate the comparative effectiveness and safety of posterior lumbar interbody fusion and the three commonly used interspinous devices including Coflex, Wallis, and X-stop for lumbar degenerative diseases. Randomized controlled trials and cohort studies comparing among posterior lumbar interbody fusion, Coflex, Wallis, and X-stop for lumbar degenerative diseases were identified using the databases including PubMed, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Wanfang data. A network meta-analysis was performed using R 3.4.3 software. 27 studies with 2241 patients were included. The results of network meta-analysis revealed that no significant differences in Oswestry Disability Index, Visual Analogue Scale, Japanese Orthopedic Association Scores, and posterior disc height were found among posterior lumbar interbody fusion group, Coflex, Wallis, or X-stop. However, compared with posterior lumbar interbody fusion, the three interspinous process devices presented with significantly more range of motion in surgical segment, but no significant difference was found among these three interspinous process devices. Node-splitting analysis showed no significant inconsistency in our network meta-analysis. We concluded that compared with posterior lumbar interbody fusion, Coflex, Wallis and X-stop had the same effectiveness in relieving pain, improving quality of life, recovering disc space height and lumbar function, but may lower incidence of adjacent segment degeneration.
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http://dx.doi.org/10.1016/j.clineuro.2018.06.030DOI Listing
September 2018

Carbon Nanotubes Reinforced Maleic Anhydride-Modified Xylan-g-Poly(N-isopropylacrylamide) Hydrogel with Multifunctional Properties.

Materials (Basel) 2018 Feb 28;11(3). Epub 2018 Feb 28.

State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering, South China University of Technology, Guangzhou 510640, China.

Introducing multifunctional groups and inorganic material imparts xylan-based hydrogels with excellent properties, such as responsiveness to pH, temperature, light, and external magnetic field. In this work, a composite hydrogel was synthesized by introducing acid treated carbon nanotubes (AT-CNTs) into the maleic anhydride modified xylan grafted with poly(N-isopropylacrylamide) (MAX-g-PNIPAM) hydrogels network. It was found that the addition of AT-CNTs affected the MAX-g-PNIPAM hydrogel structure, the swelling ratio and mechanical properties, and imparted the hydrogel with new properties of electrical conductivity and near infrared region (NIR) photothermal conversion. AT-CNTs could reinforce the mechanical properties of MAX-g-PNIPAM hydrogels, being up to 83 kPa for the compressive strength when the amount was 11 wt %, which was eight times than that of PNIPAM hydrogel and four times than that of MAX-g-PNIPAM hydrogel. The electroconductibility was enhanced by the increase of AT-CNTs amounts. Meanwhile, the composite hydrogel also exhibited multiple shape memory and NIR photothermal conversion properties, and water temperature was increased from 26 °C to 56 °C within 8 min under the NIR irradiation. Thus, the AT-CNTs reinforced MAX-g-PNIPAM hydrogel possessed promising multifunctional properties, which offered many potential applications in the fields of biosensors, thermal-arrest technology, and drug-controlled release.
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http://dx.doi.org/10.3390/ma11030354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872933PMC
February 2018
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