Publications by authors named "Minjae Cho"

7 Publications

  • Page 1 of 1

The novel prognostic value of postoperative follow-up lateral spread response after microvascular decompression for hemifacial spasm.

J Neurosurg 2021 Sep 3:1-5. Epub 2021 Sep 3.

Departments of1Neurosurgery.

Objective: The lateral spread response (LSR) is an aberrant electrophysiological response in which a stimulus on one branch of the facial nerve spills over to other branches of the nerve, which can be captured by electrodes near each branch. The authors performed this study to evaluate the prognostic value of the follow-up LSR with a sufficient time interval from intraoperative LSR (IO-LSR) after microvascular decompression (MVD) for hemifacial spasm (HFS), excluding the interference of various intraoperative situations.

Methods: A total of 247 patients treated with MVD for HFS between June 2011 and March 2019 were enrolled in this study. The IO-LSR was routinely evaluated in all patients. The LSR was checked again on postoperative day (POD) 2 after surgery (POD2-LSR). A total of 228 patients (92.3%) were considered cured at the last clinical follow-up.

Results: The IO-LSR disappeared in 189 patients (76.5%), and among them, 181 patients (95.8%) were cured 1 year after surgery. The POD2-LSR disappeared in 193 patients (78.1%), and 185 patients (95.9%) among them were cured. Among the 189 patients in which the IO-LSR disappeared, the POD2-LSR reappeared in 26 patients (13.8%). In contrast, the POD2-LSR disappeared in 30 (51.7%) of 58 patients for whom the IO-LSR continued at the end of surgery. When classified into groups according to the status of the IO-LSR and POD2-LSR, in the group of patients in whom both LSRs disappeared, the cure rate was 98.2%, which was significantly higher than that of the other 3 groups (p < 0.05, Cochran-Armitage trend test). The use of both LSRs was found to be significantly associated with better predictability (p < 0.05, McNemar's test).

Conclusions: Postoperative follow-up LSR examination may be beneficial in predicting clinical outcomes after MVD for HFS, especially when considered together with IO-LSR.
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http://dx.doi.org/10.3171/2021.3.JNS21137DOI Listing
September 2021

Clinical Factors Associated with Balance Function in the Early Subacute Phase after Stroke.

Am J Phys Med Rehabil 2021 Jul 27. Epub 2021 Jul 27.

Department of Physical Medicine and Rehabilitation, Korea University College of Medicine, Seoul, Republic of Korea Brain Convergence Research Center, Korea University, Seoul, Republic of Korea Department of Biomedical Sciences, Korea University, Seoul, Republic of Korea.

Objective: To investigate the key factors of balance function in the early subacute phase after stroke.

Design: Ninety-four stroke patients were included. Multiple variables were evaluated, including demographic factors, clinical variables (stroke type; lesion site; Korean Mini-Mental State Examination [MMSE]; motor strength of the hip, knee, and ankle joints; Fugl-Meyer Assessment of lower extremity [FMA-LE]); neurophysiologic variables (amplitude ratio of somatosensory evoked potential [SEP] of the tibial nerves), and laterality index of fractional anisotropy (FA-LI) of the corticospinal tract using diffusion tensor imaging. Balance function was measured using the Berg balance scale (BBS).

Results: The BBS score was significantly negatively correlated with age and FA-LI and positively correlated with MMSE; FMA-LE; motor strength of the affected hip, knee, and ankle joint; and SEP amplitude ratio (p < 0.05). The abnormal SEP group and poor integrity of the corticospinal tract group showed significantly decreased BBS scores. In multivariable logistic regression analysis, age, FMA-LE score, and ankle plantar flexion strength were significantly associated with balance function (odds ratios: 0.919, 1.181, and 15.244, respectively, p < 0.05).

Conclusion: Higher age, severe initial motor impairment, and strength of the affected lower extremity muscles, especially the ankle plantar flexor, are strongly associated with poor balance function early after stroke.
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http://dx.doi.org/10.1097/PHM.0000000000001856DOI Listing
July 2021

The Role of Adjuvant Treatment in Patients with High-Grade Meningioma.

J Korean Neurosurg Soc 2017 Sep 30;60(5):527-533. Epub 2017 Aug 30.

Department of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Objective: To investigate the efficacy of adjuvant treatment in patients with high-grade meningioma.

Methods: A retrospective analysis was performed for patients with high-grade meningioma, World Health Organization grade 2 or 3, in a single center between 2003 and 2014. The patients were reviewed according to age at diagnosis, sex, the location of meningioma, degree of tumor resection, histological features, and type of adjuvant treatment. These factors were analyzed by Firth logistic regression analyses.

Results: Fifty-three patients with high-grade meningioma were enrolled. Thirty-four patients received adjuvant treatment; conventional radiotherapy or radiosurgery. Clinical follow-up ranged from 13-113 months with a median follow-up of 35.5 months. Gross total removal (GTR), Simpson grade 1 or 2, was achieved in 29 patients and, among them, 13 patients received adjuvant treatment. In the other 24 patients with non-GTR, conventional adjuvant radiotherapy and radiosurgery were performed in 11 and 10 patients, respectively. The other 3 patients did not receive any adjuvant treatment. Radiation-related complications did not occur. Of the 53 patients, 19 patients had suffered from recurrence. The recurrence rate in the adjuvant treatment group was 23.5% (8 out of 34). On the other hand, the rate for the non-adjuvant treatment group was 57.9% (11 out of 19) (odds ratio [OR]=0.208, p=0.017). In the GTR group, the recurrence rate was 7.5% (1 out of 13) for patients with adjuvant treatment and 50% (8 out of 16) for patients without adjuvant treatment (OR=0.121, p=0.04).

Conclusion: Adjuvant treatment appears to be safe and effective, and could lead to a lower recurrence rate in high-grade meningioma, regardless of the extent of removal. Our results might be used as a reference for making decisions when planning adjuvant treatments for patients with high-grade meningioma after surgery.
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http://dx.doi.org/10.3340/jkns.2016.1111.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594630PMC
September 2017

Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy.

Brain Tumor Res Treat 2016 Apr 29;4(1):35-9. Epub 2016 Apr 29.

Seoul National University College of Medicine, Seoul, Korea.; Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Extra ventricular neurocytoma (EVN) is a rare brain tumor with histologic features similar with a central neurocytoma, but located outside of the ventricular system. In this study, we present an unusual case of hypothalamic EVN in a 14-year-old patient. The patient underwent subtotal removal and had tumor relapse. The patient was then treated using intensity modulated radiation therapy, and the tumor remained stable for 24 months. This case report may be important in that this is the first pediatric case of EVN located in the hypothalamic region. EVN has similar radiologic features with pilocytic astrocytomas and therefore a hypothalamic EVN may be misdiagnosed as a hypothalamic glioma. Also, the pathologic-radiologic-clinical correlation of EVN located in the hypothalamic area may be different from that of EVNs originating from other usual sites.
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http://dx.doi.org/10.14791/btrt.2016.4.1.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868816PMC
April 2016

Design and Evaluation of ω-Hydroxy Fatty Acids Containing α-GalCer Analogues for CD1d-Mediated NKT Cell Activation.

ACS Med Chem Lett 2014 Apr 4;5(4):331-5. Epub 2014 Feb 4.

College of Pharmacy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.

CD1d molecules recognize glycolipid antigens with straight chain fatty acid moieties. Although most of the residues in the CD1d binding groove are hydrophobic, some of the amino acids can form hydrogen bonds. Consequently, we have designed ω-hydroxy fatty acid-containing glycolipid derivatives of the prototypical CD1d ligand α-GalCer. The potency of the ω-hydroxy analogues of the proper length is comparable to that of α-GalCer. We propose, based on the biological results and molecular modeling studies, that a hydrogen bonding interaction is involved between the ω-hydroxy group and a polar amino acid residue in the hydrophobic binding groove.
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http://dx.doi.org/10.1021/ml400517bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027640PMC
April 2014

Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide.

Bioorg Med Chem Lett 2007 Aug 2;17(16):4584-7. Epub 2007 Jun 2.

College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Republic of Korea.

The amide bond of ceramide was replaced by the non-hydrolyzable 1,2,3-triazole functionality. Click chemistry was employed for synthesis of the designed analogues. Our preliminary biological evaluation indicated that the amide moiety of ceramide is amenable to bioisosteric substitution with the triazole moiety. Some of the analogues were more potent than C2-ceramide as cytotoxic agents, and the observed cytotoxicity was possibly mediated through the induction of apoptosis.
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http://dx.doi.org/10.1016/j.bmcl.2007.05.086DOI Listing
August 2007

Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant alpha-GalCer.

J Med Chem 2007 Feb;50(3):585-9

College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Korea.

alpha-GalCer is the first defined and most potent agonistic antigen of the T cell receptor of natural killer T cells. We have prepared a series of 1,2,3-triazole-containing alpha-GalCer analogues in which the lipid chain lengths have been incrementally varied. We found that this isosteric replacement of alpha-GalCer's amide moiety with triazole increases the IL-4 versus IFN-gamma bias of released cytokines. The stimulatory effect was influenced by the length of the attached chain. In particular, the long-chained triazole analogues have a comparable stimulatory effect on cytokine production as alpha-GalCer and exhibit a stronger Th2 cytokine response.
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http://dx.doi.org/10.1021/jm061243qDOI Listing
February 2007
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