Prof Dr Minja Gerber, BPharm, MSc, PhD - North-West University

Prof Dr Minja Gerber

BPharm, MSc, PhD

North-West University

Potchefstroom, North-West Province | South Africa

Main Specialties: Other

Additional Specialties: Transdermal and topical drug delivery of pharmaceuticals and cosmeceuticals; Drug delivery optimization; nano-emulsions; vesicle systems

ORCID logohttps://orcid.org/0000-0002-1473-5767


Top Author

Prof Dr Minja Gerber, BPharm, MSc, PhD - North-West University

Prof Dr Minja Gerber

BPharm, MSc, PhD

Introduction

I obtained my BPharm at the end of 2001 and began my research in 2002 with my MSc in Pharmaceutical Chemistry at Potchefstroom University for Christian Higher Education and synthesised novel derivatives of acetylsalicylic acid which I tested transdermally. In 2003, I obtained my MSc (Cum Laude). In January 2004 I started with my PhD in Pharmaceutical Chemistry at the North-West University where I studied zalcitabine and lamivudine. I synthesised novel derivatives of lamivudine and tested them transdermally with and without the use of Pheroid™ (drug delivery system).

In 2008, I accepted a position at the North-West University (after completing community service and working as pharmacist in the private sector) as a Senior Lecturer in the Centre of Excellence for Pharmaceutical Sciences (Pharmacen™) at the North-West University. In 2018, I was promoted to associate-professor. My focus areas are currently nano-emulsions together with topical and transdermal drug delivery of pharmaceuticals and cosmeceuticals.

At present, I am the author/co-author of 29 International, peer-reviewed, ISI publications and have presented my research results at various scientific conferences, nationally and internationally. I have been invited and reviewed numerous publications for numerous journals since 2009. Since 2006 I have been involved in 52 postgraduate students (4 Post-doc, 7 PhD, 40 MSc and 1 Hons); 40 postgraduate students have successfully completed their studies of which 17 of them, passed with distinction. Of the 52 postgraduate students, I am currently leader/co-leader of 1 PhD students, 10 MSc and 1 Hons students. In 2016, Ms C Csongradi, to whom I was supervisor (Co-supervisor: Prof J du Plessis and Assistant-supervisor: Prof ME Aucamp), received the Vice-Chancellor’s medal for the best Master’s degree student in the Faculty of Health Sciences at the NWU, Potchefstroom campus.

I have received several research grants of which I am the principal investigator, namely:
• NRF (National Research Fund): Thuthuka from 2012-2014;
• NRF: CSUR (Competitive Support for Unrated Researchers) from 2017-2019 and
• joint principal investigator (with Prof ME Aucamp and Prof J du Plessis) of Technology Innovation Agency (TIA) Seed Fund
Programme for 2016/2017.

In June - December 2012 I completed a Sabbatical at the Division of Drug Delivery Technology, LACDR (Leiden Academic Centre for Drug Research), Leiden University, The Netherlands under the guidance of Prof Joke Bouwstra with funding I from The Researcher Development Program: Strategic Project 6, NWU.

Primary Affiliation: North-West University - Potchefstroom, North-West Province , South Africa

Specialties:

Additional Specialties:

Research Interests:


View Prof Dr Minja Gerber’s Resume / CV

Education

Sep 2007
North-West University (NWU): Potchefstroom Campus
Philosophiae Doctor (PhD): Pharmaceutical Chemistry
Jan 2004 - Dec 2006
North-West University
PhD
Pharmaceutical Chemistry
May 2004
NWU previously registered as Potchefstroom University for Christian Higher Education (PU for CHE)
Magister Scientiae (MSc): Pharmaceutical Chemistry
Cum Laude
Mar 2002
NWU previously registered as PU for CHE
Baccalaureus Pharmaciae (BPharm)
Jan 1997 - Dec 2001
North-West University (Former Potchefstroom University for Christian Higher Education)
BPharm

Experience

Dec 2018
NRF GRANT for 2019: COMPETITIVE SUPPORT FOR UNRATED RESEARCHERS (CSUR)
Grant-holder and principal investigator
Grant
Dec 2018
NRF GRANT for 2019: COMPETITIVE SUPPORT FOR UNRATED RESEARCHERS (CSUR)
Grant-holder
Grant
Dec 2018
NRF GRANT for 2019: COMPETITIVE SUPPORT FOR UNRATED RESEARCHERS (CSUR)
Grant-holder
Grant
Dec 2017
NRF GRANT for 2018: COMPETITIVE SUPPORT FOR UNRATED RESEARCHERS (CSUR)
Grant-holder and principal investigator
Grant
Dec 2016
NRF GRANT for 2017: COMPETITIVE SUPPORT FOR UNRATED RESEARCHERS (CSUR)
Grant-holder and principal investigator
Grant
Nov 2016
Ms C Csongradi received the Vice-Chancellor’s medal for the best Master’s degree student in the Faculty of Health Sciences at the NWU, Potchefstroom campus
Supervisor: Prof M Gerber; Co-supervisor: Prof J du Plessis and Assistant-supervisor: Prof ME Aucamp
Award
Sep 2016
Technology Innovation Agency (TIA) Seed Fund
Joint principal investigator (with Dr ME Aucamp and Prof J du Plessis)
Grant
Dec 2013
NRF GRANT FOR 2014: THUTHUKA FUNDING INSTRUMENT
Grant-holder and principal investigator
Grant
Mar 2013
NRF GRANT FOR 2013: THUTHUKA FUNDING INSTRUMENT
Grant-holder and principal investigator
Grant
Mar 2013
NRF GRANT FOR 2013: THUTHUKA FUNDING INSTRUMENT
Grant-holder and principal investigator
Grant
Jul 2012
NRF GRANT FOR 2012: THUTHUKA FUNDING INSTRUMENT
Grant-holder and principal investigator
Grant
Jun 2011
Researcher Development Program: Strategic Project 6 for Sabbatical at the Division of Drug Delivery Technology, LACDR (Leiden Academic Centre for Drug Research), Leiden University, The Netherlands
Sabbatical under the guidance of Prof J Bouwstra
Award
Mar 2008 - Dec 2010
Dis-Chem
Pharmacist
Mar 2008 - Mar 2008
Dis-Chem Pharmacies
Pharmacist
Private sector
Mar 2007 - Feb 2008
Free State Department of Health
Com-Serve
Jan 2004 - Dec 2006
North-West University
Junior Researcher
Pharmaceutical Chemistry
Jan 2004 - Dec 2006
North-West University
Junior Researcher
Pharmaceutical Chemistry
Sep 2006
Ms E-M Holmes won the “Young Scientist” award after a podium presentation at The 4th ICPPS Congress in Vanderbijlpark, South Africa
Supervisor: Prof JC Breytenbach; Co-supervisor: Prof J du Plessis and Assistant-supervisor: Ms M Gerber
Award
Jan 2002 - Dec 2003
North-West University (Former Potchefstroom University for Christian Higher Education)
Academic Intern
Pharmaceutical Chemistry
Jan 2018
North West University Faculty of Health Sciences
Associate Professor
Centre of Excellence for Pharmaceutical Sciences (Pharmacen™)
North-West University , South Africa

Publications

29Publications

413Reads

427Profile Views

53PubMed Central Citations

Formulation of Natural Oil Nano-Emulsions for the Topical Delivery of Clofazimine, Artemisone and Decoquinate.

Pharm Res 2018 Aug 7;35(10):186. Epub 2018 Aug 7.

Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.1007/s11095-018-2471-9DOI Listing
August 2018
9 Reads
3.420 Impact Factor

Traversing the Skin Barrier with Nano-emulsions.

Curr Drug Deliv 2017 ;14(4):458-472

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.2174/1567201813666160824125444DOI Listing
May 2018
17 Reads
1 Citation
2.250 Impact Factor

Topical Delivery of Crude Extracts in Niosomes and Solid Lipid Nanoparticles.

Pharmacogn Mag 2017 Oct 11;13(Suppl 3):S663-S671. Epub 2017 Oct 11.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.4103/pm.pm_489_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669113PMC
October 2017
56 Reads
1.112 Impact Factor

Topical delivery of roxithromycin solid-state forms entrapped in vesicles.

Eur J Pharm Biopharm 2017 May 22;114:96-107. Epub 2017 Jan 22.

Centre of Excellence for Pharmaceutical Sciences (Pharmacen), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.01.006DOI Listing
May 2017
12 Reads
3.383 Impact Factor

In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species.

J Ethnopharmacol 2017 Mar 14;200:1-7. Epub 2017 Feb 14.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.02.017DOI Listing
March 2017
14 Reads
2 Citations
3.000 Impact Factor

Topical delivery of acyclovir and ketoconazole.

Drug Deliv 2016 9;23(2):631-41. Epub 2014 Jul 9.

a Faculty of Health Sciences , Centre of Excellence for Pharmaceutical Sciences, North-West University , Potchefstroom , South Africa.

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http://dx.doi.org/10.3109/10717544.2014.933283DOI Listing
December 2016
10 Reads
2.202 Impact Factor

In vitro skin permeation of sinigrin from its phytosome complex.

J Pharm Pharmacol 2016 Dec 2;68(12):1577-1583. Epub 2016 Oct 2.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.1111/jphp.12594DOI Listing
December 2016
11 Reads
1 Citation
2.161 Impact Factor

Penetration enhancing effects of selected natural oils utilized in topical dosage forms.

Drug Dev Ind Pharm 2015 10;41(12):2045-54. Epub 2015 Jul 10.

a Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University , Potchefstroom , South Africa.

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http://dx.doi.org/10.3109/03639045.2015.1047847DOI Listing
August 2016
6 Reads
2 Citations
2.010 Impact Factor

Treatment Modalities for Acne.

Molecules 2016 Aug 13;21(8). Epub 2016 Aug 13.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.3390/molecules21081063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273829PMC
August 2016
7 Reads
3 Citations
2.420 Impact Factor

Physical stability and clinical efficacy of Crocodylus niloticus oil lotion.

Rev. bras. farmacogn., 26(4):521-529. Epub 2016 May 23 (DOI: 10.1016/j.bjp.2016.03.011)

Revista Brasileira de Farmacognosia

Abstract: The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined.  The lotion was stored at controlled conditions over six months during which several stability tests were performed.  For the clinical efficacy studies lotion was applied on volar forearm skin (female volunteers) and compared to a liquid paraffin-containing reference product.  Skin hydrating and anti-ageing effects were determined with a Corneometer®, Cutometer® and Visioscan®, following single (three hours) and multiple applications (twelve weeks).  The Vapometer® and Mexameter® were utilized to determine this lotion’s anti-erythema effects on sodium lauryl sulfate irritated skin.  The lotion demonstrated good stability over 6 months.  The reference product increased skin hydration and decreased skin wrinkles to a larger extent than the C. niloticus lotion after a single application, whereas the C. niloticus lotion decreased skin scaliness better than the reference product.  During the long-term study, the reference product overall increased skin hydration more than the C. niloticus lotion, whereas C. niloticus lotion increased skin elasticity to a larger extent than the reference product.  C. niloticus lotion increased skin wrinkles and decreased skin scaliness over 12 weeks.  Compared to non-treated, irritated skin, C. niloticus lotion demonstrated some potential anti-inflammatory characteristics.

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July 2016
1 Read

Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P.

Pharmazie 2016 Jun;71(6):311-9

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June 2016
12 Reads
1.003 Impact Factor

A novel RP-HPLC method for the detection and quantification of roxithromycin in topical delivery studies.

Pharmazie 2016 Apr;71(4):175-6

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April 2016
9 Reads
1.003 Impact Factor

In vitro skin permeation of artemisone and its nano-vesicular formulations.

Int J Pharm 2016 Apr 27;503(1-2):1-7. Epub 2016 Feb 27.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2016.02.041DOI Listing
April 2016
8 Reads
2 Citations
3.650 Impact Factor

Vesicular carriers for skin drug delivery: the Pheroid™ technology.

Curr Pharm Des 2015 ;21(20):2758-70

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

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March 2016
9 Reads
3.452 Impact Factor

Essential Fatty Acids as Transdermal Penetration Enhancers.

J Pharm Sci 2016 Jan 13;105(1):188-93. Epub 2016 Jan 13.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2015.11.032DOI Listing
January 2016
12 Reads
1 Citation
2.590 Impact Factor

Topical Delivery of 5-Fluorouracil from Pheroid™ Formulations and the In Vitro Efficacy Against Human Melanoma.

AAPS PharmSciTech 2015 Dec 9;16(6):1390-9. Epub 2015 May 9.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.1208/s12249-015-0328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666243PMC
December 2015
8 Reads
1.780 Impact Factor

Optimised transdermal delivery of pravastatin.

Int J Pharm 2015 Dec 23;496(2):518-25. Epub 2015 Oct 23.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.1016/j.ijpharm.2015.10.034DOI Listing
December 2015
11 Reads
3.650 Impact Factor

Stability, clinical efficacy, and antioxidant properties of Honeybush extracts in semi-solid formulations.

Pharmacogn Mag 2015 Oct;11(Suppl 2):S337-51

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, South Africa.

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http://dx.doi.org/10.4103/0973-1296.166063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653346PMC
October 2015
14 Reads
1 Citation
1.112 Impact Factor

Bioactive albumin-based carriers for tumour chemotherapy.

Curr Cancer Drug Targets 2014 ;14(8):752-63

Centre of Excellence for Pharmaceutical Sciences, North-West University, South Africa.

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July 2015
14 Reads
1 Citation
3.522 Impact Factor

Breaching the skin barrier through temperature modulations.

J Control Release 2015 Mar 20;202:1-13. Epub 2015 Jan 20.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.1016/j.jconrel.2015.01.019DOI Listing
March 2015
47 Reads
2 Citations
7.705 Impact Factor

Skin permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox.

J Pharm Pharmacol 2015 Jan 5;67(1):96-106. Epub 2014 Sep 5.

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.1111/jphp.12311DOI Listing
January 2015
14 Reads
3 Citations
2.161 Impact Factor

Review of natural compounds for potential skin cancer treatment.

Molecules 2014 Aug 6;19(8):11679-721. Epub 2014 Aug 6.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.3390/molecules190811679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271439PMC
August 2014
36 Reads
28 Citations
2.420 Impact Factor

In Vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications.

Pharmacogn Mag 2014 Apr;10(Suppl 2):S392-403

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.4103/0973-1296.133291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078333PMC
April 2014
23 Reads
4 Citations
1.112 Impact Factor

Topical and transdermal delivery of L-carnitine.

Skin Pharmacol Physiol 2011 11;24(6):330-6. Epub 2011 Aug 11.

Unit for Drug Research and Development, North-West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.1159/000330385DOI Listing
January 2012
11 Reads
1 Citation
2.370 Impact Factor

Transdermal Drug Delivery Enhancement by Compounds of Natural Origin

Fox, L.T. et al. 2011. Transdermal drug delivery enhancement by compounds of natural origin. Molecules, 16(12):10507-10540. [https://doi.org/10.3390/molecules161210507]

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December 2011
9 Reads

Synthesis and transdermal penetration of stavudine-5'-esters.

Med Chem 2010 Sep;6(5):271-6

Pharmaceutical Chemistry, Unit for Drug Research and Development, North-West University, Potchefstroom 2520, South Africa.

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September 2010
6 Reads
1 Citation
1.390 Impact Factor

Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine esters.

Int J Pharm 2008 Mar 6;351(1-2):186-93. Epub 2007 Oct 6.

Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.1016/j.ijpharm.2007.09.040DOI Listing
March 2008
7 Reads
3.650 Impact Factor

Synthesis and transdermal properties of acetylsalicylic acid and selected esters.

Int J Pharm 2006 Mar 26;310(1-2):31-6. Epub 2006 Jan 26.

Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom 2520, South Africa.

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http://dx.doi.org/10.1016/j.ijpharm.2005.11.018DOI Listing
March 2006
23 Reads
3.650 Impact Factor