Mingzhan Xue

Mingzhan Xue

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Mingzhan Xue

Mingzhan Xue

Publications by authors named "Mingzhan Xue"

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Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal.

Sci Rep 2019 May 27;9(1):7889. Epub 2019 May 27.

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry, CV2 2DX, UK.

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http://dx.doi.org/10.1038/s41598-019-44358-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536510PMC
May 2019

Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage.

Oxid Med Cell Longev 2018 22;2018:5642148. Epub 2018 Nov 22.

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK.

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https://www.hindawi.com/journals/omcl/2018/5642148/
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http://dx.doi.org/10.1155/2018/5642148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282131PMC
February 2019

Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy.

Semin Cancer Biol 2018 04 12;49:83-93. Epub 2017 May 12.

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospitals, Coventry CV2 2DX, UK; Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.05.006DOI Listing
April 2018

Reappraisal of putative glyoxalase 1-deficient mouse and dicarbonyl stress on embryonic stem cells in vitro.

Biochem J 2016 Nov 26;473(22):4255-4270. Epub 2016 Sep 26.

Warwick Medical School, Clinical Sciences Research Laboratories, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.

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http://dx.doi.org/10.1042/BCJ20160691DOI Listing
November 2016

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.

Clin Sci (Lond) 2016 10;130(19):1677-96

AGE-omics and Systems Biology Research Group, Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, U.K. Glyoxalase Research Group, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.

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http://dx.doi.org/10.1042/CS20160025DOI Listing
October 2016

Decreased expression of the vitamin D receptor in women with recurrent pregnancy loss.

Arch Biochem Biophys 2016 09 28;606:128-33. Epub 2016 Jul 28.

Department of Obestetrics and Gynecology in First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2016.07.021DOI Listing
September 2016

The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity.

Kidney Int 2016 08 16;90(2):396-403. Epub 2016 May 16.

Warwick Medical School, Clinical Sciences Research Laboratories, University of Warwick, University Hospital, Coventry, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.03.010DOI Listing
August 2016

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.

Diabetes 2016 08 11;65(8):2282-94. Epub 2016 May 11.

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry, U.K. Warwick Systems Biology Centre, University of Warwick, Coventry, U.K.

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http://dx.doi.org/10.2337/db16-0153DOI Listing
August 2016

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.

Glycoconj J 2016 08 12;33(4):513-25. Epub 2016 Jul 12.

Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry, CV4 7AL, UK.

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http://dx.doi.org/10.1007/s10719-016-9705-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975768PMC
August 2016

Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.

Antioxid Redox Signal 2015 Sep 3;23(7):613-29. Epub 2014 Oct 3.

1 Clinical Sciences Research Laboratories, Warwick Medical School, University Hospital , University of Warwick, Coventry, United Kingdom .

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http://dx.doi.org/10.1089/ars.2014.5962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556091PMC
September 2015

Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.

Biochem Soc Trans 2015 Aug 3;43(4):669-73. Epub 2015 Aug 3.

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K. Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry CV4 7AL, U.K.

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http://dx.doi.org/10.1042/BST20150060DOI Listing
August 2015

Activity, regulation, copy number and function in the glyoxalase system.

Biochem Soc Trans 2014 Apr;42(2):419-24

*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.

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http://dx.doi.org/10.1042/BST20140008DOI Listing
April 2014

Measurement of glyoxalase gene expression.

Biochem Soc Trans 2014 Apr;42(2):495-9

*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.

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http://dx.doi.org/10.1042/BST20140026DOI Listing
April 2014

Copy number variation of glyoxalase I.

Biochem Soc Trans 2014 Apr;42(2):500-3

*Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, U.K.

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http://www.biochemsoctrans.org/content/ppbiost/42/2/500.full
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http://biochemsoctrans.org/lookup/doi/10.1042/BST20140011
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http://dx.doi.org/10.1042/BST20140011DOI Listing
April 2014

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.

Biochem J 2012 Apr;443(1):213-22

Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK.

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http://dx.doi.org/10.1042/BJ20111648DOI Listing
April 2012

Protein damage in the ageing process: advances in quantitation and the importance of enzymatic defences.

SEB Exp Biol Ser 2009 ;62:227-65

Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK.

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July 2011

Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes.

Diabetes 2011 Jul 26;60(7):1973-80. Epub 2011 May 26.

Warwick Medical School, Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry, UK.

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http://dx.doi.org/10.2337/db11-0085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121424PMC
July 2011

Glyoxalase in ageing.

Semin Cell Dev Biol 2011 May 12;22(3):293-301. Epub 2011 Feb 12.

Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521110002
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http://dx.doi.org/10.1016/j.semcdb.2011.02.013DOI Listing
May 2011

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

Diabetes 2008 Oct 15;57(10):2809-17. Epub 2008 Jul 15.

Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK.

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http://dx.doi.org/10.2337/db06-1003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551693PMC
October 2008

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007