Publications by authors named "Mingyang Jiang"

54 Publications

Corrigendum to "Ovarian metastasis risk factors in endometrial carcinoma: A systematic review and meta-analysis" [Eur J Obstet Gynecol Reprod Biol 267 (2021) 245-255].

Eur J Obstet Gynecol Reprod Biol 2021 Dec 29;269:83. Epub 2021 Dec 29.

Department of Gynecology, Guangxi Medical University First Affiliated Hospital, Nanning, Guangxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejogrb.2021.12.005DOI Listing
December 2021

The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.

J Biol Chem 2021 Nov 25;298(1):101449. Epub 2021 Nov 25.

State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, and Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China. Electronic address:

The G-quadruplex (G4) resolvase RNA helicase associated with AU-rich element (RHAU) possesses the ability to unwind G4 structures in both DNA and RNA molecules. Previously, we revealed that RHAU plays a critical role in embryonic heart development and postnatal heart function through modulating mRNA translation and stability. However, whether RHAU functions to resolve DNA G4 in the regulation of cardiac physiology is still elusive. Here, we identified a phenotype of noncompaction cardiomyopathy in cardiomyocyte-specific Rhau deletion mice, including such symptoms as spongiform cardiomyopathy, heart dilation, and death at young ages. We also observed reduced cardiomyocyte proliferation and advanced sarcomere maturation in Rhau mutant mice. Further studies demonstrated that RHAU regulates the expression levels of several genes associated with ventricular trabeculation and compaction, including the Nkx2-5 and Hey2 that encode cardiac transcription factors of NKX2-5 and Hey2, and the myosin heavy chain 7 (Myh7) whose protein product is MYH7. While RHAU modulates Nkx2-5 mRNA and Hey2 mRNA at the post-transcriptional level, we uncovered that RHAU facilitates the transcription of Myh7 through unwinding of the G4 structures in its promoter. These findings demonstrated that RHAU regulates ventricular chamber development through both transcriptional and post-transcriptional mechanisms. These results contribute to a knowledge base that will help to understand the pathogenesis of diseases such as noncompaction cardiomyopathy.
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http://dx.doi.org/10.1016/j.jbc.2021.101449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689214PMC
November 2021

Ovarian metastasis risk factors in endometrial carcinoma: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2021 Dec 13;267:245-255. Epub 2021 Nov 13.

Department of Gynecology, Guangxi Medical University First Affiliated Hospital, Nanning, Guangxi, China. Electronic address:

Objective: To investigate the incidence of ovarian metastasis in endometrial carcinoma (EC) and analyze its risk factors and provide a theoretical basis for whether retention of the ovary in patients with EC.

Methods: A systematic search using synonyms of 'ovarian cancer' and 'metastasis' was conducted in PubMed, Cochrane database, Embase, Google Scholar, and WOS database. Meta-analysis was performed on 7 included studies, comprising 4281 clinical-stage I-IV EC patients. Studies were assessed using the Newcastle-Ottawa Scale (NOS) criteria. Odds risks (OR) and 95% confidence intervals (CI) were calculated using an inverse variance weighted random-effects model.

Results: The ovarian metastasis risk of EC was significantly higher for patients with myometrial invasion >1/2 (OR = 18.19, 95% CI 5.34 to 61.96 compared to myometrial invasion ≤1/2), any pelvic lymph node invasion (PLNI) (OR = 5.41, 95% CI 2.60-10.97 compared to without PLNI), G3 pathological grade (OR = 2.66, 95%CI 1.35-5.24 compared to G1-G2), non-endometrioid pathological type (OR = 6.46, 95% CI 3.25 to 12.83 compared to endometrioid), lymphatic vascular space invasion (LVSI) (OR = 6.46, 95% CI 3.25 to 12.83 compare to without LVSI), age >45 (OR = 2.01, 95% CI 0.29 to 14.11 compared to age ≤45), and cervical invasion (OR = 4.12, 95% CI 1.87 to 9.08 compared to without cervical invasion).

Conclusion: About 4.95% of EC patients develop ovarian metastasis. Age >45, myometrial invasion >1/2, cervical invasion, PLNI, pathological type, G3 pathological grade, and LVSI were the high-risk factors for ovarian metastasis of EC. Ovarian preservation should be carefully selected for patients with EC, and preoperative and intraoperative evaluations should be entirely performed.
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http://dx.doi.org/10.1016/j.ejogrb.2021.11.016DOI Listing
December 2021

Soft X-Ray Stimulated [email protected] Nanoprobe for Amplifying Deep Tissue Synergistic Photodynamic and Antitumor Immunotherapy.

Adv Healthc Mater 2021 11 29;10(21):e2101174. Epub 2021 Sep 29.

School of Physics and Electronics, Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education, and Key Laboratory for Matter Microstructure and Function of Hunan Province, Hunan Normal University, Changsha, 410081, P. R. China.

Combining photodynamic therapy (PDT) and immunotherapy has shown profound impact for synergistic treatment of malignant tumors. However, the shallow penetration depth of the traditional visible light activated PDT, immunosuppressive tumor microenvironment (TME), and poor immunogenicity of deep-seated solid tumors have significantly impeded the therapeutic efficiency. Herein, a soft X-ray activated nanoprobe is rationally engineered via integrating porphyrin Zr-based metal-organic framework with lanthanide NaYF :Gd,[email protected] scintillator nanoparticles (SNPs) by a new in situ growth strategy for synergistic PDT and immunotherapy of tumor. The nanoprobe possesses remarkably enhanced reactive oxygen species (ROS) generation triggered by soft X-ray via further covalently grafting rose bengal on the nanoprobe, even at tissue depths of 3 cm. Moreover, the soft X-ray induced ROS can act as potential immunogenic cell death (ICD) trigger, subsequently leading to the activation of the adaptive antitumor immune-response. Significantly, the boosted ROS generation can further modulate the immunosuppressive TME. This work provides new strategy of designing antitumor nanoprobes for soft X-ray triggered deep-tissue PDT and immune response, breaking the depth barriers suffered by the traditional photoactivated PDT or ICD using visible and near infrared light.
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http://dx.doi.org/10.1002/adhm.202101174DOI Listing
November 2021

A HS-Triggered Dual-Modal Second Near-Infrared/Photoacoustic Intelligent Nanoprobe for Highly Specific Imaging of Colorectal Cancer.

Anal Chem 2021 10 23;93(39):13212-13218. Epub 2021 Sep 23.

School of Physics and Electronics, Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, and Key Laboratory for Matter Microstructure and Function of Hunan Province, Hunan Normal University, Changsha 410081, P.R. China.

An endogenous HS-triggered intelligent optical nanoprobe combining second near-infrared (NIR-II) fluorescence with photoacoustic (PA) imaging can provide more comprehensive information to further improve the sensitivity and reliability of diagnosis for colorectal tumor, which is rarely explored. Herein, an endogenous HS-triggered [email protected] nanoprobe was designed for dual-modal NIR-II/PA imaging of colorectal cancer. The designed dual-modal nanoprobe can be converted to [email protected] after biosynthesis via a sulfuration reaction with the over-expressed endogenous HS in the colorectal tumor. More importantly, the designed [email protected] nanoprobe exhibits high sensitivity and specificity for diagnosing colorectal cancer via dual-modal NIR-II/PA imaging. These results provide a new NIR-II/PA dual-modal imaging strategy for noninvasive intelligent detection of colorectal cancer.
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http://dx.doi.org/10.1021/acs.analchem.1c02200DOI Listing
October 2021

An Improved Stacked Autoencoder for Metabolomic Data Classification.

Comput Intell Neurosci 2021 15;2021:1051172. Epub 2021 Aug 15.

College of Computer Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000, China.

Naru3 (NR) is a traditional Mongolian medicine with high clinical efficacy and low incidence of side effects. Metabolomics is an approach that can facilitate the development of traditional drugs. However, metabolomic data have a high throughput, sparse, high-dimensional, and small sample nature, and their classification is challenging. Although deep learning methods have a wide range of applications, deep learning-based metabolomic studies have not been widely performed. We aimed to develop an improved stacked autoencoder (SAE) for metabolomic data classification. We established an NR-treated rheumatoid arthritis (RA) mouse model and classified the obtained metabolomic data using the Hessian-free SAE (HF-SAE) algorithm. During training, the unlabeled data were used for pretraining, and the labeled data were used for fine-tuning based on the HF algorithm for gradient descent optimization. The hybrid algorithm successfully classified the data. The results were compared with those of the support vector machine (SVM), -nearest neighbor (KNN), and gradient descent SAE (GD-SAE) algorithms. A five-fold cross-validation was used to complete the classification experiment. In each fine-tuning process, the mean square error (MSE) and misclassification rates of the training and test data were recorded. We successfully established an NR animal model and an improved SAE for metabolomic data classification.
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http://dx.doi.org/10.1155/2021/1051172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382558PMC
August 2021

Low Dose Soft X-Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti-Tumor Immunoresponse.

Adv Sci (Weinh) 2021 06 8;8(12):e2004391. Epub 2021 Apr 8.

Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, 999077, P. R. China.

Gas-based therapy has emerged as a new green therapy strategy for anti-tumor treatment. However, the therapeutic efficacy is still restricted by the deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment (TME). Herein, a new type of nanovaccine is designed by integrating low dose soft X-ray-triggered CO releasing lanthanide scintillator nanoparticles (ScNPs: NaLuF :Gd,[email protected] ) with photo-responsive CO releasing moiety (PhotoCORM) for synergistic CO gas/immuno-therapy of tumors. The designed nanovaccine presents significantly boosted radioluminescence and enables deep tissue CO generation at unprecedented tissue depths of 5 cm under soft X-ray irradiation. Intriguingly, CO as a superior immunogenic cell death (ICD) inducer further reverses the deep tissue immunosuppressive TME and concurrently activates adaptive anti-tumor immunity through efficient reactive oxygen species (ROS) generation. More importantly, the designed nanovaccine presents efficient growth inhibition of both local and distant tumors via a soft X-ray activated systemic anti-tumor immunoresponse. This work provides a new strategy of designing anti-tumor nanovaccines for synergistic deep tissue gas-therapy and remote soft X-ray photoactivation of the immune response.
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http://dx.doi.org/10.1002/advs.202004391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224418PMC
June 2021

Investigating the Critical Factors of Professionals' BIM Adoption Behavior Based on the Theory of Planned Behavior.

Int J Environ Res Public Health 2021 03 15;18(6). Epub 2021 Mar 15.

Department of Building and Real Estate, The Hong Kong Polytechnic University, Hong Kong, China.

In recent years, building information modeling (BIM) has been receiving growing interest from the construction industry of China. Nevertheless, although BIM has many foreseeable advantages, many studies claimed that these advantages have not been sufficiently achieved in practice at the current stage. In this circumstance, it is interesting to investigate what really drives the adoption of BIM. Based on Ajzen's theory of planned behavior (TPB), a hypothetical model which involves nine latent variables is initially established. Then, a questionnaire is designed and distributed to the construction professionals in the Chinese context. After reliability and validity analysis, the goodness-of-fit of the initial model and the related theoretical assumptions are tested through structural equation modeling (SEM). Based on the modification indicators, a modified model is finally derived. Results show that economic viability and governmental supervision are the most critical factors that influence construction professionals' BIM adoption behavior in China, sharing weights of 0.37 and 0.34, respectively, whereas other factors play limited roles in this regard. The research findings revealed from this study can provide insightful references for countries that intend to promote BIM adoption in a similar circumstance.
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http://dx.doi.org/10.3390/ijerph18063022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001932PMC
March 2021

The efficacy and safety of fast track surgery (FTS) in patients after hip fracture surgery: a meta-analysis.

J Orthop Surg Res 2021 Feb 27;16(1):162. Epub 2021 Feb 27.

Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: Fast track surgery (FTS) has been gradually applied in perioperative management of orthopedic surgery, but there still some research suspected that the prognosis of patients is not as expected and the cost is high, the effect of the FTS still urgently needed for support by evidence-based medicine.

Methods: We retrieved RCTs from medical research literature databases. Risk ratios (RR), standard mean difference (SMD), and 95% confidence intervals (CI) were calculated to compare the primary and safety endpoints.

Results: Overall, a total of 8886 patients were retrieved from 57 articles, of which 4448 patients (50.06%) were randomized to experimental group whereas 4438 patients (49.94%) were randomized to control group. The result showed that FTS could significantly shorten the length of stay (LOS), decrease the visual analog scale (VAS), reduce the leaving bed time and the hospitalization costs, and improve Harris hip joint function score. The incidence of complications such as respiratory system infection, urinary system infection, venous thrombus embolism (VTE), pressure sore, incision infection, constipation, and prosthesis dislocation also has been decreased significantly. Meanwhile, FTS improved patients' satisfaction apparently.

Conclusions: This meta-analysis reveals that FTS could significantly shorten the length of stay, alleviate the pain, reduce the leaving bed time and the hospitalization costs, and improve hip function. The incidence of complications also has been decreased significantly. Meanwhile, FTS has been spoken highly in patients in terms of nursing satisfaction. Its efficacy and safety were proved to be reliable.
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http://dx.doi.org/10.1186/s13018-021-02277-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913454PMC
February 2021

Endogenous HS-Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury.

ACS Nano 2021 02 22;15(2):3201-3211. Epub 2021 Jan 22.

Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha 410081, P.R. China.

Metformin as a hypoglycemic drug for antidiabetic treatment has emerged as a multipotential drug for many disease treatments such as cognitive disorders, cancers, promoting weight loss. However, overdose uptake may upregulate the hepatic HS level, subsequently leading to serious liver injury and toxicity. Therefore, developing intelligent second near-infrared (NIR-II) emitting nanoprobes by using endogenous HS as a smart trigger for noninvasive highly specific monitoring of the metformin-induced hepatotoxicity is highly desirable, which is rarely explored. Herein, an endogenous HS activated orthogonal NIR-II emitting myrica rubra-like nanoprobe based on NaYF:Gd/Yb/[email protected]:[email protected] coated with Ag nanodots was explored for highly specific ratiometrically monitoring of hepatotoxicity. The designed nanoprobes were mainly uptaken by the liver and subsequently converted to NaYF:Gd/Yb/[email protected]:[email protected]@AgS sulfuration reaction triggered by the overexpressed endogenous HS in the injured liver tissues, finally leading to a turn-on orthogonal emission centered at 1053 nm (irradiation by 808 nm laser) and 1525 nm (irradiation by 980 nm laser). The designed nanoprobe presents a high detection limit down to 0.7 nM of HS. More importantly, the highly specific ratiometric imaging of the metformin-induced hepatotoxicity was successfully achieved by using the activatable orthogonal NIR-II emitting probe. Our results provide an NIR-II ratiometric fluorescence imaging strategy for highly sensitive/specific diagnosis of hepatotoxicity levels induced by metformin.
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http://dx.doi.org/10.1021/acsnano.0c09799DOI Listing
February 2021

The G4 resolvase RHAU modulates mRNA translation and stability to sustain postnatal heart function and regeneration.

J Biol Chem 2021 Jan-Jun;296:100080. Epub 2020 Nov 23.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China. Electronic address:

Post-transcriptional regulation of mRNA translation and stability is primarily achieved by RNA-binding proteins, which are of increasing importance for heart function. Furthermore, G-quadruplex (G4) and G4 resolvase activity are involved in a variety of biological processes. However, the role of G4 resolvase activity in heart function remains unknown. The present study aims to investigate the role of RNA helicase associated with adenylate- and uridylate-rich element (RHAU), an RNA-binding protein with G4 resolvase activity in postnatal heart function through deletion of Rhau in the cardiomyocytes of postnatal mice. RHAU-deficient mice displayed progressive pathological remodeling leading to heart failure and mortality and impaired neonatal heart regeneration. RHAU ablation reduced the protein levels but enhanced mRNA levels of Yap1 and Hexim1 that are important regulators for heart development and postnatal heart function. Furthermore, RHAU was found to associate with both the 5' and 3' UTRs of these genes to destabilize mRNA and enhance translation. Thus, we have demonstrated the important functions of RHAU in the dual regulation of mRNA translation and stability, which is vital for heart physiology.
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http://dx.doi.org/10.1074/jbc.RA120.014948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948451PMC
August 2021

Low dose soft X-ray-controlled deep-tissue long-lasting NO release of persistent luminescence nanoplatform for gas-sensitized anticancer therapy.

Biomaterials 2020 12 15;263:120384. Epub 2020 Sep 15.

Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:

Nitric oxide (NO)-based gas therapy is emerged as a new adjunct anti-tumor treatment method, which has triggered a great research interest. Nevertheless, due to the short half-life of NO gas in vivo, it is of significance to develop NO-gas based gasotransmitter with controllable NO release for deep-tissue anti-tumor therapy. Herein, a novel soft X-ray activated persistent luminescence nanotransducer is designed for controllable and long-lasting NO release and deep-tissue anti-cancer therapy by integrating ZnGaO:Mn (ZGO:Mn) nanoparticles with light-responsive NO donor (RBS). With the merits of the ultra-low dosage (down to 0.9 mGy) soft X-ray activated persistent luminescence from small sized ZGO:Mn, continuous NO release is achieved for about 40 min after stopping the irradiation of X-ray. Moreover, the green persistent luminescence can be renewably activated by in-situ soft X-ray irradiation, leading to the repeatable long-lasting NO release in deep tissue (up to 24 mm). And the designed NO-releasing platform presents efficient in vitro and in vivo anti-cancer therapy. Therefore, the designed persistent luminescence-based NO gasotransmitter provides a new NO-releasing strategy for depth-independent gas-sensitized therapeutic applications.
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http://dx.doi.org/10.1016/j.biomaterials.2020.120384DOI Listing
December 2020

808 nm light triggered lanthanide nanoprobes with enhanced down-shifting emission beyond 1500 nm for imaging-guided resection surgery of tumor and vascular visualization.

Theranostics 2020 23;10(15):6875-6885. Epub 2020 May 23.

Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, P.R. China.

Lanthanide based nanoprobe with high efficient down-shifting second near-infrared (NIR-II, 1000-1700 nm) emission has emerged as a promising agent for tumor-associated vascular visualization. However, most of the developed lanthanide-based NIR-II-emissive probes are activated by 980 nm laser, leading to the concern of biological overheating effect. Herein, the high quality 808 nm laser activated NaYF:Gd/Yb/Er/Nd/[email protected]:Nd core-shell nanoprobes with significantly improved NIR-II emission beyond 1500 nm and eliminated overheating effect were developed for imaging-guided resection surgery of tumor and vascular visualization. : The core-shell nanoprobe with boosted NIR-II emission and eliminated heating effect was achieved with combination of Nd-sensitizing and Ce-doping strategies. The NIR-II optical imaging and toxicity assessment were demonstrated by and experiments. : The designed core-shell nanoprobe presented superior NIR-II emission beyond 1500 nm than the core only nanoparticle and NIR-II emission intensity was improved up to 11.0 times by further suppressing the upconversion (UC) pathway through doping Ce. More importantly, non-invasive tumor vascular imaging and NIR-II optical imaging-guided surgical resection of tumor were successfully achieved. : It is expected that the Nd-sensitized lanthanide-based nanoprobe with significant improvement in NIR-II emission and eliminated overheating effect is a highly promising probe for NIR-II imaging, making it more competitive in non-invasive vascular imaging and imaging-guided tumor resection surgery.
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http://dx.doi.org/10.7150/thno.41967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295047PMC
May 2021

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Nat Commun 2020 06 16;11(1):3067. Epub 2020 Jun 16.

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.

Lipid transport and ATP synthesis are critical for the progression of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are largely unknown. Here, we report that the RNA-binding protein HuR (ELAVL1) forms complexes with NAFLD-relevant transcripts. It associates with intron 24 of Apob pre-mRNA, with the 3'UTR of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby regulating the splicing of Apob mRNA and the translation of UQCRB and NDUFB6. Hepatocyte-specific HuR knockout reduces the expression of APOB, UQCRB, and NDUFB6 in mice, reducing liver lipid transport and ATP synthesis, and aggravating high-fat diet (HFD)-induced NAFLD. Adenovirus-mediated re-expression of HuR in hepatocytes rescues the effect of HuR knockout in HFD-induced NAFLD. Our findings highlight a critical role of HuR in regulating lipid transport and ATP synthesis.
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http://dx.doi.org/10.1038/s41467-020-16918-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298042PMC
June 2020

A general strategy for designing NIR-II emissive silk for the in vivo monitoring of an implanted stent model beyond 1500 nm.

J Mater Chem B 2020 06 29;8(21):4587-4592. Epub 2020 Apr 29.

School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, and Key Laboratory for Matter Microstructure and Function of Hunan Province, Hunan Normal University, Changsha, 410081, P. R. China.

Silk fibroin-based materials spun by silkworms present excellent biocompatible and biodegradable properties, endowing them with broad applications for use in in vivo implanted devices. Therefore, it is highly desirable to explore functionalized silk with additional optical bioimaging abilities for the direct in situ monitoring of the status of implanted devices in vivo. Herein, a new type of silk material with a second near-infrared (NIR-II, 1000-1700 nm) emission is explored for the real-time observation of a biological stent model using a general route of feeding larval silkworms with lanthanide-based NaYF:Gd/Yb/[email protected] nanocrystals. After being fed lanthanide nanocrystals, the silk spun by silkworms shows efficient NIR-II emission beyond 1500 nm. Moreover, NIR-II bio-imaging guided biological stent model monitoring presents a superior signal-to-noise (S/N) ratio compared to the traditional optical imaging by utilizing the upconversion (UC) region. These findings open up the possibility of designing NIR-II optically functionalized silk materials for highly sensitive and deep-tissue monitoring of the in vivo states of the implanted devices.
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http://dx.doi.org/10.1039/c9tb02685aDOI Listing
June 2020

Letter regarding [Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis].

J Hepatol 2020 06 17;72(6):1216. Epub 2020 Mar 17.

Guangxi Medical University, Nanning, Guangxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.01.022DOI Listing
June 2020

The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis.

J Orthop Surg Res 2020 Feb 5;15(1):39. Epub 2020 Feb 5.

Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: Many selective cyclooxygenase (COX-2) inhibitors are currently used in clinical practice. COX-2 inhibitors have good anti-inflammatory, analgesic, antipyretic effects, and gastrointestinal safety. However, the analgesic effects and adverse reactions of COX-2 after total knee/hip arthroplasty (TKA/THA) are not fully known.

Objective: To evaluate the efficacy and safety of selective COX-2 inhibitors in postoperative pain management in patients receiving TKA/THA.

Methods: Randomized controlled trials (RCTs) were retrieved from medical literature databases. Risk ratios (RR) Std mean difference (SMD) and 95% confidence intervals (CI) were calculated to analyze the primary and safety endpoints.

Results: In total, 18 articles (23 trial comparisons) were retrieved comprising 3104 patients. Among them, 1910 patients (61.5%) were randomized to the experimental group whereas 1194 patients (38.5%) were randomized to the control group. The primary endpoints were the patients' VAS score at rest or on ambulation (within 3 days). We found that VAS score in patients that received selective COX-2 inhibitor was significantly lower compared to those of the control group.

Conclusion: This meta-analysis shows that selective COX-2 inhibitor therapy is effective, safe, and reliable in relieving postoperative pain of THA/TKA.
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http://dx.doi.org/10.1186/s13018-020-1569-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003344PMC
February 2020

NIR-Triggered Theranostic BiS Light Transducer for On-Demand NO Release and Synergistic Gas/Photothermal Combination Therapy of Tumors.

ACS Appl Bio Mater 2019 Nov 17;2(11):4769-4776. Epub 2019 Oct 17.

Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education, School of Physics and Electronics, Hunan Normal University, Changsha 410081, P.R. China.

Gaseous therapy based on nitric oxide (NO) has emerged as a potential tumor therapy route. However, the development of a NO generator with precisely controlled NO releasing in the target site is still facing enormous challenges. Herein, a typical NO delivery platform by integrating the hollow structured polydopamine (PDA) coated BiS nanohybrids (denoted as [email protected]) with a heat-sensitive -nitrosothiol (RSNO) molecule was explored for near-infrared (NIR) light-responsive on-demand NO-releasing and synergetic gas/photothermal combination therapy of tumors. The designed [email protected] nanocomposites hold high photothermal conversion efficiency of 46.13% under irradiation of a NIR laser, leading to NIR light-triggered controllable generation of NO gas via breaking the S-NO bonds of the heat-sensitive RSNO molecules. More importantly, synergistic gas/photothermal therapy of the tumor was also achieved, which presented remarkable inhibition growth and ablation of tumors. These findings provide the opportunity to design a NIR light-activated NO generator with a combination of photothermal materials and heat-sensitive molecules for integrative gas/photothermal therapy in deep tumors.
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http://dx.doi.org/10.1021/acsabm.9b00522DOI Listing
November 2019

Studies Making Use of the Same Randomized Clinical Trial Cohorts.

JAMA Intern Med 2019 10;179(10):1446-1447

Basic Medical College, Department of Biochemistry and Molecular Biology, Guangxi Medical University, Nanning, Guangxi, China.

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http://dx.doi.org/10.1001/jamainternmed.2019.4621DOI Listing
October 2019

Developing a strategic framework for adopting water-saving measures in construction projects.

Environ Geochem Health 2020 Mar 29;42(3):955-968. Epub 2019 Aug 29.

Sino-Australia Joint Research Center in BIM and Smart Construction, College of Civil and Transportation Engineering, Shenzhen University, Shenzhen, China.

The construction industry consumes substantial water resources. Thus, there is a necessity to adopt effective water-saving measures to reduce water consumption in construction projects. The aim of this paper is providing a strategic framework of water-saving measures for different phases of a construction project. To start with, the prevailing green building rating tools were investigated to explore the alternative water-saving measures. Then, a comparative analysis utilizing relative significance indexing was conducted to identify the foci of water-saving measures in various green building rating tools. Based on the derived results, ten water-saving measures, namely rainwater harvesting, usage of recycled water, NEWater, water-saving technologies, water-saving devices, water-saving efficiency, water monitoring system, monitoring of major water uses, leak detection, and continuous water monitoring, were identified. These measures were further categorized into three strategic aspects, such as water sources substitution, water consumption reduction, and water use monitoring. Based on the results, a strategic framework was developed for reducing water consumption and improving water use efficiency. The developed framework can serve as a systematic guideline for formulating water-saving schemes in different stages of construction projects.
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http://dx.doi.org/10.1007/s10653-019-00407-2DOI Listing
March 2020

What Hinders the Development of Green Building? An Investigation of China.

Int J Environ Res Public Health 2019 08 28;16(17). Epub 2019 Aug 28.

Department of Construction Management and Real Estate, College of Civil and Transportation Engineering, Shenzhen University, Shenzhen 518060, China.

With the rapid development of the economy, people are paying more and more attention to the environmental problems. In this circumstance, the concept of a circular economy is proposed for making efficient use of resources and minimizing the production of waste and other emissions. Each year, the construction sector consumes a vast volume of resources and makes impacts on the environment. To align with the development of the circular economy, the concept of green building is proposed. In China, though the concept of green building has been promoted for decades, the development status is far from optimistic. Thus, this paper aims to investigate the barriers that hinder green building development (GBD) in China. Through a systematic review and semi-structured interviews with experienced industrial practitioners, 24 potential barriers of GBD in China were identified. A questionnaire survey was then conducted for data collection. After descriptive and inferential statistical analyses, a partial least squares structural equation model (PLS-SEM) was established to investigate the impacts of different barriers on GBD. Results showed that the lack of policy and industry guidance, the immature market environment, and the lack of environmental awareness are the most important GBD barriers in China. This research can assist stakeholders in better understanding the status of GBD in China and enable decision-makers to formulate appropriate strategies to promote green building.
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http://dx.doi.org/10.3390/ijerph16173140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747372PMC
August 2019

Letter by Xie et al Regarding Article, "Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications".

Circulation 2019 08 26;140(9):e513-e514. Epub 2019 Aug 26.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, China (J.X., L.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040624DOI Listing
August 2019

Re: Effect of Alprostadil in the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials.

Angiology 2020 01 19;71(1):97. Epub 2019 Aug 19.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.

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http://dx.doi.org/10.1177/0003319719870398DOI Listing
January 2020

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.

Cardiovasc Res 2020 04;116(5):944-955

>Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

Aims: The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulation of PLB remains to be further studied. The present study aims to test the role of RNA-binding protein HuR in the regulation of PLB and the impact of this regulatory process in cardiac remodelling.

Methods And Results: A mouse model specifically deleted HuR in cardiomyocytes were used for testing the role of HuR in regulating PLB during isoproterenol (ISO)-induced cardiac remodelling. HuR deficiency did not significantly influence the phenotype and function of mouse heart under static status. However, deletion of HuR in cardiomyocytes mitigated the effect of ISO in inducing PLB expression and reducing β1-AR expression, in turn aggravating ISO-induced myocardial hypertrophy and cardiac fibrosis. In H9C2 cells, association of HuR with PLB and β1-AR mRNAs stabilized PLB mRNA and destabilized β1-AR mRNA, respectively.

Conclusion: HuR stabilizes PLB mRNA and destabilizes β1-AR mRNA. The HuR-PLB and HuR-β1-AR regulatory processes impact on ISO-induced cardiac remodelling.
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http://dx.doi.org/10.1093/cvr/cvz205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868665PMC
April 2020

Rivaroxaban versus Aspirin in Prevention of Venous Thromboembolism: A Meta-Analysis of 9 Randomized Controlled Trials comprising 7,656 Patients.

Thromb Haemost 2019 Sep 31;119(9):1517-1526. Epub 2019 Jul 31.

Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.

Aim:  This article evaluates the preventive effects of rivaroxaban versus aspirin on venous thromboembolism (VTE) through meta-analysis of recent randomized controlled trials (RCTs).

Methods:  RCTs were retrieved from medical literature databases. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated to compare the primary and safety endpoints.

Results:  In total, 9 trials (11 trial comparisons) were retrieved which contained 7,656 patients. Among these patients, 4,383 patients (57.2%) received rivaroxaban, whereas 3,273 patients (42.8%) received aspirin. Compared with aspirin, rivaroxaban significantly reduced VTE (1.3% vs. 3.5%) (RR: 0.36, 95% CI, 0.26-0.48,  = 27.9%), but significantly increased nonmajor bleeding (11.5% vs. 7.5%) (RR: 1.28, 95% CI, 1.13-1.44,  = 38.6%). There were no significant differences in the all-cause mortality (0.3% vs. 0.3%) (RR: 0.75, 95% CI, 0.35-1.61,  = 32.0%) and major bleeding (0.3% vs. 0.4%) (RR: 0.81, 95% CI, 0.42-1.55,  = 33.7%) between the two groups.

Conclusion:  This meta-analysis indicated that rivaroxaban can significantly reduce the incidence of VTE when compared with aspirin. The preventive effect of rivaroxaban on VTE was more potent than that of aspirin. However, rivaroxaban had some negative side effects to patients such as nonmajor bleeding compared to aspirin.
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http://dx.doi.org/10.1055/s-0039-1693460DOI Listing
September 2019

Endogenous HS-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer.

iScience 2019 Jul 27;17:217-224. Epub 2019 Jun 27.

Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:

Overexpression of endogenous HS is one of the key characteristic in colon cancer. However, developing endogenous HS-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ HS-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous HS-induced in situ chemical reaction to form AgS quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous HS activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.
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http://dx.doi.org/10.1016/j.isci.2019.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625970PMC
July 2019

Polydopamine coated multifunctional lanthanide theranostic agent for vascular malformation and tumor vessel imaging beyond 1500 nm and imaging-guided photothermal therapy.

Theranostics 2019 31;9(13):3866-3878. Epub 2019 May 31.

School of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081 (China).

The optical imaging guided tumor vessels and vascular malformation visualization by using the second near infrared emission beyond 1500 nm (NIR-II) is emerged as the next generation fluorescence imaging technique for early tumor diagnosis and identification of tumor-associated vascular features. On the other hand, developing theranostic probes for NIR-II imaging guided photothermal therapy (PTT) is of great significance, which is rarely explored. Herein, a high performance theranostic nanoplatform based on the core-shell structured NaLuF [email protected] (denoted as [email protected]) by integrating the new advanced NIR-II imaging beyond 1500 nm with PTT function was developed for tumor-associated vascular malformation visualization and imaging-guided PTT. : In this work, the hydrophilic NaLuF [email protected] therapeutic probe was synthesized by using a reverse microemulsion method. The crystal phase, morphology, emission spectra and photothermal performance of the synthesized samples were systematically characterized. The NIR-II optical imaging and photothermal properties were investigated by and in experiments. : The NaLuF [email protected] therapeutic probe possessed efficient NIR-II emission centered at 1525 nm with high quantum yield (QY), good photo-stability and high biocompatibility. NIR-IIb imaging based on the designed probe can clearly visualize the whole-body vessel and brain vessel with high spatial resolution, especially tumor-associated vessels. In addition, and experiments also demonstrated that the designed NaLuF [email protected] probe possessed efficient photothermal conversion efficiency (40.18%) for PTT ablation of tumor. : With the excellent NIR-II imaging ability and PTT of tumor, the designed theranostic nanoplatform successfully realize the simultaneous tumor vessel diagnosis and tumor therapy, which may provide the opportunity of designing new theranostic bioprobes with combination of the NIR-II optical imaging technique and PTT function for tumor diagnosis and therapy.
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http://dx.doi.org/10.7150/thno.31864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587345PMC
September 2020

Re: Global inequities in dietary calcium intake during pregnancy: a systematic review and meta-analysis.

BJOG 2019 09 3;126(10):1290-1291. Epub 2019 Jul 3.

Guangxi Medical University, Nanning, Guangxi, China.

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http://dx.doi.org/10.1111/1471-0528.15834DOI Listing
September 2019
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