Publications by authors named "Mingyang Cheng"

3 Publications

  • Page 1 of 1

Targeting macrophages using nanoparticles: a potential therapeutic strategy for atherosclerosis.

J Mater Chem B 2021 Apr 30;9(15):3284-3294. Epub 2021 Mar 30.

School of Basic Medicine, Qingdao University, Ningxia Road 308, Qingdao, P. R. China.

Atherosclerosis is one of the leading causes of vascular diseases, with high morbidity and mortality worldwide. Macrophages play a critical role in the development and local inflammatory responses of atherosclerosis, contributing to plaque rupture and thrombosis. Considering their central roles, macrophages have gained considerable attention as a therapeutic target to attenuate atherosclerotic progression and stabilize existing plaques. Nanoparticle-based delivery systems further provide possibilities to selectively and effectively deliver therapeutic agents into intraplaque macrophages. Although challenges are numerous and clinical application is still distant, the design and development of macrophage-targeting nanoparticles will generate new knowledge and experiences to improve therapeutic outcomes and minimize toxicity. Hence, the review aims to discuss various strategies for macrophage modulation and the development and evaluation of macrophage targeting nanomedicines for anti-atherosclerosis.
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http://dx.doi.org/10.1039/d0tb02956dDOI Listing
April 2021

Stimuli-responsive nanoparticles based on poly acrylic derivatives for tumor therapy.

Int J Pharm 2021 Mar 31;601:120506. Epub 2021 Mar 31.

School of Basic Medicine, Qingdao University, Ningxia Road 308, Qingdao, PR China. Electronic address:

Serve side effects caused by discriminate damage of chemotherapeutic drugs to normal cell and cancer cells remain a main obstacle in clinic. Hence, continuous efforts have been made to find ways to effectively enhance drug delivery and reduce side effects. Recent decades have witnessed impressive progresses in fighting against cancer, with improved understanding of tumor microenvironment and rapid development in nanoscale drug delivery system (DDS). Nanocarriers based on biocompatible materials provide possibilities to improve antitumor efficiency and minimize off-target effects. Among all kinds of biocompatible materials applied in DDS, polymeric acrylic derivatives such as poly(acrylamide), poly(acrylic acid), poly(N-isopropylacrylamide) present inherent biocompatibility and stimuli-responsivity, and relatively easy to be functionalized. Furthermore, nanocarrier based on polymeric acrylic derivatives have demonstrated high drug encapsulation, improved uptake efficiency, prolonged circulation time and satisfactory therapeutic outcome in tumor. In this review, we aim to discuss recent progress in design and development of stimulus-responsive poly acrylic polymer based nanocarriers for tumor targeting drug delivery.
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http://dx.doi.org/10.1016/j.ijpharm.2021.120506DOI Listing
March 2021

Cloning and Characterization of a New Chitosanase From a Deep-Sea Bacterium sp. QD07.

Front Microbiol 2021 24;12:619731. Epub 2021 Feb 24.

Department of Pharmacology, School of Basic Medicine, Qingdao University, Qingdao, China.

Chitosanase is a significant chitosan-degrading enzyme involved in industrial applications, which forms chitooligosaccharides (COS) as reaction products that are known to have various biological activities. In this study, the gene was cloned from a deep-sea bacterium sp. QD07, as well as over-expressed in , which is a new chitosanase encoding gene. The recombinant strain was cultured in a 5 L fermenter, which yielded 324 U/mL chitosanases. After purification, CsnS is a cold-adapted enzyme with the highest activity at 60°C, showing 37.5% of the maximal activity at 0°C and 42.6% of the maximal activity at 10°C. It exhibited optimum activity at pH 5.8 and was stable at a pH range of 3.4-8.8. Additionally, CsnS exhibited an endo-type cleavage pattern and hydrolyzed chitosan polymers to yield disaccharides and trisaccharides as the primary reaction products. These results make CsnS a potential candidate for the industrial manufacture of COS.
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http://dx.doi.org/10.3389/fmicb.2021.619731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943732PMC
February 2021