Mingxing Ouyang - Changzhou University - Professor

Mingxing Ouyang

Changzhou University

Professor

Changzhou, Jiangsu | China

Main Specialties: Biology, Biotechnology

ORCID logohttps://orcid.org/0000-0002-2910-0713

Mingxing Ouyang - Changzhou University - Professor

Mingxing Ouyang

Introduction

Primary Affiliation: Changzhou University - Changzhou, Jiangsu , China

Specialties:

Education

Sep 1999 - Jun 2005
Institute of Biophysics Chinese Academy of Sciences
Ph.D.

Experience

Sep 2017
Changzhou University
Professor
University of Illinois, Urbana-Champaign
Postdoc Scholar
California Institute of Technology
Postdoc Scholar
California Institute of Technology
Postdoc Scholar
Yale University
Associate Research Scientist
Yale University
Associate Research Scientist
Yale University
Associate Research Scientist
University of California, San Diego
Assistant Project Scientist
University of California, San Diego
Assistant Project Scientist
University of California, San Diego
Assistant Project Scientist
University of California, San Diego
Assistant Project Scientist

Publications

27Publications

272Reads

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Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor.

Sci Adv 2019 Jun 19;5(6):eaau2001. Epub 2019 Jun 19.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/sciadv.aau2001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584686PMC
June 2019
4 Reads

Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Submembrane Localization.

ACS Sens 2019 Jan 9;4(1):76-86. Epub 2019 Jan 9.

Department of Bioengineering , University of California at San Diego , La Jolla , California 92093 , United States.

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http://pubs.acs.org/doi/10.1021/acssensors.8b00896
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http://dx.doi.org/10.1021/acssensors.8b00896DOI Listing
January 2019
32 Reads

Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.

Nat Commun 2017 09 7;8(1):477. Epub 2017 Sep 7.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

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http://dx.doi.org/10.1038/s41467-017-00569-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589908PMC
September 2017
56 Reads
10.742 Impact Factor

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.

J Cell Biol 2016 05;213(3):371-83

Yale Cardiovascular Research Center, Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT 06511 Department of Cell Biology, Yale University, New Haven, CT 06520 Department of Biomedical Engineering, Yale University, New Haven, CT 06520

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http://dx.doi.org/10.1083/jcb.201510012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862330PMC
May 2016
15 Reads
9.834 Impact Factor

RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.

Sci Rep 2014 Nov 12;4:7008. Epub 2014 Nov 12.

1] Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [2] Department of Integrative and Molecular Physiology, Center for Biophysics and Computational Biology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA [3] Department of Bioengineering, University of California at San Diego, CA 92093, USA.

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http://dx.doi.org/10.1038/srep07008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228346PMC
November 2014
8 Reads
5.078 Impact Factor

Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding.

Chem Commun (Camb) 2014 Oct;50(78):11536-9

School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1039/c4cc04730cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783554PMC
October 2014
6 Reads
6.834 Impact Factor

Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells.

Sci Rep 2014 Jul 24;4:5756. Epub 2014 Jul 24.

1] Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093-0435 [2] Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [3] Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801 [4] Center of Biophysics and Computational Biology, Beckman Institute for Advanced Science and Technology, Department of Molecular and Integrative Physiology and, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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http://www.nature.com/articles/srep05756
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http://dx.doi.org/10.1038/srep05756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108961PMC
July 2014
6 Reads
5.078 Impact Factor

Genetically encoded fluorescent biosensors for live-cell imaging of MT1-MMP protease activity.

Methods Mol Biol 2014 ;1071:163-74

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

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http://dx.doi.org/10.1007/978-1-62703-622-1_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550515PMC
April 2014
4 Reads

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

Nat Commun 2013 ;4:2037

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1038/ncomms3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777412PMC
December 2013
8 Reads
10.742 Impact Factor

Integrins in mechanotransduction.

Curr Opin Cell Biol 2013 Oct 21;25(5):613-8. Epub 2013 Jun 21.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, United States.

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http://dx.doi.org/10.1016/j.ceb.2013.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757118PMC
October 2013
3 Reads
8.467 Impact Factor

Long-range mechanical force enables self-assembly of epithelial tubular patterns.

Proc Natl Acad Sci U S A 2012 Apr 16;109(15):5576-82. Epub 2012 Mar 16.

Bioengineering, California Institute of Technology, MS 138-78, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.1114781109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326479PMC
April 2012
5 Reads
9.809 Impact Factor

Computational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cells.

PLoS One 2011 27;6(6):e21293. Epub 2011 Jun 27.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124492PMC
December 2011
7 Reads
3.234 Impact Factor

Wide-field optical sectioning for live-tissue imaging by plane-projection multiphoton microscopy.

J Biomed Opt 2011 Nov;16(11):116009

California Institute of Technology, Bioengineering, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1117/1.3647570DOI Listing
November 2011
8 Reads
2.859 Impact Factor

Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.

Nat Commun 2011 Jul 26;2:406. Epub 2011 Jul 26.

Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1038/ncomms1414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373894PMC
July 2011
27 Reads
10.742 Impact Factor

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

PLoS One 2010 Jun 24;5(6):e11305. Epub 2010 Jun 24.

Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892035PMC
June 2010
5 Reads
3.234 Impact Factor

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

Cancer Res 2010 Mar 2;70(6):2204-12. Epub 2010 Mar 2.

Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840183PMC
March 2010
8 Reads
9.329 Impact Factor

Rapid activation of Rac GTPase in living cells by force is independent of Src.

PLoS One 2009 Nov 18;4(11):e7886. Epub 2009 Nov 18.

Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773925PMC
November 2009
12 Reads
3.234 Impact Factor

Plectin contributes to mechanical properties of living cells.

Am J Physiol Cell Physiol 2009 Apr 25;296(4):C868-77. Epub 2009 Feb 25.

Dept. of Mechanical Science, Univ. of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1152/ajpcell.00604.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670656PMC
April 2009
7 Reads
3.780 Impact Factor

Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells.

J Cell Physiol 2009 Feb;218(2):285-93

Neuroscience Program, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1002/jcp.21598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592496PMC
February 2009
4 Reads
3.839 Impact Factor

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

Chem Biol 2009 Jan;16(1):48-57

Neuroscience Program, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647969PMC
January 2009
2 Reads
6.645 Impact Factor

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors.

Proc Natl Acad Sci U S A 2008 Sep 17;105(38):14353-8. Epub 2008 Sep 17.

Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0807537105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567163PMC
September 2008
4 Reads
9.809 Impact Factor

The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging.

PLoS Comput Biol 2008 Jul 25;4(7):e1000127. Epub 2008 Jul 25.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517613PMC
July 2008
3 Reads

Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.

J Biol Chem 2008 Jun 25;283(25):17740-8. Epub 2008 Apr 25.

Department of Bioengineering and the Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61801, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M709872200
Publisher Site
http://dx.doi.org/10.1074/jbc.M709872200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427332PMC
June 2008
6 Reads
4.573 Impact Factor

Rapid signal transduction in living cells is a unique feature of mechanotransduction.

Proc Natl Acad Sci U S A 2008 May 2;105(18):6626-31. Epub 2008 May 2.

Departments of Mechanical Science and Engineering and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0711704105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373315PMC
May 2008
5 Reads
9.809 Impact Factor

Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.

J Neurochem 2006 Apr 3;97(1):234-44. Epub 2006 Mar 3.

Institute of Biophysics, Chinese Academy of Science, Graduate School of the Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03730.xDOI Listing
April 2006
3 Reads
4.281 Impact Factor

Top co-authors

Yingxiao Wang
Yingxiao Wang

University of Illinois

21
Shaoying Lu
Shaoying Lu

University of Illinois

14
Jihye Seong
Jihye Seong

University of Illinois

9
Shu Chien
Shu Chien

University of California

6
Jie Sun
Jie Sun

University of Washington

5
Martin A Schwartz
Martin A Schwartz

University of Virginia

4
Ning Wang
Ning Wang

School of Chinese Medicine

4
Keiichiro Tanaka
Keiichiro Tanaka

Jikei University School of Medicine

3
Farhan Chowdhury
Farhan Chowdhury

University of Illinois at Urbana-Champaign

3
Sungsoo Na
Sungsoo Na

University of Illinois at Urbana-Champaign

3