Publications by authors named "Mingxia Ji"

15 Publications

  • Page 1 of 1

Effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation.

Pak J Pharm Sci 2021 Jan;34(1(Special)):423-428

Intensive Care Unit, Fuyuan Hospital of Yiwu City, Yiwu, Zhejiang Province, China.

To investigate the effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation. 70 patients with severe pneumonia complicated with respiratory failure who were treated with mechanical ventilation were selected and divided into the combined group and the control group. The control group underwent mechanical ventilation treatment and used dexmedetomidine for sedation and analgesia, while the combined group had sufentanil analgesia in addition to the treatment of the control group. Ramsay sedation score, visual analogue scale (VAS) and pulmonary function indicators were compared between the two groups before treatment, 24h after treatment, and after extubation. After 24h treatment and extubation, the blood oxygen saturation (SpO), oxygenation index (OI) and arterial oxygen partial pressure (PaO) in the combined group were higher than those in the control group; at the same time, the serum interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and malondialdehyde (MDA) levels were lower (P<0.05). Mortality during hospitalization of the combined group was lower than the control group (P<0.05). Dexmedetomidine combined with sufentanil citrate can effectively improve sedative and analgesic effects, stress response, pulmonary function and prognosis in patients with severe respiratory failure requiring mechanical ventilation.
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January 2021

Water-soluble brown carbon in atmospheric aerosols along the transport pathway of Asian dust: Optical properties, chemical compositions, and potential sources.

Sci Total Environ 2021 Oct 24;789:147971. Epub 2021 May 24.

Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

As an important type of light-absorbing aerosol, brown carbon (BrC) has the potential to affect the atmospheric photochemistry and Earth's energy budget. A comprehensive field campaign was carried out along the transport pathway of Asian dust during the spring of 2016, including a desert site (Erenhot), a rural site (Zhangbei), and an urban site (Jinan), in northern China. Optical properties, bulk chemical compositions, and potential sources of water-soluble brown carbon (WS-BrC) were investigated in atmospheric total suspended particulate (TSP) samples. Samples from Zhangbei had higher mass absorption efficiency at 365 nm (MAE, 1.32 ± 0.34 m g) than those from Jinan (1.00 ± 0.23 m g) and Erenhot (0.84 ± 0.30 m g). Compere to the non-dust samples, elevated water-soluble organic carbon (WSOC) concentrations and MAE values of dust samples from Erenhot are related to the input of high molecular weight organic compounds and biogenic matter from the Gobi Desert, while lower values from Zhangbei and Jinan are attributed to the dilution effect caused by strong northwesterly winds. Based on fluorescence excitation-emission matrix spectra and parallel factor analysis, two humic-like (C1 and C2) and two protein-like (C3 and C4) substances were identified. Together, C1 and C2 accounted for ~64% of total fluorescence intensity at the highly polluted urban Jinan site; C3 represented ~45% at the rural Zhangbei site where local biomass burning affects; and C4 contributed ~24% in the desert region (Erenhot) due to dust-sourced biogenic substances. The relative absorptive forcing of WS-BrC compared to black carbon at 300-400 nm was about 31.3%, 13.9%, and 9.2% during non-dust periods at Erenhot, Zhangbei, and Jinan, respectively, highlighting that WS-BrC may significantly affect the radiative balance of Earth's climate system and should be included in radiative forcing models.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147971DOI Listing
October 2021

A Pilot Study for Forgiveness Intervention in Adolescents With High Trait Anger: Enhancing Empathy and Harmony.

Front Psychol 2020 23;11:569134. Epub 2020 Dec 23.

Personnel Department, Suzhou Vocational Institute of Industrial Technology, Suzhou, China.

Forgiveness interventions benefit victims' mental health, reduce levels of anger, and promote forgiveness. However, forgiveness interventions are rarely used to improve the offender's anger and mental health, especially in specific situations such as juvenile correctional facilities. The offender is often also a victim, and reducing the offender's excessive anger may prevent or decrease the likelihood of future interpersonal violence. This study examined the effects of forgiveness interventions on anger, forgiveness, empathy, and harmony of juvenile delinquents with high levels of trait anger. Eighteen adolescents with trait anger in a juvenile correctional facility volunteered to participate in group counseling. A pretest-posttest method of quasi-experimental design was used, with 8 participants in the intervention group and 10 in the control group; the intervention group received forgiveness group counseling, and the control group did not. The results revealed that the intervention group had significantly higher scores for forgiveness, empathy, and harmony than the control group, although no significant differences in the scores of state and trait anger were found. The forgiveness intervention had significantly improved the levels of forgiveness toward specific perpetrators of childhood victimization for the juvenile delinquents with high levels of trait anger, raising their levels of empathy and harmony; there was no significant increase in trait anger. The findings indicated that forgiveness intervention provides an effective way to improve the positive mental strength of adolescents with high levels of trait anger.
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http://dx.doi.org/10.3389/fpsyg.2020.569134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785983PMC
December 2020

Interannual variability of dust height and the dynamics of its formation over East Asia.

Sci Total Environ 2021 Jan 11;751:142288. Epub 2020 Sep 11.

Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Institute of Surface-Earth System Science, Tianjin University, Tianjin 300072, China. Electronic address:

The vertical structure of dust layers is rarely investigated, despite its critical role in exploring the radiative and microphysical effects of dust aerosols. In this study, we primarily investigate the temporal variability of most probable dust height (MPDH) over dust source regions in East Asia and its interactions with climate parameters using CALIPSO lidar measurements under cloud-free conditions in spring from 2007 to 2018. The vertical profile of dust aerosols exhibits significant interannual variability over this time; dust is mainly concentrated below 7 km and associated with a dust occurrence frequency (DOF) of 0.6, and the DOF is much higher than that over the Sahara and West Asia. We also found that high Indian Ocean sea surface temperature (SST) significantly contributes to the transport of dust aerosols to downstream areas by changing the circulation field near the equator and in the mid-low latitudes of the Northern Hemisphere, which results in low MPDH over northern China. MPDH is significantly negatively correlated with 500-hPa westerly wind and precipitation, and is positively correlated with surface air temperature (SAT) and normalized difference vegetation index (NDVI). Furthermore, MPDH is positively correlated with the Arctic Oscillation (AO) and the Atlantic Multidecadal Oscillation (AMO), but negatively correlated with the El Niño-Southern Oscillation (ENSO). The correlation coefficient between AMO and MPDH is 0.71 after detrending, which indicates that the AMO also plays an important role in the interannual variability of MPDH over East Asia. Furthermore, the Indian Ocean SST is the main influencing factor of the interannual variability of MPDH over northern China, but zonal wind is probably only the intermediate mechanism.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142288DOI Listing
January 2021

Dietary inflammatory index and cardiovascular risk and mortality: A meta-analysis of cohort studies.

Medicine (Baltimore) 2020 May;99(20):e20303

Department of Critical Care Medicine, Lishui City People's Hospital, Lishui, Zhejiang Province, China.

Background: The role of dietary inflammatory index (DII) in cardiovascular disease (CVD) risk and mortality is still controversial. This systematic review and meta-analysis of cohort studies aimed to evaluate the effect of DII, indicating a pro-inflammatory diet, on the incidence and mortality of CVD.

Methods: A comprehensive literature search of articles published through August 2019 was performed in Medline, EMBASE, and Web of Science. The pooled relative risks (RRs) and 95% confidence intervals (CIs) for highest vs lowest DII in relation to CVD risk or mortality were estimated using a DerSimonian and Laird random effects model. The heterogeneity among studies was tested using Cochran's Q test and I statistic.

Results: A total of 15 cohort studies were finally included in this meta-analysis. The highest DII score was significantly associated with a higher risk of CVD incidence (RR = 1.41, 95% CI 1.12-1.78) or mortality (RR = 1.31, 95% CI 1.19-1.44), compared with the lowest DII score. There was statistically significant heterogeneity among the studies on the association between DII and CVD mortality (P < .001; I = 70.8%). No obvious heterogeneity was observed among the studies on the association between DII and CVD risk (P = .160; I = 37.0%). In the sensitivity analysis, exclusion of any single study did not materially alter the pooled RRs.

Conclusion: The present systematic review and meta-analysis indicates that a higher DII score is related to a higher risk of CVD. Further well-designed prospective cohort or trials are warranted to validate our preliminary findings.
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http://dx.doi.org/10.1097/MD.0000000000020303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253850PMC
May 2020

Alcohol Consumption and Risk for Venous Thromboembolism: A Meta-Analysis of Prospective Studies.

Front Nutr 2020 2;7:32. Epub 2020 Apr 2.

Department of Emergency, Yiwu Central Hospital, Yiwu, China.

The association between alcohol consumption and venous thromboembolism (VTE) risk has been investigated by various observational studies with inconsistent results. We examined this association by performing a meta-analysis of prospective studies. A comprehensive literature search was carried out in the PubMed, EMBASE, and Web of Science from its inception to February 2020. Pooled effect estimates were calculated using a random effect model. Ten prospective studies (14 cohorts) were included in this meta-analysis with a total of 441,128 individuals and 10,221 VTE cases. Overall, the highest consumption of alcohol was not associated with the VTE risk compared with the lowest group [relative risk (RR), 0.96 (95% CI, 0.89-1.04), = 0.293]. No obvious heterogeneity of RRs was observed across these studies ( = 0.249 for heterogeneity, = 18.8%). Egger's and Begg's tests showed no evidence of publication bias (Egger, = 0.443; Begg, = 0.730). In the subgroup analysis by sex, a borderline significant association between alcohol consumption and VTE risk was observed in women [RR, 0.91 (95% CI, 0.82-1.00)]. In the dose-response analysis, we observed a linear decrease in VTE risk with increasing alcohol intake ( = 0.634 for nonlinearity). However, the reduced risk was not statistically significant. In conclusion, the results from this meta-analysis suggest that alcohol intake is not related with the risk of VTE. Further large well-designed cohort studies are warranted to investigate a potential protective role of alcohol against VTE in women.
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http://dx.doi.org/10.3389/fnut.2020.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145405PMC
April 2020

Inhibitory effect of 5-Fluorouracil on the proliferation of human osteosarcoma cells in vitro.

J BUON 2019 Jul-Aug;24(4):1706-1711

Department of Orthopedics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, P.R. China.

Purpose: To evaluate the inhibitory effect of 5-fluorouracil (5-FU) in combination with cisplatin on the proliferation of human osteosarcoma cells in vitro.

Methods: Three groups of human osteosarcoma U2OS cells were cultured in DMEM medium supplemented with the following drugs: 20 µg/mL 5-FU, 50 µg/mL 5-FU and 50 µg/mL 5-FU in combination with 0.5 mg/L cisplatin. After culture at 24, 48 and 72 h, the inhibition of proliferation rate of U2OS cells was calculated by CCK-8 cell kit. Cell invasiveness was assessed by Transwell assay. Flow cytometry was used for monitoring the cell apoptosis.

Results: 5-FU inhibited the growth of osteosarcoma cells, and the results of different concentrations of 5-FU were significantly different. The growth of U2OS cells decreased significantly within 24-72 h, and the concentration of 5-FU increased with time. The inhibition of the shift was more obvious, and the combined drug inhibition was significantly higher than the 20μg/ml 5-FU Group, 0.5mg/L Cisplatin Group and 50μg/ml 5-FU Group. After 72 h, the mean inhibitory rates of 20 μg/mL 5-FU, 50 μg/mL 5-FU, 50 μg/ml 5-FU in combination with 0.5 mg/L cisplatin, and 0.5 mg/L cisplatin were 12.54±1.26%, 22.17±0.59%, 32.54±1.25%, 20.84±0.83% respectively, and the difference was significant (p<0.05). Results of cell invasion assay showed that after culturing for 48 h, the mean number of cells penetrating the membrane was 22.84±5.27 in the culture group of 0.5 mg/L cisplatin, 30.57±5.68 in the culture group of 20 µg/mL 5-FU, 18.68±4.88 in the culture group of 50 µg/mL 5-FU, and 9.84±3.64 in the culture group of 50 µg/mL 5-FU in combination with 0.5 mg/L cisplatin, respectively, and 72.00±7.52 in the control group, showing statistical differences in each group (p<0.05). The apoptosis of the control group was significantly lower than that of the other groups (p<0.05). Apoptosis rate of the 20μg/mL 5-FU group was significantly lower than that of the 0.5mg/L cisplatin group, the 50μg/mL 5-FU group and the 50 μg/ml 5-FU group in combination with 0.5mg/L cisplatin (p<0.05). There was no difference in apoptosis between 0.5mg/L cisplatin and 50μg/mL 5-FU group (p>0.05).

Conclusion: 5-FU in combination with cisplatin exerts an inhibitory effect on the proliferation and invasion of human osteosarcoma cells in vitro, and can promote cell apoptosis.
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March 2020

The effect of diabetes on the risk and mortality of acute lung injury/acute respiratory distress syndrome: A meta-analysis.

Medicine (Baltimore) 2019 Mar;98(13):e15095

Department of Critical Care Medicine, Lishui City People's Hospital, Lishui, Zhejiang Province, China.

Background: The role of pre-existing diabetes in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is still controversial. This systematic review and meta-analysis of observational studies aimed to evaluate the effect of diabetes on the risk and mortality of ALI/ARDS.

Methods: A comprehensive literature search was performed in PubMed, Scopus, Cochrane Central Register of Controlled Trails and Web of Science for their inception to September 2018. Summary risk estimates were calculated with a DerSimonian and Laird random-effects model. Heterogeneity was evaluated using Cochran chi-square test and the I statistic.

Results: Ultimately, 14 studies with a total of 6613 ALI/ARDS cases were included. The risk of ALI/ARDS was not significantly reduced in diabetes patients (OR 0.82, 95% CI 0.57-1.18, P = .283), with obvious heterogeneity across studies (I = 72.5%, P < .001). Further analyses in the meta-analysis also showed no statistically significant associations between pre-existing diabetes and in-hospital mortality (OR 0.79, 95% CI 0.51-1.21, P = .282) or 60-day mortality of ALI/ARDS (OR 0.91, 95% CI 0.75-1.11, P = .352).

Conclusion: This systematic review and meta-analysis of observational studies indicates that pre-existing diabetes have no effect on the risk and mortality of ALI/ARDS.
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http://dx.doi.org/10.1097/MD.0000000000015095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456090PMC
March 2019

Effects of SI and PCV on respiratory mechanics, early central drive and hemodynamics in patients with ARDS.

Exp Ther Med 2019 Apr 30;17(4):2708-2714. Epub 2019 Jan 30.

Department of ICU, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China.

Effects of sustained inflation (SI) and pressure- controlled ventilation (PCV) on respiratory mechanics, early central drive, and hemodynamics in patients with acute respiratory distress syndrome (ARDS) were investigated and compared. A retrospective analysis of 26 patients with ARDS, who were admitted to the Yiwu Central Hospital from March 2015 to March 2016, was performed. According to the ventilation method adopted by the patients with ARDS, 13 patients who received SI treatment were included in the SI group and 13 patients who received PCV treatment were included in the PCV group. The condition of central drive of the patients in the two groups was recorded and calculated continuously before and after recruitment maneuver (RM), the changes of each indicator of the respiratory function and hemodynamics were recorded and calculated before and after RM at 1, 10, 20 and 30 min. The differences were not statistically significant when comparing PIP, Pplate and Crs in patients in the SI group and the PCV group before RM with those after RM at 1, 10, 20 and 30 min (P>0.05), the differences were not statistically significant when comparing heart rate and mean arterial pressure in patients in the SI group and the PCV group before RM with those after RM at 1, 10, 20 and 30 min (P>0.05). Ηowever, central venous pressure in patients in the SI group after RM at 10 and 20 min was significantly higher than that in the PCV group, and the differences were statistically significant (P<0.05). VT/RMS, VE/RMS and ΔPdi/RMS in the SI group and the PCV group after RM were significantly higher than those before RM, and the differences were statistically significant (P<0.05). There was little difference in the effect between SI and PCV on respiratory mechanics, early central drive and hemodynamics in patients with ARDS, and both mechanical ventilation methods enhanced the effect of central-mechanical-ventilation coupling after RM. Therefore, the two mechanical ventilation methods, SI and PCV, were equally available for patients with ARDS.
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http://dx.doi.org/10.3892/etm.2019.7218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425255PMC
April 2019

The effects of statin therapy on mortality in patients with sepsis: A meta-analysis of randomized trials.

Medicine (Baltimore) 2018 Aug;97(31):e11578

Intensive Care Unit, Yiwu Central Hospital, Yiwu, Zhejiang Province, China.

Background: Much controversy persists regarding the role of statins therapy in patients with sepsis. This systematic review and meta-analysis of randomized trials aimed to evaluate the clinical efficacy of statin therapy on mortality from sepsis.

Methods: We comprehensively searched PubMed, Embase, and Cochrane controlled trials register for relevant clinical studies. Randomized controlled trials reporting the effect of statin therapy on mortality in septic patients were included. Pooled risk estimates were calculated with a fixed-effects model. Heterogeneity was determined by Cochran chi-square test and the I statistic.

Results: Nine trials with a total of 2333 patients were included. Seven randomized trials were eligible for the in-hospital mortality analysis. There were 257 deaths among 1078 individuals in the statin treatment group and 268 deaths among 1081 individuals in the control group. There was no statistically significant difference (RR, 0.96; 95% CI, 0.83-1.11). Five randomized trials reported data on 28 day-hospital mortality. There were 123 deaths among 613 individuals in the statin treatment group and 141 deaths among 633 individuals in the control group. There was no statistically significant difference (RR, 0.90; 95% CI, 0.73-1.11).

Conclusion: This systematic review and meta-analysis of randomized trials indicates that statin therapy has no effect on mortality outcomes in patients with sepsis compared with placebo.
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http://dx.doi.org/10.1097/MD.0000000000011578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081129PMC
August 2018

Effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response and antioxidant capacity of ARDS.

Exp Ther Med 2018 Jun 30;15(6):4665-4670. Epub 2018 Mar 30.

Department of Emergency, Yiwu Central Hospital, Yiwu, Zhejiang 322000, P.R. China.

Acute respiratory distress syndrome (ARDS) is a disease that seriously threatens human life and health. The aim of the study was to investigate the effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response, as well as the antioxidant capacity of ARDS. Eighty patients with ARDS treated in Yiwu Central Hospital from January, 2015 to December, 2016 were enrolled in the present study and divided into the observation (n=40) and control (n=40) groups, using a random number table. The control group was treated with mechanical ventilation, while the observation group, based on treatment of the control group, was treated with ulinastatin for 14 consecutive days as one course of treatment. The changes in the relevant indexes of oxygen metabolism, lung function, time of ventilator treatment, total hospital stay, and St. George's Respiratory Questionnaire (SGRQ) score of the two groups after intervention were compared, and the changes in inflammatory cytokine levels, dopamine receptor-related hormone levels, superoxide dismutase (SOD), malondialdehyde (MDA) and total antioxidant capacity of the two groups before intervention and at 1 and 4 weeks after intervention were compared. After intervention, the arterial blood lactate in the observation group was significantly lower than that in the control group (P<0.05), the oxygen uptake rate was significantly higher than that in the control group (P<0.05) and the arterial oxygen content was significantly higher than that in the control group (P<0.05). In the lung function indexes, the FEV and FEV/FVC levels in the observation group were smaller than those in the control group (P<0.05), the duration of ventilator treatment was significantly shorter than that in the control group (P<0.05), and the hospital stay was significantly less than that in the control group (P<0.05). Prior to intervention, SGRQ scores in the two groups were not statistically significant (P>0.05). At 1 and 4 weeks after intervention, the SGRQ scores of the observation group were significantly increased to those of the control group (P<0.05). The tumor levels of necrosis factor-α (TNF-α), interleukin-6 (IL-6) and CRP were significantly lower than those of the control group (P<0.05). The levels of adrenaline and norepinephrine were significantly lower than those of the control group (P<0.05). The levels of MDA, SOD and the total antioxidant capacity were significantly increased to those of control group (P<0.05). The application of ulinastatin combined with mechanical ventilation in ARDS patients is of great significance in improving the oxygen delivery-consumption balance of body, increasing the lung function, reducing the inflammatory and stress response, and improving the antioxidant capacity.
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http://dx.doi.org/10.3892/etm.2018.6012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952097PMC
June 2018

Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: A before and after study.

PLoS One 2017 3;12(8):e0182393. Epub 2017 Aug 3.

Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P. R. China.

Background And Objective: Enteral nutrition (EN) feeding protocol was proposed to have positive impact on critically ill patients. However, current studies showed conflicting results. The present study aimed to investigate whether enteral feeding protocol was able to improve clinical outcomes in critically ill patients.

Methods: A before (stage 1) and after (stage 2) interventional study was performed in 10 tertiary care hospitals. All patients expected to stay in the intensive care unit (ICU) for over three days were potentially eligible. Clinical outcomes such as 28-day mortality, ICU length of stay, duration of mechanical ventilation (MV), and nosocomial infection were compared between the two stages.

Main Results: A total of 410 patients were enrolled during the study period, including 236 in stage 1 and 174 in stage 2. EN feeding protocol was able to increase the proportion of EN in day 2 (41.8±22.3 vs. 50.0±28.3%; p = 0.006) and day 6 (70.3±25.2 vs. 77.6±25.8%; p = 0.006). EN percentages tended to be higher in stage 1 than that in stage 2 on other days, but statistical significance was not reached. There was no difference in 28-day mortality between stage 1 and 2 (0.14 vs. 0.14; p = 0.984). Implementation of EN feeding protocol marginally reduced ICU length of stay (19.44±18.48 vs. 16.29±16.19 days; p = 0.077). There was no difference in the duration of MV between stage a and stage 2 (14.24±14.49 vs. 14.51±17.55 days; p = 0.877).

Conclusions: The study found that the EN feeding protocol was able to increase the proportion of EN feeding, but failed to reduce 28-day mortality, incidence of nosocomial infection or duration of MV.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182393PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542540PMC
October 2017

Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome.

Rev Assoc Med Bras (1992) 2017 May;63(5):435-440

Critical Care Medicine, Yiwu Central Hospital, Yiwu, Zhejiang Province, China.

Objective:: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS).

Method:: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment.

Results:: The oxygenation index was higher and the levels of EVLWI and PVPI were lower after treatment in the two groups; however, these indexes showed significant differences on the 5th and 7th days after rhubarb treatment compared with the results in the control group (p<0.05).

Conclusion:: Rhubarb can decrease EVLWI and PVPI, and improve oxygenation in patients with ARDS.
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http://dx.doi.org/10.1590/1806-9282.63.05.435DOI Listing
May 2017

Peripheral arterial volume distensibility changes with applied external pressure: significant difference between arteries with different compliance.

Sci Rep 2017 01 17;7:40545. Epub 2017 Jan 17.

Health and Wellbeing Academy, Faculty of Medical Science, Anglia Ruskin University, Chelmsford, UK.

This study aimed to quantify the different effect of external cuff pressure on arterial volume distensibility between peripheral arteries with different compliance. 30 healthy subjects were studied with the arm at two positions (0° and 45° from the horizontal level) to introduce different compliance of arteries. The electrocardiogram and finger and ear photoplethysmograms were recorded simultaneously under five external cuff pressures (0, 10, 20, 30 and 40 mmHg) on the whole arm to obtain arterial volume distensibility. With the applied external cuff pressures of 10, 20, 30 and 40 mmHg, the overall changes in arterial volume distensibility referred to those without external pressure were 0.010, 0.029, 0.054 and 0.108% per mmHg for the arm at the horizontal level, and 0.026, 0.071, 0.170 and 0.389% per mmHg for the arm at 45° from the horizontal level, confirming the non-linearity between arterial volume distensibility and external pressure. More interestingly, the significant differences in arterial volume distensibility changes were observed between the two arm positions, which were 0.016, 0.043, 0.116 and 0.281% per mmHg (all P < 0.01). Our findings demonstrated that arterial volume distensibility of peripheral arm arteries increased with external pressure, with a greater effect for more compliant arteries.
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http://dx.doi.org/10.1038/srep40545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240166PMC
January 2017

Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: a study protocol for before-and-after design.

Ann Transl Med 2016 Aug;4(16):308

Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310000, China ;

Introduction: Enteral feed is an important component of nutritional therapy in critically ill patients and underfeeding has been associated with adverse outcomes. The article developed an enteral feeding protocol and planed a before-and-after comparative trial to explore whether implementation of enteral feeding protocol was able to improve clinical outcomes.

Methods And Analysis: The study will be conducted in intensive care units (ICUs) of ten tertiary care academic centers. Critically ill patients expected to stay in ICU for over 3 days and require enteral nutrition (EN) were potentially eligible. This is a before-and-after study comprising three phases: The first phase is the period without enteral feeding protocol; the second phase involves four-week training program, and the last phase is to perform the protocol in participating centers. We plan to enroll a total of 350 patients to provide an 80% power and 0.05 error rate to detect a 15% reduction of mortality. The primary outcome is 28-day mortality.

Ethics And Dissemination: Ethical approval to conduct the research has been obtained from all participating centers. Additionally, the results will be published in peer-reviewed journal.

Trial Registration: The study was registered at International Standard Registered Clinical/soCial sTudy Number (ISRCTN) registry (ISRCTN10583582).
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http://dx.doi.org/10.21037/atm.2016.07.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009025PMC
August 2016
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