Publications by authors named "Mingming Zhang"

521 Publications

Pathogenetic mechanisms of septic cardiomyopathy.

J Cell Physiol 2021 Jul 18. Epub 2021 Jul 18.

Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Sepsis is a serious complication after infection, whose further development may lead to multiple organ dysfunction syndrome and so on. It is an important cause of death in critically ill patients who suffered an infection. Sepsis cardiomyopathy is a common complication that exacerbates the prognosis of patients. At present, though the pathogenesis of sepsis cardiomyopathy is not completely clear, in-depth study of the pathogenesis of sepsis cardiomyopathy and the discovery of its potential therapeutic targets may decrease the mortality of sepsis patients and bring clinical benefits. This article reviews mitochondrial dysfunction, mitophagy, oxidation stress, and other mechanisms in sepsis cardiomyopathy.
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http://dx.doi.org/10.1002/jcp.30527DOI Listing
July 2021

New-Onset Severe Cytopenia After CAR-T Cell Therapy: Analysis of 76 Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia.

Front Oncol 2021 30;11:702644. Epub 2021 Jun 30.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Although chimeric antigen receptor T (CAR-T) cell therapy has proven to be effective in treating relapsed or refractory B-cell hematological malignancies, severe hematological toxicities remain an intractable issue. This retrospective study assessed the characteristics and risk factors of new-onset severe cytopenia following CAR-T cell infusion in 76 patients with r/r acute lymphoblastic leukemia. The rates of new-onset severe cytopenia were high, including severe neutropenia (SN) (39/56, 70%), severe anemia (SA) (35/66, 53%), and severe thrombocytopenia (ST) (31/64, 48%). Comparatively, cohorts with higher cytokine release syndrome (CRS) grades had higher incidence of severe cytopenia with prolonged duration. Multivariable analyses showed that elevated maximum (max) lg D-dimer and delayed peak time of CRS are independent risk factors for SN recovery; increased max lg IL-10 and delayed CRS recovery are risk factors for SA; high max lg ferritin is a risk factor for ST; and longer period to CRS onset or CRS recovery and higher grade of CRS are risk factors for prolonged hematological toxicities. These observations led to the conclusion that profiles of CRS, including its duration, severity and serum markers are correlated to the incidence and recovery of new-onset severe cytopenia, prompting clinical intervention for post-CAR-T severe cytopenia.
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http://dx.doi.org/10.3389/fonc.2021.702644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278328PMC
June 2021

Recent advances in the application of water-stable metal-organic frameworks: Adsorption and photocatalytic reduction of heavy metal in water.

Chemosphere 2021 Jul 6;285:131432. Epub 2021 Jul 6.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, PR China.

Heavy metals pollution in water is a global environmental issue, which has threatened the human health and environment. Thus, it is important to remove them under practical water environment. In recent years, metal-organic frameworks (MOFs) with water-stable properties have attracted wide interest with regard to the capture of hazardous heavy metal ions in water. In this review, the synthesis strategy and postsynthesis modification preparation methods are first summarized for water-stable MOFs (WMOFs), and then the recent advances on the adsorption and photocatalytic reduction of heavy metal ions in water by WMOFs are reviewed. In contrast to the conventional adsorption materials, WMOFs not only have excellent adsorption properties, but also lead to photocatalytic reduction of heavy metal ions. WMOFs have coupling and synergistic effects on the adsorption and photocatalysis of heavy metal ions in water, which make it more effective in treating single pollutants or different pollutants. In addition, by introducing appropriate functional groups into MOFs or synthesizing MOF-based composites, the stability and ability to remove heavy metal ions of MOFs can be effectively enhanced. Although WMOFs and WMOF-based composites have made great progress in removing heavy metal ions from water, they still face many problems and challenges, and their application potential needs to be further improved in future research. Finally, this review aims at promoting the development and practical application of heavy metal ions removal in water by WMOFs.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131432DOI Listing
July 2021

Pericardial tamponade after chronic total occlusion revascularization: a case report and literature review.

Ann Palliat Med 2021 Jul 7. Epub 2021 Jul 7.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Pericardial tamponade is a complication of percutaneous coronary intervention (PCI) with extremely high mortality. The rupture of coronary artery causes hypotension and shock, eventually resulting in death due to pericardial tamponade. Because of the complex operation in revascularization of chronic total occlusion (CTO-PCI) lesion, the incidence of pericardial tamponade increases. Usually, we use coronary angiogram to identify the rupture of coronary artery after PCI by the contrast agent. We presented a 67-year-old woman with pericardial tamponade after CTO revascularization. She had chest pain and out of breath for nearly two years. The coronary angiogram showed three branch lesion and CTO lesion of the right coronary artery (RCA). After revascularization of the RCA CTO lesion, the pericardial effusion and low blood pressure occurred, but we didn't find the leak of contrast agents during the final angiography. Then the patient was transferred to cardiac surgery department for emergency thoracotomy. They found the hematoma on the surface of the RCA and finally discharged without any symptoms. Our case approved: (I) there was still the possibility of coronary artery rupture even the coronary angiogram showed no contrast agent leakage from the coronary artery after PCI; (II) the combined use of IVUS and coronary angiogram may improve the accuracy and safety of CTO revascularization procedure.
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http://dx.doi.org/10.21037/apm-20-2455DOI Listing
July 2021

LncRNA CYTOR drives L-OHP resistance and facilitates the epithelial-mesenchymal transition of colon carcinoma cells via modulating miR-378a-5p/SERPINE1.

Cell Cycle 2021 Jul 5:1-16. Epub 2021 Jul 5.

The First Department of General Surgery, The Second People's Hospital of Yunnan Province, Kunming, China.

Long non-coding RNAs (lncRNAs) play a vital regulatory role in many human cancers. However, their underlying effect and molecular mechanism in chemoresistance need to be fully researched. This study found that lncRNA CYTOR expression was significantly up-regulated in colon carcinoma tissue and cells. Silencing lncRNA CYTOR facilitated L-OHP sensitivity of colon carcinoma cells and restrained epithelial-mesenchymal transition (EMT). Furthermore, lncRNA CYTOR could inhibit miR-378a-5p expression, while suppressing miR-378a-5p could attenuate the inhibition of lncRNA CYTOR silencing on L-OHP resistance and EMT. The downstream target mRNA of miR-378a-5p was further explored, and it was discovered that miR-378a-5p restrained SERPINE1 expression. Rescue assay indicated that overexpressing miR-378a-5p or silencing SERPINE1 expression counteracted the promotion of lncRNA CYTOR overexpression on L-OHP resistance and EMT of colon carcinoma cells. experiment exhibited that silencing lncRNA CYTOR repressed colon carcinoma growth, while miR-378a-5p inhibition diminished the suppression of silencing lncRNA CYTOR on colon carcinoma. These results testified that lncRNA CYTOR enhanced L-OHP drug resistance and induced EMT in colon carcinoma. It was also suggested that lncRNA CYTOR/miR-378a-5p/SERPINE1 axis was a regulatory pathway of L-OHP resistance in colon carcinoma. They could be potential therapeutic targets and prognostic biomarkers.ATG: autophagy related; EPG: ectopic PGL granules; GFP: green fluorescent protein; LGG-1: LC3, GABARAP and GATE-16 family; LPLA-2: lysosomal phospholipase A2; PGL: P granule abnormality protein; PLA2: phospholipase A2; SD: standard deviation; SEPA-1: suppressor of ectopic P granules in autophagy mutant; SQST-1: sequestosome related.
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http://dx.doi.org/10.1080/15384101.2021.1934626DOI Listing
July 2021

Do we need more patient-friendly treatment options for overactive bladder (OAB)?

Neurourol Urodyn 2021 Aug 21;40(6):1433-1440. Epub 2021 Jun 21.

Avation Medical Inc, Columbus, Ohio, USA.

Aims: To collect feedback from subjects diagnosed with overactive bladder (OAB) on its impact on their quality of life, their satisfaction with current treatment options, and to assess nonsurgical, tibial nerve stimulation as a treatment option.

Methods: Subjects were asked a variety of questions about the impact of OAB on their lives, their satisfaction with current and previous treatment approaches. Subjects evaluated the comfort of a nonworking prototype garment and were given electrical stimulation over their posterior tibial nerve to assess comfort and tolerability. Electromyographic (EMG) signals were recorded.

Results: A total of 40 subjects with OAB symptoms were evaluated in the study. Urgency (55%), frequency (47.5%), nocturia (40%), and incontinence (30%) were the most bothersome symptoms. At the time of the study only 32.5% of the subjects were treating their OAB symptoms. Of those that had tried and discontinued treatments, most had failed medications (n = 14) due to no improvements or side effects. Only 2 subjects found stimulation to be uncomfortable before an EMG signal could be detected. The most common word used to describe the feeling of stimulation was "constant," followed by "tingling," "vibrating," and "comfortable."

Conclusions: Most subjects who had tried OAB treatments were dissatisfied and discontinued their use. A new patient-friendly approach to OAB therapy that delivers efficacy but overcomes drawbacks associated with currently available treatments is needed. Subjects found electrical stimulation over the tibial nerve to be comfortable and tolerable and this should be considered as an alternative treatment approach for OAB.
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http://dx.doi.org/10.1002/nau.24731DOI Listing
August 2021

Complete mitochondrial DNA sequence of yellow-legged buttonquail ().

Mitochondrial DNA B Resour 2021 Jun 7;6(7):1914-1916. Epub 2021 Jun 7.

Forestry College, Guizhou University, Guiyang, China.

The Yellow-legged Buttonquail is a species of the genus , which belongs to the order Charadriiformes. It is distributed across almost all of China. The International Union for Conservation of Nature has assessed the bird's conservation status as 'Least Concern (LC).' We sequenced the complete mitogenome of and examined its phylogenetic relationship with other charadriiformes species. The mitochondrial DNA is packaged in a compact 17,620 base pair circular molecule with A + T content of 57.90%. It contains 37 typical mitochondrial genes, including 13 protein-coding genes, two rRNAs and 22 tRNAs, and two non-coding regions. We reconstructed a phylogenetic tree based on mitogenome sequences of five Turnicidae species and one outgroup. Phylogenetic analysis indicated that is a sister to
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http://dx.doi.org/10.1080/23802359.2021.1935341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189131PMC
June 2021

All-optical polarization split of the signal and LO for a bi-directional self-homodyne coherent system.

Opt Lett 2021 Jun;46(12):2819-2822

In this Letter, we propose a cost-efficient bi-directional (BiDi) polarization-multiplexed self-homodyne coherent detection (SHCD) system, in which only one fiber link and one adaptive polarization controller (APC) are required. By employing the correlation of the state of polarization (SOP) between the upstream and downstream light, one APC is capable of stabilizing SOPs of the counterpropagating waves at the same time. The signal and local oscillator (LO) can be optically split by a polarization beam splitter (PBS), relaxing pressure of the digital signal processing (DSP) and simplifying the coherent receiver. The impact induced by polarization cross talk and delay mismatch is collectively investigated by theoretical analysis and simulation. Finally, the proposed scheme is experimentally verified through 120 Gbit/s 16-quadrature amplitude modulation (16-QAM) transmission, achieving a satisfying laser-linewidth tolerance of 10 MHz and a polarization rotation tolerance of up to 45 rad/s.
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http://dx.doi.org/10.1364/OL.427789DOI Listing
June 2021

Facile one-pot synthesis of carbon self-doped graphitic carbon nitride loaded with ultra-low ceric dioxide for high-efficiency environmental photocatalysis: Organic pollutants degradation and hexavalent chromium reduction.

J Colloid Interface Sci 2021 May 25;601:196-208. Epub 2021 May 25.

College of Environmental Science and Engineering, Hunan University, Changsha 410082, Hunan, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, Hunan, PR China.

In the present study, an innovative carbon self-doped g-CN (CCN) loaded with ultra-low CeO (0.067-0.74 wt%) composite photocatalyst is successfully synthesized via a facile one-pot hydrothermal and calcination method. The CeO/CCN exhibits superior photocatalytic performance for tetracycline degradation (78.9% within 60 min), HO production (151.92 μmol L within 60 min), and Cr(VI) reduction (99.5% within 40 min), which much higher than that of g-CN, CCN, CeO, and CeO/g-CN. The enhanced photocatalytic performance is originated from the fact that the doping of C can efficaciously broaden the utilization range of solar light and improve the reduction ability of photogenerated electrons. Meanwhile, the ultra-low loading of CeO can effectually promote the migration of photogenerated electrons and enhance the specific surface area. Besides, the experiments of pH effect and cycle ability indicate that CeO/CCN has excellent durability and stability. Finally, the photocatalytic mechanism of CeO/CCN is systematically discussed. This work proves that combining element doping and semiconductor coupling is a promising strategy to design high-efficiency g-CN-based photocatalysts.
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http://dx.doi.org/10.1016/j.jcis.2021.05.124DOI Listing
May 2021

MXenes as Superexcellent Support for Confining Single Atom: Properties, Synthesis, and Electrocatalytic Applications.

Small 2021 Jul 28;17(29):e2007113. Epub 2021 May 28.

Faculty of Life Science and Technology, Central South University of Forestry and Technology, Shaoshan Road, Changsha, 410004, China.

Single atom catalysts (SACs) have shown their noticeable potential and gradually become a new favorite in catalytic field due to the particular selectivity, high catalytic performance, and strong durability. The most important factor in the synthesis of SACs is the selection of appropriate support and formation of metal-support interaction. Among a large number of nanomaterials, MXenes can be utilized as benign supports for fixing SACs because of their expansive specific surface area, regulable bandgap, superior electronic conductivity, and strong mechanical stability. The structure and property of MXenes can be manipulated by changing transition metal elements and surface termination. Here, the uniqueness and superiority of MXenes as superexcellent supports for confining SACs are analyzed from structure and property. The synthetic strategy of MXene-supported SACs is also summarized, especially emphasizing the immobilization of isolated atom against aggregation by utilizing the formidable metal-support covalent coordination interaction. In addition, the applications of MXene-supported SACs in electrocatalytic field are highlighted, including hydrogen evolution reaction, oxygen evolution reaction, overall water splitting, oxygen reduction reaction, and nitrogen reduction reaction. Finally, the challenges and prospects are pointed out for the further understanding and practical application of MXene-supported SACs in electrocatalysis.
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http://dx.doi.org/10.1002/smll.202007113DOI Listing
July 2021

Engineered macrophage membrane-enveloped nanomedicine for ameliorating myocardial infarction in a mouse model.

Bioeng Transl Med 2021 May 19;6(2):e10197. Epub 2020 Nov 19.

Department of Cardiology Tangdu Hospital, Air force Military Medical University Xi'an Shaanxi China.

Myocardial infarction (MI) is the serious condition causing lots of death over the world. Myocytes apoptosis, inflammation, and fibrosis are three important factors implicated in pathogenesis of MI. Targeting these three factors has been shown to ameliorate MI and rescue cardiac function. Previous studies have demonstrated that microRNA (miR) 199a-3p protect against MI. In this study, we prepare macrophage membrane coated nanoparticles (MMNPs) containing miR199a-3p. We evaluate the effects of these NPs on apoptosis and cell proliferation and the effects on inflammation cytokine production, expression of fibrosis related proteins, cardiac injuries, and functions in MI mice. We find that the MMNPs have receptors of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) and can bind to these cytokines. MMNPs prevent hypoxia-induced apoptosis and promote cell proliferation, suppress the inflammation, and inhibit the cardiac fibrosis in MI mice. These results demonstrate that MMNPs ameliorate left ventricular remodeling and cardiac functions, and protect against MI, suggesting MMNPs containing miR199a-3p is a potential therapeutic approach to treat MI.
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http://dx.doi.org/10.1002/btm2.10197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126824PMC
May 2021

Refractory Kawasaki disease: modified methylprednisolone regimen decreases coronary artery dilatation.

Pediatr Res 2021 May 21. Epub 2021 May 21.

Department of Cardiology, Children's Hospital Capital Institute of Pediatrics, Beijing, China.

Background: The use of corticosteroids in Kawasaki disease (KD) is still controversial. The aim of this study was to investigate the safety and effectiveness of modified methylprednisolone (mPSL) regimen as an initial treatment for refractory KD.

Methods: This is a real-world observational study. We identified refractory KD with a self-developed scoring system. Patients were divided into the intravenous immunoglobulin (IVIG) + mPSL group and the IVIG group. Clinical outcomes and changes in coronary arteries after the treatment during a 12-week period were observed. Propensity-score matching was used to analyze those patients with similar baseline characteristics.

Results: Of a total of 168 patients, 104 patients were assigned into the IVIG group and 64 patients into the IVIG + mPSL group. The therapeutic response rate of the IVIG + mPSL group was significantly higher than that of the IVIG group (98.4 vs 76.0%, P < 0.05). The IVIG + mPSL group had a shorter duration of fever and a higher rate of C-reactive protein decline than the IVIG group (1.17 ± 0.64 vs 1.81 ± 1.16 days; 88.1 vs 83.5%; P < 0.05). The luminal diameter and Z-score of the left circumflex coronary artery (LCX) were significantly smaller and lower in the IVIG + mPSL group than that in the IVIG group at weeks 2 and 12.

Conclusions: Modified mPSL regimen has minimal side effects. It might improve the initial response to IVIG and decrease the dilation of LCX for refractory KD.

Impact: Modified mPSL regimen (2-4 mg/kg/day, divided into 2-3 doses for 3-5 days, then 1 mg/kg/day, once a day for 3-5 days, then oral prednisone was tapered over 3-5 weeks in 5-7 days steps) as an intensive initial treatment can decrease LCX dilation in high-risk IVIG-resistant KD patients. Our self-developed scoring system has been proven validated and can be used to identify high-risk IVIG-resistant KD patients in North China. The present study provides an alternative therapeutic regimen for high-risk refractory KD patients.
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http://dx.doi.org/10.1038/s41390-021-01576-6DOI Listing
May 2021

Optimal design of aeroacoustic airfoils with owl-inspired trailing-edge serrations.

Bioinspir Biomim 2021 Jul 15;16(5). Epub 2021 Jul 15.

Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.

The trailing-edge serration that imitates the silent owl wing is used as a flow control method to suppress the aerodynamic noise generated from the rotating wind turbine blade. Recent studies have found that the addition of serrations could degrade the overall aerodynamic performance of the airfoil. To this end, an optimal design method for airfoils with the trailing-edge serration is developed. Combined with the modeling methods of aerodynamics for serrations, the fundamental parameters of serrations are integrated into the optimal design of wind turbine airfoils. Specifically, based on the existing multidisciplinary optimization method for airfoils, the aerodynamic prediction and evaluation module for the serrated airfoil was introduced to develop an aerodynamic-structural optimal design platform. In this way, a novel serrated airfoil equipped with high aerodynamic performance can be designed. Compared with the reference airfoil, the maximum lift-to-drag ratio and lift coefficient of the optimal serrated airfoil at the design point have been increased by 1.9% and 32.5%, while the aerodynamic noise could also be reduced. Finally, experiments were conducted in an anechoic chamber to verify the noise-reduction level of the optimal serrated airfoil, which sufficiently demonstrate the capability to improve the comprehensive performance of the airfoil using such a developed optimal scheme.
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http://dx.doi.org/10.1088/1748-3190/ac03bdDOI Listing
July 2021

Enhanced visible-light-driven photocatalytic activity of bismuth oxide via the decoration of titanium carbide quantum dots.

J Colloid Interface Sci 2021 Oct 8;600:161-173. Epub 2021 May 8.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

In TiC quantum dots (TiC QDs)/BiO photocatalysts system, TiC QDs can act as a co-catalyst to greatly boost the photocatalytic performance of BiO. TiC QDs with excellent light adsorption ability can improve the light response of the system, and the fascinating electronic property can function as a channel for electron transfer. Moreover, TiC QDs possess larger specific area and more active edge atoms thanks to the size effect. The best TiC QDs/BiO composite with the loading amounts of 75 mL of TiC QDs solution showed much higher photocatalytic performance (nearly 5.85 times) for tetracycline (TC) degradation than that of pristine BiO under visible light irradiation. These different photocatalytic performances shed light on the key role of TiC QDs in stimulating the photocatalytic activity of BiO. Moreover, TiC QDs/BiO composites exhibited excellent stability in recycling experiments and actual water sample treatment.
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http://dx.doi.org/10.1016/j.jcis.2021.05.022DOI Listing
October 2021

Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy.

Asian J Urol 2021 Apr 23;8(2):227-234. Epub 2020 May 23.

Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

Objective: To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively.

Methods: The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented.

Results: Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13-0.47 and HR=0.26, 95% CI 0.17-0.40, respectively; after matching: HR=0.18, 95% CI 0.04-0.82 and HR=0.28, 95% CI 0.11-0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06-0.57, <0.01 and HR=0.17, 95% CI 0.06-0.54, <0.01).

Conclusion: Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP.
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http://dx.doi.org/10.1016/j.ajur.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099636PMC
April 2021

Fabrication of PεCL-AuNP-BSA core-shell-corona nanoparticles for flexible spatiotemporal drug delivery and SERS detection.

Biomater Sci 2021 Jun;9(12):4440-4447

College of Chemistry and Key Laboratory of Functional Polymer Materials of the Ministry of Education, Nankai University, weijing road #94, Tianjin 300071, China.

Nanoparticles with protein coronae can be used as promising multifunctional platforms for nanomedicine due to the possibility of performing surface functionalization on protein molecules and the achievement of biomedical properties. In this research, nanoparticles (NPs) with poly(ε-caprolactone) (PεCL) cores, gold NP (AuNP) shells and BSA coronae were fabricated by a self-assembly approach. The hydrophobic PεCL cores were used to encapsulate curcumin (CUR), the AuNP shells were decorated with a Raman probe, and the protein molecules in the coronae were functionalized with folic acid (FA). The self-assembly behaviors, drug delivery and the surface-enhanced Raman scattering (SERS) effect of the hybrid NPs were investigated in this research. The sizes of the core-shell-corona NPs (CSCNPs) are dependent on the initial concentrations of PεCL and AuNPs. The CUR in CSCNPs show enzyme-triggered release properties. The added lipase or trypsin can facilitate the CUR release from the hybrid NPs. The functionalization of CSCNPs with FA can significantly improve the internalization of NPs into 4T1 tumor cells due to the overexpressed folate receptors on the cells. In addition, the SERS effect of CSCNPs can be achieved when the AuNPs are decorated with 2-naphthalenethiol. The hybrid CSCNPs can be used as a promising platform for spatiotemporal drug delivery, cell imaging, and theranostics. Based on the same CSCNP platform, flexible functions can be adjusted according to the application needs.
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http://dx.doi.org/10.1039/d1bm00388gDOI Listing
June 2021

IL-17-producing γδT cells ameliorate intestinal acute graft-versus-host disease by recruitment of Gr-1CD11b myeloid-derived suppressor cells.

Bone Marrow Transplant 2021 May 13. Epub 2021 May 13.

Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Acute graft-versus-host disease (aGVHD) is the most severe complication and the major cause of morbidity and mortality in patients who have received hematopoietic stem cell transplantation. Inflammation mediated by donor T cells and neighboring recipient cells is considered to be responsible for intestinal aGVHD. Interleukin (IL)-17A-producing γδT (γδT17) cells have been investigated as key players in cancer, immunity, and inflammatory responses because of their phenotypic plasticity, memory-like activity, and unique migratory features. However, the precise roles and underlying mechanisms of γδT17 cells in aGVHD immunopathogenesis remain elusive. Here, we found that γδT17 cells constituted the major resident γδT population in the intestinal lamina propria of aGVHD mice. Adoptive infusion of induced γδT17 cells markedly attenuated murine aGVHD and increased infiltration of Gr-1CD11b myeloid-derived suppressor cells (MDSCs) into the inflammatory intestine, and did not affect graft-versus-leukemia(GVL) effect. Further experiments indicated that γδT17 cells enhanced both migration ability and immunosuppressive activity of MDSCs. γδT17 cell-mediated protection in aGVHD was blunted by depletion of IL-17A or MDSCs. Our study clarifies an immune pathway where γδT17 cells play a protective role in murine aGVHD by recruiting MDSCs to the inflammatory intestine.
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http://dx.doi.org/10.1038/s41409-021-01299-6DOI Listing
May 2021

Critical review of advanced oxidation processes in organic wastewater treatment.

Chemosphere 2021 Jul 27;275:130104. Epub 2021 Feb 27.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan, 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan, 410082, China.

With the development of industrial society, organic wastewater produced by industrial manufacturing has caused many environmental problems. The vast majority of organic pollutants in water bodies are persistent in the environment, posing a threat to human and animal health. Therefore, efficient treatment methods for highly concentrated organic wastewater are urgently needed. Advanced oxidation processes (AOPs) are widely noticed in the area of treating organic wastewater. Compared with other chemical methods, AOPs have the characteristics of high oxidation efficiency and no secondary pollution. In this paper, the mechanisms, advantages, and limitations of AOPs are comprehensively reviewed. Besides, the basic principles of combining different AOPs to enhance the treatment efficiency are described. Furthermore, the applications of AOPs in various wastewater treatments, such as oily wastewater, dyeing wastewater, pharmaceutical wastewater, and landfill leachate, are also presented. Finally, we conclude that the main direction in the future of AOPs are the modification of catalysts and the optimization of operating parameters, with the challenges focusing on industrial applications.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130104DOI Listing
July 2021

The burden of premature ventricular contractions predicts adverse fetal and neonatal outcomes among pregnant women without structural heart disease: A prospective cohort study.

Clin Cardiol 2021 Jun 6;44(6):833-838. Epub 2021 May 6.

Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

Background: Premature ventricular contractions (PVCs) may increase during pregnancy, however, few studies have evaluated the relationship between PVCs and the pregnant outcomes.

Hypothesis: PVCs may increase the adverse fetal/neonatal outcomes in pregnant women.

Methods: Six thousand one hundred and forty-eight pregnant women were prospectively enrolled in our center between 2017 and 2019 in the study. The average PVC burden was determined by calculating the number of PVCs in total beats. Those who had a PVC burden >0.5% were divided into two groups based on the presence or absence of adverse fetal or neonatal events. The adverse outcomes were compared between the groups to assess the impact of PVCs on pregnancy.

Results: A total of 103 (1.68%) women with a PVC burden >0.5% were recorded. Among them, 17 adverse events (12 cases) were documented, which was significantly higher than that among women without PVCs (11.65% vs. 2.93%, p < .01). The median PVC burden among pregnant women with PVCs was 2.84% (1.02%-6.1%). Furthermore, compared with that of the women without adverse events, the median PVC burden of women with adverse fetal or neonatal outcomes was significantly higher (9.02% vs. 2.30%, p < .01). Multivariate logistic regression analysis demonstrated that not the LVEF, heart rate and bigeminy, but only the PVC burden was associated with adverse fetal or neonatal outcomes among pregnant women with PVCs (OR: 1.34, 95% CI [1.11-1.61], p < .01).

Conclusions: Frequent PVCs have adverse effects on pregnancy, and the PVC burden might be an important factor associated with adverse fetal and neonatal outcomes among pregnant women with PVCs.
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http://dx.doi.org/10.1002/clc.23612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207974PMC
June 2021

Exercise alleviates cardiac remodelling in diabetic cardiomyopathy via the miR-486a-5p-Mst1 pathway.

Iran J Basic Med Sci 2021 Feb;24(2):150-159

Department of Cardiology, Xijing Hospital, Air Force Medical University of PLA, Xi'an 710032, P.R. China.

Objectives: Physical exercise has emerged as an effective therapy to mitigate cardiac remodelling in diabetic cardiomyopathy (DCM). The results of our previous studies revealed mammalian sterile 20-like kinase 1 (Mst1) is a key regulator of the progression of DCM. However, the precise molecular mechanism of physical exercise-induced cardiac protection and its association with Mst1 inhibition remain unclear.

Materials And Methods: Wildtype and Mst1 transgenic mice were challenged with streptozotocin (STZ) to induce experimental diabetes and were divided into sedentary and exercise groups. The DCM phenotype was evaluated by echocardiography, Masson's trichrome staining, TUNEL and immunoblotting analyses. The exercise-regulated miRNAs targeting Mst1 were predicted by bioinformatic analysis and later confirmed by RT-qPCR, immunoblotting, and dual-luciferase reporter assays. In addition, cultured neonatal mouse cardiomyocytes were subjected to simulate diabetes to elucidate the underlying mechanisms.

Results: Compared to the sedentary diabetic control, physical exercise inhibited Mst1 and alleviated cardiac remodelling in mice with DCM, as evidenced by decreases in the left ventricular end-systolic internal dimension (LVESD) and left ventricular end-diastolic internal dimension (LVEDD), increases in the left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS), attenuation of collagen deposition, and the suppression of apoptosis. Bioinformatic analysis and apoptosis assessments revealed exercise exerted protective effects against DCM through miR-486a-5p release. Moreover, luciferase reporter assays confirmed miR-486a-5p directly suppressed the expression of Mst1, thereby inhibiting the apoptosis of cardiomyocytes subjected to high glucose treatment.

Conclusion: Physical exercise inhibits cardiac remodelling in DCM, and the mechanism is associated with miR-486a-5p release-induced Mst1 inhibition.
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http://dx.doi.org/10.22038/IJBMS.2020.50808.11564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061331PMC
February 2021

A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells.

J Cell Commun Signal 2021 Sep 4;15(3):393-403. Epub 2021 May 4.

Department of Nephrology, The Second Affiliated Hospital, Anhui Medical University (AHMU), No. 678 Fu Rong Road, Hefei, China.

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor (IL-1R) also participate in RIF development, and Toll/IL-1R 8 (TIR8), a member of the Toll-like receptor superfamily, has been identified as a negative regulator of IL-1R signaling. However, the functions of TIR8 in IL-1-induced RIF remain unknown. Here, human embryonic kidney epithelial cells (HKC) and unilateral ureteric obstruction (UUO)-induced RIF models on SD rats were used to investigate the functions of TIR8 involving IL-1β-induced EMT. We showed that IL-1β primarily triggers TIR8 expression by activating nuclear factor-κB (NF-κB) in HKC cells. Conversely, high levels of TIR8 in HKC cells repress IL-1β-induced NF-κB activation and inhibit IL-1β-induced EMT. Moreover, in vitro and in vivo findings revealed that TIR8 downregulation facilitated IL-1β-induced NF-κB activation and contributed to TGF-β1-mediated EMT in renal tubular epithelial cells. These results suggested that TIR8 exerts a protective role in IL-1β-mediated EMT and potentially represents a new target for RIF treatment.
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http://dx.doi.org/10.1007/s12079-021-00620-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222463PMC
September 2021

Impact of renewable energy investment on carbon emissions in China - An empirical study using a nonparametric additive regression model.

Sci Total Environ 2021 Sep 15;785:147109. Epub 2021 Apr 15.

College of Economics and Management, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.

This study analyzed the comprehensive impact of renewable energy investment on carbon emissions in China. To achieve this, a nonparametric additive regression model was built. Using the STIRPAT model, we considered six influencing factors: economic growth, industrialization level, urbanization level, population aging, trade openness, and renewable energy investment. This enabled the exploration of the existence, direction, and intensity of the impact of renewable energy investment on carbon emissions. The results of the linear component of the model showed that renewable energy investment can slightly reduce carbon emissions. The results of the nonlinear component of the model showed that the impacts of renewable energy investment on carbon emissions were inconsistent at different stages of the investment. In the early stage, the renewable energy investment can increase carbon emissions. In the middle stage, the renewable energy investment begins to play a role in reducing emissions. In the later stage, renewable energy investment may be associated with increased carbon emissions again. The relationship between carbon emissions and the other five influencing factors can be represented by an inverted U-shaped curve, a U-shaped curve, or a slow rising curve. The results above provide useful references to adjust renewable energy investment and reduce carbon emissions.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147109DOI Listing
September 2021

Real-Time HD Map Change Detection for Crowdsourcing Update Based on Mid-to-High-End Sensors.

Sensors (Basel) 2021 Apr 2;21(7). Epub 2021 Apr 2.

School of Geodesy and Geomatics, Wuhan University, Wuhan 430072, China.

Continuous maintenance and real-time update of high-definition (HD) maps is a big challenge. With the development of autonomous driving, more and more vehicles are equipped with a variety of advanced sensors and a powerful computing platform. Based on mid-to-high-end sensors including an industry camera, a high-end Global Navigation Satellite System (GNSS)/Inertial Measurement Unit (IMU), and an onboard computing platform, a real-time HD map change detection method for crowdsourcing update is proposed in this paper. First, a mature commercial integrated navigation product is directly used to achieve a self-positioning accuracy of 20 cm on average. Second, an improved network based on BiSeNet is utilized for real-time semantic segmentation. It achieves the result of 83.9% IOU (Intersection over Union) on Nvidia Pegasus at 31 FPS. Third, a visual Simultaneous Localization and Mapping (SLAM) associated with pixel type information is performed to obtain the semantic point cloud data of features such as lane dividers, road markings, and other static objects. Finally, the semantic point cloud data is vectorized after denoising and clustering, and the results are matched with a pre-constructed HD map to confirm map elements that have not changed and generate new elements when appearing. The experiment conducted in Beijing shows that the method proposed is effective for crowdsourcing update of HD maps.
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http://dx.doi.org/10.3390/s21072477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038307PMC
April 2021

Preferentially released miR-122 from cyclodextrin-based star copolymer nanoparticle enhances hepatoma chemotherapy by apoptosis induction and cytotoxics efflux inhibition.

Bioact Mater 2021 Nov 7;6(11):3744-3755. Epub 2021 Apr 7.

Department of Hepatobiliary Cancer, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China.

Chemotherapy, as one of the most commonly used treatment modalities for cancer therapy, provides limited benefits to hepatoma patients, owing to its inefficient delivery as well as the intrinsic chemo-resistance of hepatoma. Bioinformatic analysis identified the therapeutic role of a liver-specific microRNA - miR-122 for enhancing chemo-therapeutic efficacy in hepatoma. Herein, a cyclodextrin-cored star copolymer nanoparticle system (sCDP/DOX/miR-122) is constructed to co-deliver miR-122 with doxorubicin (DOX) for hepatoma therapy. In this nanosystem, miR-122 is condensed by the outer cationic poly (2-(dimethylamino) ethyl methacrylate) chains of sCDP while DOX is accommodated in the inner hydrophobic cyclodextrin cavities, endowing a sequential release manner of miR-122 and DOX. The preferentially released miR-122 not only directly induces cell apoptosis by down regulation of Bcl-w and enhanced p53 activity, but also increases DOX accumulation through inhibiting cytotoxic efflux transporter expression, which realizes synergistic performance on cell inhibition. Moreover, sCDP/DOX/miR-122 displays remarkably increased anti-tumor efficacy compared to free DOX and sCDP/DOX alone, indicating its great promising in hepatoma therapy.
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http://dx.doi.org/10.1016/j.bioactmat.2021.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056416PMC
November 2021

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.

Front Cell Dev Biol 2021 1;9:650666. Epub 2021 Apr 1.

Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22) mice and miR-22 cardiac-specific transgenic (miR-22) mice were subjected to a cecal ligation and puncture (CLP) operation, while a sham operation was used in the control group. The echocardiogram results suggested that miR-22 CLP mice cardiac dysfunction was alleviated. The serum LDH and CK-MB were reduced in the miR-22 CLP mice. As expected, there was reduced apoptosis, increased autophagy and alleviated mitochondrial dysfunction in the miR-22 CLP mice, while it had contrary role in the miR-22 group. Inhibiting miR-22 promoted autophagy by increasing the LC3II/GAPDH ratio and decreasing the p62 level. Additionally, culturing primary cardiomyocytes with lipopolysaccharide (LPS) simulated sepsis-induced cardiomyopathy . Inhibiting miR-22 promoted autophagic flux confirmed by an increased LC3II/GAPDH ratio and reduced p62 protein level under bafilomycin A1 conditions. Knocking out miR-22 may exert a cardioprotective effect on sepsis by increasing autophagy and decreasing apoptosis via sirt1. Our results revealed that targeting miR-22 may become a new strategy for septic cardiomyopathy treatment.
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http://dx.doi.org/10.3389/fcell.2021.650666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047209PMC
April 2021

MiR-22 Inhibition Alleviates Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy by Targeting the sirt1/PGC-1α Pathway.

Front Physiol 2021 1;12:646903. Epub 2021 Apr 1.

Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

Doxorubicin (DOX) cardiotoxicity is a life-threatening side effect that leads to a poor prognosis in patients receiving chemotherapy. We investigated the role of miR-22 in doxorubicin-induced cardiomyopathy and the underlying mechanism and . Specifically, we designed loss-of-function and gain-of-function experiments to identify the role of miR-22 in doxorubicin-induced cardiomyopathy. Our data suggested that inhibiting miR-22 alleviated cardiac fibrosis and cardiac dysfunction induced by doxorubicin. In addition, inhibiting miR-22 mitigated mitochondrial dysfunction through the sirt1/PGC-1α pathway. Knocking out miR-22 enhanced mitochondrial biogenesis, as evidenced by increased PGC-1α, TFAM, and NRF-1 expression . Furthermore, knocking out miR-22 rescued mitophagy, which was confirmed by increased expression of PINK1 and parkin and by the colocalization of LC3 and mitochondria. These protective effects were abolished by overexpressing miR-22. In conclusion, miR-22 may represent a new target to alleviate cardiac dysfunction in doxorubicin-induced cardiomyopathy and improve prognosis in patients receiving chemotherapy.
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http://dx.doi.org/10.3389/fphys.2021.646903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047466PMC
April 2021

SSVEP-Based Brain-Computer Interface With a Limited Number of Frequencies Based on Dual-Frequency Biased Coding.

IEEE Trans Neural Syst Rehabil Eng 2021 28;29:760-769. Epub 2021 Apr 28.

How to encode as many targets as possible with a limited-frequency resource is a difficult problem in the practical use of a steady-state visual evoked potential (SSVEP) based brain-computer interface (BCI) speller. To solve this problem, this study developed a novel method called dual-frequency biased coding (DFBC) to tag targets in a SSVEP-based 48-character virtual speller, in which each target is encoded with a permutation sequence consisting of two permuted flickering periods that flash at different frequencies. The proposed paradigm was validated by 11 participants in an offline experiment and 7 participants in an online experiment. Three occipital channels (O1, Oz, and O2) were used to obtain the SSVEP signals for identifying the targets. Based on the coding characteristics of the DFBC method, the proposed approach has the ability of self-correction and thus achieves an accuracy of 76.6% and 79.3% for offline and online experiments, respectively, which outperforms the traditional multiple frequencies sequential coding (MFSC) method. This study demonstrates that DFBC is an efficient method for coding a high number of SSVEP targets with a small number of available frequencies.
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http://dx.doi.org/10.1109/TNSRE.2021.3073134DOI Listing
June 2021

Complete mitochondrial genome of Eurasian Hobby (Falconiformes:Falconidae) and phylogenetic analyses.

Mitochondrial DNA B Resour 2021 Mar 26;6(3):1273-1275. Epub 2021 Mar 26.

Forestry College, Guizhou University, Guiyang, China.

The Eurasian Hobby is a bird belonging to the group Falconiformes, and was listed in Appendices II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora and listed as a Class II protected species on China's List of Wildlife under Special State Protection. In this study, the complete mitogenome of was determined. The mitochondrial DNA is packaged in a compact 17,678 based pair (bp) circular molecule with A + T content of 54.70%. It contains 37 typical mitochondrial genes, including 13 protein-coding genes, 2 rRNAs and 22 tRNAs, and 2 non-coding regions (D-Loop). We reconstructed a phylogenetic tree based on mitogenome sequences of 13 Falconidae species and one outgroup. Phylogenetic analysis indicated that was a sister taxon to with node support 100. The new mitogenome data would provide useful information for application in conservation genetics and further clarify the phylogenetic evolution of this species.
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http://dx.doi.org/10.1080/23802359.2021.1907247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008880PMC
March 2021

Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder.

J Stud Alcohol Drugs 2021 03;82(2):197-203

Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian 116029, China.

Objective: Inhibitory deficits contribute to impulsive drug-seeking behavior in individuals with methamphetamine use disorder (MUD). Whether abstinent individuals with MUD exhibit greater cognitive disinhibition when the suppressed response is associated with drug-related images is not fully known. This study evaluated the potency of drug-associated cue exposure in this process.

Method: We recruited 54 abstinent men with MUD and 46 healthy control (HC) subjects to complete a novel go/no-go task in which drug-associated cues were presented in 240 trials.

Results: Upon exposure to drug-associated cues, the numbers of commission errors increased significantly only in the abstinent MUD group (p < .001), and the abstinent MUD group produced higher levels of commission errors than the HC group (p = .009). When drug-associated cues were not available (in scrambled trials), the abstinent MUD group produced similar levels of commission errors when compared with the HC group (p = .336). The reaction times in drug cue exposure trials were longer than in scrambled trials across groups (p < .001), whereas the abstinent MUD group produced shorter reaction times than HCs, regardless of trial conditions (p = .004).

Conclusions: The novel go/no-go task is a useful method for detecting impulsivity in abstinent individuals with MUD. Cue exposure triggers impairment of inhibitory control in individuals with MUD at abstinence.
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March 2021

Investigation on the Mechanism and Parametric Description of Non-Synchronous Blade Vibration.

Entropy (Basel) 2021 Mar 24;23(4). Epub 2021 Mar 24.

School of Energy and Power, Beihang University, Beijing 100191, China.

In order to explore the mechanism during the process of the non-synchronous vibration (NSV), the flow field formation development is investigated in this paper. Based on the fluid-structure interaction method, the vibration of rotor blades is found to be in the first bending mode with a non-integral order (4.6) of the rotation speed. Referring to the constant inter blade phase angle (IBPA), the appearances of frequency-locking and phase-locking can be identified for the NSV. A periodical instability flow emerges in the tip region with the mixture of separation vortex and tip leakage flow. Due to the nonlinearities of fluid and structure, the blade vibration exhibits a limit cycle oscillation (LCO) response. The separation vortex presenting a spiral structure propagates in the annulus, indicating a pattern as modal oscillation. A flow induced vibration is initiated by the spiral vortex in the tip. The large pressure oscillation caused by the movement of the spiral vortex is regarded as a main factor for the presented NSV. As the oscillation of blade loading occurs with blade rotating pass the disturbances, the intensity of the reverse leakage flow in adjacent channels also plays a crucial role in the blade vibration.
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http://dx.doi.org/10.3390/e23040383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063821PMC
March 2021