Publications by authors named "Mingchun Chen"

4 Publications

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Association of child maltreatment and bullying victimization among chinese adolescents: The mediating role of family function, resilience, and anxiety.

J Affect Disord 2021 Nov 22;299:12-21. Epub 2021 Nov 22.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Among adolescents, child maltreatment is linked to being bullied at school. Nevertheless, little is known about the mediating mechanisms underlying this association. Therefore, our research aimed to explore and evaluate the potential mediators of the relationship between child maltreatment and bullying victimization among Chinese adolescents.

Methods: From October to December 2020, a population-based cross-sectional survey was conducted among 6247 adolescents (3401 males, 2846 females) in Anhui Province, China. The subjects of the survey were elementary and middle school students from grades 4 to 9. The data were collected through self-report questionnaires. Pearson correlation and linear regression were used to examine the relationships among child maltreatment, bullying victimization, family function, resilience, and anxiety. Structural equation modeling (SEM) was employed to conduct mediation analyses.

Results: The results indicated that child maltreatment positively predicted the later bullying victimization of adolescents. Resilience and anxiety were each shown to separately mediate this relationship. Moreover, the sequential mediating effects of family function, resilience, and anxiety also mediated the predictive effect of child maltreatment on bullying victimization.

Conclusions: Resilience and anxiety were both shown to be important independent mediators for the relationship between child maltreatment and bullying victimization. Furthermore, the combined mediating effects of family function, resilience, and anxiety were also of great significance. These findings provide additional evidence that family and individual factors are critical to understanding bullying victimization. Effective prevention and intervention strategies for school bullying should target family and individual vulnerabilities in adolescents.
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http://dx.doi.org/10.1016/j.jad.2021.11.053DOI Listing
November 2021

[Depressive symptoms and related factors among primary and middle school students in Changfeng county of Anhui province:a two-year longitudinal study].

Zhonghua Liu Xing Bing Xue Za Zhi 2014 May;35(5):505-9

Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, China. Email:

Objective: To assess the prevalence of depressive symptoms, trends on its longitudinal development and related influencing factors among primary and middle school students in Changfeng county of Anhui province.

Methods: Through cluster sampling methods, all students from 3 to 9 grades in 5 primary schools and 3 middle schools in Changfeng county of Anhui province were investigated through questionnaire as subjects of baseline survey in December 2009. Subjects of this longitudinal study were students in grades 3, 4 and 7 at the time of the baseline survey and were contacted once a year for two years. At last, a total of 816 students participated in all the three surveys. A structured questionnaire including Children's Depression Inventory, socio-demographic characteristics and some potential influential factors was employed for this study. A Generalized Estimating Equation (GEE) was used to evaluate the related influencing factors of children's depressive symptoms in the longitudinal study.

Results: Prevalence rates of depressive symptoms were 11.3% , 10.4% and 8.5% , respectively, at the baseline, 1-year and 2-year follow-up studies, among primary and middle school students. Scores on depressive symptoms of total subjects and children who had always been left at home in the follow-up process showed significant differences at the three surveys (F = 13.423, P < 0.001; F = 5.761, P = 0.003). 25 percent of the 92 students who showed depressive symptoms at the baseline survey remained those depressive symptoms at the 1-year follow-up study and 87 percent of the 23 students who had depressive symptoms at the baseline and 1-year follow-up surveys still showing depressive symptoms at the 2-year follow-up study. Results from the GEE program indicated that grade 3 students, having syblings, family with dysfunction or at low level of self-esteem etc., were prone to development while sex and parents' educational level were not correlated with depressive symptoms.

Conclusion: Prevalence of depressive symptoms among primary and middle school students in Changfeng county of Anhui province appeared a decreasing tendency during the follow-up process in our study. Through the longitudinal development, we noticed that the prevalence of depressive symptoms seemed to be related to the personal characteristics, education and family environment of the subjects under our study. Improving the level of family function as well as individual's self-esteem might positively contribute to mental health of those primary and middle school students.
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May 2014

[Reevaluation of the scale of psychological resilience for middle and primary school students].

Wei Sheng Yan Jiu 2013 Mar;42(2):257-62

School of the Public Health of Anhui Medical University, Hefei 230032, China.

Objective: To evaluate the feasibility of applying the self-rating scale of psychological resilience for middle school students among students of grade four to six in primary school and grade one to three in middle school in Changfeng county, Anhui province. To provide evidence for future study on mental health of middle and primary school students and left-behind children in Changfeng county.

Methods: The cluster sampling method were used to select three middle schools and five primary schools from Changfeng County in Hefei City. The psychological resilience among 2655 students of grade four to six were evaluated. The reliability and validity were analyzed. The self-rating scale of psychological resilience measures six dimensions included problem solving, cooperation and communication, self-efficacy, goals and aspirations, self-awareness, and empathy.

Results: The coefficient of Cronbach's a of the total scale scores was 0.944, that of grade four to six in primary school and grade one to three in middle school were from 0.932 to 0.947, and that of six factors were from 0.772 to 0.883. The correlation coefficient of split-half of the total scores was 0.874, and that of grade four to six in primary school and grade one to three in middle school were from 0.848 to 0.892. The test-retest reliability of the total scores was 0.894, and that of six factors were from 0.753 to 0.839, all correlations were significant statistically. Varimax rotation factor analysis was adopted and got six factors. Their accumulative contribution to total variance was 64.532%. The correlation coefficients between each item and the total scores were from 0.434 to 0.717, between each item and corresponding factors scores were from 0.683 to 0.876, between the total scores and six factors scores were from 0.692 to 0.846, among six factors scores were from 0.401 to 0.689, all correlations were significant statistically. The correlation coefficient between the total scores of the scale and depression was -0.493, and anxiety was -0.290, all correlations were significant statistically at the level of 0.01 with both side.

Conclusion: The reliability and validity of the self-rating scale of psychological resilience for middle school students are well among students of grade four to six in primary school and grade one to three in middle school and it can be used to evaluate the psychological resilience level of these people including left-behind children.
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March 2013

Psoriasis is associated with low serum levels of hydrogen sulfide, a potential anti-inflammatory molecule.

Tohoku J Exp Med 2012 12;228(4):325-32

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P.R. China.

Psoriasis, characterized by circumscribed, red, thickened plaques with an overlying silver-white scale, is a common T-cell-mediated chronic inflammatory skin disease. Although hydrogen sulfide (H(2)S) has been shown to be a signaling molecule with both pro- or anti-inflammatory effects, its relationship with psoriasis has not been elucidated. In the present study, 15 patients with chronic progressive psoriasis and 15 healthy volunteers were investigated. Serum H(2)S levels in psoriasis patients were significantly lower than those of healthy controls (16.69 ± 5.47 μM vs. 34.5 ± 6.39 μM). In contrast, serum levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly higher in psoriasis patients than healthy controls (22.88 ± 6.24 pg/ml vs. 12.07 ± 3.68 pg/ml; 61.47 ± 8.21 pg/ml vs. 31.54 ± 13.73 pg/ml; and 39.43 ± 8.56 pg/ml vs. 20.55 ± 6.45 pg/ml, respectively). The serum H(2)S levels negatively correlated with clinical disease severity. Furthermore, treatment of HaCaT human keratinocytes with TNF-α increased the levels of nitric oxide (NO), IL-6 and IL-8 (32.21 ± 5.71 μM vs. 3.22 ± 0.98 μM; 203.96 ± 13.16 pg/ml vs. 13.57 ± 3.75 pg/ml; and 301.24 ± 30.17 pg/ml vs. 29.06 ± 10.91 pg/ml, respectively) in the culture media. Exogenous H(2)S inhibited the TNF-α-mediated upregulation of NO, IL-6 and IL-8 in a dose-dependent manner. In addition, H(2)S inhibited TNF-α-mediated activation of p38, extracellular-signal-regulated kinase and nuclear factor kappa B. In conclusion, H(2)S may play a protective role in the pathogenesis of psoriasis. H(2)S-releasing agents may be promising therapeutics for psoriasis.
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http://dx.doi.org/10.1620/tjem.228.325DOI Listing
December 2012
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