Publications by authors named "Ming-Hua Jing"

2 Publications

  • Page 1 of 1

Construction of multifunctional electrochemical sensor based on electroactivity-adjustable poly (ionic liquids)/reduced graphene oxide.

Talanta 2019 May 2;197:277-283. Epub 2019 Jan 2.

College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address:

In this article, a novel electroactivity-adjustable poly (ionic liquids)/reduced graphene oxide (PIL-GP) was developed and utilized for the fabrication of multifunctional, high stable electrochemical sensors. The structure, morphology and surface charge properties of PIL-GP have been systematically studied. And the selective detection performance of dopamine (DA) on PIL-GP modified glassy carbon electrode (GCE) were further explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). More importantly, by virtue of the anion exchange property of PIL, electroactive Fe(CN)/PIL-GP/GCE and Polyoxometalates (PWA)/PIL-GP/GCE were easily fabricated and their electrochemical detection performance of ascorbic acid (AA) and bromate were investigated respectively. The results showed that PIL-GP/GCE based electrochemical sensors provided higher sensitivity, lower detection limits and outstanding anti-interference ability in certain detection system. It was indicated that this general approach to construct electroactivity-adjustable sensors with various electroactive anions possessed a broad application prospect.
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May 2019

Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.

Neurochem Res 2016 Jul 2;41(7):1806-17. Epub 2016 Apr 2.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and γ-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced β-amyloid (Aβ) aggregation and also β-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, α-Mangostin, Gartanin, Garcinone C and γ-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical than Trolox, and potent neuroprotective effects against glutamate-induced HT22 cell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and γ-Mangostin could be able to penetrate the blood-brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.
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July 2016