Publications by authors named "Ming Wen"

267 Publications

Effect of Lipopolysaccharide (LPS) stimulation on apoptotic process and oxidative stress in fibroblast cell of hybrid crucian carp compared with those of Carassius cuvieri and Carassius auratus red var.

Comp Biochem Physiol C Toxicol Pharmacol 2021 May 27;248:109085. Epub 2021 May 27.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, PR China.

Bacterial LPS is a heat-stable endotoxin and wall components of gram negative bacteria, which can exhibit a toxicological effect on physiology and biochemical activities of fish. In this study, we investigated the effect of LPS exposure on cell viability, oxidative stress, caspase activity and immune-related gene expressions in cultured fin cell lines of red crucian carp, white crucian carp and their hybrid offspring. LPS stimulation could reduce fish cell viability, whereas gene expression levels and promoter activities in inflammatory signals increased dramatically. Moreover, enhanced levels of intracellular oxidative stress and decreased levels of mitochondrial membrane potential (MMP) were observed in LPS-induced fish cells. N-Acetyl-L-cysteine (NAC) could alleviate LPS-stimulated reactive oxygen species (ROS) generation and caspase-3 activity in fish cells. These results suggested that ROS-mediated cytotoxic stress was involved in LPS-induced inflammation and mitochondrial damage in cultured fish cells.
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http://dx.doi.org/10.1016/j.cbpc.2021.109085DOI Listing
May 2021

Active alignment of complex perturbed pupil-offset off-axis telescopes using the extension of nodal aberration theory.

Appl Opt 2021 May;60(13):3874-3887

This paper presents an optical alignment strategy for complex perturbed pupil-offset off-axis reflective telescopes, based on the extension of nodal aberration theory (NAT). First, the direct expansion of the wave aberration function in the vector form for perturbed off-axis systems is given, which is especially convenient for the expansion of the corresponding higher-order terms. The inherent vector relationships between the contributions generated by the aberrations of the on-axis parent systems through pupil transformation are disclosed in detail, which is helpful to understand the aberration behavior of off-axis systems. Then, according to the inherent vector relationships, an analytical alignment model based on NAT for complex cases of perturbed off-axis telescopes is established. It can quantitatively separate the effects of misalignments and surface figure errors from the total aberration fields. The alignment model is solved by using particle swarm optimization algorithm. Then, an optical alignment example of the off-axis three-mirror anastigmatic telescope with misalignments and complex surface figure errors based on the proposed method is demonstrated. After correction, the perturbed telescope can be nearly restored to the nominal states. Finally, Monte Carlo simulations are carried out to show the effectiveness and accuracy of the proposed method.
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http://dx.doi.org/10.1364/AO.421611DOI Listing
May 2021

Filial Piety and Parental Depressive Symptoms: All Children Matter - Evidence from Rural Northern China.

J Cross Cult Gerontol 2021 Apr 26. Epub 2021 Apr 26.

Department of Sociology, University of Utah, Salt Lake City, UT, 84112-0250, USA.

Little research has considered all children while investigating adult children's role in their older parents' health and well-being. In this study, we examine the effect of filial piety across all children on parental depressive symptoms. A sample of 432 older parents with 1,223 adult children in a rural county in northern China rated the filial piety level for each child individually. Ratings were then combined across multiple children and organized into an ordinal variable of filial piety including three levels: all children being filial, some of the children being filial, and none of the children being filial. Ordinary least squares linear regression analyses were performed. The results reveal a significant and negative relationship between adult children's filial piety levels and older parents' depressive symptoms after controlling for age, gender, marital status, financial strain, chronic conditions, and social support from family and friends, respectively. That is, one level lower in the adult children's filial piety corresponds to increase in level of older parents' depressive symptoms. Filial piety seems to benefit older Chinese parents' mental health net of social support from family and friends in this sample. Including information from all children in the analyses is informative for better understanding the psychological significance of filial piety for healthy aging in China.
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http://dx.doi.org/10.1007/s10823-021-09430-2DOI Listing
April 2021

Multiple Primary Osseous B-Lymphoblastic Lymphoma/Leukemia Shown on Bone Scintigraphy.

Clin Nucl Med 2021 Apr 1. Epub 2021 Apr 1.

From the Departments of Radiology Nuclear Medicine, The Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.

Abstract: Primary osseous B-lymphoblastic lymphoma/leukemia is very rare, especially multiple bones involved. Herein, we reported the bone scintigraphy findings in a 16-year-old adolescent boy with a 20-day history of right thigh pain caused by B-lymphoblastic lymphoma/leukemia. Multiple abnormal MDP-avid foci were noted on 99mTc-MDP bone scintigraphy. Interestingly, the CT images of corresponding lesions were unrevealing. Finally, the B-lymphoblastic lymphoma/leukemia was confirmed by pathology and immunohistochemistry.
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http://dx.doi.org/10.1097/RLU.0000000000003651DOI Listing
April 2021

Active compensation for optimal RMS wavefront error in perturbed off-axis optical telescopes using nodal aberration theory.

Appl Opt 2021 Feb;60(6):1790-1800

This paper presents an active compensation strategy for RMS wavefront error of perturbed off-axis telescopes in the framework of nodal aberration theory. First, the orthogonalized expression of the wave aberration function in the vector form for perturbed off-axis telescopes is derived by using RMS normalization. The orthogonalized aberration function is applied to analytically describe the RMS wavefront error in perturbed off-axis telescopes with circular apertures. Then, the system compensation model for perturbed off-axis telescopes is established. The compensation model takes the weighted square sum of the RMS wavefront errors at representative field points as the objective function, which is minimized to obtain the optimal compensation solution of off-axis systems with perturbation constraints. The compensation model is solved by using a particle swarm optimization algorithm. Then, the off-axis three-mirror anastigmatic telescope is taken as an example, and the system compensations for the misaligned tertiary mirror and deformed primary mirror are discussed. After compensation, the average RMS wavefront errors in the perturbed off-axis systems are greatly reduced, which can well meet the system requirements. Finally, Monte Carlo simulations of the optimal compensation method and sensitivity table method are carried out to demonstrate the correctness and accuracy of the proposed method.
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http://dx.doi.org/10.1364/AO.414596DOI Listing
February 2021

The Validity of MotionSense HRV in Estimating Sedentary Behavior and Physical Activity under Free-Living and Simulated Activity Settings.

Sensors (Basel) 2021 Feb 18;21(4). Epub 2021 Feb 18.

Department of Health and Kinesiology, University of Utah, Salt Lake City, UT 84112, USA.

MotionSense HRV is a wrist-worn accelerometery-based sensor that is paired with a smartphone and is thus capable of measuring the intensity, duration, and frequency of physical activity (PA). However, little information is available on the validity of the MotionSense HRV. Therefore, the purpose of this study was to assess the concurrent validity of the MotionSense HRV in estimating sedentary behavior (SED) and PA. A total of 20 healthy adults (age: 32.5 ± 15.1 years) wore the MotionSense HRV and ActiGraph GT9X accelerometer (GT9X) on their non-dominant wrist for seven consecutive days during free-living conditions. Raw acceleration data from the devices were summarized into average time (min/day) spent in SED and moderate-to-vigorous PA (MVPA). Additionally, using the Cosemed K5 indirect calorimetry system (K5) as a criterion measure, the validity of the MotionSense HRV was examined in simulated free-living conditions. Pearson correlations, mean absolute percent errors (MAPE), Bland-Altman (BA) plots, and equivalence tests were used to examine the validity of the MotionSense HRV against criterion measures. The correlations between the MotionSense HRV and GT9X were high and the MAPE were low for both the SED (r = 0.99, MAPE = 2.4%) and MVPA (r = 0.97, MAPE = 9.1%) estimates under free-living conditions. BA plots illustrated that there was no systematic bias between the MotionSense HRV and criterion measures. The estimates of SED and MVPA from the MotionSense HRV were significantly equivalent to those from the GT9X; the equivalence zones were set at 16.5% for SED and 29% for MVPA. The estimates of SED and PA from the MotionSense HRV were less comparable when compared with those from the K5. The MotionSense HRV yielded comparable estimates for SED and PA when compared with the GT9X accelerometer under free-living conditions. We confirmed the promising application of the MotionSense HRV for monitoring PA patterns for practical and research purposes.
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http://dx.doi.org/10.3390/s21041411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922785PMC
February 2021

Novel Core-Sheath Cu/CuO-ZnO-FeO Nanocomposites with High-Efficiency Chlorine-Resistant Bacteria Sterilization and Trichloroacetic Acid Degradation Performance.

ACS Appl Mater Interfaces 2021 Mar 26;13(9):10878-10890. Epub 2021 Feb 26.

College of Environmental Science and Engineering, School of Chemical Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092, PR China.

In order to solve two issues of chlorine-resistant bacteria (CRB) and disinfection byproducts (DBPs) in tap water after the chlorine-containing treatment process, an innovative core-sheath nanostructured Cu/CuO-ZnO-FeO was designed and synthesized. The fabrication mechanism of the materials was then systematically analyzed to determine the component and valence state. The properties of CRB inactivation together with trichloroacetic acid (TCAA) photodegradation by Cu/CuO-ZnO-FeO were investigated in detail. It was found that Cu/CuO-ZnO-FeO displayed excellent antibacterial activity with a relatively low cytotoxicity concentration due to its synergism of nanowire structure, ion release, and reactive oxygen species generation. Furthermore, the Cu/CuO-ZnO-FeO nanocomposite also exhibited outstanding photocatalytic degradation activity on TCAA under simulated sunlight irradiation, which was verified to be dominated by the surface reaction through kinetic analysis. More interestingly, the cell growth rate of Cu/CuO-ZnO-FeO was determined to be 50% and 10% higher than those of Cu/CuO and Cu/CuO-ZnO after 10 h incubation, respectively, manifesting a weaker cytotoxicity. Therefore, the designed Cu/CuO-ZnO-FeO could be a promising agent for tap water treatment.
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http://dx.doi.org/10.1021/acsami.0c21336DOI Listing
March 2021

Nanophyto-gel against multi-drug resistant burn wound infection.

Drug Deliv 2021 Dec;28(1):463-477

Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.

Burn wound is usually associated by antibiotic-resistant infection that worsens and complicates its management. An effective approach is to use natural antibiotics such as cinnamon oil as a powerful alternative. This study aims to investigate topical nanostructured lipid carrier (NLC) gel loaded cinnamon oil for wound infection. A 2 full factorial design was performed to optimize the formulation with particle size 108.48 ± 6.35 nm, zeta potential -37.36 ± 4.01 mV, and EE% 95.39 ± 0.82%. FTIR analysis revealed no excipient interaction. Poloxamer 407 in a concentration 20% w/w NLC gel was prepared for topical application. Drug release exhibited an initial burst release in the first five hours, followed by a slow, sustained release of up to five days. NLC-cinnamon gel has a significant ability to control the drug release with the lowest minimum inhibitory concentration again compared to other formulations ( < .05). study also showed NLC-cinnamon gel effectively healed the infected burned wound after a six-day treatment course with better antibacterial efficacy in burned animal models. Histological examination ensured the tolerability of NLC-cinnamon gel. The results suggest that nanoparticle-based cinnamon oil gel is a promising natural product against antibiotic-resistant strains of in wound infection.
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http://dx.doi.org/10.1080/10717544.2021.1889720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906617PMC
December 2021

RADSex: A computational workflow to study sex determination using restriction site-associated DNA sequencing data.

Mol Ecol Resour 2021 Jul 9;21(5):1715-1731. Epub 2021 Mar 9.

Physiological Chemistry, Biocenter, University of Wuerzburg, Wuerzburg, Germany.

The study of sex determination and sex chromosome organization in nonmodel species has long been technically challenging, but new sequencing methodologies now enable precise and high-throughput identification of sex-specific genomic sequences. In particular, restriction site-associated DNA sequencing (RAD-Seq) is being extensively applied to explore sex determination systems in many plant and animal species. However, software specifically designed to search for and visualize sex-biased markers using RAD-Seq data is lacking. Here, we present RADSex, a computational analysis workflow designed to study the genetic basis of sex determination using RAD-Seq data. RADSex is simple to use, requires few computational resources, makes no prior assumptions about the type of sex-determination system or structure of the sex locus, and offers convenient visualization through a dedicated R package. To demonstrate the functionality of RADSex, we re-analysed a published data set of Japanese medaka, Oryzias latipes, where we uncovered a previously unknown Y chromosome polymorphism. We then used RADSex to analyse new RAD-Seq data sets from 15 fish species spanning multiple taxonomic orders. We identified the sex determination system and sex-specific markers in six of these species, five of which had no known sex-markers prior to this study. We show that RADSex greatly facilitates the study of sex determination systems in nonmodel species thanks to its speed of analyses, low resource usage, ease of application and visualization options. Furthermore, our analysis of new data sets from 15 species provides new insights on sex determination in fish.
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http://dx.doi.org/10.1111/1755-0998.13360DOI Listing
July 2021

Immunosuppressant quantification in intravenous microdialysate - towards novel quasi-continuous therapeutic drug monitoring in transplanted patients.

Clin Chem Lab Med 2021 Apr 15;59(5):935-945. Epub 2020 Dec 15.

Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Objectives: Therapeutic drug monitoring (TDM) plays a crucial role in personalized medicine. It helps clinicians to tailor drug dosage for optimized therapy through understanding the underlying complex pharmacokinetics and pharmacodynamics. Conventional, non-continuous TDM fails to provide real-time information, which is particularly important for the initial phase of immunosuppressant therapy, e.g., with cyclosporine (CsA) and mycophenolic acid (MPA).

Methods: We analyzed the time course over 8 h of total and free of immunosuppressive drug (CsA and MPA) concentrations measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 16 kidney transplant patients. Besides repeated blood sampling, intravenous microdialysis was used for continuous sampling. Free drug concentrations were determined from ultracentrifuged EDTA-plasma (UC) and compared with the drug concentrations in the respective microdialysate (µD). µDs were additionally analyzed for free CsA using a novel immunosensor chip integrated into a fluorescence detection platform. The potential of microdialysis coupled with an optical immunosensor for the TDM of immunosuppressants was assessed.

Results: Using LC-MS/MS, the free concentrations of CsA (CsA) and MPA (MPA) were detectable and the time courses of total and free CsA comparable. CsA and MPA and area-under-the-curves (AUCs) in µDs correlated well with those determined in UCs (r≥0.79 and r≥0.88, respectively). Moreover, CsA in µDs measured with the immunosensor correlated clearly with those determined by LC-MS/MS (r=0.82).

Conclusions: The new microdialysis-supported immunosensor allows real-time analysis of immunosuppressants and tailor-made dosing according to the AUC concept. It readily lends itself to future applications as minimally invasive and continuous near-patient TDM.
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http://dx.doi.org/10.1515/cclm-2020-1542DOI Listing
April 2021

[Relationship of ADC histogram parameters with pathological grade and lymph node metastasis of prostate cancer].

Zhonghua Nan Ke Xue 2020 Nov;26(10):881-887

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Objective: To investigate the relationship between the apparent diffusion coefficient (ADC) histogram parameters based on the whole tumor and the pathological grade and lymph node metastasis (LNM) of PCa.

Methods: This retrospective study included 82 cases of PCa confirmed pathologically and subjected to MRI preoperatively. We obtained a series of ADC histogram parameters, such as ADCmean, ADCmedian, ADC25%, ADC75%, entropy, and histogram width, by processing the ADC images via the Firevoxel Post-Processing and the SPSS24 software. We compared the parameters between the high-risk and low- or moderate-risk groups as well as between the LNM-positive and LNM-negative groups of the patients, and analyzed the diagnostic performance of the parameters with statistically significant differences.

Results: The high-risk group, compared with the low- or moderate-risk one, showed a significantly lower ADCmean ([590 ± 120] vs [837 ± 142] ×10-6 mm2/s, P < 0.01), ADCmedian ([560 ± 117] vs [804 ± 139] ×10-6 mm2/s, P < 0.01), ADC25% ([446.5 ± 98] vs [717 ± 118] ×10-6 mm2/, P < 0.01) and ADC75% ([667 ± 132] vs [931 ± 167] ×10-6 mm2/s, P < 0.01). The ADCmean manifested the highest diagnostic performance, with an AUC of 0.907, a sensitivity of 0.933 and a specificity of 0.796. No statistically significant difference was found between the high-risk and the low- or moderate-risk one in entropy (3.58 ± 0.39 vs 3.63 ± 0.42, P = 0.238) or the histogram width ([540 ± 73] vs [520 ± 65] ×10-6 mm2/s, P = 0.086). Both entropy and the histogram width were remarkably higher in the LNM-positive than in the LNM-negative group (3.95 ± 0.41 vs 3.12 ± 0.45, P < 0.01; [578 ± 59] vs [455 ± 68] ×10-6 mm2/s, P < 0.01), and the former had an even higher diagnostic performance, with an AUC of 0.836, a sensitivity of 0.887 and a specificity of 0.781. There were no statistically significant differences between the LNM-positive and LNM-negative groups in the ADCmean ([768 ± 135] vs [790±128] ×10-6 mm2/s, P = 0.402), ADCmedian ([759 ± 110] vs [775 ± 121] ×10-6 mm2/s, P = 0.225), ADC25% ([643 ± 91] vs [657 ± 89] ×10-6 mm2/s, P = 0.654) or ADC75% ([895 ± 127] vs [872 ± 129] ×10-6 mm2/s, P = 0.926).

Conclusions: ADC histogram parameters are related to pathological grade and LNM of PCa, and the analysis of the ADC histogram based on the whole tumor has an important value for preoperative evaluation and prognostic estimation of the malignancy.
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November 2020

Kidney transplantation after rescue allocation-meticulous selection yields the chance for excellent outcome.

Nephrol Dial Transplant 2021 02;36(3):551-560

TransplanTUM, Munich Transplant Center, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

Background: The small number of organ donors forces transplant centres to consider potentially suboptimal kidneys for transplantation. Eurotransplant established an algorithm for rescue allocation (RA) of kidneys repeatedly declined or not allocated within 5 h after procurement. Data on the outcomes and benefits of RA are scarce to date.

Methods: We conducted a retrospective 8-year analysis of transplant outcomes of RA offers based on our in-house criteria catalogue for acceptance and decline of organs and potential recipients.

Results: RA donors and recipients were both older compared with standard allocation (SA). RA donors more frequently had a history of hypertension, diabetes or fulfilled expanded criteria donor key parameters. RA recipients had poorer human leucocyte antigen (HLA) matches and longer cold ischaemia times (CITs). However, waiting time was shorter and delayed graft function, primary non-function and biopsy-proven rejections were comparable to SA. Five-year graft and patient survival after RA were similar to SA. In multivariate models accounting for confounding factors, graft survival and mortality after RA and SA were comparable as well.

Conclusions: Facing relevant comorbidities and rapid deterioration with the risk of being removed from the waiting list, kidney transplantation after RA was identified to allow for earlier transplantation with excellent outcome. Data from this survey propose not to reject categorically organs from multimorbid donors with older age and a history of hypertension or diabetes to aim for the best possible HLA matching and to carefully calculate overall expected CIT.
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http://dx.doi.org/10.1093/ndt/gfaa286DOI Listing
February 2021

Extension of shelf life of semi-dry longan pulp with gaseous chlorine dioxide generating film.

Int J Food Microbiol 2021 Jan 28;337:108938. Epub 2020 Oct 28.

Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, 133 Dongguanzhuang Yiheng Road, Tianhe District, Guangdong 510610, China.

A packaging system using gaseous chlorine dioxide generating film (CDGF) in a sealed container was developed to extend the shelf life of semi-dry longan pulp (moisture content 38.8 wt%; a0.8). The antimicrobial properties, formation of chloroxyanion residues and effects of CDGF on the quality of semi-dry longan pulp were investigated. CDGF was triggered by the moisture vapor from semi-dry longan pulp in the sealed container and released gaseous ClO into the headspace of the container. The antifungal test showed that CDGF significantly inactivated artificially inoculated molds in semi-dry longan pulp and achieved reductions of over 3 log CFU/g after 28 days storage at room temperature (25 °C). CDGF reduced total aerobic bacterial populations by over 6.4 log CFU/g and maintained these population levels at around 2.0 log CFU/g throughout the 180-day storage period at room temperature. The residual concentrations of chloride, chlorate and perchlorate in longan pulp increased and then decreased during the 180-day storage. Residual chloride levels were maintained at 1.5 mg/g after Day 120 and residual chlorate and perchlorate levels were not detected after Day 120 and Day 180, respectively, in CDGF-treated samples. CDGF treatments reduced total polyphenol content but didn't have any significant impact on the levels of polysaccharides in samples. There were no significant differences between CDGF-treated and control samples in color changes during storage. The content of 5-hydroymethylfurfural (5-HMF) in both samples increased during storage, suggesting that the Maillard reaction occurred. This study demonstrated an effective approach to develop a new antimicrobial packaging system for semi-dry longan pulp.
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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108938DOI Listing
January 2021

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.

Cell Rep 2020 11;33(5):108345

Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. Electronic address:

Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and high expression of interferon regulated genes (IRGs). CRISPR knockout (KO) of IRF 1/3/7 in cells reveals distinct subsets of genes affected by each IRF in an IFN-ligand signaling-dependent and largely independent manner. As the master regulators of innate immunity, the IRFs control the kinetics and maintenance of the IRG response and play essential roles in response to influenza A virus (IAV), herpes simplex virus 1 (HSV-1), Melaka virus/Pteropine orthoreovirus 3 Melaka (PRV3M), and Middle East respiratory syndrome-related coronavirus (MERS-CoV) infection. With its differential expression in bats compared to that in humans, this highlights a critical role for basal IRF expression in viral responses and potentially immune cell development in bats with relevance for IRF function in human biology.
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http://dx.doi.org/10.1016/j.celrep.2020.108345DOI Listing
November 2020

Optimal scanning concentration of MR imaging for tumor-bearing nude mice with SPIO-shRNA molecular probe.

Sci Rep 2020 10 29;10(1):18655. Epub 2020 Oct 29.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

The objective of this study is to investigate the signal changes and optimal scanning concentration of MRI in tumor tissues of tumor-bearing nude mice by SPIO-shRNA molecular probes. 30 BALB/c tumor-bearing nude mice were randomly divided into 5 groups with 6 mice in each group. At the given scanning time (before and 27 h after injection), the caudal vein was respectively injected with iron content of 6 mg·kg, 12 mg·kg, 18 mg·kg, 24 mg·kg, and 30 mg·kg, and MR examination was simultaneously performed to measure signal intensity changes of tumor tissue and contralateral muscle tissue in each concentration group. After each examination above, the nude mice were sacrificed immediately, and the tumor and muscle tissues were removed for HE and Prussian blue staining,and observed under light microscope. Nude mice in 6 mg, 12 mg and 18 mg groups all survived after probe injection, but some nude mice died in 24 mg and 30 mg groups after probe injection or during scanning. The signal changes of T2WI and T2*WI sequences were the most obvious in MR scanning sequences. Compared with other groups, the signal intensity of the tumor tissue in 18 mg, 24 mg and 30 mg groups were most obvious (P < 0.05), while the 18 mg, 24 mg and 30 mg groups reached no statistical difference (P > 0.05 ); HE staining indicated that structural disorder of tumor tissue as well as increase of nuclear atypia. Prussian Blue staining showed that blue-stained iron particles were present in each experimental group,and the most densely distributed were in 18 mg,24 mg and 30 mg groups. Tumor tissue could be well labeled with SPIO-shRNA molecular probes, and the optimal MR scanning concentration (iron content) is 18 mg·kg.
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http://dx.doi.org/10.1038/s41598-020-73923-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596719PMC
October 2020

Duck enteritis virus infection suppresses viability and induces apoptosis and endoplasmic reticulum stress in duck embryo fibroblast cells via the regulation of Ca.

J Vet Med Sci 2021 Apr 28;83(3):549-557. Epub 2020 Oct 28.

College of Animal Science, Guizhou University, Guiyang 550025, PR China.

Duck viral enteritis (DVE) is a lethal viral disease caused by duck enteritis virus (DEV) via an unknown mechanism. This study explores the relationship between Chinese standard challenge strain DEV (DEV-CSC)-induced apoptosis and endoplasmic reticulum stress (ERS) in duck embryo fibroblast (DEF) cells. Here we examined changes in Ca concentration, cell proliferation, apoptosis, and the differential expression of C/EBP homologous protein (CHOP), glucose regulatory protein 78 (GRP78), and activating transcription factor 6 (ATF6) in infected cells. The results revealed that DEV-CSC infection significantly decreased Ca concentration, suppressed cell viability, and induced apoptosis in DEF cells. Further experiments also demonstrated that DEV-CSC infection significantly upregulates CHOP, GRP78, and ATF6 expression. In addition, we show that the addition of ethylenediaminetetraacetic acid (EDTA) reverses the induction of apoptosis and the ERS mediated inhibition of cell viability in DEF cells associated with DEV-CSC infection. Therefore, we can conclude that infection with DEV-CSC induces apoptosis and ERS reducing the viability of DEF cells via the regulation of Ca. These findings may provide a new target for the treatment of DVE.
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http://dx.doi.org/10.1292/jvms.19-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025435PMC
April 2021

A Comparative Study of 2 Different Segmentation Methods of ADC Histogram for Differentiation Genetic Subtypes in Lower-Grade Diffuse Gliomas.

Biomed Res Int 2020 28;2020:9549361. Epub 2020 Sep 28.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Background: To evaluate the diagnostic performance of apparent diffusion coefficient (ADC) histogram parameters for differentiating the genetic subtypes in lower-grade diffuse gliomas and explore which segmentation method (ROI-1, the entire tumor ROI; ROI2, the tumor ROI excluding cystic and necrotic portions) performs better.

Materials And Methods: We retrospectively evaluated 56 lower-grade diffuse gliomas and divided them into three categories: IDH-wild group (IDH, 16cases); IDH mutant with the intact 1p or 19q group (IDH/1p19q, 18cases); and IDH mutant with the 1p/19q codeleted group (IDH/1p19q, 22cases). Histogram parameters of ADC maps calculated with the two different ROI methods: ADCmean, min, max, mode, P5, P10, P25, P75, P90, P95, kurtosis, skewness, entropy, StDev, and inhomogenity were compared between these categories using the independent test or Mann-Whitney test. For statistically significant results, a receiver operating characteristic (ROC) curves were constructed, and the optimal cutoff value was determined by maximizing Youden's index. Area under the curve (AUC) results were compared using the method of Delong et al.

Results: The inhomogenity from the two different ROI methods for distinguishing IDH gliomas from IDH gliomas both showed the biggest AUC (0.788, 0.930), the optimal cutoff value was 0.229 (sensitivity, 81.3%; specificity, 75.0%) for the ROI-1 and 0.186 (sensitivity, 93.8%; specificity, 82.5%) for the ROI-2, and the AUC of the inhomogenity from the ROI-2 was significantly larger than that from another segmentation, but no significant differences were identified between the AUCs of other same parameters from the two different ROI methods. For the differentiaiton of IDH/1p19q tumors and IDH/1p19q tumors, with the ROI-1, the ADCmode showed the biggest AUC (AUC: 0.784; sensitivity, 61.1%; specificity, 90.9%), with the ROI-2, and the skewness performed best (AUC, 0.821; sensitivity, 81.8%; specificity, 77.8%), but no significant differences were identified between the AUCs of the same parameters from the two different ROI methods.

Conclusion: ADC values analyzed by the histogram method could help to classify the genetic subtypes in lower-grade diffuse gliomas, no matter which ROI method was used. Extracting cystic and necrotic portions from the entire tumor lesions is preferable for evaluating the difference of the intratumoral heterogeneity and classifying IDH-wild tumors, but not significantly beneficial to predicting the 1p19q genotype in the lower-grade gliomas.
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http://dx.doi.org/10.1155/2020/9549361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539099PMC
May 2021

FBI-1 enhanced the resistance of triple-negative breast cancer cells to chemotherapeutic agents via the miR-30c/PXR axis.

Cell Death Dis 2020 10 13;11(10):851. Epub 2020 Oct 13.

Department of the Medical Oncology, the PLA General Hospital, Beijing, 100853, China.

The factor that binds to the inducer of short transcripts-1 (FBI-1) is a transcription suppressor and an important proto-oncogene that plays multiple roles in carcinogenesis and therapeutic resistance. In the present work, our results indicated that FBI-1 enhanced the resistance of triple-negative breast cancer (TNBC) cells to chemotherapeutic agents by repressing the expression of micoRNA-30c targeting the pregnane X receptor (PXR). The expression of FBI-1 was positively related to PXR and its downstream drug resistance-related genes in TNBC tissues. FBI-1 enhanced the expression of PXR and enhanced the activation of the PXR pathway. The miR-30c decreased the expression of PXR by targeting the 3'-UTR of PXR, and FBI-1 increased the expression of PXR by repressing miR-30c's expression. Through the miR-30c/PXR axis, FBI-1 accelerated the clearance or elimination of antitumor agents in TNBC cells (the TNBC cell lines or the patients derived cells [PDCs]) and induced the resistance of cells to antitumor agents. Therefore, the results indicated that the miR-30c/PXR axis participates in the FBI-1-mediated drug-resistance of TNBC cells.
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http://dx.doi.org/10.1038/s41419-020-03053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554048PMC
October 2020

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.

Elife 2020 09 11;9. Epub 2020 Sep 11.

Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, the detailed mechanism by which Mamba1 inhibits ASIC1s, especially how Mamba1 binding to the extracellular domain affects the conformational changes of the transmembrane domain of ASICs remains elusive. Here, we present single-particle cryo-EM structures of human ASIC1a (hASIC1a) and the hASIC1a-Mamba1 complex at resolutions of 3.56 and 3.90 Å, respectively. The structures revealed the inhibited conformation of hASIC1a upon Mamba1 binding. The combination of the structural and physiological data indicates that Mamba1 preferentially binds hASIC1a in a closed state and reduces the proton sensitivity of the channel, representing a closed-state trapping mechanism.
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http://dx.doi.org/10.7554/eLife.57096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553779PMC
September 2020

[Apparent Diffusion Coefficient Histogram Analysis:Differentiation of Genetic Subtypes of Diffuse Lower-grade Gliomas].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Aug;42(4):444-451

To explore the utility of apparent diffusion coefficient(ADC)histogram analysis for differentiating genetic subtypes of diffuse lower-grade gliomas. A total of 55 patients with WHO grade Ⅱ/Ⅲ diffuse lower-grade gliomas who underwent preoperative routine brain magnetic resonance imaging and diffusion weighted imaging in our center were retrospectively evaluated.Among whom there were 14 patients with isocitrate dehydrogenase(IDH)wild-type gliomas(IDH group),19 patients with IDH-mutant 1p19q intact gliomas(IDH 1p19q group),and 22 patients with IDH-mutant 1p19q co-deleted gliomas(IDH 1p19q group).The whole-lesion ADC values derived from histogram analysis(including ADC,ADC,ADC5%,ADC10%,ADC25%,ADC50%,ADC75%,ADC90%,ADC95%,ADC,mode,range,skewness,kurtosis,standard deviation,inhomogeneity,and entrophy)were measured for each patient.All parameters between the different genetic subtypes were compared by using the Student's test or Mann-Whitney test.Receiver operating curve(ROC)analysis was used to assess the diagnostic performance of ADC histogram in distinguishing the different genetic subtypes. Compared with IDH group,the ADC75%(=0.021),ADC90%(=0.015),ADC95%(=0.014),ADC (=0.035),range(=0.009),standard deviation(=0.001)and inhomogeneity(=0.001)were significantly lower in IDH group;in contrast,the ADC (=0.031)and kurtosis(=0.020)of IDH group were significantly higher than those in IDH group.The ADC(=0.010),ADC5%(=0.016),ADC10%(=0.012),ADC25%(=0.007),ADC50%(=0.005),ADC75%(=0.015),and mode(=0.002)were significantly higher in IDH 1p19q group than in IDH 1p19q group.Inhomogeneity achieved the highest area under ROC(AUC)(0.811)in differentiating IDH gliomas and IDH gliomas,with a cutoff value of 0.229;the sensitivity and specificity were 85.7% and 73.2%.The mode achieved the highest AUC(0.744)in differentiating IDH 1p19q gliomas and IDH 1p19q gliomas,with a cutoff value was 1448.75×10 mm /s;the sensitivity and specificity were 57.9% and 90.9%. ADC histograms analysis may be helpful to differentiate genetic subtypes in lower-grade gliomas.
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http://dx.doi.org/10.3881/j.issn.1000-503X.11608DOI Listing
August 2020

Clinical characteristics of coronavirus disease 2019 patients complicated with liver injury.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 May;45(5):555-559

Department of Infectious Disease, First Hospital of Changsha, Changsha 410005, China.

Objectives: To analyze the clinical characteristics in patients of coronavirus disease 2019 (COVID-19) complicated with liver injury, to explore the relationship between COVID-19 clinical classification and liver injury, and to elucidate whether COVID-19 complicated with hepatitis B virus can aggravate liver injury.

Methods: The abnormal liver function in 110 patients in the First Hospital of Changsha, who were confirmed COVID-19 and admitted to the designated hospital from January 17, 2020 to February 20, 2020, wereretrospectively analyzed. The detection indexes included serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), and total bilirubin (TBIL).

Results: A total of 49.1% of the COVID-19 patients had liver injury. There were significant difference in the ALT, AST, ALB (all <0.05), but there was no significant difference in the TBIL (>0.05) between the severe (critical) patients and the general (light) patients. There was also no significant difference in the liver function injury between the HBsAg-positive COVID-19 patients and HBsAg-negative COVID-19 patients (>0.05). Acute liver injury was not found to be a direct cause of death in the patients.

Conclusions: In the COVID-19 patients, the incidence of liver injury is high with the increase of ALT and AST and the decrease of ALB. Severe and critical patients have obvious liver injury, and those patients complicated with hepatitis B virus infection don't show aggravated liver injury.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.200225DOI Listing
May 2020

Diversified carbon intensity under global value chains: A measurement and decomposition analysis.

J Environ Manage 2020 Oct 23;272:111076. Epub 2020 Jul 23.

Economic & Technical Research Institute, State Grid Hunan Electric Power Company Limited, Changsha, 410004, China.

The rise and gradually developing of global value chains (GVC) have changed the essence of international trade, and further complicated the issue of carbon emission. It is of great significance to identify and study the practical carbon intensity in a country under the condition of GVC. Based on Inter-country Input-Output (ICIO) model, this paper establishes a framework for measuring the carbon intensities embodied in aggregated demand and distinguishing pure domestic demand, traditional trade, simple GVC route, complex GVC route at the global level and for 41 economies from 2010 to 2014 according to demand heterogeneity, and uses multiplicative structural decomposition analysis (SDA) method to decompose the driving factors affecting their changes. The results indicate that, in most developed countries, the carbon intensities embodied in international trade were significantly greater than pure domestic carbon intensity, whereas it was opposite in most developing countries. The carbon intensity embodied in traditional trade was generally lower than that in GVC routes, and in low carbon intensity (high carbon intensity) sub-group, the carbon intensity embodied in simple GVC route was lower (higher) than that in complex GVC route. Moreover, the emission coefficient effect was the main driver of the decline in almost all carbon intensities, especially embodied carbon intensity in GVC routes. On the contrary, the intermediate import effect was the main inhibitor, and this effect would cause more rise to embodied carbon intensity in simple GVC route, compared to embodied carbon intensity in complex GVC route.
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http://dx.doi.org/10.1016/j.jenvman.2020.111076DOI Listing
October 2020

Sex chromosome and sex locus characterization in goldfish, Carassius auratus (Linnaeus, 1758).

BMC Genomics 2020 Aug 11;21(1):552. Epub 2020 Aug 11.

INRAE, LPGP, 35000, Rennes, France.

Background: Goldfish is an important model for various areas of research, including neural development and behavior and a species of significant importance in aquaculture, especially as an ornamental species. It has a male heterogametic (XX/XY) sex determination system that relies on both genetic and environmental factors, with high temperatures being able to produce female-to-male sex reversal. Little, however, is currently known on the molecular basis of genetic sex determination in this important cyprinid model. Here we used sequencing approaches to better characterize sex determination and sex-chromosomes in an experimental strain of goldfish.

Results: Our results confirmed that sex determination in goldfish is a mix of environmental and genetic factors and that its sex determination system is male heterogametic (XX/XY). Using reduced representation (RAD-seq) and whole genome (pool-seq) approaches, we characterized sex-linked polymorphisms and developed male specific genetic markers. These male specific markers were used to distinguish sex-reversed XX neomales from XY males and to demonstrate that XX female-to-male sex reversal could even occur at a relatively low rearing temperature (18 °C), for which sex reversal has been previously shown to be close to zero. We also characterized a relatively large non-recombining region (~ 11.7 Mb) on goldfish linkage group 22 (LG22) that contained a high-density of male-biased genetic polymorphisms. This large LG22 region harbors 373 genes, including a single candidate as a potential master sex gene, i.e., the anti-Mullerian hormone gene (amh). However, no sex-linked polymorphisms were detected in the coding DNA sequence of the goldfish amh gene.

Conclusions: These results show that our goldfish strain has a relatively large sex locus on LG22, which is likely the Y chromosome of this experimental population. The presence of a few XX males even at low temperature also suggests that other environmental factors in addition to temperature could trigger female-to-male sex reversal. Finally, we also developed sex-linked genetic markers, which will be important tools for future research on sex determination in our experimental goldfish population. However, additional work would be needed to explore whether this sex locus is conserved in other populations of goldfish.
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http://dx.doi.org/10.1186/s12864-020-06959-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430817PMC
August 2020

A case of pulmonary embolism caused by compression of the vena cava by intra-abdominal masses in autosomal polycystic kidney disease.

Clin Case Rep 2020 Jul 13;8(7):1149-1152. Epub 2020 Apr 13.

Department of Nephrology School of Medicine Klinikum Rechts der Isar Technical University of Munich Munich Germany.

Dyspnea can have among other reasons pulmonological and cardiological causes. In cases with intra-abdominal masses such as in severe autosomal dominant polycystic kidney disease, mechanical occlusion of the vena cava may result in pulmonary embolism.
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http://dx.doi.org/10.1002/ccr3.2852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364094PMC
July 2020

Self-rated Health Disparities Among Asian Americans: Mediating Roles of Education Level and Household Income.

J Immigr Minor Health 2021 Jun;23(3):583-590

Department of Sociology, California State University-Dominguez Hills, Carson, CA, USA.

Asian Americans represent an understudied racial category in health disparity research. Using data from the National Asian American Survey, we examined self-rated health (SRH) disparities in eight Asian subgroups compared to Whites, explored the moderating effect of nativity status, and investigated the mediating effect of socioeconomic status. None of the Asian subgroups fared better than Whites. Across Asian subgroups, South Asians, Japanese, and Filipinos had the best SRH, with Cambodians being the most disadvantaged. Nativity was a significant moderator in that SRH disadvantages were only manifested among immigrants for Chinese, Korean, Hmong, and Vietnamese and only among natives for Filipinos. For most groups showing SRH disadvantages, SES played partial mediating roles. Education showed a higher explanatory power than income for inter-ethnic SRH disparities. Contrary to popular perception, Asian Americans are not the model minority in terms of SRH. Cultural influences on SRH reporting biases were discussed.
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http://dx.doi.org/10.1007/s10903-020-01051-0DOI Listing
June 2021

Is less more? Examining the relationship between food assistance benefit levels and childhood weight.

SSM Popul Health 2020 Aug 25;11:100573. Epub 2020 Mar 25.

Department of Obstetrics/Gynecology, University of Utah, United States.

Background: The Supplementary Nutrition Assistance Program (SNAP) is a critical lifeline for millions of low-income US families, but some studies suggests that it may inadvertently increase obesity risk. Building on research contesting the SNAP-obesity link, we examine the effect of SNAP participation on BMI among multiyear participants at varying levels of SNAP benefit levels to provide some of the first evidence on the relationship between SNAP participation, state-level SNAP resources, and body weight. We focus on children given the strong links between early-life obesity and later-life health.

Methods: Linking state-level data on SNAP benefit levels with three waves of longitudinal individual-level data from the Child Development Supplement of the Panel Study of Income Dynamics, we use child- and state-level fixed effects to examine whether exogenous differences in SNAP benefit allotments influence the relationship between SNAP participation and weight gain.

Results: Lower SNAP benefit levels were associated with only modest increases in BMI among children; higher benefit levels showed no association with BMI.

Conclusions: Although concerns that more food assistance promotes obesity have spurred calls for cuts in the SNAP program, we find the opposite - that SNAP participation is associated with an increase in childhood BMI only when benefit levels are low. This study adds to the mounting evidence suggesting that SNAP does not cause obesity. It also contributes to the literature on the political economy of health, especially that pertaining to social policy variation across US states.
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http://dx.doi.org/10.1016/j.ssmph.2020.100573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252206PMC
August 2020

LiCaBO: A Borate with a Unique Fundamental Building Block and a Short Cutoff Edge.

Inorg Chem 2020 Jun 1;59(12):8396-8403. Epub 2020 Jun 1.

CAS Key Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics & Chemistry, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Chinese Academy of Sciences, Urumqi 830011, China.

A complex alkali and alkaline-earth metal borate LiCaBO has been synthesized successfully via the high-temperature solution method. LiCaBO crystallizes into the space group 1̅ (No. 2) of the triclinic crystal system. The crystal structure exhibits a three-dimensional framework consisting of the [BO] chains connected by the [LiO] ( = 3, 4, 6) and [CaO] polyhedra. The fundamental building block [BO] differs from those of other anhydrous octa-borates, which can be identified as a unique one. Furthermore, LiCaBO shows three different Li-O units, which is unique among all non-disordered anhydrous borates. It shows a short UV cutoff edge less than 190 nm. To better study the relationships between the crystal structure and properties, the DFT calculations were used for the evaluations of the optical band gap and birefringence.
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http://dx.doi.org/10.1021/acs.inorgchem.0c00821DOI Listing
June 2020

Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China.

Am J Obstet Gynecol 2020 08 11;223(2):240.e1-240.e9. Epub 2020 May 11.

Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China.

Background: On January 20, 2020, a new coronavirus epidemic with human-to-human transmission was officially declared by the Chinese government, which caused significant public panic in China. In light of the coronavirus disease 2019 outbreak, pregnant women may be particularly vulnerable and in special need for preventive mental health strategies. Thus far, no reports exist to investigate the mental health response of pregnant women to the coronavirus disease 2019 outbreak.

Objective: This study aimed to examine the impact of coronavirus disease 2019 outbreak on the prevalence of depressive and anxiety symptoms and the corresponding risk factors among pregnant women across China.

Study Design: A multicenter, cross-sectional study was initiated in early December 2019 to identify mental health concerns in pregnancy using the Edinburgh Postnatal Depression Scale. This study provided a unique opportunity to compare the mental status of pregnant women before and after the declaration of the coronavirus disease 2019 epidemic. A total of 4124 pregnant women during their third trimester from 25 hospitals in 10 provinces across China were examined in this cross-sectional study from January 1, 2020, to February 9, 2020. Of these women, 1285 were assessed after January 20, 2020, when the coronavirus epidemic was publicly declared and 2839 were assessed before this pivotal time point. The internationally recommended Edinburgh Postnatal Depression Scale was used to assess maternal depression and anxiety symptoms. Prevalence rates and risk factors were compared between the pre- and poststudy groups.

Results: Pregnant women assessed after the declaration of coronavirus disease 2019 epidemic had significantly higher rates of depressive symptoms (26.0% vs 29.6%, P=.02) than women assessed before the epidemic declaration. These women were also more likely to have thoughts of self-harm (P=.005). The depressive rates were positively associated with the number of newly confirmed cases of coronavirus disease 2019 (P=.003), suspected infections (P=.004), and deaths per day (P=.001). Pregnant women who were underweight before pregnancy, primiparous, younger than 35 years, employed full time, in middle income category, and had appropriate living space were at increased risk for developing depressive and anxiety symptoms during the outbreak.

Conclusion: Major life-threatening public health events such as the coronavirus disease 2019 outbreak may increase the risk for mental illness among pregnant women, including thoughts of self-harm. Strategies targeting maternal stress and isolation such as effective risk communication and the provision of psychological first aid may be particularly useful to prevent negative outcomes for women and their fetuses.
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http://dx.doi.org/10.1016/j.ajog.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211756PMC
August 2020

Associations of Neighborhood Factors and Activity Behaviors: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.

J Immigr Minor Health 2021 Feb;23(1):54-61

Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Social and built environments may influence physical activity (PA). However, evidence for South Asian Americans (SAA), a group with low PA levels and high cardiometabolic risk, is lacking. We assessed the association between five neighborhood factors and PA behaviors in a community-based cohort of SAA. Data were from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study 2010-2013 (n = 906). Adjusted multivariable models stratified by sex regressing PA behaviors on neighborhood factors were run. Higher neighborhood social cohesion was associated with 17% more PA MET minutes/week in men (p < 0.01), but not in women. Having a park/playground near home was associated with meeting PA guidelines (odds ratio (95% CI): men: 3.14 (1.20-8.24); women: 3.67 (1.17-11.52). Neighborhood factors were associated with favorable PA behaviors in SAA. PA interventions for SAA that increase neighborhood social cohesion or focus on linking individuals with local resources may be effective.
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http://dx.doi.org/10.1007/s10903-020-01021-6DOI Listing
February 2021

Three diphosphates, α-LiNaPO, LiPbBa(PO) and LiRb(PO): influences of co-substitution on the crystal structure.

Dalton Trans 2020 May 6;49(20):6744-6750. Epub 2020 May 6.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.

Three diphosphates, α-LiNaPO, LiPbBa(PO) and LiRb(PO), were synthesized via a high-temperature solution method. α-LiNaPO crystallized into a non-centrosymmetric space group Ama2, while LiPbBa(PO) and LiRb(PO) crystallized into the centrosymmetric space groups C2/c and P1[combining macron]respectively. α-LiNaPO, LiPbBa(PO) and LiRb(PO) could be obtained by co-substitution from each other. Also, we found that the high valence state and small atomic radius of the substituted cations resulted in a larger cation-cation distance, which led to a lower dimension of the structure. LiNaPO possessed two phases, namely, α- and β-LiNaPO, and their second harmonic generation (SHG) responses were compared. We also reported the syntheses, IR spectra, UV-vis-NIR diffuse reflectance spectroscopy data, thermal properties and first principles calculations of the title compounds.
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http://dx.doi.org/10.1039/d0dt01070gDOI Listing
May 2020