Publications by authors named "Ming Liu"

2,954 Publications

  • Page 1 of 1

Reinforcement Learning based Diagnosis and Prediction for COVID-19 by Optimizing A Mixed Cost Function from CT Images.

IEEE J Biomed Health Inform 2022 Aug 11;PP. Epub 2022 Aug 11.

A novel coronavirus disease (COVID-19) is a pandemic disease has caused 4 million deaths and more than 200 million infections worldwide (as of August 4, 2021). Rapid and accurate diagnosis of COVID-19 infection is critical to controlling the spread of the epidemic. In order to quickly and efficiently detect COVID-19 and reduce the threat of COVID-19 to human survival, we have firstly pro- posed a detection framework based on reinforcement learn- ing for COVID-19 diagnosis, which constructs a mixed loss function that can integrate the advantages of multiple loss functions. This paper uses the accuracy of the validation set as the reward value, and obtains the initial model for the next epoch by searching the model corresponding to the maximum reward value in each epoch. We also have pro- posed a prediction framework that integrates multiple de- tection frameworks using parameter sharing to predict the progression of patients' disease without additional training. This paper also constructed a higher-quality version of the CT image dataset containing 247 cases screened by profes- sional physicians, and obtained more excellent results on this dataset. Meanwhile, we used the other two COVID-19 datasets as external verifications, and still achieved a high accuracy rate without additional training. Finally, the exper- imental results show that our classification accuracy can reach 98.31%, and the precision, sensitivity, specificity, and AUC (Area Under Curve) are 98.82%, 97.99%, 98.67%, and0.989, respectively. The accuracy of external verification can reach 93.34% and 91.05%. What's more, the accuracy of our prediction framework is 91.54%. A large number of experiments demonstrate that our proposed method is effective and robust for COVID-19 detection and prediction.
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http://dx.doi.org/10.1109/JBHI.2022.3197666DOI Listing
August 2022

Interfacial Modulation on CoFeO Epitaxial Thin Films for Anomalous Hall Sensor Applications.

ACS Appl Mater Interfaces 2022 Aug 11. Epub 2022 Aug 11.

School of Microelectronics, Xi'an Jiaotong University, Xi'an 710049, China.

Magnetic oxide films with a strong anomalous Hall effect (AHE) have attracted much attention due to their strong sensitivity and high polarization for magnetic sensor applications. However, the linearity of the anomalous Hall sensors still needs improving. In this work, we propose to use the interface regulation to improve the linearity of the AHE. We grow spinel ferrite CoFeO (CoFeO) thin films on MgAlO (MAO) substrates and alter their interfacial properties by inserting a graphene layer between the MAO substrate and the CoFeO film. Through a detailed structure and performance analysis, it reveals that the insertion of graphene has not broken the epitaxial nature of the films but endows the film with a nanopillar-like structure. A series of electrical tests show that the Hall resistance signal of our thin film system has high sensitivity and high linearity to the magnetic field. Reduced hysteresis and better linearity of the anomalous Hall resistance were found in the graphene-inserted heterostructure due to differences in the nanostructure and possibly interfacial coupling. These results suggest that interfacial engineering offers a pathway to tune the performance of ferrite thin film systems for sensor applications.
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http://dx.doi.org/10.1021/acsami.2c07575DOI Listing
August 2022

The Integration of Legal Education and Mental Health Education of College Students in the Contemporary Network Environment Facing the Cultivation of Civic Awareness.

J Environ Public Health 2022 30;2022:4858156. Epub 2022 Jul 30.

University of International Business and Economics, Beijing 10029, China.

Since the world entered the era of network information, the influence of the Internet has been expanding day by day, and today's college students are deeply affected by the network environment, which has also brought unprecedented challenges to the moral education work of colleges and universities. The rule of law education for college students is a key point for the comprehensive implementation of the strategy of governing the country by law. How to enhance the effectiveness and recognition of the rule of law education for college students has become an important task of higher education. Therefore, strengthening the legal education of college students is not only an inevitable choice to fully implement the rule of law but also a realistic requirement to improve the level of higher education and realize the all-round development of college students. College students' mental health education is an important part of the talent training system of colleges and universities, and in-depth exploration of the ideological and political laws of college students' mental health education courses is an inevitable requirement for implementing the fundamental task of Lide Shuren. College students' mental health education courses must be integrated into the ideological and political concepts of the curriculum, reflect the political orientation of ideological and political work, embody the law of educating people with morality as the first, and embody the practical purpose of psychology to pay attention to personality improvement. It is necessary to optimize the content of education and teaching, excavate the elements of ideological politics in the curriculum, enrich the resources of ideological politics in the curriculum, and explore a new way of reforming the ideological and political education curriculum for college students from the aspects of deeply planting family and national feelings, enhancing political identity, strengthening cultural self-confidence, cultivating Chinese temperament, clarifying the meaning of life, strengthening mission responsibility, enhancing civic awareness, and developing law-abiding habits. Strictly regulate the behavior of contemporary college students in the online environment, give full play to the role of legal education, and reduce the incidence of online incidents such as online fraud and cyber violence. This paper puts forward some problems in the current legal education of college students in China and points out the root causes of these problems. Methods for structural reform and advanced cultural construction based on social development are proposed. From a strategic point of view, it is believed that only by managing the reform of legal education and cultivating civic awareness can we completely solve various contradictions and problems among college students in the network environment and pave the way for the development of college students.
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http://dx.doi.org/10.1155/2022/4858156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356843PMC
August 2022

Near-Infrared Light-Driven Photoredox Catalysis by Transition-Metal-Complex Nanodots.

Angew Chem Int Ed Engl 2022 Aug 5. Epub 2022 Aug 5.

Fuzhou University, College of Chemistry, 350002, Fuzhou, CHINA.

Developing light-harvesting materials with broad spectral response is of fundamental importance in full-spectrum solar energy conversion. We found that, when a series of earth-abundant metal (Cu, Co, Ni and Fe) salts are dissolved in coordinating solvents uniformly dispersed nanodots (NDs) are formed rather than fully dissolving as molecular species. The previously unrecognized formation of this condensed state is ascribed to spontaneous aggregation of molecular transition metal complexes (TMCs) via weak intermolecular interactions, which results in redshifted and broadened absorption into the NIR region (200-1100 nm). Typical photoredox reactions, such as carbonylation and oxidative dehydrogenation, well demonstrate the feasibility of efficient utilization of NIR light (λ>780 nm) by TMCs NDs. Our finding provides a conceptually new strategy for extending the absorption towards low energy photons in solar energy harvesting and conversion via photoredox transformations.
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http://dx.doi.org/10.1002/anie.202204561DOI Listing
August 2022

Synergy of Spin-Orbit Torque and Built-In Field in Magnetic Tunnel Junctions with Tilted Magnetic Anisotropy: Toward Tunable and Reliable Spintronic Neurons.

Adv Sci (Weinh) 2022 Aug 4:e2203006. Epub 2022 Aug 4.

Key Laboratory of Microelectronic Devices and Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing, 100029, China.

Owing to programmable nonlinear dynamics, magnetic domain wall (DW)-based devices can be configured to function as spintronic neurons, promising to execute sophisticated tasks as a human brain. Developing energy-efficient, CMOS compatible, reliable, and tunable spintronic neurons to emulate brain-inspired processes has been a key research goal for decades. Here, a new type of DW device is reported with biological neuron characteristics driven by the synergistic interaction between spin-orbit torque and built-in field (H ) in magnetic tunnel junctions, enabling time- and energy-efficient leaky-integrate-and-fire and self-reset neuromorphic implementations. A tilted magnetic anisotropic free layer is proposed and further executed to mitigate the DW retrograde motion by suppressing the Walker breakdown. Complementary experiments and micromagnetic co-simulation results show that the integrating/leaking time of the developed spintronic neuron can be tuned to 12/15 ns with an integrating power consumption of 65 µW, which is 36× and 1.84× time and energy efficient than the state-of-the-art alternatives, respectively. Moreover, the spatial distribution of H can be modulated by adjusting the width and compensation of the reference layer, facilitating tunable activation function generator exploration. Such architecture demonstrates great potential in both fundamental research and new trajectories of technology advancement for spintronic neuron hardware applications.
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http://dx.doi.org/10.1002/advs.202203006DOI Listing
August 2022

Polymeric micelle-based nanoagents enable phototriggering combined chemotherapy and photothermal therapy with high sensitivity.

Biomater Sci 2022 Aug 4. Epub 2022 Aug 4.

School of Chemical Sciences, University of Chinese Academy of Sciences (UCAS), Beijing 100049, China.

A new type of polymeric nanomicelle-based nanoagent (denoted as [email protected] hereafter) capable of the highly sensitive release of the chemotherapeutic drug paclitaxel (PTX) upon exposure to a near-infrared (NIR) laser trigger was developed. Specifically, PTX and a photothermal polymer (T-DPPT) were encapsulated in the cavity of nanomicelles, which were constructed from an amphiphilic block copolymer (PCL-PEEP) with a lower critical solution temperature (LCST) of ∼54 °C. Owing to the unprecedented ability of the T-DPPT moiety to harvest near-infrared light, with a mass extinction coefficient at 808 nm of up to ∼80.8 L g cm, and convert NIR light to heat, with a photothermal conversion efficiency () of up to ∼70%, local hyperthermia was promptly realized irradiation from an 808 nm laser with extraordinarily low output power. This enabled remarkable contrast in the local temperature and drug release between the "silent" state (prior to phototriggering) and the "activated" state (after phototriggering). This NIR-light-activated local hyperthermia and drug release presented the basis for combined chemotherapy and photothermal therapy (PTT) in antitumor treatment and displayed superb therapeutic efficacy. This pattern together with the high spatial precision imparted by laser triggering jointly contributed to the maximum combined antitumor efficacy to the tumor, while exhibiting minimal side effects on the normal tissues, as preliminarily verified in the experiment regarding the ability of [email protected] to efficiently inhibit tumor growth in tumor-bearing model mice.
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http://dx.doi.org/10.1039/d2bm00652aDOI Listing
August 2022

Multi-organ Immune-Related Adverse Event Is a Risk Factor of Immune Checkpoint Inhibitor-Associated Myocarditis in Cancer Patients: A Multi-center Study.

Front Immunol 2022 18;13:879900. Epub 2022 Jul 18.

Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background And Objective: Immune checkpoint inhibitor (ICI)-associated myocarditis is a fatal immune-related adverse events (irAEs), which is prone to affecting multiple organ systems. Multi-organ irAEs have not been fully studied in ICI-associated myocarditis. Therefore, we aimed to explore the impact of multi-organ irAEs on ICI myocarditis in terms of clinical features, treatment, and prognosis.

Methods: This was a retrospective study. The clinical data of ICI myocarditis patients were collected from 6 hospitals in China. The risk factors and characteristics of pure myocarditis and multi-organ irAEs were analyzed. The overall survival (OS) after myocarditis was analyzed and univariate and multivariate regression analysis were performed.

Results: A total of 46 patients were analyzed in this study. Multi-organ irAEs were common (30/46, 65.2%) and prone to severe heart failure. The severe myocarditis was observed in 32 patients (69.6%). When myocarditis occurred, neutrophil to lymphocyte ratio, C-reactive protein, lactate dehydrogenase, interleukin (IL)-6, IL-10, creatine kinase, MB isoenzyme of creatine kinase, and brain natriuretic peptide increased from baseline, but absolute lymphocyte count decreased. Thymoma (B2/B3) was a risk factor for multi-organ irAEs. Heart failure and myocarditis were more severe in patients with multi-organ irAEs and require early corticosteroid therapy (<24 hours). Univariate analysis showed that age ≥ 60 years, myocarditis (grade 3-4), heart failure (grade 3-4), multi-organ irAEs, and severe myocarditis were associated with OS after myocarditis. After adjusting for other factors, heart failure (grade 3-4) was an independent risk factor for immune-related myocarditis (HR: 6.655, 95% CI: 1.539-28.770, p=0.011).

Conclusion: Patients with ICI-associated myocarditis had multi-organ irAEs with a high incidence of severe myocarditis, mortality, and poor prognosis. Thymoma was prone to those patients with multiple organs involvement. Patients could benefit from early corticosteroid intervention. Heart failure (grade 3-4) was an independent risk factor for OS after myocarditis.
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http://dx.doi.org/10.3389/fimmu.2022.879900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340212PMC
August 2022

The fault detection of transmitting current encoded by m-sequence using triple-correlation function in helicopter-borne electromagnetic method.

Rev Sci Instrum 2022 Jul;93(7):074501

Key Laboratory of Geo-exploration Instruments, Ministry of Education of China, Changchun 130061, China.

An m-sequence is applied to the helicopter-borne electromagnetic method system for the first time, and there are many problems to be solved, one of which is the detection of the quality of the transmitting current waveform, which directly affects the resource survey results. In this research, we found that the triple-correlation function (TCF) can reveal the bit integrity characteristics of the m-sequence encoded transmitting current. On this basis, this paper proposes to extract the three-dimensional information of the normalized TCF plot by using a peak detection method and, then, proposes to use a dual-threshold method to clarify the detection results. The whole process realizes the fault detection of the transmitting current waveform. We propose a reasonable transmitting current modeling method and conduct 1200 random experiments in 12 groups. The statistics of the experimental results show that when the number of missing bits is 1, 2, 4, and 8, the fault detection accuracy can reach more than 83%. A comparative experiment using the Field Programmable Gate Array. in the laboratory validates the feasibility of the fault detection method. This method is beneficial to improve the quality of detection data and avoid economic losses caused by invalid detection flights.
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http://dx.doi.org/10.1063/5.0090992DOI Listing
July 2022

Enhancing the Spin-Orbit Torque Efficiency by the Insertion of a Sub-nanometer β-W Layer.

ACS Nano 2022 Jul 31. Epub 2022 Jul 31.

Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, School of Electronics and Information Engineering, the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technology, Xi'an Jiaotong University, Xi'an 710049, China.

Spin-orbit torque (SOT) efficiency is one of the key issues of spintronics. However, enhancing the SOT efficiency is usually limited by the positive correlation between resistivity and the spin Hall ratio, where a high resistivity often accompanies a large spin Hall ratio. Here, we demonstrate that sub-nanometer β-W intercalation has a considerable impact on the SOT efficiency in α-W (6 nm)/Co (8 nm)/Pt (3 nm) samples. The damping-like SOT efficiency per unit current density, ξ, of α-W (5.7 nm)/β-W (0.3 nm)/Co (8 nm)/Pt (3 nm) shows a ∼ 296% enhancement compared to that of the α-W/Co/Pt system. Meanwhile, a resistivity similar to that of α-W and the spin Hall ratio larger than β-W induce a giant damping-like SOT efficiency per applied electric field, ξ, which is about 12.1 times larger than that of β-W. Our findings will benefit the SOT devices by reducing energy consumption.
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http://dx.doi.org/10.1021/acsnano.2c00093DOI Listing
July 2022

Construction of a Prognostic Evaluation Model for Stomach Adenocarcinoma on the Basis of Immune-Related lncRNAs.

Appl Biochem Biotechnol 2022 Jul 29. Epub 2022 Jul 29.

Department of Gastrointestinal Surgery, Lishui City People's Hospital, 15# Dazhong Street Zhejiang Province, 323000, Lishui, China.

Progression, prognosis, and therapeutic strategy of stomach adenocarcinoma (STAD) have a close connection with tumor microenvironment (TME). Thus, it is pivotal to delve into the TME and immune-related genes, which may bring possibilities for improving patient's prognosis. TCGA-STAD dataset was analyzed to acquire differentially expressed lncRNAs in tumor samples, which were overlapped with the immune-related lncRNA datasets in the ImmLnc database. Twenty-six lncRNAs related to STAD immunity and patient's prognosis were acquired by univariate Cox analysis. Following lncRNA expression patterns, STAD samples could be classified into two clusters with completely different immune patterns. We performed multivariate Cox regression analysis on lncRNAs to identify 7-feature lncRNAs and constructed a corresponding prognostic model. The model validity was verified by survival analysis and ROC curve in validation and training sets. To explore connection between model and TME and tumor drug resistance, this study analyzed differences in immune cell infiltration between samples from high- and low-risk groups and then revealed immune cells follicular helper with significant differences in tumor tissue infiltration. Analysis of resistance to chemotherapeutic drugs revealed that samples in the high-risk group had resistance to cisplatin, doxorubicin, bleomycin, and gemcitabine. Through univariate and multivariate Cox analyses, we manifested that risk score could be an independent prognostic factor. Combining risk score and clinical factors, a nomogram was constructed to accurately predict patient's prognosis. This model can effectively predict prognosis, TME, and drug resistance of STAD patients, which may provide a reference for tumor development evaluation and precise treatment for clinical STAD.
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http://dx.doi.org/10.1007/s12010-022-04098-xDOI Listing
July 2022

Plasma PRPC Levels Correlate With Severity and Prognosis of Intracerebral Hemorrhage.

Front Neurol 2022 11;13:913926. Epub 2022 Jul 11.

Department of Neurosurgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Cellular prion protein (PRPC) exerts brain-protective effects. We determined the relationship between plasma PRPC levels and disease severity plus clinical outcome after acute intracerebral hemorrhage (ICH).

Methods: A total of 138 ICH patients and 138 healthy controls were included in this prospective, observational study. Hematoma volume and Glasgow coma scale (GCS) score were used to assess disease severity. Glasgow outcome scale (GOS) scores of 1-3 and 4-5 at 90 days after stroke were defined as a poor outcome and good outcome, respectively. Using multivariate analysis, we discerned the relation of plasma PRPC levels to disease severity and poor outcome. The receiver operating characteristic (ROC) curve was built to evaluate the prognostic predictive capability.

Results: Plasma PRPC levels in ICH patients were significantly higher than those in healthy controls (median, 4.20 vs. 2.02 ng/ml; < 0.001), and were independently correlated with GCS score ( = -0.645, < 0.001) and hematoma volume ( = 0.627, < 0.001). Plasma PRPC levels were highly correlated with GOS score ( = -0.762, < 0.001), and were substantially higher in patients with poor outcomes than in those with the good outcomes. Using maximum Youden index, plasma PRPC levels >3.893 ng/ml distinguished the risk of poor outcome at 90 days, with a sensitivity of 86.4% and a specificity of 65.8% (area under the curve, 0.809; 95% confidence interval (CI), 0.737-0.881, < 0.001). Plasma PRPC levels >3.893 ng/ml were independently associated with a poor 90-day outcome with an odds ratio of 12.278 (95% CI, 5.101-29.554).

Conclusion: Elevated plasma PRPC levels are significantly associated with disease severity and poor 90-day outcome in ICH patients, indicating that plasma PRPC may be used as a potential prognostic biomarker after ICH.
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http://dx.doi.org/10.3389/fneur.2022.913926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309369PMC
July 2022

Complete chloroplast genome of (Lam.) DC (Rutaceae: ).

Mitochondrial DNA B Resour 2022 22;7(7):1329-1331. Epub 2022 Jul 22.

College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.

In this study, the chloroplast (Cp) genome of (Lam.) DC was sequenced by high-throughput sequencing technology. The length of the Cp genome of was 158,568 bp, and the total GC content was 38.4%, including a large single-copy (LSC) region of 86,318 bp, a small single-copy (SSC) region of 18,250 bp, and 27,000 bp of inverted repeats (IRs). The Cp genome encoded 131 genes, including 88 protein-coding, 37 tRNA, and six rRNA genes. Phylogenetic analysis of the genome sequence showed that was closely related to , and of the Rutaceae family.
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http://dx.doi.org/10.1080/23802359.2022.2097894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310787PMC
July 2022

Radioimmunotherapy-induced intratumoral changes in cervical squamous cell carcinoma at single-cell resolution.

Cancer Commun (Lond) 2022 Jul 27. Epub 2022 Jul 27.

Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, P. R. China.

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http://dx.doi.org/10.1002/cac2.12342DOI Listing
July 2022

Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19.

Crit Care Med 2022 Jul 27. Epub 2022 Jul 27.

Biomedical and Behavioral Methodology Core, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Objectives: To determine the association of prior use of renin-angiotensin-aldosterone system inhibitors (RAASIs) with mortality and outcomes in hospitalized patients with COVID-19.

Design: Retrospective observational study.

Setting: Multicenter, international COVID-19 registry.

Subjects: Adult hospitalized COVID-19 patients on antihypertensive agents (AHAs) prior to admission, admitted from March 31, 2020, to March 10, 2021.

Interventions: None.

Measurements And Main Results: Data were compared between three groups: patients on RAASIs only, other AHAs only, and those on both medications. Multivariable logistic and linear regressions were performed after controlling for prehospitalization characteristics to estimate the effect of RAASIs on mortality and other outcomes during hospitalization. Of 26,652 patients, 7,975 patients were on AHAs prior to hospitalization. Of these, 1,542 patients (19.3%) were on RAASIs only, 3,765 patients (47.2%) were on other AHAs only, and 2,668 (33.5%) patients were on both medications. Compared with those taking other AHAs only, patients on RAASIs only were younger (mean age 63.3 vs 66.9 yr; p < 0.0001), more often male (58.2% vs 52.4%; p = 0.0001) and more often White (55.1% vs 47.2%; p < 0.0001). After adjusting for age, gender, race, location, and comorbidities, patients on combination of RAASIs and other AHAs had higher in-hospital mortality than those on RAASIs only (odds ratio [OR] = 1.28; 95% CI [1.19-1.38]; p < 0.0001) and higher mortality than those on other AHAs only (OR = 1.09; 95% CI [1.03-1.15]; p = 0.0017). Patients on RAASIs only had lower mortality than those on other AHAs only (OR = 0.87; 95% CI [0.81-0.94]; p = 0.0003). Patients on ACEIs only had higher mortality compared with those on ARBs only (OR = 1.37; 95% CI [1.20-1.56]; p < 0.0001).

Conclusions: Among patients hospitalized for COVID-19 who were taking AHAs, prior use of a combination of RAASIs and other AHAs was associated with higher in-hospital mortality than the use of RAASIs alone. When compared with ARBs, ACEIs were associated with significantly higher mortality in hospitalized COVID-19 patients.
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http://dx.doi.org/10.1097/CCM.0000000000005627DOI Listing
July 2022

Association between Deep Medullary Veins in the Unaffected Hemisphere and Functional Outcome in Acute Cardioembolic Stroke: An Observational Retrospective Study.

Brain Sci 2022 Jul 25;12(8). Epub 2022 Jul 25.

Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore whether deep medullary veins (DMVs) in the unaffected hemisphere were associated with functional outcome in acute cardioembolic stroke patients.

Methods: Acute cardioembolic stroke patients at a single center were retrospectively included. DMVs visibility in the unaffected hemisphere was assessed using a well-established four-grade scoring method based on susceptibility-weighted imaging (SWI): grades 0-3 (grade 0 for no visible DMVs; grade 1 for the numbers of conspicuous DMVs < 5; grade 2 for numbers raging from 5 to 10; grade 3 for more than 10). Patients were further divided into mild-to-moderate (grade 0-2) and severe DMVs (grade 3) groups. Functional outcomes were evaluated using the modified Rankin scale (mRS) score at three months. Poor outcome was defined as mRS ≥ 3. Binary logistic regression analysis was used to explore the association between DMVs grade and functional outcome.

Results: A total of 170 patients were finally included. Compared with the mild-to-moderate DMVs group (149 patients), the severe DMVs group (21 patients) had higher baseline National Institutes of Health Stroke Scale (NIHSS) scores ( = 0.002), lower levels of admission systolic blood pressure (BP) ( = 0.031), and elevated rates of large infarction ( = 0.003). At three months, the severe DMVs group had higher mRS ( = 0.002). Patients in the poor outcome group (82/170, 48.2%) had older age, higher baseline NIHSS score, lower admission diastolic BP, higher rates of hemorrhagic transformation and large infarction, and an increased proportion of severe DMVs (all < 0.05). After adjusting for confounders, multivariable regression analysis showed that the severe DMVs grade (adjusted odds ratio [OR] = 5.830, 95% confidence interval [CI] = 1.266-26.856, = 0.024) was significantly associated with three-month functional outcomes without interaction with other potential risk factors ( for interaction > 0.05).

Conclusions: DMVs grade in the unaffected hemisphere was independently associated with three-month functional outcome in acute cardioembolic stroke patients. Patients with severe DMVs were more likely to have a poor functional outcome at three months.
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http://dx.doi.org/10.3390/brainsci12080978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330894PMC
July 2022

Time-Dependent Seismic Fragility of Typical Concrete Girder Bridges under Chloride-Induced Corrosion.

Materials (Basel) 2022 Jul 19;15(14). Epub 2022 Jul 19.

Center for Advancing Materials Performance from the Nanoscale (CAMP-Nano), State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Recent studies highlighted the importance of the combined effects of prestress loss and corrosion deterioration for concrete girder bridge structures when the effect of damage on the performance level is estimated. The multi-deterioration mechanisms connected with chloride erosion include the cross-sectional area loss of longitudinal bars and stirrups, the reduction in the ductility, the decrease in the strength of steels and the strength loss of concrete in RC columns. For the corroded RC columns and corroded elastomeric bridge bearings, analytical models of the material degradation phenomena were employed for performing the probabilistic seismic performance analysis, which could obtain the system seismic fragility of aging bridges by considering the failure functionality of multiple correlated components (e.g., columns, bearings). The combined effects of prestress loss and cracking were also considered when developing time-dependent system seismic fragility functions. Here, a typical multi-span reinforced concrete girder bridge was used as a case study for studying the time-variant seismic performance. The results revealed the importance of the joint effects of the multi-deterioration mechanisms when modeling the time-dependent seismic fragility of aging bridge systems, as well as the significance of considering the combined effects of prestress loss and cracking.
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http://dx.doi.org/10.3390/ma15145020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317766PMC
July 2022

Comparative Transcriptome and Interaction Protein Analysis Reveals the Mechanism of -Overexpressing Transgenic Sweet Potato Response to Low-Temperature Stress.

Genes (Basel) 2022 Jul 14;13(7). Epub 2022 Jul 14.

Xuzhou Sweet Potato Research Center, Xuzhou Institute of Agricultural Sciences Jiangsu, China/Key Laboratory of Sweet Potato Biology and Genetic Breeding, Ministry of Agriculture/National Agricultural Experimental Station for Soil Quality, Xuzhou 221000, China.

The sweet potato is very sensitive to low temperature. Our previous study revealed that -overexpressing transgenic sweet potato (M3) plants showed stronger low-temperature stress tolerance than wild-type plants (WT). However, the mechanism of M3 plants in response to low-temperature stress is unclear. To further analyze how mediates low-temperature stress in sweet potato, WT and M3 plants were exposed to low-temperature stress for 2 h and 12 h for RNA-seq analysis, whereas normal conditions were used as a control (CK). In total, 3436 and 8718 differentially expressed genes (DEGs) were identified in WT at 2 h (vs. CK) and 12 h (vs. CK) under low-temperature stress, respectively, whereas 1450 and 9291 DEGs were detected in M3 plants, respectively. Many common and unique DEGs were analyzed in WT and M3 plants. DEGs related to low temperature were involved in Ca signaling, MAPK cascades, the reactive oxygen species (ROS) signaling pathway, hormone transduction pathway, encoding transcription factor families (, , and ), and downstream stress-related genes. Additionally, more upregulated genes were associated with the MAPK pathway in M3 plants during short-term low-temperature stress (CK vs. 2 h), and more upregulated genes were involved in secondary metabolic synthesis in M3 plants than in the WT during the long-time low-temperature stress treatment (CK vs. 12 h), such as fatty acid biosynthesis and elongation, glutathione metabolism, flavonoid biosynthesis, carotenoid biosynthesis, and zeatin biosynthesis. Moreover, the interaction proteins of IbMPK3 related to photosynthesis, or encoding CaM, NAC, and ribosomal proteins, were identified using yeast two-hybrid (Y2H). This study may provide a valuable resource for elucidating the sweet potato low-temperature stress resistance mechanism, as well as data to support molecular-assisted breeding with the gene.
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http://dx.doi.org/10.3390/genes13071247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317282PMC
July 2022

Febuxostat protects HAVECs from ox-LDL-induced injury and monocyte attachment.

J Cardiovasc Pharmacol 2022 Jul 5. Epub 2022 Jul 5.

Department of Cardiology, the First People's Hospital of Yulin, Yulin, Guangxi, 537000, China.

Abstract: Atherosclerosis (AS) is a common cardiovascular disease with high morbidity and mortality. The pathogenesis of AS is closely related to endothelial dysfunction, which is mainly induced by oxidative stress, inflammation, and enhanced adhesion of monocytes to endothelial cells on the vessel wall. Febuxostat is a novel anti-gout agent recently reported to exert protective effects on endothelial dysfunction. The present study aims to investigate the protective capacity of Febuxostat against ox-LDL-induced injury and monocyte attachment to endothelial cells. Human aortic valve endothelial cells (HAVECs) were stimulated with ox-LDL in the presence or absence of Febuxostat (5, 10 μM) for 6 hours. Mitochondrial ROS were measured using MitoSox red staining and the level of protein carbonyl was detected using ELISA. The expressions of IL-6, TNF-α, tissue factor (TF), VCAM-1, and ICAM-1 were evaluated with qRT-PCR and ELISA assays. Calcein-AM staining was utilized to determine the attachment of U937 monocytes to HAVECs. qRT-PCR and Western blot were used to measure the expression level of early growth response 1 (Egr-1) in HAVECs. Firstly, the elevated expression of LOX-1, activated oxidative stress, excessive secreted inflammatory factors, and promoted expression of TF induced by stimulation with ox-LDL were significantly reversed by Febuxostat, indicating a protective effect of Febuxostat against endothelial dysfunction. Secondly, the upregulated VCAM-1 and ICAM-1, as well as the increased proportion of adhered monocytes to HAVECs induced by ox-LDL were significantly alleviated by Febuxostat. Lastly, the promoted expression level of Egr-1 induced by ox-LDL was pronouncedly suppressed by Febuxostat. We conclude that Febuxostat protected HAVECs from ox-LDL-induced injury and monocytes attachment.
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http://dx.doi.org/10.1097/FJC.0000000000001326DOI Listing
July 2022

WNT1-inducible signalling pathway protein 1 stabilizes atherosclerotic plaques in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway.

J Hypertens 2022 Sep 25;40(9):1666-1681. Epub 2022 Jul 25.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.

Background: The migration, proliferation and apoptosis of vascular smooth muscle cells (VSMCs) are critical for plaque stability. WNT-inducible signalling pathway protein-1 (WISP1), a member of the CCN family of extracellular matrix proteins, can expedite the migration and proliferation of VSMCs. However, its underlying mechanism and relationship with atherosclerosis remain elusive. The relationship between WISP1 and apoptosis of VSMCs has not been determined previously.

Method: In the study, we aimed to investigate the relationship between WISP1 and plaque stability and its related mechanism.ApoE-/- mice were divided following groups: the null lentivirus (NC), lentivirus WISP1 (IvWISP1) and WISP1-shRNA (shWISP1) groups. Immunofluorescence, Oil Red O and Masson's staining of the carotid arteries were performed. Transwell wound healing assay, CCK8 assay, and TdT-mediated dUTP nick-end labeling (TUNEL) staining were performed using VSMCs. The levels of WISP1, P38, C-Jun N-terminal kinase, extracellular signal-regulated kinase (ERK), mitogen-activated extracellular signal-regulated kinase (MEK), focal adhesion kinase (FAK), phosphatidylinositol 3-kinase (PI3K), Akt (also known as PKB, protein kinase B), mammalian target of rapamycin (mTOR), cleaved caspase3, Bcl2 and Bax were detected by western blotting.

Results: The relative area of lipids and monocytes/macrophages in the shWISP1 group increased compared with that of the NC group. However, the relative area of smooth muscle cell and collagen in the IvWISP1 group increased compared with that in the NC group. Therefore, WISP1 could stabilize atherosclerotic plaques. Besides, WISP1 accelerate the migration and proliferation of VSMCs via integrin α5β1 and FAK/MEK/ERK signalling pathways. In addition, WISP1 can inhibit the apoptosis of VSMCs via the PI3K/Akt/mTOR pathway.

Conclusion: WISP1 not only inhibits the apoptosis of VSMCs via the PI3K/Akt/mTOR pathway but also enhances the migration and proliferation of VSMCs via the integrin α5β1 and FAK/MEK/ERK pathways. Therefore, WISP1 could enhance the stability of atherosclerotic plaques.
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http://dx.doi.org/10.1097/HJH.0000000000003195DOI Listing
September 2022

Commercially Viable Hybrid Li-Ion/Metal Batteries with High Energy Density Realized by Symbiotic Anode and Prelithiated Cathode.

Nanomicro Lett 2022 Jul 22;14(1):149. Epub 2022 Jul 22.

Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, People's Republic of China.

The energy density of commercial lithium (Li) ion batteries with graphite anode is reaching the limit. It is believed that directly utilizing Li metal as anode without a host could enhance the battery's energy density to the maximum extent. However, the poor reversibility and infinite volume change of Li metal hinder the realistic implementation of Li metal in battery community. Herein, a commercially viable hybrid Li-ion/metal battery is realized by a coordinated strategy of symbiotic anode and prelithiated cathode. To be specific, a scalable template-removal method is developed to fabricate the porous graphite layer (PGL), which acts as a symbiotic host for Li ion intercalation and subsequent Li metal deposition due to the enhanced lithiophilicity and sufficient ion-conducting pathways. A continuous dissolution-deintercalation mechanism during delithiation process further ensures the elimination of dead Li. As a result, when the excess plating Li reaches 30%, the PGL could deliver an ultrahigh average Coulombic efficiency of 99.5% for 180 cycles with a capacity of 2.48 mAh cm in traditional carbonate electrolyte. Meanwhile, an air-stable recrystallized lithium oxalate with high specific capacity (514.3 mAh g) and moderate operating potential (4.7-5.0 V) is introduced as a sacrificial cathode to compensate the initial loss and provide Li source for subsequent cycles. Based on the prelithiated cathode and initial Li-free symbiotic anode, under a practical-level 3 mAh capacity, the assembled hybrid Li-ion/metal full cell with a P/N ratio (capacity ratio of LiNiCoMnO to graphite) of 1.3 exhibits significantly improved capacity retention after 300 cycles, indicating its great potential for high-energy-density Li batteries.
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http://dx.doi.org/10.1007/s40820-022-00899-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307699PMC
July 2022

Intrinsic Differences in Immune Checkpoint Inhibitor-Induced Myocarditis: A Retrospective Analysis of Real World Data.

Front Pharmacol 2022 5;13:914928. Epub 2022 Jul 5.

Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.

Immune-related myocarditis is a severe and even life-threatening immune-related adverse event (irAE) which may also be underestimated due to the challenge in diagnosis. The inherent difference between individuals with immune-associated myocarditis has received little attention. Our study aimed to identify which baseline characteristics could contribute to distinguishing mild from severe ICI myocarditis. A retrospective analysis was conducted between March 2019 and June 2020 in West China Hospital, and 18 patients with immune-related myocarditis were studied. Patients were classified as having mild ( = 12) or severe myocarditis ( = 6), according to the clinical manifestations and hemodynamic complications. Factors associated with severe myocarditis were identified by comparing covariates derived from medical records in various groups. In this retrospective analysis, the median age of the 18 patients was 60 years old. Most myocarditis cases occur early and approximately after the first or second ICI infusion. The severity of myocarditis may be correlated with lactate dehydrogenase (LDH) ( = 0.04) and troponin levels ( = 0.0057). The relationship between troponin and myocarditis was further confirmed in another cohort, which included 30 patients. In addition, patients are more likely to develop multi-irAEs, and myositis was the most common second irAE. Those who experience multi-irAEs usually had significantly higher LDH ( = 0.02) and myoglobin levels ( = 0.02) than those who did not experience them. All patients were treated with steroids timely, and the mortality rate was 5.6% in our study. In this study, we explored risk factors for severe myocarditis and emphasized the importance of a multidisciplinary team in assisting diagnosis and treatment options. It is critical to initiate corticosteroid therapy, regardless of the severity of the myocarditis.
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http://dx.doi.org/10.3389/fphar.2022.914928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294234PMC
July 2022

Binding model-tuned room-temperature phosphorescence of the bromo-naphthol derivatives based on cyclodextrins.

RSC Adv 2022 Jun 1;12(30):19313-19316. Epub 2022 Jul 1.

School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University Wenzhou Zhejiang 32503 China

Herein, bromo-naphthol derivatives were synthesized to investigate the influence on their phosphorescence emission efficiency resulting from different binding models with cyclodextrins. And the results indicated that α-cyclodextrin could result in the highest phosphorescence emission efficiency, due to the tight encapsulation of the bromo-naphthol motif into the cavity.
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http://dx.doi.org/10.1039/d2ra03046bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248367PMC
June 2022

Improving Li-ion interfacial transport in hybrid solid electrolytes.

Nat Nanotechnol 2022 Jul 21. Epub 2022 Jul 21.

Section Storage of Electrochemical Energy, Radiation Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

The development of commercial solid-state batteries has to date been hindered by the individual limitations of inorganic and organic solid electrolytes, motivating hybrid concepts. However, the room-temperature conductivity of hybrid solid electrolytes is still insufficient to support the required battery performance. A key challenge is to assess the Li-ion transport over the inorganic and organic interfaces and relate this to surface chemistry. Here we study the interphase structure and the Li-ion transport across the interface of hybrid solid electrolytes using solid-state nuclear magnetic resonance spectroscopy. In a hybrid solid polyethylene oxide polymer-inorganic electrolyte, we introduce two representative types of ionic liquid that have different miscibilities with the polymer. The poorly miscible ionic liquid wets the polymer-inorganic interface and increases the local polarizability. This lowers the diffusional barrier, resulting in an overall room-temperature conductivity of 2.47 × 10 S cm. A critical current density of 0.25 mA cm versus a Li-metal anode shows improved stability, allowing cycling of a LiFePO-Li-metal solid-state cell at room temperature with a Coulombic efficiency of 99.9%. Tailoring the local interface environment between the inorganic and organic solid electrolyte components in hybrid solid electrolytes seems to be a viable route towards designing highly conducting hybrid solid electrolytes.
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http://dx.doi.org/10.1038/s41565-022-01162-9DOI Listing
July 2022

Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value.

Front Cell Dev Biol 2021 4;9:760618. Epub 2022 Jul 4.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Hepatopancreatobiliary Surgery Department I, Peking University Cancer Hospital and Institute, Beijing, China.

Colorectal liver metastases (CRLMs) are clinically heterogeneous lesions with poor prognosis. Genetic alterations play a crucial role in their progression. The traditional Fong clinical risk score (Fong-CRS) is commonly used for risk stratification and prognosis prediction. By identifying the genomic alterations of CRLMs, we aimed to develop a mutation-based gene-signature-based clinical score (mut-CS) system to improve clinical prognostication. Tumour tissues from 144 patients with CRLMs were analysed with next-generation sequencing (NGS). A mut-CS scoring system considering the unique mutation-based gene signature, primary site, and Fong-CRS was developed and could identify CRLM patients with poor prognosis. The mean time-dependent receiver operating characteristic curve AUC value of the mut-CS system was greater than that of previously established scoring measures (the Fong-CRS, the e-clinical score, the presence of concomitant RAS and TP53 mutations, and other clinical traits). Taking together, we identified a mutant signature that exhibits a strong prognostic effect for CRLMs. Traditional clinical scoring system characteristics were incorporated into the new mut-CS scoring system to help determine the appropriate treatment for CRLMs.
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http://dx.doi.org/10.3389/fcell.2021.760618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289210PMC
July 2022

Association between preoperative dementia and hospital mortality in old old patients undergoing elective gastrointestinal surgery.

Aging Clin Exp Res 2022 Jul 19. Epub 2022 Jul 19.

Surgery Intensive Care Unit, China-Japan Friendship Hospital, Beijing, China.

Background: Although many reports have shown that preoperative dementia affects surgical prognosis, it is unclear whether the dementia based on Mini-Mental State Examination (MMSE) affect hospital mortality in old old patients undergoing elective gastrointestinal surgery.

Aims: This study aims to investigate whether preoperative dementia might affect the outcomes of old old patients undergoing elective gastrointestinal surgery by evaluating with the MMSE.

Methods: All patients aged ≥ 75 years who undergoing elective gastrointestinal surgery form January 2015 to December 2021 in a Chinese tertiary hospital were retrospectively analyzed. Their preoperative cognitive status was evaluated using the MMSE, and analysis was performed to compare the patients with MMSE score < 24 (dementia group) or MMSE score 24-30 (non-dementia group). Risk factors for hospital mortality were explored using multivariate logistic regression analysis.

Results: 980 patients were rolled in the study, and 102 (10.4%) patients were in the dementia group. ICU and hospital stay were longer in the dementia group. Regarding the postoperative complications, the incidence of cerebral infarction (P = 0.014), delirium (P = 0.019), and pulmonary infection (P = 0.017) was more frequent in dementia group. Hospital mortality was 11% in the dementia group and 3% in the non-dementia group (P = 0.009). Multivariate logistic regression analysis revealed that dementia (P = 0.0135), preoperative lower albumin (P = 0.0018) and malignancy (P = 0.0212) were independent risk factors for hospital mortality.

Conclusions: Among old old patients undergoing elective gastrointestinal surgery, hospital mortality was increased significantly for patients with dementia evaluating with the MMSE.
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http://dx.doi.org/10.1007/s40520-022-02197-7DOI Listing
July 2022

How does the brain represent the semantic content of an image?

Neural Netw 2022 Jul 2;154:31-42. Epub 2022 Jul 2.

Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou 510631, China; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China; Plateau Brain Science Research Center, South China Normal University, Guangzhou 510631, China; Plateau Brain Science Research Center, Tibet University, Lhasa 850000, China. Electronic address:

Using deep neural networks (DNNs) as models to explore the biological brain is controversial, which is mainly due to the impenetrability of DNNs. Inspired by neural style transfer, we circumvented this problem by using deep features that were given a clear meaning-the representation of the semantic content of an image. Using encoding models and the representational similarity analysis, we quantitatively showed that the deep features which represented the semantic content of an image mainly predicted the activity of voxels in the early visual areas (V1, V2, and V3) and these features were essentially depictive but also propositional. This result is in line with the core viewpoint of the grounded cognition to some extent, which suggested that the representation of information in our brain is essentially depictive and can implement symbolic functions naturally.
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http://dx.doi.org/10.1016/j.neunet.2022.06.034DOI Listing
July 2022

Strain Modulation of Perpendicular Magnetic Anisotropy in Wrinkle-Patterned (Co/Pt)/BaTiO Magnetoelectric Heterostructures.

ACS Nano 2022 Jul 18. Epub 2022 Jul 18.

The Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, School of Electronic Science and Engineering, State Key Laboratory for Mechanical Behavior of Materials, the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technology, Xi'an Jiaotong University, Xi'an 710049, China.

The rapid development of spintronics requires the devices to be flexible, to be used in wearable electronics, and controllable, to be used with magnetoelectric (ME) structures. However, the clamping effect inevitably leads to a decreased ME effect on the rigid substrate, and it remains challenging to directly prepare high-quality ferroelectric (FE) membranes on the widely used flexible substrate such as MICA or polyimide (PI). Here, periodic wrinkle-patterned flexible (Co/Pt)/BaTiO (BTO) perpendicular magnetic anisotropy (PMA) heterostructures were prepared using the water-soluble method. The high-quality single-crystal BTO membrane ensures that intricate wrinkles do not fracture and a high ME coefficient is achievable. The transferred sample that is released from the clamping effect shows an enhanced ME effect in both in-plane and out-of-plane directions, with the ME coefficient reaching up to 68 Oe °C. The ferromagnetic resonance (FMR) field of the flexible sample can be tuned by tensile strain up to 272 Oe. The finely controlled wrinkle shows periodic strain variations at peak and valley regions that switch the PMA magnetic domain motion as an effective control method. The proposed ultraflexible wrinkle sample shows great potential for combining multiple magnetization tuning approaches, allowing it to potentially serve as a tunable high-density 3D storage prototype.
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http://dx.doi.org/10.1021/acsnano.2c04754DOI Listing
July 2022

Acute iron overload aggravates blood-brain barrier disruption and hemorrhagic transformation after transient focal ischemia in rats with hyperglycemia.

IBRO Neurosci Rep 2022 Dec 3;13:87-95. Epub 2022 Jul 3.

Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Hemorrhagic transformation (HT) has been reported to be associated with a poor prognosis after acute ischemic stroke. Blood-brain barrier (BBB) damage is considered as the major pathophysiologic mechanism of HT. Our aim was to investigate the role of acute iron overload in BBB damage and HT after transient focal ischemia in rats with hyperglycemia. Transient middle cerebral artery occlusion (MCAO) was induced in rats with hyperglycemia. Animals were assigned to four groups: Sham, Vehicle, Iron overload and Iron chelator treatment groups. Brain samples were collected at 24 h after surgery to quantify the amount of hemorrhage, determine extravasation of Evans blue and detect the levels of following proteins: ferritin, matrix metalloproteinase-9 (MMP-9), zonula occludens-1 (ZO-1), Occludin and Claudin-5 by western blot analysis and immunohistochemistry. Compared to the Vehicle group, the Iron overload group had a significantly higher amount of hemorrhage and more extravasation of Evans blue. The Iron overload group had lower levels of ZO-1, Occludin and Claudin-5 and higher levels of ferritin and MMP-9 than the Vehicle group. Administering iron chelator reduced the extension of hemorrhage and extravasation of Evans blue, reversed the MCAO-induced reduction of ZO-1, Occludin and Claudin-5 and decreased the levels of ferritin and MMP-9. Our results suggest that acute iron overload aggravates BBB damage and HT after transient ischemia in rats with hyperglycemia, which provides basic evidence for iron overload as a potential factor associated with BBB damage and HT in ischemic stroke patients when accompanied with hyperglycemia.
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http://dx.doi.org/10.1016/j.ibneur.2022.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284446PMC
December 2022

Carbonyls from commercial, canteen and residential cooking activities as crucial components of VOC emissions in China.

Sci Total Environ 2022 Jul 13;846:157317. Epub 2022 Jul 13.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.

Cooking in China supply the large population with nutrition and, as a commercial activity, it also promotes the economic growth of Chinese society. The specific cooking styles in China can produce complex volatile organic compound (VOC) emissions. The resulting adverse effects on the environment and human health of carbonyls from cooking should not be ignored. We quantitatively evaluated the contribution of carbonyls to common VOCs (carbonyl/VOC ratio) from cooking activities in China through the establishment and comparison of the source profiles, emission factors (EFs), emission amount and ozone formation potential (OFP). It was found that carbonyls are crucial components of VOCs from commercial, canteen and residential cooking activities (COC, CAC and REC, respectively). The carbonyl/VOC ratio from cooking activities in China had EFs, emissions, and a total OFP of 22-65 %, 23-34 %, and 49-104 %, respectively. The high OFP was due to the high OFP emissions intensity (OFP) and maximum incremental reactivity (MIR) values of carbonyls. This indicates that to alleviate O pollution, OFP-based control measures that target carbonyls might be more efficient than measures that target common VOCs. Priority should be given to emission controlling COC emissions, specifically those from medium- and large-scale catering. Formaldehyde, acetaldehyde, and hexanal were the key carbonyl species that form O in the environment. Our findings imply that cooking-emitted carbonyls should not be overlooked in investigations of O formation and that these compounds should be subject to strict regulations.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157317DOI Listing
July 2022
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