Publications by authors named "Minchang Wang"

12 Publications

  • Page 1 of 1

New Steroidal Saponins Isolated from the Rhizomes of .

Molecules 2021 Oct 21;26(21). Epub 2021 Oct 21.

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.

The genus is an excellent source of steroidal saponins that exhibit various bioactivities. is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A-E (-), along with five known steroidal saponins -, were isolated from the rhizomes of . The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
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http://dx.doi.org/10.3390/molecules26216366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588014PMC
October 2021

Recent advances in polysaccharides from Lentinus edodes (Berk.): Isolation, structures and bioactivities.

Food Chem 2021 Oct 20;358:129883. Epub 2021 Apr 20.

College of Food Science & Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address:

Lentinus edodes, an important edible mushroom cultivated in East Asia for thousands of years, has been widely used as food and medicinal ingredient worldwide. Modern phytochemistry studies have demonstrated that L. edodes is very rich in bioactive polysaccharides, especially the β-glucans. Over the past two decades, the isolation, chemical properties, and bioactivities of polysaccharides from fruiting bodies, mycelium and fermentation broth of L. edodes have been drawing much attention from scholars around the world. It has been demonstrated that L. edodes polysaccharides possess various remarkable biological activities, including anti-oxidant, anti-tumor, anti-aging, anti-inflammation, immunomodulatory, antiviral, and hepatoprotection effects. This review summarizes the recent development of polysaccharides from L. edodes including the isolation methods, structural features, bioactivities and mechanisms, and their structure-activity relationship, which can provide useful research underpinnings and update information for their further application as therapeutic agents and functional foods.
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http://dx.doi.org/10.1016/j.foodchem.2021.129883DOI Listing
October 2021

Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae.

Mar Drugs 2018 Mar 13;16(3). Epub 2018 Mar 13.

Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Four new polyhydroxysteroidal glycosides-culcinosides A-D (, , , and )-along with three known compounds-echinasteroside C (), linckoside F (), and linckoside L3 ()-were isolated from the ethanol extract of starfish collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated.
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http://dx.doi.org/10.3390/md16030092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867636PMC
March 2018

New Steroidal Saponins from the Rhizomes of Paris vietnamensis and Their Cytotoxicity.

Molecules 2018 Mar 6;23(3). Epub 2018 Mar 6.

Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.

Four new spirostanol saponins, named pavitnosides A-D (-), with six known steroidal saponins - were isolated from the rhizomes of . Their chemical structures were determined based on extensive spectroscopic studies and chemical methods. The aglycones of pavitnoside B and pavitnoside C were not reported in previous work. The cytotoxicity of all saponins was evaluated against human glioblastoma U87MG and U251 cell lines. The new spirostanol saponin displayed weak anti-proliferative activity against U87MG cell line and the known saponins and exhibited significant cytotoxicity against the two tumor cell lines, with IC values of 2.16 to 3.14 μM, but did not affect the growth of primary cultures of human astrocytes.
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http://dx.doi.org/10.3390/molecules23030588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017139PMC
March 2018

New steroidal saponins from the rhizomes of Paris delavayi and their cytotoxicity.

Fitoterapia 2016 Jun 23;111:130-7. Epub 2016 Apr 23.

State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi'an 710065, PR China; Xi'an Modern Chemistry Research Institute, Xi'an 710065, PR China. Electronic address:

Four new furostanol saponins, named padelaosides C-F (1-4), together with four known spirostanol saponins 5-8 were isolated from the rhizomes of Paris delavayi Franchet. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidences. The discovery of the new compounds 1-4 extended the diversity and complexity of this furostanol saponin family. The cytotoxicity of all the saponins was evaluated for their cytotoxicity against human glioblastoma U87MG and human hepatocellular carcinoma Hep-G2 cell lines. The known spirostanol saponins 7 and 8 exhibited notable cytotoxicity against the two tumor cell lines with IC50 values of 1.13 and 3.42μM, respectively, while the new furostanol saponins 3 and 4 showed moderate cytotoxicity with IC50 values of 15.28 to 16.98μM.
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http://dx.doi.org/10.1016/j.fitote.2016.04.018DOI Listing
June 2016

Three new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta tenuis.

Fitoterapia 2015 Oct 15;106:226-30. Epub 2015 Sep 15.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.

Three new isomalabaricane-type triterpenes named stellettins N (1), O (2) and P (3), together with four known compounds (4–7),were isolated from the CCl4 extract of the marine sponge Stelletta tenuis Lindgren. Compound 4 was reported as a natural α-pyrone for the first time, which had been synthesized from gibepyrone B, while 5 was found in the genus Stelletta for the first time. The structures of the new compounds were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR. The inhibitory activities of compounds 1–3 against three human cancer cell lines (A549, AGS and U-251MG) were evaluated and all the tested compounds exhibited significant cytotoxicity to AGS cells, with IC50 values of 4.52, 9.61 and 7.44 μM, respectively.
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http://dx.doi.org/10.1016/j.fitote.2015.09.012DOI Listing
October 2015

Cytotoxic oleanane-type triterpenoid saponins from the Rhizomes of Anemone rivularis var. flore-minore.

Molecules 2014 Feb 18;19(2):2121-34. Epub 2014 Feb 18.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 1-5, together with five known saponins 6-10. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 6-8 exhibited cytotoxic activity toward all tested cancer cell lines, with IC50 values in the 7.25-22.38 μM range.
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http://dx.doi.org/10.3390/molecules19022121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270712PMC
February 2014

Chemical constituents of the root of Jasminum giraldii.

Molecules 2013 Apr 22;18(4):4766-75. Epub 2013 Apr 22.

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China.

Two new compounds, ethylconiferin and (-)-lariciresinol 4-(6'''-O-cinnamyl-β-D-glucopyranoside), along with the three known compounds (+)-pinoresinol, (+)-cycloolivil, nobiletin, were isolated from the root of Jasminum girialdii. All these compounds were isolated for the first time from this source. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical methods. In addition, the in vitro cytotoxic activity of these compounds was evaluated. The results showed that none of the compounds had any significant inhibitory activities on the proliferation of HCT-116 and SW-620 cells.
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http://dx.doi.org/10.3390/molecules18044766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270083PMC
April 2013

Triterpenoid saponins from Clematis tangutica and their cardioprotective activities.

Fitoterapia 2013 Jan 22;84:326-31. Epub 2012 Dec 22.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.

Phytochemical investigation of the whole plants of Clematis tangutica led to the isolation of three new triterpenoid saponins (1-3), together with four known saponins (4-7). Their structures were determined by extensive spectral analysis and chemical evidences. Compounds 1-7 were evaluated for their cardioprotective activities in cardiomyocytes anoxia/reoxygenation (A/R) model. The results showed that those saponins exhibited cardioprotective effects by decreasing the levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH).
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http://dx.doi.org/10.1016/j.fitote.2012.12.011DOI Listing
January 2013

Improved therapeutic effect of DOX-PLGA-PEG micelles decorated with bivalent fragment HAb18 F(ab')(2) for hepatocellular carcinoma.

Biomacromolecules 2010 Sep;11(9):2422-31

Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Although surgery offers the only hope of cure for hepatocellular carcinoma (HCC), patients with inoperable or metastatic disease have a dismal prognosis. Therefore, there is an urgent need for new and effective treatment strategies. Polymeric micelles composed of drug conjugated to a diblock copolymer have attracted great interest for clinical administration of anticancer drugs. In this work, characteristics and cytotoxicity of doxorubicin-poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) (DOX-PLGA-PEG) micelle and its targeted micelle decorated with bivalent fragment HAb18 F(ab')(2) for HCC were studied. These micelles possessed spherical morphology and higher loading efficiency. Cellular uptake and accumulation in tumor tissue of micelles was observed. The accumulation of the targeted micelles depends on dual effects of passive and active targeting. The drug-loading micelles showed cytotoxicity on tumor cells in vitro and in vivo. The targeted micelles resulted in significant improvement in therapeutic response. These results suggest that the novel micelles could be a promising candidate with excellent therapeutic efficacy for targeting the drugs to cancer cells.
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http://dx.doi.org/10.1021/bm1005992DOI Listing
September 2010

Three new insecticidal sesquiterpene polyol esters from Celastrus angulatus.

Nat Prod Commun 2010 Mar;5(3):355-9

Institute of Pesticide Science, Northwest A&F University, Yangling, Shaanxi 712100, China.

Three new insecticidal sesquiterpene polyol esters with dihydro-beta-agarofuran skeletons, Kupiteng esters A (1), B (2) and C (3), were isolated from the methanol extracts of the root bark of Celastrus angulatus and their structures elucidated by analyses of MS and NMR spectral data. The insecticidal activities of these compounds against the 4th instar larvae of Mythimna separata were evaluated. The KD50 values of compounds 1-3, were 260.2, 445.5 and 1260.0 microg x g(-1), respectively.
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March 2010

Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels.

Carbohydr Res 2006 Aug 8;341(11):1870-7. Epub 2006 May 8.

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an, China.

Two water-soluble glucans (designated APS-1cI and APS-1cII) were extracted from the roots of Angelica sinensis (Oliv.) Diels and further purified by anion-exchange and gel-filtration chromatography. Their molecular weights were determined to be 1.7 x 10(5) and 3.9 x 10(4)Da, respectively. The structures of the purified glucans were investigated by a combination of chemical and instrumental analysis, such as methylation analysis, periodate oxidation, GC-MS, as well as FTIR and NMR spectroscopy ((1)H, (13)C, H-H COSY, HSQC, HMBC, TOCSY and NOESY). The data obtained indicated that APS-1cI was a linear alpha-glucan composed of only (1-->6)-alpha-D-Glcp, and APS-1cII had a repeating unit consisting of (1-->4)-alpha-D-Glcp and (1-->6)-alpha-D-Glcp in a molar ratio of 4:1. Such glucans isolated from A. sinensis (Oliv.) Diels have not been previously reported.
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http://dx.doi.org/10.1016/j.carres.2006.04.017DOI Listing
August 2006
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