Publications by authors named "Min Zhang"

5,094 Publications

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HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production.

Environ Toxicol 2021 May 11. Epub 2021 May 11.

Division of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Brominated flame retardants (BFRs), such as, 1,2,5,6-tetrabromocyclooctane (HBCD), 1,2-dibromo-4-(1,2-dibromopropyl)cyclohexane (TBECH), and 1 1,2-bis-(2,4,6-tribromophenoxy)ethane (BTBPE), have garnered increasing attention due to their potent biological effects. In the present study, the toxicity of HBCD, TBECH, and BTBPE in human vascular endothelial cells (ECs) was explored. The data showed that HBCD, TBECH, and BTBPE induced cytotoxicity, namely dose-dependent cell viability reduction, cell membrane permeability and apoptosis increase, migration, and lumen formation inhibition. Moreover, HBCD was found to be more toxic than BTBPE or TBECH. Exposure to HBCD, TBECH, and BTBPE led to the production of reactive oxygen species, mitochondrial superoxide generation, and mitochondrial membrane potential collapse, implying that reactive stress caused the cytotoxicity. The ATP content, glutathione content, superoxide dismutase, and MDA activities were reduced, indicating that mitochondrial dysfunction may be the key mechanisms responsible for apoptosis. The present study suggested that mitochondria are a new target of BFRs in ECs and further deepened our understanding of the developmental toxicity of BFRs.
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http://dx.doi.org/10.1002/tox.23163DOI Listing
May 2021

Author Correction: Copper-catalyzed dehydrogenative γ-C(sp)-H amination of saturated ketones for synthesis of polysubstituted anilines.

Nat Commun 2021 May 10;12(1):2820. Epub 2021 May 10.

School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

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http://dx.doi.org/10.1038/s41467-021-23464-7DOI Listing
May 2021

Studies on the control effect of Bacillus subtilis on wheat powdery mildew.

Pest Manag Sci 2021 May 9. Epub 2021 May 9.

College of Agronomy, Sichuan Agricultural University, Chengdu, China.

Background: Wheat powdery mildew is a worldwide fungal disease and one of the main diseases harming wheat production. Bacillus subtilis is a vital biocontrol bacteria with broad-spectrum antimicrobial activity. In this study, we systematically studied the control effect of B. subtilis on wheat powdery mildew.

Results: The control efficiency of 4×10 CFU/ml B. subtilis on wheat leaves was 71.75% in vitro and 70.31% in a pot experiment. 4×10 CFU/ml B. subtilis significantly inhibited spore germination (spore germination rate of 22.23%) and increase appresorium deformity (appresorium deformity rate of 69.33%), which was significantly different from the results in the sterile water-treatment. Through transcriptome sequencing (RNA-seq) analysis, we found that the differentially expressed genes (DEGs) were mainly enriched in the biosynthesis and metabolism of amino acids (including phenylalanine), carbon metabolism, the pentose phosphate pathway and other pathways. In particular, the plant hormone signal pathway gene nonexpressor of pathogenesis-related genes 1 (NPR1) was significantly upregulated.

Conclusion: B. subtilis at concentrations of 4 × 10 CFU/ml had a significant control effect on wheat powdery mildew and can inhibit the germination of the conidial germ tubes and the normal development of appressorium. B. subtilis may induce disease resistance in wheat to control wheat powdery mildew, and this effect is related to the SA-dependent signal pathway.
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http://dx.doi.org/10.1002/ps.6471DOI Listing
May 2021

Direct Z-Scheme Heterojunction of Ligand-Free FAPbBr/α-FeO for Boosting Photocatalysis of CO Reduction Coupled with Water Oxidation.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

MOE International Joint Laboratory of Materials Microstructure, Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.

Up to now, the majority of the developed photocatalytic CO reduction systems need to use expensive sacrificial reductants as electron source. It is still a huge challenge to drive the photocatalytic CO reduction using water as an electron source. Herein, we report a facile strategy for the construction of direct Z-scheme heterojunction of LF-FAPbBr/α-FeO, which is manufactured by the in situ and two-step controlled growth of ligand-free formamidinium lead bromide (LF-FAPbBr) nanocrystals on the surface of α-FeO nanorods. The matchable energy levels and direct contact between LF-FAPbBr and α-FeO significantly accelerate the interfacial charge transfer, with a charge separation efficiency (η) of 93%, much higher than that of 11% shown by the ligand-capped FAPbBr/α-FeO heterojunction. The resulting efficient separation and raised redox ability of photogenerated carriers endow the LF-FAPbBr/α-FeO heterojunction with an outstanding photocatalytic performance for CO reduction (to CO and CH) coupled with water oxidation (to O), achieving a highest electron consumption rate of 175.0 μmol g h among the reported metal halide perovskite-based photocatalysts, which are 5 and 11 times higher in comparison with those of sole LF-FAPbBr and ligand-capped FAPbBr/α-FeO, respectively.
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http://dx.doi.org/10.1021/acsami.1c01718DOI Listing
May 2021

Metal-Bridged Graphene-Protein Supraparticles for Analog and Digital Nitric Oxide Sensing.

Adv Mater 2021 May 7:e2007900. Epub 2021 May 7.

School of Chemistry and Chemical Engineering and Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200241, China.

Self-limited nanoassemblies, such as supraparticles (SPs), can be made from virtually any nanoscale components, but SPs from nanocarbons including graphene quantum dots (GQDs), are hardly known because of the weak van der Waals attraction between them. Here it is shown that highly uniform SPs from GQDs can be successfully assembled when the components are bridged by Tb ions supplementing van der Waals interactions. Furthermore, they can be coassembled with superoxide dismutase, which also has weak attraction to GQDs. Tight structural integration of multilevel components into SPs enables efficient transfer of excitonic energy from GQDs and protein to Tb . This mechanism is activated when Cu is reduced to Cu by nitric oxide (NO)-an important biomarker for viral pulmonary infections and Alzheimer's disease. Due to multipronged fluorescence enhancement, the limit of NO detection improves 200 times reaching 10 × 10 m. Furthermore, the uniform size of SPs enables digitization of the NO detection using the single particle detection format resulting in confident registration of as few as 600 molecules mL . The practicality of the SP-based assay is demonstrated by the successful monitoring of NO in human breath. The biocompatible SPs combining proteins, carbonaceous nanostructures, and ionic components provide a general path for engineering uniquely sensitive assays for noninvasive tracking of infections and other diseases.
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http://dx.doi.org/10.1002/adma.202007900DOI Listing
May 2021

Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance.

Biochem Biophys Res Commun 2021 May 3;559:217-221. Epub 2021 May 3.

Beijing Institute of Basic Medical Sciences, Beijing, 100850, China; School of Pharmacy, Jiamus University, Jiamusi, 154007, China; Anhui Medical University, 81 Meishan Road, Hefei, 230032, China; College of Life Science, Henan Normal University, 46 Jianshe Road, Xinxiang, 473007, China. Electronic address:

Ornithine transcarbamylases (OTC), a key enzyme in urea cycle, is an important marker for some liver injury or diseases. However, whether OTC could be a sensitive indicator for liver dysfunction under sleep disturbance condition remains unknown. The present study aimed to explore the circadian oscillation expression of OTC and its significance in disturbed sleep condition. Sleep disturbance was conducted by a sleep deprivation (SD) instrument. Our results found that SD for 72h induced abnormal increasing of OTC levels in serum and liver of rats. And, serum OTC concentration and liver OTC expression could return to normal levels after recovery sleep following SD. Moreover, hepatic OTC expression showed circadian oscillation in day and night, characterized with occurrence of a peak between ZT 22 and ZT 2, and a nadir between ZT 14 and ZT 18. Further analysis suggested the existence of ROR response element (RORE) for potential RORɑ binding sites in OTC promoter region, and elevated RORɑ expression in rat livers under sleep disturbance condition. Additionally, oscillation expression of OTC induced by serum shock in HepG2 cells was characterized with a peak occurred between ZT 12 and ZT 16, and RORɑ knockdown at ZT 16 significantly lowered OTC expression. The results together indicate that OTC is closely correlated with circadian clock, and could be a sensitive indicator for sleep disturbance stress.
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http://dx.doi.org/10.1016/j.bbrc.2021.04.100DOI Listing
May 2021

Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV and FEV/FVC.

J Inflamm Res 2021 28;14:1677-1687. Epub 2021 Apr 28.

Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: Whether COVID-19 comorbidities and risk factors such as old age, male gender, smoking, obesity, eosinophils and blood types have direct contact with expression of ACE2 and pro-inflammation cytokines in human lung tissues were still unclear.

Patients And Methods: Sixty-four patients with normal FEV and FEV/FVC underwent thoracotomy for pulmonary nodules were included. Blinded histological assessments were performed by two pathologists. Clinical features and results of the immunohistochemical staining of ACE2 were collected and analyzed.

Results: ACE2 expressed in alveolar macrophages (most obvious), alveolar epithelia and vascular endothelia, but not in small-airway epithelia. ACE2 expressions are positively related to age ( =0.26, =0.040), weight ( =0.43, <0.001), as well as BMI ( = 0.38, =0.002), and male patients show higher expressions of ACE2 in lungs ( <0.05). ACE2 expressions are negatively related to peripheral eosinophils ( = -0.30, =0.017). There was no correlation between ABO blood types and ACE2 expression in normal lung tissues ( > 0.05). IL-13 and IL-6R expression in lung tissue increased with age ( =0.26, <0.05, for both).

Conclusion: Our pathological evidences showed that the alveolar epithelia, vascular endothelia, and alveolar macrophages are susceptible in human lungs for SARS-CoV-2 infection. The risk factors such as high body weight/BMI, old age, male gender, and eosinopenia may be related to ACE2 expression in human lungs, and associated with more chance to develop the severe cases. IL-6R expression in lung tissue also increased with age. Therefore, weight control and smoking cessation are essential to reduce the susceptibility of SARS-CoV-2 infection, especially in obesity, old or male patients. Peripheral eosinophils monitor is also quite necessary to detect severe tendency in COVID-19 patients.
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http://dx.doi.org/10.2147/JIR.S300747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091594PMC
April 2021

Synthesis of dendritic mesoporous organosilica nanoparticles under a mild acidic condition with homogeneous wall structure and near-neutral surface.

Chem Commun (Camb) 2021 May;57(36):4416-4419

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. and School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China.

Dendritic mesoporous organosilica nanoparticles were synthesized under a mild acidic condition (pH 6.2), featuring a molecularly homogeneous wall structure and an unusual near-neutral charged surface, consequently enabling reduced protein fouling property.
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http://dx.doi.org/10.1039/d0cc08017aDOI Listing
May 2021

Comparison on Tensile Characteristics of Plain C-Mn Steel with Ultrafine Grained Ferrite/Cementite Microstructure and Coarse Grained Ferrite/Pearlite Microstructure.

Materials (Basel) 2021 Apr 29;14(9). Epub 2021 Apr 29.

School of Mechanical and Mining Engineering, University of Queensland, Brisbane, QLD 4072, Australia.

This work investigated the tensile characteristics of plain C-Mn steel with an ultrafine grained ferrite/cementite (UGF/C) microstructure and coarse-grained ferrite/pearlite (CGF/P) microstructure. The tensile tests were performed at temperatures between 77 K and 323 K. The lower yield and the ultimate tensile strengths were significantly increased when the microstructure was changed from the CGF/P to the UGF/C microstructures, but the total elongation and the uniform elongation decreased. A microstructural change from the CGF/P microstructure to the UGF/C microstructure had an influence on the athermal component of the lower yield and the ultimate tensile strengths but not on the thermal component. The UGF/C microstructure with a higher carbon content provided a higher strength without losing ductility because cementite particles restrained necking.
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http://dx.doi.org/10.3390/ma14092309DOI Listing
April 2021

A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells.

J Cell Commun Signal 2021 May 4. Epub 2021 May 4.

Department of Nephrology, The Second Affiliated Hospital, Anhui Medical University (AHMU), No. 678 Fu Rong Road, Hefei, China.

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor (IL-1R) also participate in RIF development, and Toll/IL-1R 8 (TIR8), a member of the Toll-like receptor superfamily, has been identified as a negative regulator of IL-1R signaling. However, the functions of TIR8 in IL-1-induced RIF remain unknown. Here, human embryonic kidney epithelial cells (HKC) and unilateral ureteric obstruction (UUO)-induced RIF models on SD rats were used to investigate the functions of TIR8 involving IL-1β-induced EMT. We showed that IL-1β primarily triggers TIR8 expression by activating nuclear factor-κB (NF-κB) in HKC cells. Conversely, high levels of TIR8 in HKC cells repress IL-1β-induced NF-κB activation and inhibit IL-1β-induced EMT. Moreover, in vitro and in vivo findings revealed that TIR8 downregulation facilitated IL-1β-induced NF-κB activation and contributed to TGF-β1-mediated EMT in renal tubular epithelial cells. These results suggested that TIR8 exerts a protective role in IL-1β-mediated EMT and potentially represents a new target for RIF treatment.
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http://dx.doi.org/10.1007/s12079-021-00620-8DOI Listing
May 2021

Arthroscopic Internal Drainage with Cyst Wall Resection and Arthroscopic Internal Drainage with Cyst Wall Preservation to Treat Unicameral Popliteal Cysts: A Retrospective Case-Control Study.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To compare the clinical efficacy and safety of arthroscopic internal drainage for the treatment of unicameral popliteal cysts with or without cyst wall resection.

Methods: This was a retrospective case-control study of 73 patients diagnosed with unicameral popliteal cysts from January 2012 to January 2019 who received arthroscopic treatment. The study included 38 cases with cyst wall resection (CWR group) and 35 cases with cyst wall preservation (CWP group). The CWR group consisted of 14 men and 24 women with an average age of 51.8 years, while the CWP group consisted of 13 men and 22 women with an average age of 52.0 years. All patients were examined for intra-articular lesions and communicating ports by magnetic resonance imaging (MRI) prior to surgery, and recurrence of cysts was evaluated at the last follow-up examination. Rauschning and Lindgren grade (R-L grade) and Lysholm score were used to evaluate clinical outcomes. In addition, operation time and complications were recorded.

Results: The average length of follow-up was 24.2 months (range, 16 to 32 months). There were no considerable differences in age, gender, cyst size, Lysholm score, R-L grade and concomitant intra-articular cases between the CWR group and CWP group prior to surgery (P > 0.05). The last follow-up MRI scans showed that in the CWR group, the cyst disappeared in 25 cases and shrunk in 13 cases. In the CWP group, the cyst disappeared in 22 cases, shrunk in 12 cases and persisted in one case. There was no obvious difference in recurrence rate between the two groups (0% vs 2.9%, P = 0.899). At the last follow-up, there were no differences in the R-L grade (P = 0.630) and Lysholm score (88.3 ± 5.6 points vs 90.1 ± 3.8 points, P = 0.071) between the two groups. Compared with the CWP group, operation time was significantly prolonged in the CWR group (38.3 ± 3.1 min vs 58.3 ± 4.4 min, P < 0.05). In the CWR group, three cases occurred fluid infiltration under the gastrocnemius muscle, which improved after pressure bandaging and cold compress. In another three cases, hematoma was found. The incidence of complications in the CWR group was markedly higher than that in the CWP group (15.8% vs 0%, P < 0.05). During the follow-up period, none of the patients developed serious complications such as neurovascular injury, deep venous thrombosis, or infection.

Conclusion: For unicameral popliteal cysts, arthroscopic internal drainage combined with resection of the cyst wall did not further improve the clinical outcomes or reduce the recurrence rate, while prolonging the operation time and increasing the possibility of complications.
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http://dx.doi.org/10.1111/os.12917DOI Listing
May 2021

Novel dibenzofuran and biphenyl phytoalexins from Sorbus pohuashanensis suspension cell and their antimicrobial activities.

Fitoterapia 2021 Apr 30:104914. Epub 2021 Apr 30.

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:

Two novel sulfur-containing dibenzofurans, sorbusins A (1) and B (2), two unprecedented biphenyl glycosides, 2'-hydroxyaucuparin 2'-O-ɑ-L-rhamnoside (3) and noraucuparin 5-O-ɑ-L-rhamnoside (4), and four known analogues (5-8), were isolated from Sorbus pohuashanensis suspension cell induced by yeast extract. Their structures were elucidated based on spectroscopic analyses and quantum calculation of C NMR data. Structurally, compound 1 possessed a rare naturally occurring benzothiazole moiety and represents the first example of thiazole fused dibenzofuran. A plausible biosynthetic pathway for the sulfur-containing dibenzofurans is proposed. These dibenzofuran and biphenyl phytoalexins were evaluated for their antimicrobial activities against pathogenic fungi and drug-resistant bacteria. Compound 7 exhibited significant antibacterial activity against methicinllin-resistant Staphylococcus aureus with an MIC value of 3.13 μg/mL.
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http://dx.doi.org/10.1016/j.fitote.2021.104914DOI Listing
April 2021

Progresses in processing technologies for special foods with ultra-long shelf life.

Crit Rev Food Sci Nutr 2020 Dec 1:1-20. Epub 2020 Dec 1.

China Astronaut Research and Training Center, Beijing, China.

Foods for special applications have recently received much attention due to rapid development of space and military industries as well as to frequent occurrence of natural and man-made disasters. Since the way such foods are processed clearly and directly affects their consumer's acceptability and shelf life, it is of interest to explore in detail how these special foods can be processed. This article presents a review on the difficulties in the processing, application and storage as well as on how to ensure the shelf life and acceptability of special foods through the use of efficient processing technologies. Emphasis is made on the use of both conventional and alternative thermal processing and irradiation technologies. Appropriate packaging technologies for each of the discussed special foods are also mentioned along with the way to overcome the problem of product quality degradation. Through comparison and analysis, it is found that foods with different attributes require different technologies and processes to achieve desirable results. Combined use of multiple technologies has also noted to be advantageous.
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http://dx.doi.org/10.1080/10408398.2020.1853034DOI Listing
December 2020

Asymmetric Total Synthesis of Hetidine-Type C-Diterpenoid Alkaloids: (+)-Talassimidine and (+)-Talassamine.

J Am Chem Soc 2021 May 3. Epub 2021 May 3.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.

Here, we report the first asymmetric total synthesis of (+)-talassimidine and (+)-talassamine, two hetidine-type C-diterpenoid alkaloids. A highly regio- and diastereoselective 1,3-dipolar cycloaddition of an azomethine ylide yielded a chiral tetracyclic intermediate in high enantiopurity, thus providing the structural basis for asymmetric assembly of the hexacyclic hetidine skeleton. In this key step, the introduction of a single chiral center induces four new continuous chiral centers. Another key transformation is the dearomative cyclopropanation of the benzene ring and subsequent S2-like ring opening of the resultant cyclopropane ring with water as a nucleophile, which not only establishes the B ring but also precisely installs the difficult-to-achieve equatorial C7-OH group.
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http://dx.doi.org/10.1021/jacs.1c01865DOI Listing
May 2021

An Update on Cardiovascular Risk Factors After Kawasaki Disease.

Front Cardiovasc Med 2021 16;8:671198. Epub 2021 Apr 16.

Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.

First described in Japan 50 years ago, Kawasaki disease is a worldwide multisystem disease. It is an acute self-limited vasculitis of unknown etiology that can lead to coronary artery lesions, such as dilatation, aneurysms, and stenosis in children. It is one of the common causes of acquired heart disease among children in developed countries. The coronary aneurysm is a severe complication in the acute stage, possibly leading to stenotic lesions or myocardial ischemia. More concerns have centered on endothelial damage and the early onset of atherosclerosis in patients with KD. Although the coronary artery aneurysm is small or degenerated, the vascular structure does not return to normal, vascular endothelial dysfunction and remodeling continue. Most patients diagnosed with coronary artery sequelae are at risk of long-term complications. There are still many unknown aspects regarding the long-term prognosis of patients. Concerns have centered on the early onset of atherosclerosis in patients with KD. There is still no consensus on the relationship between Kawasaki disease and atherosclerosis. This study aimed to evaluate if patients with a history of KD were at risk of accelerated atherosclerosis.
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http://dx.doi.org/10.3389/fcvm.2021.671198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086797PMC
April 2021

Urine Cadmium as a Risk Factor for Osteoporosis and Osteopenia: A Meta-Analysis.

Front Med (Lausanne) 2021 16;8:648902. Epub 2021 Apr 16.

Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

As society ages, the incidence of osteoporosis increases. In several studies, cadmium (Cd) is thought to be related to osteoporosis. However, there are conflicting reports about the relationship between Cd and the risk of osteoporosis and osteopenia. Therefore, the purpose of this meta-analysis was to explore the relationship between Cd and osteoporosis and osteopenia. Through a review of the literature, articles published in PubMed as of December 2020 were identified and the references of related publications and reviews were reviewed. Ultimately, 17 eligible articles were selected to determine the relationship between blood and urine Cd concentrations for the risk of osteoporosis or osteopenia. In this study, we performed a classification analysis, heterogeneity test, subgroup analysis, and evaluated publication bias. A total of 17 studies were included, including seven on blood Cd and 10 on urine Cd. By combining the odds ratio (OR) and 95% confidence interval (CI) for the lowest and highest categories, the odds ratio of blood Cd concentration that increased the risk of osteoporosis or osteopenia was OR 1.21 (95% CI: 0.84-1.58) and that of urine Cd concentration that increased the risk of osteoporosis or osteopenia was OR 1.80 (95% CI: 1.42-2.18), and the results of the subgroup analysis were also consistent. Our research indicates that while urine cadmium (Cd) concentration may be related to increased risk of osteoporosis and osteopenia, blood Cd concentration may not. Therefore, compared to blood Cd concentration, urine Cd concentration may be more reliable as a risk factor for osteoporosis and osteopenia. This result should be interpreted with caution. Currently. research on the relationship between Cd concentration and osteoporosis and osteopenia is limited, thus, further large, high-quality prospective studies are required to elucidate the relationship between Cd concentration and osteoporosis and osteopenia.
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http://dx.doi.org/10.3389/fmed.2021.648902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085254PMC
April 2021

A preliminary study identifies early postoperative lung volume changes in patients with non-small cell lung cancer following video-assisted thoracic surgery using CT volumetry.

Mol Clin Oncol 2021 Jun 22;14(6):124. Epub 2021 Apr 22.

Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China.

The present study aimed to investigate the changes in early postoperative lung volume in patients with non-small cell lung cancer (NSCLC) following video-assisted thoracic surgery (VATS) and to analyze the effects of the clinical characteristics on the lung volume of the patients. Therefore, 38 patients with NSCLC, who planned to undergo VATS at the Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University in June 2019, were enrolled into the present study. The clinical and computed tomography (CT) scan data from the patients was prospectively collected within 1 week preoperatively, and at 1, 3 and 6 months following surgery, then subsequently analyzed. A total of 34 patients successfully completed follow-up and were included in the datasets. The results showed that the volume of the right lung was larger compared with that in the left one, at each observational time point. The whole, right and left lung held the same trendline of volume changes, which was sharply decreased during the first postoperative month, increased quickly over the next 3 months, and slowly increased from months 3 to 6. There were 7 patients, whose whole lung volume was increased at 6 months following surgery compared with that preoperatively. In addition, significant differences were observed between males and females in the whole, right and left lung volume. However, the differences on the postoperative net expansion volume of the whole lung were not significant among sex, age, body mass index (BMI), smoking status and surgical side subgroups. The early changes of the postoperative lung volume were not linear, since the lung volume was significantly reduced during the first postoperative month, quickly increased in the next 3 months, and slowly increased from months 3 to 6. Sex, age, BMI, smoking status and surgical sides was not found to affect the postoperative volume and net expansion of the whole lung following VATS lobectomy.
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http://dx.doi.org/10.3892/mco.2021.2286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082225PMC
June 2021

Digital Detectives: Websleuthing Reduces Eyewitness Identification Accuracy in Police Lineups.

Front Psychol 2021 15;12:640513. Epub 2021 Apr 15.

School of Computing & Communications, The Open University, Milton Keynes, United Kingdom.

Eyewitnesses to crimes sometimes search for a culprit on social media before viewing a police lineup, but it is not known whether this affects subsequent lineup identification accuracy. The present online study was conducted to address this. Two hundred and eighty-five participants viewed a mock crime video, and after a 15-20 min delay either (i) viewed a mock social media site including the culprit, (ii) viewed a mock social media site including a lookalike, or (iii) completed a filler task. A week later, participants made an identification from a photo lineup. It was predicted that searching for a culprit on social media containing the lookalike (rather than the culprit) would reduce lineup identification accuracy. There was a significant association between social media exposure and lineup accuracy for the Target Present lineup (30% more of the participants who saw the lookalike on social media failed to positively identify the culprit than participants in the other conditions), but for the Target Absent lineup (which also included the lookalike) there was no significant association with lineup identification accuracy. The results suggest that if an eyewitness sees a lookalike (where they are expecting to see the culprit) when conducting a self-directed search on social media, they are less likely to subsequently identify the culprit in the formal ID procedure.
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http://dx.doi.org/10.3389/fpsyg.2021.640513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081957PMC
April 2021

Development of the yeast and lactic acid bacteria co-culture agent for atmospheric ammonia removing: Genomic features and on-site applications.

Ecotoxicol Environ Saf 2021 Apr 29;218:112287. Epub 2021 Apr 29.

School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China; Key Laboratory of Biometallurgy, Ministry of Education, Central South University, Changsha 410083, China. Electronic address:

Odorous gas (e.g. atmospheric ammonia) in low ventilation public places, such as public toilets and waste transfer stations, causes severe health problems. Many technologies are developed to purify the atmospheric ammonia, among which the microbial agents are supposed to be a green and economical approach. In this study, we developed a yeast, Pichia sp. J1, and a lactic acid bacterium (LAB), Lactobacillus paracasei B1, co-culture agent for atmospheric ammonia removing. The on-site application results indicated the yeast and LAB mixed fermented agent had a maximum ammonia removing efficiency of 98.78%, which is significantly higher than the pure cultures (78.93% for B1 and 75.00% for J1), indicating the co-culture agent is an excellent biological product for ammonia removal. The excellent performance of the agent is closely related to the synergy behaviors between the yeast and LAB. In the co-culture agents, some of the LAB cells adhered closely to the yeast, and the growth and lactic acid producing ability of LAB were significantly promoted by yeast. Genomic analysis indicated the complementary of nutrients, i.e. carbon and nitrogen resources, signal transduction, and adhesion proteins (regulates adhesion behavior) played roles in regulating the synergy effects. Our study offers a novel biological solution of odorous gas purification.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112287DOI Listing
April 2021

Overview on population screening for carriers with germline mutations in mismatch repair (MMR) genes in China.

Hered Cancer Clin Pract 2021 May 1;19(1):26. Epub 2021 May 1.

Department of Cancer Prevention/Experimental Research Center, Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Chinese Academy of Sciences, Hangzhou, China.

DNA mismatch repair (MMR) genes play an important role in maintaining genome stability. Germline mutations in MMR genes disrupt the mismatch repair function and cause genome instability. Carriers with MMR germline mutations are more likely to have MMR deficiency and microsatellite instability (MSI) than non-carriers and are prone to develop colorectal cancer (CRC) and extracolorectal malignancies, known as Lynch syndrome (LS). MMR gene testing for suspected mutation carriers is a reliable method to identify the mutation types and to discover mutation carriers. Given that carriers of MMR germline mutations have a higher risk of LS-related cancers (LS-RC) and a younger age at onset than non-carriers, early surveillance and regular screening of relevant organs of carriers are very important for early detection of related cancers. This review mainly focuses on the general status of MMR carriers, the approaches for early detection and screening, and the surveillance of MMR mutation carriers in China. Population screening of MMR germline mutation carriers in China will be helpful for early detection, early diagnosis and treatment of MMR mutation carriers, which may improve the 5-year survival, and reduce mortality and incidence rate in the long term.
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http://dx.doi.org/10.1186/s13053-021-00182-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088635PMC
May 2021

Effect of konjac glucomannan/carrageenan-based edible emulsion coatings with camellia oil on quality and shelf-life of chicken meat.

Int J Biol Macromol 2021 Apr 28;183:331-339. Epub 2021 Apr 28.

Anhui Engineering Laboratory for Agro-products Processing, College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address:

The quality and safety of chicken meat are prone to deteriorate due to bacteria reproduction and oxidation reaction. In this study, the antimicrobial and antioxidant effects of KGM-KC coatings incorporated camellia oil were evaluated to extend the shelf-life of chicken meat. The result showed that the KGM/KC-CO coating significantly (P < 0.05) decreased weight loss, pH, thiobarbituric acid reactive substance (TBARS), total volatile nitrogen (TVN) and microbial counts when compared to uncoated samples. The obtained results revealed that KGM/KC-based coating incorporated with CO significantly extended the shelf-life of chicken meat by restraining the oxidation of lipid and protein, and retarding the microbial growth. The sensory evaluation showed that the addition of CO did not affect the odor of chicken meat, maintained the overall acceptability of coated samples. The shelf-life of chicken meat was extended up to 10 days using KGM/KC-based coating containing 3.5% CO at refrigeration (4 °C) compared to control samples. These results indicated CO could be used as an active agent to be dispersed in KGM/KC matrix by emulsification method, and the prepared emulsion coating had positive effects on extending the shelf-life of chicken meat.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.04.165DOI Listing
April 2021

Identification of Differentially Expressed Genes and Lipid Metabolism Signaling Pathways between Muscle and Fat Tissues in Broiler Chickens.

J Poult Sci 2021 Apr;58(2):131-137

College of Life Science, Longyan University, Longyan, Fujian 364012, China.

In this study, signaling pathways and key differentially expressed genes (DEGs) involved in lipid metabolism in muscle and fat tissues were investigated. Muscle and abdominal fat tissues were obtained from 35-day-old female broilers for RNA sequencing. DEGs between muscle and fat tissues were identified. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of DEGs were performed. A total of 6130 DEGs were identified to be significantly enriched in 365 GO terms, most of which were involved in biological processes, cellular components, and molecular functions in muscle and fat tissues. Three important lipid signaling pathways (pyruvate metabolism, the insulin signaling pathway, and the adipocytokine signaling pathway) were identified among the fat and muscle tissues of broilers. The key common DEGs in these pathways included phosphoenolpyruvate carboxykinase 2 (), acetyl-CoA carboxylase 1 alpha and beta ( and ), and the mitogen-activated protein kinase () gene family. Hence, our findings revealed the pathways and key genes and gene families involved in the regulation of fat deposition in the muscle and fat tissues of broilers.
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http://dx.doi.org/10.2141/jpsa.0200040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076620PMC
April 2021

Transcriptome Analysis of Eggplant Root in Response to Root-Knot Nematode Infection.

Pathogens 2021 Apr 13;10(4). Epub 2021 Apr 13.

State Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

Eggplant ( L.), which belongs to the Solanaceae family, is an important vegetable crop. However, its production is severely threatened by root-knot nematodes (RKNs) in many countries. , a wild relative of eggplant, is employed worldwide as rootstock for eggplant cultivation due to its resistance to soil-borne diseases such as RKNs. In this study, to identify the RKN defense mechanisms, the transcriptomic profiles of eggplant and were compared. A total of 5360 differentially expressed genes (DEGs) were identified for the response to RKN infection. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that these DEGs are mainly involved in the processes of response to stimulus, protein phosphorylation, hormone signal transduction, and plant-pathogen interaction pathways. Many phytohormone-related genes and transcription factors (MYB, WRKY, and NAC) were differentially expressed at the four time points (ck, 7, 14, and 28 days post-infection). The abscisic acid signaling pathway might be involved in plant-nematode interactions. qRT-PCR validated the expression levels of some of the DEGs in eggplant. These findings demonstrate the nematode-induced expression profiles and provide some insights into the nematode resistance mechanism in eggplant.
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http://dx.doi.org/10.3390/pathogens10040470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069755PMC
April 2021

Tenuazonic Acid-Triggered Cell Death Is the Essential Prerequisite for (Fr.) Keissler to Infect Successfully Host .

Cells 2021 Apr 25;10(5). Epub 2021 Apr 25.

Weed Research Laboratory, Nanjing Agricultural University, Nanjing 210095, China.

The necrotrophic fungus contains different pathotypes that produce different mycotoxins. The pathotype secretes the non-host-selective toxin tenuazonic acid (TeA), which can cause necrosis in many plants. Although TeA is thought to be a central virulence factor of the pathotype, the precise role of TeA in different stages of host infection by pathogens remains unclear. Here, an wild-type and the toxin-deficient mutant with a 75% reduction in TeA production were used. It was observed that wild-type pathogens could induce the reactive oxygen species (ROS) bursts in host leaves and killed photosynthetic cells before invading hyphae. The ROS interceptor catalase remarkably inhibited hyphal penetration and invasive hyphal growth and expansion in infected leaves and suppressed necrotic leaf lesion. This suggests that the production of ROS is critical for pathogen invasion and proliferation and disease symptom formation during infection. It was found that the mutant pathogens did not cause the formation of ROS and cell death in host leaves, showing an almost complete loss of disease susceptibility. In addition, the lack of TeA resulted in a significant reduction in the ability of the pathogen to penetrate invasive hyphal growth and spread. The addition of exogenous TeA, AAL-toxin, and bentazone to the mutant pathogens during inoculation resulted in a significant restoration of pathogenicity by increasing the level of cell death, frequency of hyphal penetration, and extent of invasive hyphal spread. Our results suggest that cell death triggered by TeA is the essential requirement for successful colonization and disease development in host leaves during infection with pathogens.
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http://dx.doi.org/10.3390/cells10051010DOI Listing
April 2021

Imaging of Strong Nanoscale Vortex Pinning in GdBaCuO High-Temperature Superconducting Tapes.

Nanomaterials (Basel) 2021 Apr 22;11(5). Epub 2021 Apr 22.

Department of Physics, University of Bath, Claverton Down, Bath BA2 7AY, UK.

The high critical current density of second-generation high-temperature superconducting (2G-HTS) tapes is the result of the systematic optimisation of the pinning landscape for superconducting vortices through careful engineering of the size and density of defects and non-superconducting second phases. Here, we use scanning Hall probe microscopy to conduct a vortex-resolved study of commercial GdBaCuO tapes in low fields for the first time and complement this work with "local" magnetisation and transport measurements. Magnetic imaging reveals highly disordered vortex patterns reflecting the presence of strong pinning from a dense distribution of nanoscale GdO secondphase inclusions in the superconducting film. However, we find that the measured vortex profiles are unexpectedly broad, with full-width-half-maxima typically of 6 μm, and exhibit almost no temperature dependence in the range 10-85 K. Since the lateral displacements of pinned vortex cores are not expected to exceed the superconducting layer thickness, this suggests that the observed broadening is caused by the disruption of the circulating supercurrents due to the high density of nanoscale pinning sites. Deviations of our local magnetisation data from an accepted 2D Bean critical state model also indicate that critical state profiles relax quite rapidly by flux creep. Our measurements provide important information about the role second-phase defects play in enhancing the critical current in these tapes and demonstrate the power of magnetic imaging as a complementary tool in the optimisation of vortex pinning phenomena in 2G-HTS tapes.
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http://dx.doi.org/10.3390/nano11051082DOI Listing
April 2021

Aggregation and Deposition Kinetics of Polystyrene Microplastics and Nanoplastics in Aquatic Environment.

Bull Environ Contam Toxicol 2021 Apr 29. Epub 2021 Apr 29.

Environment Research Institute, Shandong University, Qingdao, 266237, China.

Microplastics (MPs) and nanoplastics (NPs) attract widespread attention due to their final threats to human health. Here, 50 nm and 500 nm polystyrene particles (PS50 and PS500) were selected as the typical NPs and MPs, respectively. Their aggregation kinetics was monitored, and their deposition was investigated on silica and alumina surfaces using quartz crystal microbalance with dissipation monitoring (QCM-D). PS500 has higher critical coagulation concentration (CCC) values than PS50, because of the weaker Brownian diffusion, less particle number and lower collision chance. PS50 has smaller values of critical deposition concentration (CDC) than PS500, indicating the stronger adsorption on silica. Derjaguin-Landau-Verwey-Overbeek (DLVO) calculations explain that PS500 has weaker attachment on silica and slower deposition rate on alumina than PS50. Our results demonstrate that solution chemistry, particle size and mineral surfaces determine the transport and distribution of plastic particles together.
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http://dx.doi.org/10.1007/s00128-021-03239-yDOI Listing
April 2021

Construction of Bio-Nano Interfaces on Nanozymes for Bioanalysis.

ACS Appl Mater Interfaces 2021 Apr 29. Epub 2021 Apr 29.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

Nanomaterials with enzyme-like activity (nanozymes) have been of great interest in broad applications ranging from biosensing to biomedical applications. Despite that much effort has been devoted to the development of the synthesis and applications of nanozymes, it is essential to understand the interactions between nanozymes and most commonly used biomolecules, i.e., avidin, streptavidin (SA), bovine serum albumin (BSA), immunoglobulin G (IgG), and glutathione (GSH), yet they have been rarely explored. Here, a series of bio-nano interfaces were constructed through direct immobilization of proteins on a variety of iron oxide and carbon-based nanozymes with different dimensions, including FeO nanoparticles (NPs, 0D), FeO@C NPs (0D), FeO@C nanowires (NWs, 1D), and graphene oxide nanosheets (GO NSs, 2D). Such interfaces enabled the modulation of the catalytic activities of the nanozymes with varying degrees, which allowed a good identification of multiplex proteins with high accuracy. Given the maximum inhibition on FeO@C NP by BSA, we established molecular switches based on aptamer and toehold DNA, as well as Boolean logic gates (AND and NOR) in response to both DNA and proteins. Also importantly, we developed an on-particle reaction strategy for colorimetric detection of GSH with ultrahigh sensitivity and good specificity. The proposed sensor achieved a broad dynamic range spanning 7 orders of magnitude with a detection limit down to 200 pg mL, which was better than that of an in-solution reaction-based biosensor by 2 orders of magnitude. Furthermore, we explored the mechanisms of the interactions at bio-nano interfaces by studying the interfacial factors, including surface coverage, salt concentration, and the curvature of the nanozyme. This study offered new opportunities in the elaborate design and better utilization of nanozymes for bioanalysis in clinical diagnosis and in vivo detection.
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http://dx.doi.org/10.1021/acsami.1c04241DOI Listing
April 2021

Endovascular intervention for basilar artery occlusion in the elderly.

Ther Adv Neurol Disord 2021 12;14:17562864211000453. Epub 2021 Apr 12.

Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), No. 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.

Background: To date, few data have been reported on clinical outcomes following interventions in elderly populations with acute basilar artery occlusion. Using data from the Endovascular Treatment for Acute Basilar Artery Occlusion Study (BASILAR), we evaluated the efficacy and safety of intervention and determined predictors of outcomes among elderly patients in China.

Methods: Patients from January 2014 to May 2019 were dichotomized into elderly (75 years or older) and nonelderly patients (under 75 years). Pearson's Chi-square test and multivariate logistic regression were performed to assess 90-day favorable functional outcome (defined as a modified Rankin scale score of 0-3), mortality and symptomatic intracranial hemorrhage between intervention and conservative cohorts in elderly patients.

Results: Among the 829 patients in the BASILAR, 182 patients aged 75 years or older were analyzed. These patients were divided into intervention (127 patients) and conservative (55 patients) cohorts. Compared with the conservative cohort, the intervention cohort presented more frequently with a favorable functional outcome (28.3% 12.7%;  = 0.023) and with a decreased mortality (54.3% 76.4%;  = 0.005). There was no difference in symptomatic intracranial hemorrhage (4.7% 0,  = 0.235). Multivariate analysis indicated that intervention was associated with favorable functional outcome (adjusted odds ratio, 0.262; 95% confidence interval, 0.088-0.778,  = 0.016) and lower mortality (adjusted odds ratio, 0.257; 95% confidence interval, 0.109-0.606,  = 0.002). In the intervention cohort, initial National Institutes of Health Stroke Scale (NIHSS) score and occlusion site were associated with functional outcome, and initial NIHSS score and recanalization were associated with mortality.

Conclusions: Although the overall outcome following intervention was worse with age, intervention was more effective and safer than conservative treatment for elderly Chinese patients with basilar artery occlusion. Predictors of desirable outcome in elderly patients undergoing intervention included lower initial NIHSS score, occlusion site and successful recanalization.Clinical Trial Registration-URL: http://www.chictr.org. Unique identifier: ChiCTR-1800014759.
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http://dx.doi.org/10.1177/17562864211000453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047973PMC
April 2021

Optimization of Early Mobilization Program for Patients With Acute Ischemic Stroke: An Orthogonal Design.

Front Neurol 2021 12;12:645811. Epub 2021 Apr 12.

Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Early mobilization is considered to have favorable outcomes for stroke patients, but there is currently a lack of specific data to guide this early mobilization, including the initiation time, intensity, frequency, and duration of each activity. Therefore, the optimal strategy for early mobilization is unclear. In this study, we investigated the best combination of different factors to achieve early mobilization, to develop the optimal program. We conducted an L (3) orthogonal experiment with a blinded follow-up assessment. Patients with ischemic stroke, admitted to a stroke unit within 24-72 h of its onset, were recruited. Eligible subjects were randomly assigned to one of nine different programs of early mobilization. The outcomes were assessed at baseline, discharge, and 1 and 3 months after discharge to observe the changes in various efficacy indicators and determine the main factors affecting outcome. We analyzed 57 of 63 patients, after six were excluded for poor compliance, failure to cooperate with the study, or worsening of the disease. The initiation time, intensity, and frequency of mobilization were the main factors affecting outcome (all < 0.05), and the duration of each activity was a secondary factor ( > 0.05). A comprehensive analysis of the various parameters showed that the optimal level of the early mobilization program was an initiation time: 24-48 h after stroke; intensity: bed and chair transfer, sitting out of bed, standing and walking or climbing stairs when mobility permitted; frequency: 2-3 times/day; duration of each mobilization: determined according to the actual situation of the patient. Early rehabilitation with high-intensity physical exercise at 24-48 h after the onset of stroke, 2-3 times/day, may benefit stroke patients. Applying the optimized program of early mobilization to stroke patients effectively alleviated their symptoms of neurological deficit, improved their capacity for self-care, restored their self-efficacy, improved their quality of life and social participation, and reduced post-stroke fatigue at 3 months.
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http://dx.doi.org/10.3389/fneur.2021.645811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072335PMC
April 2021

Nature-inspired self-powered cellulose nanofibrils hydrogels with high sensitivity and mechanical adaptability.

Carbohydr Polym 2021 Jul 26;264:117995. Epub 2021 Mar 26.

College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou City, Fujian Province 350002, China; Limerick Pulp and Paper Centre, Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B5A3, Canada.

It is still a challenge to integrate high sensitivity, mechanical adaptability, and self-powered properties for hydrogels. Herein, we report a conductive polyvinyl alcohol (PVA) hydrogel based on natural nanoclay and cellulose nanofibrils (CNFs). The CNFs and PVA chains could construct a double network structure, resulting in a high mechanical composite hydrogel. Meanwhile, the nanoclay could be well dispersed and immobilized in the network of the hydrogel, thus improving mechanical adaptability of the hydrogel for curved and dynamic surfaces. Moreover, the conductive ions (Al) imparted the hydrogel with high conductivity (6.67 S m) and gauge factor (1.17). Therefore, the composite hydrogel exhibited high sensitivity to tiny pressure changes, enabling recognition of the complicated sounding and handwriting. More importantly, the composite hydrogel possessed self-powered property, which could generate an output voltage of up to 78 mV. In summary, the multi-functional composite hydrogel may have giant applications in artificial electronic skins or wearable devices.
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http://dx.doi.org/10.1016/j.carbpol.2021.117995DOI Listing
July 2021