Publications by authors named "Min Young Jung"

55 Publications

A Systematic Review of Clinical Interventions Facilitating End-of-Life Communication Between Patients and Family Caregivers.

Am J Hosp Palliat Care 2021 Feb 28;38(2):180-190. Epub 2020 May 28.

Department of Health Systems Science, 14681College of Nursing, University of Illinois at Chicago, IL, USA.

Communication between patients and family caregivers plays a key role in successful end-of-life (EOL) care. In the majority of cases, health-care providers (HCP) are responsible for leading this communication in clinical settings. This systematic review aimed to examine the evidence for the efficacy of HCP-led interventions in enhancing communication between patients and family caregivers. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and involved a search of MEDLINE via PubMed, CINAHL, Scopus, Embase, and PsycINFO as well as a manual search for additional articles on Google Scholar without date restrictions. Of 2955 articles retrieved, 8 meeting the eligibility criteria were included in the review. A quality appraisal of the selected studies was performed using the van Tulder Scale, with 5 of 8 studies rated as high quality. All 8 studies employed psychoeducational interventions involving both patients and surrogate/family caregivers. Common elements of the interventions reviewed included encouraging participant dyads to share their concerns about the patient's medical condition, clarify their goals and values for EOL care, and discuss their EOL care preferences. Of 8 interventions reviewed, 6 measured EOL care preference congruence within dyads as a primary outcome, and all 6 interventions were effective in increasing congruence. Secondary outcomes measured included decisional conflict and relationship quality, with mixed outcomes reported. This review suggests that HCP-led EOL communication interventions show promise for improving EOL care preference congruence. However, further studies with improved methodological rigor are needed to establish the optimal timing, intensity, and duration of interventions.
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http://dx.doi.org/10.1177/1049909120929323DOI Listing
February 2021

Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses.

BMC Microbiol 2020 05 27;20(1):136. Epub 2020 May 27.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755, Republic of Korea.

Background: Lactococcus members belonging to lactic acid bacteria are widely used as starter bacteria in the production of fermented dairy products. From kimchi, a Korean food made of fermented vegetables, Lactococcus raffinolactis WiKim0068 was isolated and its genome was analyzed.

Results: The complete genome of the strain WiKim0068 consists of one chromosome and two plasmids that comprises 2,292,235 bp, with a G + C content of 39.7 mol%. Analysis of orthoANI values among Lactococcus genome sequences showed that the strain WiKim0068 has > 67% sequence similarity to other species and subspecies. In addition, it displayed no antibiotic resistance and can metabolize nicotinate and nicotinamide (vitamin B3).

Conclusion: These results augments our understanding of the genus Lactococcus and suggest that this new strain has potential industrial applications.
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http://dx.doi.org/10.1186/s12866-020-01820-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251713PMC
May 2020

Investigating the probiotic characteristics of four microbial strains with potential application in feed industry.

PLoS One 2019 26;14(6):e0218922. Epub 2019 Jun 26.

Center for Industrialization of Agricultural and Livestock Microorganisms, Jeongeup-si, Korea.

The present study aimed to evaluate the probiotic characteristics of certain microbial strains for potential use as feed additives. Three bacterial strains and a yeast previously isolated from different environments were investigated. The strains were subjected to molecular identification and established as Lactobacillus paracasei CP133, Lactobacillus plantarum CP134, Bacillus subtilis CP350 and Saccharomyces cerevisiae CP605. Lactobacillus sp. CP133 and CP134 exhibited antibiosis, antibiotic activity, and relative odor reduction ability. Bacillus subtilis CP350 was thermotolerant, reduced hydrogen sulfide gas and showed significant proteolytic activity, whereas Saccharomyces cerevisiae CP605 exhibited high acid and bile salt tolerance. In general, the isolates in this study demonstrated improved functional characteristics, particularly acid and bile tolerance and relative cell adhesion to HT-29 monolayer cell line. Results in this work provides multifunctional probiotic characteristics of the strains for potential development of probiotics and cleaning of the environment.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218922PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594638PMC
February 2020

Community structures and genomic features of undesirable white colony-forming yeasts on fermented vegetables.

J Microbiol 2019 Jan 25;57(1):30-37. Epub 2018 Oct 25.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755, Republic of Korea.

White colony-forming yeasts (WCFYs) often appear in fermented foods, depending on the storage method. Despite the ongoing research on fermented foods, the community and genome features of WCFYs have not been well studied. In this study, the community structures of WCFYs on fermented vegetables (kimchi) prepared with various raw materials were investigated using deep sequencing. Only eight operational taxonomic units (OTUs) were detected, indicating that the community structure of WCFYs on kimchi is very simple. The five most abundant OTUs represented Pichia kluyveri, Yarrowia lipolytica, Candida sake, Hanseniaspora uvarum, and Kazachstania servazzii. Using a culture-dependent method, 41 strains representing the five major OTUs were isolated from the surface of the food samples. Whole genomes of the five major yeast strains were sequenced and annotated. The total genome length for the strains ranged from 8.97 Mbp to 21.32 Mbp. This is the first study to report genome sequences of the two yeasts Pichia kluyveri and Candida sake. Genome analysis indicated that each yeast strain had core metabolic pathways such as oxidative phosphorylation; purine metabolism; glycolysis/gluconeogenesis; aminoacyl-tRNA biosynthesis; citrate cycle; but strain specific pathways were also found. In addition, no toxin or antimicrobial resistance genes were identified. Our study provides genome information for five WCFY strains that may highlight their potential beneficial or harmful metabolic effects in fermented vegetables.
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http://dx.doi.org/10.1007/s12275-019-8487-yDOI Listing
January 2019

Safety and Usability Guidelines of Clinical Information Systems Integrating Clinical Workflow: A Systematic Review.

Healthc Inform Res 2018 Jul 31;24(3):157-169. Epub 2018 Jul 31.

Department of Biomedical Informatics, Asan Medical Center, Seoul, Korea.

Objectives: The usability of clinical information systems (CISs) is known to be an essential consideration in ensuring patient safety as well as integrating clinical flow. This study aimed to determine how usability and safety guidelines of CIS consider clinical workflow through a systematic review in terms of the target systems, methodology, and guideline components of relevant articles.

Methods: A literature search was conducted for articles published from 2000 to 2015 in PubMed, Cochrane, EMBASE, Web of Science, and CINAHL. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement method was employed. Articles containing recommendations, principles, and evaluation items for CIS usability and safety were included. The selected articles were classified according to article type, methodology, and target systems. Taking clinical workflow into consideration, the components of guidelines were extracted and classified.

Results: A total of 7,401 articles were identified by keyword search. From the 76 articles remaining after abstract screening, 15 were selected through full-text review. Literature review (n = 7) was the most common methodology, followed by expert opinions (n = 6). Computerized physician order entry (n = 6) was the most frequent system. Four articles considered the entire process of clinical tasks, and two articles considered the principles of the entire process of user interface affecting clinical workflow. Only two articles performed heuristic evaluations of CISs.

Conclusions: The usability and safety guidelines of CISs need improvement in guideline development methodology and with consideration of clinical workflow.
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http://dx.doi.org/10.4258/hir.2018.24.3.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085203PMC
July 2018

Role of jeotgal, a Korean traditional fermented fish sauce, in microbial dynamics and metabolite profiles during kimchi fermentation.

Food Chem 2018 Nov 22;265:135-143. Epub 2018 May 22.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea. Electronic address:

We investigated the effects of jeotgal (fermented fish sauce) on kimchi fermentation, with or without saeu-jeot and myeolchi-jeot. Bacterial community analysis showed that Leuconostoc, Weissella, Lactobacillus, and Tetragenococcus were the dominant genera; however, their succession depended on the presence of jeotgal. Leuconostoc gasicomitatum was the dominant species in kimchi without jeotgal, whereas Weissella koreensis and Lactobacillus sakei were the dominant species in kimchi with myeolchi-jeot and saeu-jeot, respectively. Metabolite analysis, using H NMR, showed that the amounts of amino acids and gamma-aminobutyric acid (GABA) were higher in kimchi with jeotgal. Increases in acetate, lactate, and mannitol contents depended on fructose consumption and were more rapid in kimchi with jeotgal. Moreover, the consumption of various amino acids affected the increase in kimchi LAB. Thus, the role of jeotgal in kimchi fermentation was related to enhancement of taste, the amino acid source, and the increases in levels of functional metabolites.
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http://dx.doi.org/10.1016/j.foodchem.2018.05.093DOI Listing
November 2018

Novel haloarchaeon Natrinema thermophila having the highest growth temperature among haloarchaea with a large genome size.

Sci Rep 2018 05 17;8(1):7777. Epub 2018 May 17.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755, Republic of Korea.

Environmental temperature is one of the most important factors for the growth and survival of microorganisms. Here we describe a novel extremely halophilic archaeon (haloarchaea) designated as strain CBA1119 isolated from solar salt. Strain CBA1119 had the highest maximum and optimal growth temperatures (66 °C and 55 °C, respectively) and one of the largest genome sizes among haloarchaea (5.1 Mb). It also had the largest number of strain-specific pan-genome orthologous groups and unique pathways among members of the genus Natrinema in the class Halobacteria. A dendrogram based on the presence/absence of genes and a phylogenetic tree constructed based on OrthoANI values highlighted the particularities of strain CBA1119 as compared to other Natrinema species and other haloarchaea members. The large genome of strain CBA1119 may provide information on genes that confer tolerance to extreme environmental conditions, which may lead to the discovery of other thermophilic strains with potential applications in industrial biotechnology.
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http://dx.doi.org/10.1038/s41598-018-25887-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958107PMC
May 2018

Development of Safety and Usability Guideline for Hospital Information System.

Stud Health Technol Inform 2017 ;245:1368

Department of Biomedical Informatics, Asan Medical Center, Seoul, Republic of Korea.

Hospital Information systems (HIS) provide efficiency in clinical practice, and give users the chances of systemic feedback, recommendations based on evidences. However, HIS without consideration of usability or patient safety could make adverse events. In this study, we suggest safety/usability guideline of HIS, extracted via systemic review of related articles. We categorized the guidelines and recommendations by clinical workflow.
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June 2018

Lactobacillus allii sp. nov. isolated from scallion kimchi.

Int J Syst Evol Microbiol 2017 Dec 18;67(12):4936-4942. Epub 2017 Oct 18.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea.

A novel strain of lactic acid bacteria, WiKim39, was isolated from a scallion kimchi sample consisting of fermented chili peppers and vegetables. The isolate was a Gram-positive, rod-shaped, non-motile, catalase-negative and facultatively anaerobic lactic acid bacterium. Phylogenetic analysis of the 16S rRNA gene sequence showed that strain WiKim39 belonged to the genus Lactobacillus, and shared 97.1-98.2 % pair-wise sequence similarities with related type strains, Lactobacillus nodensis, Lactobacillus insicii, Lactobacillus versmoldensis, Lactobacillus tucceti and Lactobacillus furfuricola. The G+C content of the strain based on its genome sequence was 35.3 mol%. The ANI values between WiKim39 and the closest relatives were lower than 80 %. Based on the phenotypic, biochemical, and phylogenetic analyses, strain WiKim39 represents a novel species of the genus Lactobacillus, for which the name Lactobacillus allii sp. nov. is proposed. The type strain is WiKim39 (=KCTC 21077=JCM 31938).
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http://dx.doi.org/10.1099/ijsem.0.002327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845750PMC
December 2017

Evaluation of ginsenoside bioconversion of lactic acid bacteria isolated from kimchi.

J Ginseng Res 2017 Oct 10;41(4):524-530. Epub 2016 Oct 10.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju 61755, Republic of Korea.

Background: is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation.

Methods: To investigate the bioconversion of ginsenoside Rb1, we prepared kimchi originated bacterial strains WiKim19, WiKim20, WiKim47 WiKim48, and WiKim49 and analyzed bioconversion products using LC-MS/MS mass spectrometer.

Results: WiKim19 and WiKim20 converted ginsenoside Rb1 into the ginsenoside Rg3 approximately five times more than WiKim47 WiKim48, and WiKim49. WIKim19 showed positive correlation with β-glucosidase activity and higher transformation ability of ginsenoside Rb1 into Rg3 than the other strains whereas, WiKim20 showed an elevated production of Rb3 even with lack of β-glucosidase activity but have the highest acidity among the five lactic acid bacteria (LAB).

Conclusion: Ginsenoside Rg5 concentration of five LABs have ranged from ∼2.6 μg/mL to 6.5 μg/mL and increased in accordance with the incubation periods. Our results indicate that the enzymatic activity along with acidic condition contribute to the production of minor ginsenoside from lactic acid bacteria.
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http://dx.doi.org/10.1016/j.jgr.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628348PMC
October 2017

Identification of 2-hydroxyisocaproic acid production in lactic acid bacteria and evaluation of microbial dynamics during kimchi ripening.

Sci Rep 2017 09 7;7(1):10904. Epub 2017 Sep 7.

World Institute of Kimchi, Gwangju, 61755, Republic of Korea.

Lactic acid bacteria produce diverse functional metabolites in fermented foods. However, little is known regarding the metabolites and the fermentation process in kimchi. In this study, the culture broth from Leuconostoc lactis, a lactic acid bacterium isolated from kimchi, was analysed by liquid chromatography-tandem mass spectrometry and identified by the MS-DIAL program. The MassBank database was used to analyse the metabolites produced during fermentation. A mass spectrum corresponding to 2-hydroxyisocaproic acid (HICA) was validated based on a collision-induced dissociation (CID) fragmentation pattern with an identified m/z value of 131.07. HICA production by lactic acid bacteria was monitored and showed a positive correlation with hydroxyisocaproate dehydrogenases (HicDs), which play a key role in the production of HICA from leucine and ketoisocaproic acid. Interestingly, the HICA contents of kimchi varied with Leuconostoc and Lactobacillus content during the early stage of fermentation, and the addition of lactic acid bacteria enhanced the HICA content of kimchi. Our results suggest that HICA production in kimchi is dependent on the lactic acid bacterial composition.
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http://dx.doi.org/10.1038/s41598-017-10948-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589888PMC
September 2017

Large-scale targeted metagenomics analysis of bacterial ecological changes in 88 kimchi samples during fermentation.

Food Microbiol 2017 Sep 6;66:173-183. Epub 2017 May 6.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755, Republic of Korea. Electronic address:

The microbial communities in kimchi vary widely, but the precise effects of differences in region of origin, ingredients, and preparation method on the microbiota are unclear. We analyzed the bacterial community composition of household (n = 69) and commercial (n = 19) kimchi samples obtained from six Korean provinces between April and August 2015. Samples were analyzed by barcoded pyrosequencing targeting the V1-V3 region of the 16S ribosomal RNA gene. The initial pH of the kimchi samples was 5.00-6.39, and the salt concentration was 1.72-4.42%. Except for sampling locality, all categorical variables, i.e., salt concentration, major ingredient, fermentation period, sampling time, and manufacturing process, influenced the bacterial community composition. Particularly, samples were highly clustered by sampling time and salt concentration in non-metric multidimensional scaling plots and an analysis of similarity. These results indicated that the microbial community differed according to fermentation conditions such as salt concentration, major ingredient, fermentation period, and sampling time. Furthermore, fermentation properties, including pH, acidity, salt concentration, and microbial abundance differed between kimchi samples from household and commercial sources. Analyses of changes in bacterial ecology during fermentation will improve our understanding of the biological properties of kimchi, as well as the relationships between these properties and the microbiota of kimchi.
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http://dx.doi.org/10.1016/j.fm.2017.05.002DOI Listing
September 2017

Complete Genome Sequence of Strain WiKim38 Isolated from Kimchi.

Genome Announc 2017 May 4;5(18). Epub 2017 May 4.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, Republic of Korea

WiKim38 is a potential probiotic strain isolated from kimchi, a traditional Korean fermented food. The complete genome of the WiKim38 strain consisted of a circular chromosome of 1,940,170 bp in length with a G+C content of 41.93%.
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http://dx.doi.org/10.1128/genomeA.00273-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477189PMC
May 2017

Applicability of a colorimetric method for evaluation of lactic acid bacteria with probiotic properties.

Food Microbiol 2017 Jun 18;64:33-38. Epub 2016 Dec 18.

World Institute of Kimchi, Gwangju 61755, Republic of Korea. Electronic address:

Rapid colorimetric methods using various indicator reagents have been developed to monitor bacterial viability. Here, we examined the applicability of a method based on the reduction of resazurin or water-soluble tetrazolium salt-8 (WST-8) to screen lactic acid bacteria (LAB) for growth, tolerance against bile acid and low pH. The resazurin reduction test proved unsuitable for screening LAB such as Lactobacillus plantarum and Leuconostoc mesenteroides since it reacted with acid present in the cultures. LAB growth could be indirectly quantified by measuring WST-8 reduction. This method proved more sensitive and quickly results than counting bacterial colony forming units and turbidity at 600 nm in the presence of bile and acid. Our results suggested that the WST-8-based method could be useful for the characterization of growth and tolerance of the lactic acid producing bacteria.
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http://dx.doi.org/10.1016/j.fm.2016.12.008DOI Listing
June 2017

Complete Genome Sequence of Pediococcus pentosaceus Strain wikim 20, Isolated from Korean Kimchi.

Genome Announc 2016 Nov 10;4(6). Epub 2016 Nov 10.

World Institute of Kimchi, Gwangju, Republic of Korea

Pediococcus pentosaceus strain wikim 20 is a lactic acid bacterium that was isolated from kimchi, a representative traditional Korean fermented food. Here, we announce the complete genome sequence of P. pentosaceus strain wikim 20 consisting of a 1,830,629-bp chromosome and provide a description of its annotation.
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http://dx.doi.org/10.1128/genomeA.01233-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105092PMC
November 2016

Pulmonary thromboembolism in patient with coexistence of Behçet's disease and antiphospholipid syndrome.

Int J Rheum Dis 2018 Dec 26;21(12):2188-2192. Epub 2016 Jul 26.

Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea.

Pulmonary thromboembolism (PTE) is rarely reported in Behçet's disease (BD) due to its distinctive thrombus-forming mechanism. In BD, the inflammation on vessel walls causes venous thrombosis. The thrombi are considered to be tethered to the inflamed walls making embolization less frequent. Thus, immunosuppressive agents are the mainstay of treatment. However, the necessity of anticoagulation therapy is controversial because of its uncertain efficacy of resolving thrombi and the possibility of fatal side effects of hemorrhage. A 25-year-old man with recurrent oral aphthae visited with abrupt onset of dyspnea and chest pain. Based on history, imaging studies and laboratory results, he was diagnosed with BD with vascular involvement and antiphospholipid syndrome (APS), causing PTE from deep vein thrombosis. The co-existing APS may have further promoted the thrombosis, shifting his blood profile toward the hypercoagulable state. Immunosuppressive therapy with glucocorticoid and azathioprine, and concomitant anticoagulation with warfarin were achieved successfully without any fatal complications. When atypical features of vascular involvement in BD develop, other coexisting diseases should be considered to design an optimal therapeutic plan.
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http://dx.doi.org/10.1111/1756-185X.12923DOI Listing
December 2018

Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model.

Arch Dermatol Res 2015 Sep 19;307(7):569-81. Epub 2015 Mar 19.

Department of Dermatology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Republic of Korea.

Congenitally or early impaired skin barrier as the first event starting the 'atopic march' in atopic dermatitis (AD) patients can increase allergen penetration that results in sensitization, even in the airways, followed by asthma and allergic rhinitis. Thymic stromal lymphopoietin (TSLP) is a cytokine existing in high levels in AD skin and is considered as a novel therapeutic target for atopic disease. We generated oxazolone (Ox)-induced AD-like (Ox-AD) hairless mice and divided them into four groups according to the therapeutic challenges: topical glucocorticoid, pimecrolimus, emollient, and control (acetone-only treated). We assessed the functional studies of skin barrier, epidermal expressions of differentiation markers, IL-1α, TNF-α, proteinase-activated receptor-2 (PAR-2), TSLP and antimicrobial peptides (AMP), and serum IgE in each group. Topical glucocorticoid or pimecrolimus treatment improved AD-like skin lesions and barrier functions, and restored the epidermal expression of differentiation markers, IL-1α, TNF-α, PAR-2, and TSLP, in Ox-AD mice. The improvement was relatively better with the glucocorticoid than pimecrolimus. Epidermal AMP expression was restored by topical glucocorticoid, but not pimecrolimus. Our result showed that topical glucocorticoid or pimecrolimus improved the AD-like skin lesions and barrier impairment by suppressing TSLP-related allergic inflammation.
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http://dx.doi.org/10.1007/s00403-015-1558-yDOI Listing
September 2015

Intractable hiccup as the presenting symptom of cavernous hemangioma in the medulla oblongata: a case report and literature review.

J Korean Neurosurg Soc 2014 Jun 30;55(6):379-82. Epub 2014 Jun 30.

Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Hwasun, Korea.

A case of intractable hiccup developed by cavernous hemangioma in the medulla oblongata is reported. There have been only five previously reported cases of medullary cavernoma that triggered intractable hiccup. The patient was a 28-year-old man who was presented with intractable hiccup for 15 days. It developed suddenly, then aggravated progressively and did not respond to any types of medication. On magnetic resonance images, a well-demarcated and non-enhancing mass with hemorrhagic changes was noted in the left medulla oblongata. Intraoperative findings showed that the lesion was fully embedded within the brain stem and pathology confirmed the diagnosis of cavernous hemangioma. The hiccup resolved completely after the operation. Based on the presumption that the medullary cavernoma may trigger intractable hiccup by displacing or compression the hiccup arc of the dorsolateral medulla, surgical excision can eliminate the symptoms, even in the case totally buried in brainstem.
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http://dx.doi.org/10.3340/jkns.2014.55.6.379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166338PMC
June 2014

Peptoniphilus rhinitidis sp. nov., isolated from specimens of chronic rhinosinusitis.

Anaerobe 2014 Dec 2;30:30-4. Epub 2014 Aug 2.

Korean Collection for Type Cultures, Biological Resource Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea. Electronic address:

Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nasal cavity and paranasal sinus related to bacterial infection. A previous study suggested that a specific bacterial group may have an important role in the course of CRS. In this study, bacteria isolated from CRS patients were characterized. A total of 15 strains were identified as Gram-positive anaerobic cocci (GPAC), which were able to utilize peptone as a sole carbon source. Sequencing of the 16S ribosomal RNA gene revealed that the isolates were closely related to members of the genus Peptoniphilus (>97% similarity) within the Clostridiales Family XI. Incertae Sedis. Genotypic and phenotypic characterization suggests that these isolates represent a novel species of the genus Peptoniphilus associated with CRS. The type strain of Peptoniphilus rhinitidis is 1-13T (=KCTC 5985T=JCM 17448T).
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http://dx.doi.org/10.1016/j.anaerobe.2014.07.005DOI Listing
December 2014

Characteristics of brain magnetic resonance images at symptom onset in children with moyamoya disease.

Brain Dev 2015 Mar 9;37(3):299-306. Epub 2014 Jul 9.

Department of Pediatrics, Chonnam National University Medical School, Gwangju, Republic of Korea.

Objectives: To clarify the characteristics of brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) at symptom onset in patients with childhood moyamoya disease (MD) according to developmental stage.

Methods: In 26 childhood MD patients who underwent brain MRI and MRA within 3 months from symptom onset, MRA scores and grades and MRI findings from symptomatic hemispheres were summarized according to developmental stage: infancy (0-1 years, three patients), toddlerhood/preschool age (2-5 years, nine patients), school age (6-10 years, seven patients), and adolescence (11-18 years, seven patients).

Results: Mean MRA score was 5.6, which was higher in adolescents (6.9). The most common MRA grade was grade 3, particularly in those under 10 years. Acute ischemic infarction presented in 17 patients (65%), was more common in patients below 5 years (83%) and was mainly in a gyral pattern (47%). Most hemorrhagic infarctions occurred in adolescents. Moyamoya vessels in the Sylvian valleys were apparent in 22 patients (85%), which were the most sensitive non-ischemic findings on T2 weighted images. The signal void in the distal internal carotid artery was diminished in 73% and apparent signal voids in basal ganglia were seen in three patients. The ivy sign was positive in 81% on fluid attenuated inversion recovery images and 69% on contrast-enhanced T1-weighted images in 21 and 16 patients, respectively.

Conclusions: Brain MRIs and MRAs at symptom onset in childhood MD have characteristic findings, which differ in different developmental stage.
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http://dx.doi.org/10.1016/j.braindev.2014.06.008DOI Listing
March 2015

Cerebral aspergillosis with multiple enhancing nodules in the right cerebral hemisphere in the immune-competent patient.

J Korean Neurosurg Soc 2013 May 31;53(5):312-5. Epub 2013 May 31.

Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Gwangju, Korea.

Aspergillosis in the central nervous system (CNS) is a very rare disease in immune-competent patients. There was a case of a healthy man without a history of immune-compromised disease who had invasive aspergillosis with unusual radiologic findings. A 48-year-old healthy man with diabetes mellitus, presented with complaints of blurred vision that persisted for one month. Brain magnetic resonance imaging (MRI) showed multiple nodular enhancing lesions on the right cerebral hemisphere. The diffusion image appeared in a high-signal intensity in these areas. Cerebrospinal fluid examination did not show any infection signs. An open biopsy was done and intraoperative findings showed grayish inflammatory and necrotic tissue without a definitive mass lesion. The pathologic result was a brain abscess caused by fungal infection, morphologically aspergillus. Antifungal agents (Amphotericin B, Ambisome and Voriconazole) were used for treatment for 3 months. The visual symptoms improved. There was no recurrence or abscess pocket, but the remaining focal enhanced lesions were visible in the right temporal and occipital area at a one year follow-up MRI. This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents.
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http://dx.doi.org/10.3340/jkns.2013.53.5.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730037PMC
May 2013

Outcome of mechanical thrombectomy with Solitaire stent as first-line intra-arterial treatment in intracranial internal carotid artery occlusion.

Neuroradiology 2013 Aug 24;55(8):999-1005. Epub 2013 May 24.

Department of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, 671 Jebong-Ro, Dong-gu, Gwangju, 501-757, Republic of Korea.

Introduction: Acute stroke from occlusion of the intracranial internal carotid artery (ICA) is associated with a poor clinical outcome despite a thrombolytic treatment. The purpose of this study was to evaluate the outcome of mechanical thrombectomy using the Solitaire stent for the treatment of acute stroke patients with intracranial ICA occlusion.

Methods: A total of 104 consecutive patients with acute stroke were treated with mechanical thrombectomy using the Solitaire stent as a first-line intra-arterial treatment. We retrospectively reviewed data from 26 of these patients who presented with acute stroke attributable to intracranial ICA occlusion. Rescue treatments in cases of failed Solitaire thrombectomy included intra-arterial urokinase, angioplasty, and forced suction thrombectomy. Successful recanalization was defined as thrombolysis in cerebral ischemia grades 2b to 3. Outcome measure was the modified Rankin Scale (mRS) score of 0-2 at 3 months.

Results: Successful recanalization was achieved in 77% (20/26) of patients. Recanalization was achieved with the Solitaire stent alone in 69% (18/26) of patients. Ten patients (39%) had a good clinical outcome (mRS score of 0-2) at 3 months. There was a good outcome in 50% of patients (10/20) with recanalization and no good outcome in patients (0/6) without recanalization (P = 0.027). None of eight patients who received rescue treatments showed a good outcome. No symptomatic intracerebral hemorrhage occurred. Mortality was 8% (2/26) at 3 months.

Conclusion: Mechanical thrombectomy using the Solitaire stent can achieve a high rate of successful recanalization and a very low rate of symptomatic hemorrhage and thus improve a clinical outcome in patients with acute intracranial ICA occlusion.
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http://dx.doi.org/10.1007/s00234-013-1205-2DOI Listing
August 2013

Subarachnoid hemorrhage in a multimodal approach heavily weighted toward mechanical thrombectomy with solitaire stent in acute stroke.

Stroke 2013 Feb 3;44(2):414-9. Epub 2013 Jan 3.

Department of Radiology, Chonnam National University Hospital, 671 Jebong-Ro, Dong-gu, Gwangju, 501-757, South Korea.

Background And Purpose: Subarachnoid hemorrhage (SAH) may appear on computerized tomography scans after mechanical thrombectomy for acute ischemic stroke. The incidence and prognosis of this observation remain unknown. We investigated the frequency and clinical consequences of SAH after treating acute ischemic stroke with a multimodal approach heavily weighted toward mechanical thrombectomy with Solitaire stent.

Methods: Seventy-four consecutive patients with acute ischemic stroke underwent mechanical thrombectomy with a Solitaire stent as a first-line treatment. Nonenhanced computerized tomography scans were performed before, immediately after, and 24 hours after treatment to detect SAH. Clinical outcome was assessed after treatment, on day 1, at discharge, and at 3 months. Clinical and radiological data were compared between patients with and without SAH.

Results: Twelve patients (16.2%) exhibited SAH associated with pure SAH (n=4) or mixed SAH and contrast extravasation (n=8). The SAH was located in the ipsilateral Sylvian fissure (n=11) or bilateral parietooccipital sulci (n=1). Patients with SAH had no periprocedural vessel perforations or arterial dissections and no postprocedural neurological deteriorations. Rescue angioplasty was performed more frequently in SAH group than in control group (33.3% vs 9.7%; P=0.05). Patients with SAH and those without had similar recanalization rates and clinical outcomes.

Conclusions: SAH on post-therapeutic computerized tomography scans were not uncommon after primary mechanical thrombectomy with a Solitaire stent, but they seemed to be benign. Rescue angioplasty and unidentified, small vessel ruptures due to mechanical stretch during stent retrieval might give rise to these lesions.
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http://dx.doi.org/10.1161/STROKEAHA.112.675546DOI Listing
February 2013

Maribacter chungangensis sp. nov., isolated from a green seaweed, and emended descriptions of the genus Maribacter and Maribacter arcticus.

Int J Syst Evol Microbiol 2013 Jul 14;63(Pt 7):2553-2558. Epub 2012 Dec 14.

Department of Microbiology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

A Gram-stain-negative, non-spore-forming, strictly aerobic, orange-pigmented bacterial strain, motile by gliding, designated CAU 1044(T), was isolated from a green seaweed and its taxonomic position was investigated using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CAU 1044(T) formed a distinct lineage within the genus Maribacter and was most closely related to Maribacter antarcticus JCM 15445(T) and Maribacter arcticus KOPRI 20941(T) (96.3 and 95.7 % similarity, respectively). Strain CAU 1044(T) contained menaquinone 6 as the only isoprenoid quinone and iso-C15 : 0, summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c and/or iso-C15 : 0 2-OH), iso-C17 : 0 3-OH and iso-C15 : 1 G as the major fatty acids. The cell wall peptidoglycan of strain CAU 1044(T) contained meso-diaminopimelic acid and the major whole-cell sugars were glucose and ribose. The polar lipids were composed of phosphatidylethanolamine, one unidentified phospholipid, six unidentified aminolipids and four unidentified lipids. The DNA G+C content was 40.2 mol%. On the basis of phenotypic data and phylogenetic inference, strain CAU 1044(T) should be classified as a representative of a novel species in the genus Maribacter for which the name Maribacter chungangensis sp. nov. is proposed. The type strain is CAU 1044(T) ( = KCTC 23735(T) = CCUG 61948(T)). Emended descriptions of the genus Maribacter and the species M. arcticus KCTC 22053(T) are also proposed.
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http://dx.doi.org/10.1099/ijs.0.039628-0DOI Listing
July 2013

Genome sequence of the probiotic bacterium Sporolactobacillus vineae SL153T.

J Bacteriol 2012 Jun;194(11):3015-6

Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, Republic of Korea.

The novel Sporolactobacillus vineae SL153(T) strain has excellent intestinal adherence and growth inhibitory effect on pathogenic microorganisms, including Vibrio genus microorganisms, and therefore can be effectively used for the prevention and treatment of disease caused by pathogenic microorganisms. Here, we first report the draft genome sequence of a novel species in the genus Sporolactobacillus.
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http://dx.doi.org/10.1128/JB.00452-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370620PMC
June 2012

Algoriphagus chungangensis sp. nov., isolated from a tidal flat sediment.

Int J Syst Evol Microbiol 2013 Feb 27;63(Pt 2):648-653. Epub 2012 Apr 27.

Department of Microbiology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

A Gram-stain-negative, non-spore-forming, non-motile, strictly aerobic, rod-shaped bacterial strain, designated CAU 1002(T), was isolated from a tidal flat sediment and its taxonomic position was investigated using a polyphasic approach. Strain CAU 1002(T) grew optimally at 30 °C and pH 7.5. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CAU 1002(T) formed a distinct lineage within the genus Algoriphagus and was most closely related to Algoriphagus lutimaris KCTC 22630(T) and Algoriphagus halophilus KCTC 12051(T) (97.75 and 97.74 % 16S rRNA gene sequence similarity, respectively). The strain contained MK-7 as the major isoprenoid quinone and iso-C(15 : 0) and C(16 : 1)ω7c and/or iso-C(15 : 0) 2-OH (summed feature 3) as the major fatty acids. The cell-wall peptidoglycan of strain CAU 1002(T) contained meso-diaminopimelic acids. The major whole-cell sugars were glucose, arabinose, sucrose, and ribose. The polar lipid profile was composed of phosphatidylethanolamine, five unidentified aminolipids, one unidentified aminophospholipid, one unidentified phospholipid, one unidentified aminoglycolipid, one unidentified glycolipid and twelve unidentified lipids. The DNA G+C content of strain CAU 1002(T) was 38.0 mol%. On the basis of phylogenetic inference, phenotypic, chemotaxonomic and genotypic data, strain CAU 1002(T) should be classified into the genus Algoriphagus as a member of a novel species, for which the name Algoriphagus chungangensis sp. nov. is proposed. The type strain is CAU 1002(T) ( = KCTC 23759(T) = CCUG 61890(T)). The description of the genus Algoriphagus is emended.
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http://dx.doi.org/10.1099/ijs.0.039214-0DOI Listing
February 2013

[Adrenal metastasis from hepatocellular carcinoma without intrahepatic recurrence after hepatic resection].

Korean J Gastroenterol 2012 Apr;59(4):308-12

Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea.

Although the adrenal gland is a common site of metastasis from hepatocellular carcinoma (HCC), adrenal metastases are rarely seen in clinical practice because of its lower metastatic potential compared to the other malignancies. Adrenal metastases usually were detected at the time of diagnosis of primary HCC or simultaneously with intrahepatic recurrence after curative management of HCC. It is very rare that only metastatic HCC is detected without evidence of intrahepatic recurrence. Hereby, we report two cases of adrenal metastasis from HCC without intrahepatic recurrence after hepatic resection.
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http://dx.doi.org/10.4166/kjg.2012.59.4.308DOI Listing
April 2012

Genome sequence of the anaerobic bacterium Clostridium arbusti SL206(T).

J Bacteriol 2012 May;194(10):2758

Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

A new Clostridium species has been isolated from pear orchard soil in Daejeon, Republic of Korea. The isolate, Clostridium arbusti SL206(T) (KCTC 5449(T)), showed a nitrogenase activity as well as an organic acid production. Here we first report the draft genome sequence of a novel species in the genus Clostridium within the largest Gram-positive group.
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http://dx.doi.org/10.1128/JB.00368-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347162PMC
May 2012

Genome sequence of Myroides injenensis M09-0166(T), isolated from clinical specimens.

J Bacteriol 2012 May;194(10):2748-9

Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, Republic of Korea.

A new Myroides species has been isolated from the urine of a patient with fever in spite of multiple antibiotic treatments who had undergone a radical hysterectomy for cervical cancer and percutaneous nephrostomies for hydronephrosis in the past. The isolate, Myroides injenensis M09-0166(T) (KCTC 23367(T)), showed a high level of resistance to multiple antibiotic agents. Here we provide the first report of the draft genome sequence of a novel species in the genus Myroides within the nonfermenting Gram-negative group.
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http://dx.doi.org/10.1128/JB.00276-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347189PMC
May 2012