Publications by authors named "Min Wu"

1,961 Publications

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A Score of Low-Grade Inflammation for Predicting Stroke Recurrence in Patients with Ischemic Stroke.

J Inflamm Res 2021 14;14:4605-4614. Epub 2021 Sep 14.

Department of Neurology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, People's Republic of China.

Background And Purpose: The impact of low-grade inflammation (LGI) on stroke recurrence has not been well studied yet. We aimed to evaluate the association between LGI and stroke recurrence in patients with ischemic stroke.

Methods: Patients with first-ever ischemic stroke diagnosed within 72 hours of symptoms onset were consecutively recruited from the Nanjing Stroke Registry Program. C-reactive protein (CRP) level, white blood cell (WBC) count, platelet (PLT) count, and neutrophil-to-lymphocyte ratio (NLR) were conceived as low-grade inflammation biomarkers and combined into a standardized LGI score. The association of LGI score with the risk of stroke recurrence was analyzed with multivariate Cox regression models. Analyses accounting for the competing risk of stroke recurrence and death were also performed.

Results: Of the 1214 patients studied (median age, 61 years; male, 71.6%), 177 (14.6%) patients experienced a recurrent stroke with a median follow-up of 23.0 (interquartile ranges, 14.5-34.0) months. Patients with stroke recurrence had a higher LGI score (median, 3 versus -2; < 0.001) than those without recurrence. The univariate analysis indicated that patients with LGI scores in the fourth quartile were more likely to have a stroke recurrence (hazard ratios [HR], 4.312; 95% confidence interval [CI], 2.675-6.952; < 0.001). After adjusting for potential confounders, the association remained significant in the multivariate Cox regression model (HR, 4.080; 95% CI, 2.420-6.879; < 0.001). Competing risks model and sensitivity analysis further confirmed this conclusion.

Conclusion: This study showed that an elevated LGI score was associated with a higher risk of stroke recurrence, independent of other vascular risk factors.
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http://dx.doi.org/10.2147/JIR.S328383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449639PMC
September 2021

The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study.

Sci Rep 2021 Sep 20;11(1):18591. Epub 2021 Sep 20.

Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, China.

Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects of environmental exposures on SLE, we conducted a population-based cohort study across Jiangsu Province, China, to examine the associations between the living environment including air and water pollution, population density, economic income level, etc. and the prevalence and mortality of hospitalized SLE (h-SLE) patients. A total of 2231 h-SLE patients were retrieved from a longitudinal SLE database collected by the Jiangsu Lupus Collaborative Group from 1999 to 2009. The results showed that: It existed regional differences on the prevalence of h-SLE patients in 96 administrative districts; The distribution of NO air concentration monitored by atmospheric remote sensors showed that three of the ultra-high-prevalence districts were located in the concentrated chemical industry emission area; h-SLE patient prevalence was positively correlated with the excessive levels of nitrogen in drinking water; The positive ratio of pericarditis and proteinuria was positively correlated with the prevalence of h-SLE patients and pollution not only induced a high h-SLE patient prevalence but also a higher mortality rate, which might be attributed to NOx pollution in the air and drinking water. In summary, our data suggested that NOx in air and drinking water may be one of the important predispositions of SLE, especially for patients with renal involvement.
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http://dx.doi.org/10.1038/s41598-021-98111-8DOI Listing
September 2021

Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.

Elife 2021 Sep 20;10. Epub 2021 Sep 20.

Mechanical and Industrial Engineering, University of Massachusetts, Amherst, United States.

A monolayer of highly motile cells can establish long-range orientational order, which can be explained by hydrodynamic theory of active gels and fluids. However, it is less clear how cell shape changes and rearrangement are governed when the monolayer is in mechanical equilibrium states when cell motility diminishes. In this work, we report that rat embryonic fibroblasts (REF), when confined in circular mesoscale patterns on rigid substrates, can transition from the spindle shapes to more compact morphologies. Cells align radially only at the pattern boundary when they are in the mechanical equilibrium. This radial alignment disappears when cell contractility or cell-cell adhesion is reduced. Unlike monolayers of spindle-like cells such as NIH-3T3 fibroblasts with minimal intercellular interactions or epithelial cells like Madin-Darby canine kidney (MDCK) with strong cortical actin network, confined REF monolayers present an actin gradient with isotropic meshwork, suggesting the existence of a stiffness gradient. In addition, the REF cells tend to condense on soft substrates, a collective cell behavior we refer to as the 'condensation tendency'. This condensation tendency, together with geometrical confinement, induces tensile prestretch (i.e., an isotropic stretch that causes tissue to contract when released) to the confined monolayer. By developing a Voronoi-cell model, we demonstrate that the combined global tissue prestretch and cell stiffness differential between the inner and boundary cells can sufficiently define the cell radial alignment at the pattern boundary.
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http://dx.doi.org/10.7554/eLife.60381DOI Listing
September 2021

Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics.

Precis Clin Med 2021 Sep 10;4(3):179-191. Epub 2021 Jul 10.

Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems (Cas) are efficient tools for targeting specific genes for laboratory research, agricultural engineering, biotechnology, and human disease treatment. Cas9, by far the most extensively used gene-editing nuclease, has shown great promise for the treatment of hereditary diseases, viral infection, cancers, and so on. Recent reports have revealed that some other types of CRISPR-Cas systems may also have surprising potential to join the fray as gene-editing tools for various applications. Despite the rapid progress in basic research and clinical tests, some underlying problems present continuous, significant challenges, such as editing efficiency, relative difficulty in delivery, off-target effects, immunogenicity, etc. This article summarizes the applications of CRISPR-Cas from bench to bedside and highlights the current obstacles that may limit the usage of CRISPR-Cas systems as gene-editing toolkits in precision medicine and offer some viewpoints that may help to tackle these challenges and facilitate technical development. CRISPR-Cas systems, as a powerful gene-editing approach, will offer great hopes in clinical treatments for many individuals with currently incurable diseases.
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http://dx.doi.org/10.1093/pcmedi/pbab014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444435PMC
September 2021

Corrigendum: Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.

Front Immunol 2021 3;12:745787. Epub 2021 Sep 3.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China.

[This corrects the article DOI: 10.3389/fimmu.2019.00317.].
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http://dx.doi.org/10.3389/fimmu.2021.745787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448506PMC
September 2021

Natural sensory context drives diverse brain-wide activity during C. elegans mating.

Cell 2021 Sep 10. Epub 2021 Sep 10.

Department of Physics, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address:

Natural goal-directed behaviors often involve complex sequences of many stimulus-triggered components. Understanding how brain circuits organize such behaviors requires mapping the interactions between an animal, its environment, and its nervous system. Here, we use brain-wide neuronal imaging to study the full performance of mating by the C. elegans male. We show that as mating unfolds in a sequence of component behaviors, the brain operates similarly between instances of each component but distinctly between different components. When the full sensory and behavioral context is taken into account, unique roles emerge for each neuron. Functional correlations between neurons are not fixed but change with behavioral dynamics. From individual neurons to circuits, our study shows how diverse brain-wide dynamics emerge from the integration of sensory perception and motor actions in their natural context.
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http://dx.doi.org/10.1016/j.cell.2021.08.024DOI Listing
September 2021

The influence of gastrointestinal pH on speciation of copper in simulated digestive juice.

Food Sci Nutr 2021 Sep 26;9(9):5174-5182. Epub 2021 Jul 26.

Food Safety Key Laboratory of Zhejiang Province School of Food Science and Biotechnology Zhejiang Gongshang University Hangzhou China.

Speciation can provide knowledge about absorption, reactivity to binding sites, bioavailability, toxicity, and excretion of elements. In this study, the speciation of copper in different model solutions under the influence of gastrointestinal (GI) pH was studied by ion selective electrode (ISE) and inductively coupled plasma optical emission spectrometry (ICP OES). It was found that the electrode response (mV) against Cu decreased with the increase in pH and dropped to the lowest point at pH 7.5 in all model solutions. When amino acids and organic acids were present, the ratio of filtered copper (0.45 μm, pH 7.5) was more than 90%. When casein was present, whey protein, pancreatin, and starch were added, and the ratio of filtered copper was 85.6 ± 0.3, 56.7 ± 8.8, 38.5 ± 5.1, and 1.0 ± 0.3%, respectively. When there is not enough organic ligand, excessive copper will form copper hydroxide precipitation with the increase in pH, but it got the highest electrode response (mV) against Cu. From this study, it can be concluded that the speciation of copper in GI tract is strongly influenced by the pH and the composition of food. When there are few ligands coexisting in the GI tract, the concentration of copper ion may be relatively high.
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http://dx.doi.org/10.1002/fsn3.2490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441336PMC
September 2021

Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression.

PLoS Pathog 2021 Sep 16;17(9):e1009918. Epub 2021 Sep 16.

Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.

Under RNA virus infection, retinoic acid-inducible gene I (RIG-I) in host cells recognizes viral RNA and activates the expression of type I IFN. To investigate the roles of protein methyltransferases and demethylases in RIG-I antiviral signaling pathway, we screened all the known related enzymes with a siRNA library and identified LSD1 as a positive regulator for RIG-I signaling. Exogenous expression of LSD1 enhances RIG-I signaling activated by virus stimulation, whereas its deficiency restricts it. LSD1 interacts with RIG-I, promotes its K63-linked polyubiquitination and interaction with VISA/MAVS. Interestingly, LSD1 exerts its function in antiviral response not dependent on its demethylase activity but through enhancing the interaction between RIG-I with E3 ligases, especially TRIM25. Furthermore, we provide in vivo evidence that LSD1 increases antiviral gene expression and inhibits viral replication. Taken together, our findings demonstrate that LSD1 is a positive regulator of signaling pathway triggered by RNA-virus through mediating RIG-I polyubiquitination.
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http://dx.doi.org/10.1371/journal.ppat.1009918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445485PMC
September 2021

HFO Detection in Epilepsy: A Stacked Denoising Autoencoder and Sample Weight Adjusting Factors-Based Method.

IEEE Trans Neural Syst Rehabil Eng 2021 Sep 16;PP. Epub 2021 Sep 16.

High-frequency oscillations (HFOs) recorded by the intracranial electroencephalography (iEEG) are the promising biomarkers of epileptogenic zones. Accurate detection of HFOs is the key to pre-operative assessment for epilepsy. Due to the subjective bias caused by manual features and the class imbalance between HFOs and false HFOs, it is difficult to obtain satisfactory detection performance by the existing methods. To solve these problems, we put forward a novel method to accurately detect HFOs based on the stacked denoising autoencoder (SDAE) and the ensemble classifier with sample weight adjusting factors. First, the adjustable threshold of Hilbert envelopes is proposed to isolate the events of interest (EoIs) from background activities. Then, the SDAE network is utilized to automatically extract features of EoIs in the time-frequency domain. Finally, the AdaBoost-based support vector machine ensemble classifier with sample weight adjusting factors is devised to separate HFOs from EoIs by using the extracted features. These adjusting factors are used to solve the class imbalance problem by adjusting sample weights when learning the base classifiers. Our HFO detection method is evaluated by using clinical iEEG data recorded from 20 patients with medically refractory epilepsy. The experimental results show that our detection method outperforms some existing methods in terms of sensitivity and false discovery rate. In addition, the HFOs detected by our method are effective for localizing seizure onset zones.
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http://dx.doi.org/10.1109/TNSRE.2021.3113293DOI Listing
September 2021

[Research on the nature of micromovement and the biomechanical staging of fracture healing].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1205-1211

Department of Orthopaedics, the First Affiliated Hospital, Bengbu Medical College, Bengbu Anhui, 233000, P.R.China.

Objective: To explore the nature of micromovement and the biomechanical staging of fracture healing.

Methods: Through literature review and theoretical analysis, the difference in micromovement research was taken as the breakthrough point to try to provide a new understanding of the role of micromovement and the mechanical working mode in the process of fracture healing.

Results: The process of fracture healing is the process of callus generation and connection. The micromovement is the key to start the growth of callus, and the total amount of callus should be matched with the size of the fracture space. The strain at the fracture end is the key to determine the callus connection. The strain that can be tolerated by different tissues in the fracture healing process will limit the micromovement. According to this, the fracture healing process can be divided into the initiation period, perfusion period, contradiction period, connection period, and physiological period, i.e., the biomechanical staging of fracture healing.

Conclusion: Biomechanical staging of fracture healing incorporates important mechanical parameters affecting fracture healing and introduces the concepts of time and space, which helps to understand the role of biomechanics, and its significance needs further clinical test and exploration.
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http://dx.doi.org/10.7507/1002-1892.202103050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444125PMC
September 2021

Predictive Value of Metabolic Parameters Derived From F-FDG PET/CT for Microsatellite Instability in Patients With Colorectal Carcinoma.

Front Immunol 2021 26;12:724464. Epub 2021 Aug 26.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Microsatellite instability (MSI) is one of the important factors that determine the effectiveness of immunotherapy in colorectal cancer (CRC) and serves as a prognostic biomarker for its clinical outcomes.

Purpose: To investigate whether the metabolic parameters derived fromF-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) can predict MSI status in patients with CRC.

Materials And Methods: A retrospective analysis was performed on CRC patients who underwent F-FDG PET/CT examination before surgery between January 2015 and April 2021. The metabolic F-FDG PET/CT parameters of the primary CRC lesion were calculated and recorded with different thresholds, including the maximum, peak, and mean standardized uptake value (SUV, SUV, and SUV), as well as the metabolic tumor volume (MTV) and the total lesion glycolysis (TLG). The status of MSI was determined by immunohistochemical assessment. The difference of quantitative parameters between MSI and microsatellite stability (MSS) groups was assessed, and the receiver operating characteristic (ROC) analyses with area under ROC curves (AUC) was used to evaluate the predictive performance of metabolic parameters.

Results: A total of 44 patients (24 men and 20 women; mean ± standard deviation age: 71.1 ± 14.2 years) were included. There were 14 patients in the MSI group while there were 30 in the MSS group. MTV, MTV, MTV, and MTV, as well as TLG and TLG showed significant difference between two groups (all -values <0.05), among which MTV demonstrated the highest performance in the prediction of MSI, with an AUC of 0.805 [95% confidence interval (CI): 0.657-0.909], a sensitivity of 92.9% (95% CI: 0.661-0.998), and a specificity of 66.7% (95% CI: 0.472-0.827). Patients' age and MTV were significant predictive indicators of MSI in multivariate logistic regression.

Conclusion: The metabolic parameters derived fromF-FDG PET/CT were able to preoperatively predict the MSI status in CRC, with MTV demonstrating the highest predictive performance. PET/CT imaging could serve as a noninvasive tool in the guidance of immunotherapy and individualized treatment in CRC patients.
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http://dx.doi.org/10.3389/fimmu.2021.724464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426433PMC
August 2021

Equivalent-input-disturbance-based robust control of drilling trajectory with weight-on-bit uncertainty in directional drilling.

ISA Trans 2021 Aug 30. Epub 2021 Aug 30.

School of Automation, China University of Geosciences, Wuhan 430074, China; Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems, Wuhan 430074, China; Engineering Research Center of Intelligent Technology for Geo-Exploration, Ministry of Education, Wuhan 430074, China.

Weight-on-Bit is of vital importance to the drilling trajectory orientation in directional drilling. This paper concerns robust control of drilling trajectory with weight-on-bit uncertainty for the directional drilling process. The objective is to develop an equivalent-input-disturbance-based trajectory control scheme such that the drilling trajectory is precisely controlled by suppressing the fluctuations of weight-on-bit. The motion orientation of both the drill bit and a series of stabilizers is used to describe the evolution process of the drilling trajectory. A state-space model with weight-on-bit uncertainty is derived from the evolution equation through a variable transformation. An equivalent-input-disturbance-based trajectory control system is designed, and two control loops are to track and control the trajectory inclination and azimuth, respectively. Two internal models track the trajectory inclination and azimuth respectively to elevate the control accuracy in the trajectory system. Two observer models combined with two low-pass filters estimate the trajectory inclination and azimuth by measuring the bottom hole assembly's inclination and azimuth. Some sufficient conditions are derived using linear-matrix-inequalities to obtain the control parameters by considering a reasonable fluctuation range of weight-on-bit. Finally, the control effects in the build-up and horizontal section of the drilling trajectory illustrate the proposed approach's validity.
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http://dx.doi.org/10.1016/j.isatra.2021.08.032DOI Listing
August 2021

MSCs-Derived Extracellular Vesicles Carrying miR-212-5p Alleviate Myocardial Infarction-Induced Cardiac Fibrosis via NLRC5/VEGF/TGF-β1/SMAD Axis.

J Cardiovasc Transl Res 2021 Sep 10. Epub 2021 Sep 10.

Department of Intensive Care Unit of Cardiac Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, No. 96, Dongchuan Road, Guangzhou, 510080, People's Republic of China.

The purpose of the present study was to define the role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in the progression of myocardial infarction (MI)-induced cardiac fibrosis. An in vitro cell model of hypoxia-induced cardiac fibrosis was constructed in cardiac fibroblasts (CFs). miR-212-5p was poorly expressed in clinical pathological samples and animal models of cardiac fibrosis caused by MI, while miR-212-5p expression was enriched in EVs released from MSCs. EVs from MSCs were isolated, evaluated, and co-cultured with CFs. Dual-luciferase reporter gene assay revealed that miR-212-5p negatively targeted NLRC5 progression of cardiac fibrosis. Following loss- and gain-function assay, EVs expressing miR-212-5p protected against cardiac fibrosis evidenced by reduced levels of α-SMA, Collagen I, TGF-β1, and IL-1β. In vivo experiments further confirmed the above research results. Collectively, EVs from MSCs expressing miR-212-5p may attenuate MI by suppressing the NLRC5/VEGF/TGF-β1/SMAD axis.
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http://dx.doi.org/10.1007/s12265-021-10156-2DOI Listing
September 2021

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy.

Mol Med Rep 2021 11 7;24(5). Epub 2021 Sep 7.

Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.

Naringin (Nar) is one of the natural glycosides extracted from pomelo and other citrus fruits. It has various pharmacological activities, including anti‑inflammatory, antioxidant, anti‑proliferative and anti‑cancer. However, the underlying mechanisms by which Nar regulates apoptosis and autophagy in gastric cancer remain unclear. Thus, the present study aimed to assess the therapeutic effect of Nar and the underlying mechanisms. SNU‑1 cell proliferation was determined using Cell Counting Kit‑8 assay. Cell morphological changes were observed under a phase‑contrast microscope. The changes in the cell cycle were determined using flow cytometry analysis and the changes in cell apoptosis were determined using flow cytometry, Hoechst 33258 and TUNEL staining. The protein levels pertaining to the PI3K/AKT pathway and cell apoptosis and autophagy were monitored using western blot analysis. The results demonstrated that Nar significantly inhibited SNU‑1 cell growth and induced cell cycle arrest in the G0/G1 phase and cell apoptosis. Further mechanistic studies demonstrated that Nar blocked the PI3K/AKT pathway, activated cell autophagy and stimulated the expression of apoptosis‑associated protein cleaved caspase 3 and Bax, but decreased the expression of Bcl‑2. Preincubating SNU‑1 cells with 3‑methyladenine, a cell‑autophagy inhibitor, significantly alleviated the effects of Nar in promoting cell apoptosis and cleaved caspase 3 expression. It was concluded that Nar promoted SNU‑1 cell apoptosis via blocking the PI3K/AKT signaling pathway and activating cell autophagy.
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http://dx.doi.org/10.3892/mmr.2021.12412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441985PMC
November 2021

Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, HEC30654, in Healthy Chinese Subjects.

Front Pharmacol 2021 19;12:726536. Epub 2021 Aug 19.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

HEC30654 is a selective 5-HT6 receptor antagonist that was safe and well-tolerated in preclinical models of Alzheimer's disease. The objective of this double-blind, randomized, placebo-controlled clinical trial was to evaluate the safety, tolerability, and pharmacokinetic profile of HEC30654 after single ascending doses in healthy Chinese subjects. Healthy volunteers received a single oral dose of HEC30654 (5, 10, 15, 30, 60 mg). Safety and tolerability assessments included adverse events, vital signs, and findings on electrocardiograms, electroencephalograms, physical examination, and clinical laboratory tests. Pharmacokinetic analysis of HEC30654 and its major metabolite HEC93263 were conducted in blood, urine, and fecal samples. Single doses of HEC30654 up to 30 mg were generally safe and well tolerated, but dose escalation was terminated early as the 60 mg HEC30654 treatment group met the pre-defined stopping rules specified in the protocol. Median t of HEC30654 was 6 h (range, 4-12 h), t of 10-60 mg HEC30654 ranged from 52.1 to 63.8 h. Exposure to HEC30654 across the dose range explored in this study increased more than in proportion to dose. Metabolism of HEC30654 to HEC93263 was slow (<10%), and HEC30654 was mainly eliminated unchanged through feces. Single doses of HEC30654 up to 30 mg were generally safe and well tolerated. Based on preclinical efficacy in various models of cognition, HEC30654 may represent a therapeutic option for symptomatic treatment of cognitive disorders.
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http://dx.doi.org/10.3389/fphar.2021.726536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416768PMC
August 2021

The Experience of International Students and Institutional Recommendations: A Comparison Between the Students From the Developing and Developed Regions.

Front Psychol 2021 13;12:667230. Epub 2021 Aug 13.

Jinnah University for Women, Karachi, Pakistan.

Prior studies on the experiences of international students in China have mostly focused on their academic, sociocultural, and accommodation experiences. Hence, student health and safety, discrimination, and the services by the International Student Office (ISO) have remained unexplored. Moreover, due to the motivational differences between the students from developing and developed regions, a study that samples students from both regions may depict an exact picture of the experience of international students. Therefore, the objective of this study is to examine the influence of the dimensions (including those dimensions that have been ignored) of the experience of international students on their satisfaction. In addition, we make recommendations regarding Chinese institutes for future students based on a comparison between the students from developing and developed regions. Using hierarchical regression analysis, this study reveals that educational and non-educational experiences vary among students from different regions. Therefore, based on developing (e.g., Asia and Africa) and developed (e.g., America, Europe, and Australia) regions, important recommendations are discussed regarding how educational institutions and the Chinese government could best allocate resources and introduce policies to improve the experience of international students.
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http://dx.doi.org/10.3389/fpsyg.2021.667230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415018PMC
August 2021

ZnO nanoparticles stabilized oregano essential oil Pickering emulsion for functional cellulose nanofibrils packaging films with antimicrobial and antioxidant activity.

Int J Biol Macromol 2021 Sep 3;190:433-440. Epub 2021 Sep 3.

College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, Nanning 530004, China. Electronic address:

The growth and reproduction of microorganisms can cause food spoilage in the process of food transportation and storage. Active packaging is a good way to inhibit food spoilage and prolong the shelf lives of foods. In this study, O/W Pickering emulsion with ZnO nanoparticles as solid particles and oregano essential oil as the oil phase was prepared and used to functionalize cellulose nanofibrils (CNFs) film, and excellent antimicrobial and antioxidant activity was obtained. When the concentration of ZnO nanoparticles was 1.5 wt% and the mass fraction of the oil phase was 20%, the Pickering emulsion with a particle size of 26.85 μm exhibited strong standing stability. The Pickering emulsion was blended with the film-forming matrix CNFs to prepare active packaging films by casting. The Pickering emulsion evenly dispersed in the film to form microcapsules which encapsulated oregano essential oil entirely. The antimicrobial activity against Listeria monocytogenes was 89.61%, the DPPH radical scavenging rate was 58.52%, while the barrier properties of the developed films against oxygen, water vapor and visible light were improved. The active CNFs film prepared by Pickering emulsion could inhibit the growth of microorganism and prolong the shelf lives of foods.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.08.210DOI Listing
September 2021

Suppression of Packet Losses and Disturbances in Networked Control Systems Based on Equivalent-Input-Disturbance Approach.

IEEE Trans Cybern 2021 Sep 3;PP. Epub 2021 Sep 3.

This article presents a method of suppressing packet losses and exogenous disturbances for a networked control system (NCS) subject to network-introduced delays. The NCS has two feedback loops: 1) a local one and 2) a main one. The local feedback loop contains a state observer, an equivalent-input-disturbance (EID) estimator, and state feedback. It is used to ensure prompt disturbance suppression. The controller in the main feedback loop contains an internal model to track a reference input. The system is divided into two subsystems for the design of controllers. The state-observer gain is designed for one subsystem using the concept of perfect regulation to ensure disturbance estimation performance. The state-feedback gains of the other subsystem are designed based on a stability condition in the form of a linear matrix inequality (LMI). A tracking specification is embedded in the LMI-based stability condition to ensure satisfactory tracking performance. A case study on a two-finger robot hand control system and a comparison with a Smith-EID and controller approach validate the effectiveness and superiority of the presented method.
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http://dx.doi.org/10.1109/TCYB.2021.3080581DOI Listing
September 2021

[Development of practical liberal courses for students with non-biology majors under the "Double First-class" background].

Sheng Wu Gong Cheng Xue Bao 2021 Aug;37(8):2976-2983

National Demonstration Center for Experimental Biology Education (Zhejiang University), Hangzhou 310058, Zhejiang, China.

Life sciences are the disciplines most closely related with human beings. As experimental disciplines, life sciences develop rapidly and highly intersect in many scientific fields. Under the "double first-class" initiative, the comprehensive development-oriented talent training system has put forward an urgent need for life sciences literacy and comprehensive ability training of college students. Taking the reform of liberal education curriculum system as an opportunity, we developed a series of eight life sciences practical liberal courses for students with non-biology majors. The courses cover all sub-disciplines or directions of life sciences, and aim to foster interdisciplinary talents with life sciences knowledge and literacy, as well as practical and innovative abilities. These courses could serve as references for experimental teaching centers in colleges and universities to set up practical liberal and experimental courses.
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http://dx.doi.org/10.13345/j.cjb.200768DOI Listing
August 2021

Rapid and Sensitive Detection of by an Enhanced Nanobiosensor.

ACS Sens 2021 Sep 2. Epub 2021 Sep 2.

Tianjin Haihe Hospital, Tianjin 300350, PR China.

Tuberculosis (TB) mostly spreads from person to person through (MTB). However, the majority of conventional detection methods for MTB cannot satisfy the requirements for actual TB detection. As one of the most promising powerful platforms, a silicon nanowire field-effect transistor (SiNW-FET) biosensor shows good prospect in TB detection. In this study, an enhanced SiNW-FET biosensor was developed for the rapid and sensitive detection of MTB. The surface functional parameters of the biosensor were explored and optimized. The SiNW-FET biosensor has good sensitivity with a detection limit of 0.01 fg/mL toward protein. The current change value shows a linear upward trend with the increase in protein concentration in the range of 1 fg/mL to 100 μg/mL. One whole test cycle can be accomplished within only 30 s. More importantly, a good distinction was realized in the sputum without pretreatment between normal people and TB patients, which greatly shortened the TB detection time (only 2-5 min, considering the dilution of sputum). Compared with other methods, the SiNW-FET biosensor can detect MTB with a remarkably broad dynamic linear range in a shorter time.
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http://dx.doi.org/10.1021/acssensors.1c01227DOI Listing
September 2021

Nesterenkonia ebinurensis sp. nov., a Novel Actinobacterium Isolated From Populus euphratica.

Curr Microbiol 2021 Oct 1;78(10):3804-3810. Epub 2021 Sep 1.

Zhejiang University College of Life Sciences Hangzhou, Zhejiang, China.

During our studies focused on the microorganism diversity and community structure of Populus euphratica at Ebinur lake wetland nature reserve in Xinjiang Uyghur Autonomous Region, PR China, a Gram-positive, aerobic, short rod-shaped bacterium without flagellum, designated as MD2, was isolated from a piece of resina on Populus euphratica. The isolate grew at temperature of 10-45 °C (optimum 37 °C), pH of 7.0-12.0 (optimum pH 8.0) and NaCl concentration of 1-18% (optimum 3%, w/v). Based on the 16S rRNA gene sequences and the phylogenetic analysis, the strain shared the highest sequence similarities to Nesterenkonia alkaliphila JCM 19766 (96.3%), Nesterenkonia populi KCTC 29119 (95.9%), Nesterenkonia alba CCTCC AB 207011 (95.5%), and was placed within the radiation of Nesterenkonia species in the phylogenetic trees. The draft genome of the isolate was sequenced, which comprised 3,739,891 bp with G + C content of 63 mol%, and was annotated to contain 3614 protein-coding genes, 44 tRNA genes and 5 rRNA genes. Chemotaxonomic analysis indicated that the main respiratory quinones were MK-8 and MK-9, the predominant cellular fatty acids were anteiso-C, anteiso-C and iso-C, the major polar lipids consisted of diphosphatidylglycerol, phosphatidylglycerol andphosphatidylinositol. According to the phenotypic, chemotaxonomic and phylogenetic features, strain MD2 is considered to represent a novel species, for which the name Nesterenkonia ebinurensis sp. nov. is proposed. The type strain is MD2 (= KCTC 52999 = MCCC 1K03343).
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http://dx.doi.org/10.1007/s00284-021-02597-4DOI Listing
October 2021

Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger: A 3 Years' Study During a Epidemic.

Front Pediatr 2021 12;9:621381. Epub 2021 Aug 12.

Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.

In recent years, the incidence of infection in infants and young children has been increasing. Multiple studies have suggested that may be one of the pathogens of bronchiolitis in infants and young children. However, the prevalence and clinic characteristic of in bronchiolitis is controversial. This prospective descriptive study evaluated the prevalence and clinical manifestations of infants and young children hospitalized for bronchiolitis with . Children hospitalized with bronchiolitis were eligible for a prospective study for 36 months from January 1, 2017, to December 31, 2019. Besides , 10 common respiratory viruses and (MP) were confirmed by laboratory tests. Medical records of patients were reviewed for demographic, clinical characteristics, and laboratory examination. A total of 1,092 patients with bronchiolitis were admitted. was detected in 78/1,092 (7.1%) patients. Of the 78 patients with bronchiolitis, coinfections occurred in 45 (57.7%) patients, most frequently with human rhinovirus (28/78, 35.9%), followed by MP (9/78, 11.4%), and human bocavirus (6/78, 7.7%). The peak incidence of infection was in May. A high leukocyte count could help distinguish associated acute bronchiolitis from other acute bronchiolitis etiologies. After excluding coinfections, children with only bronchiolitis exhibited a milder clinical presentation than those with RSV-only infection; also, children with MP-only and other pathogen infections revealed similar severity. The morbidity of was common (31/78, 39.7%) in infants with bronchiolitis under 3 months. In summary, is one of the pathogens in children with bronchiolitis, and coinfection of with other viruses is common in bronchiolitis. should be considered when patients hospitalized with bronchiolitis present a longer course and have an elevated leukocyte count. Patients with associated bronchiolitis present a milder clinical presentation.
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http://dx.doi.org/10.3389/fped.2021.621381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397516PMC
August 2021

Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery.

Biomed Opt Express 2021 Jul 17;12(7):4207-4218. Epub 2021 Jun 17.

Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.
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http://dx.doi.org/10.1364/BOE.430064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367242PMC
July 2021

Breastfeeding in Mothers with COVID-19: Insights from Laboratory Tests and Follow-Up from Early Outbreak of the Pandemic in China.

J Womens Health (Larchmt) 2021 Aug 26. Epub 2021 Aug 26.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The outbreak of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens a surging number of community groups within society, including women actively breastfeeding. Breastfeeding involves intimate behaviors, a major transmission route of SARS-CoV-2, and is integral to the close mother-baby relationship highly correlated with maternal psychological status. Twenty-three pregnant women and puerperae with either confirmed or suspected diagnoses of COVID-19 were enrolled in the study. The clinical characteristics and outcomes of the mothers and neonates were recorded. The presence of SARS-CoV-2, IgG, and IgM in breast milk, maternal blood, and infant blood, together with feeding patterns, was assessed within 1 month after delivery. Feeding patterns and maternal psychological status were also recorded in the second follow-up. No positive detection of SARS-CoV-2 was found in neonates. All breast milk samples were negative for the detection of SARS-CoV-2. The presence of IgM for SARS-CoV-2 in breast milk was correlated with IgM presence in the maternal blood. The results of IgG detection for SARS-CoV-2 were negative in all breast milk samples. All infants were in a healthy condition in two follow-ups, and antibody tests for SARS-CoV-2 were negative. The rate of breast milk feeding increased during two follow-ups. All mothers receiving a second follow-up experienced negative psychological factors and status. Our findings support the feasibility of breastfeeding in women infected with SARS-CoV-2. The additional negative psychological status of mothers due to COVID-19 should also be considered during the puerperium period.
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http://dx.doi.org/10.1089/jwh.2020.8978DOI Listing
August 2021

"Bottom-Up" Assembly of Nanocellulose Microgels as Stabilizer for Pickering Foam Forming.

Biomacromolecules 2021 Sep 25;22(9):3960-3970. Epub 2021 Aug 25.

College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.

Microgels assembled from bio-based nanomaterials are a promising soft stabilizer for a Pickering system. In this study, nanocellulose microgels with foaming properties were constructed by electrostatic assembly between nisin and 2,2,6,6-tetramethyl piperidine-1-oxyl-oxidized cellulose nanocrystals (TOCNC). Pickering wet foam was prepared by using the microgels as a foaming stabilizer. Nanocellulose microgels exhibited better foaming ability and foam stability than TOCNCs. Quartz crystal microbalance with dissipation and transmission electron microscopy analyses confirmed that the nanocellulose microgels prepared under different nisin concentrations demonstrated significant differences in morphology, conformation, and structural strength. Microgel particles prepared at 0.03 and 0.06 wt % nisin concentrations had a unique dendritic microstructure. Microgels containing 0.06 wt % nisin displayed better foaming ability and foam stability. It was possible that the soft dendritic structure of the microgels could endow bubbles with sufficient thickness and strength to prevent coalescence. This novelty nanocellulose microgel is expected to be used for expanding the application of nanocellulose in the functional interfacial design of Pickering foams.
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http://dx.doi.org/10.1021/acs.biomac.1c00766DOI Listing
September 2021

"Glu/GABA-Gln" metabolic loop abnormalities in iminodipropionitrile (IDPN)-induced dyskinetic syndrome.

Neurol Sci 2021 Aug 25. Epub 2021 Aug 25.

Xin Hua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People's Republic of China.

Objective: Iminodipropionitrile (IDPN)-induced dyskinetic syndrome is characterized by abnormal repetitive involuntary movements with abnormalities in the neuro-transmission. This study explored the mechanism of glutamate (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic circuit in rat dyskinetic syndrome and the possible regulation mechanism of "tiapride (Tia)."

Methods: Male Wistar rats were assigned to the control group, dyskinetic syndrome group, and Tia group. Dyskinetic syndrome was induced by injecting with 3,3'-iminodipropionitrile for 7 days. Tia group was treated with tiapride, while the control and dyskinetic syndrome groups were gavaged with saline. Eventually the Glu, GABA, and Gln concentrations in striatum were detected using UPLC-3QMS, additionally another amino acid neurotransmitters (aspartate, glycine) were also detected. Expressions of glutamine synthetase (GS), glutamate transporter (EAAT), glutamate decarboxylase (GAD65/67), and γ-aminobutyric acid transporter protein (GAD-T) were observed using Western blot and real-time polymerase chain reaction.

Results: The behavior test scores of dyskinetic syndrome group were increased compared with the control group. Tia group decreased the behavior test scores compared with dyskinetic syndrome group. For amino acid neuro-transmission, dyskinetic syndrome group increased Glu level (p < 0.01), decreased GABA level (p < 0.01), increased Glu/GABA ratio (p < 0.01), and decreased Asp level (p < 0.01) compared with control group. Tia group decreased Glu level (p < 0.01), increased GABA level (p < 0.01), decreased Glu/GABA ratio (p < 0.01), and increased Asp level (p < 0.05) compared with dyskinetic syndrome group. For Glu/GABA-Gln circuit, the protein and mRNA expression of GS and EAAT in dyskinetic syndrome group were decreased (p < 0.05). Tia group increased protein and mRNA expression level of GS (p < 0.05) and EAAT (p < 0.01).

Conclusion: The rat dyskinetic syndrome has Glu/GABA-Gln abnormalities. "Tiapride" upregulated the protein expression of GS and EAAT, reduce Glu levels, increase γ-GABA levels, and eventually improve amino acid neurotransmitter imbalance.
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http://dx.doi.org/10.1007/s10072-021-05570-yDOI Listing
August 2021

Application of artificial intelligence in gastrointestinal disease: a narrative review.

Ann Transl Med 2021 Jul;9(14):1188

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.

Objective: We collected evidence on the application of artificial intelligence (AI) in gastroenterology field. The review was carried out from two aspects of endoscopic types and gastrointestinal diseases, and briefly summarized the challenges and future directions in this field.

Background: Due to the advancement of computational power and a surge of available data, a solid foundation has been laid for the growth of AI. Specifically, varied machine learning (ML) techniques have been emerging in endoscopic image analysis. To improve the accuracy and efficiency of clinicians, AI has been widely applied to gastrointestinal endoscopy.

Methods: PubMed electronic database was searched using the keywords containing "AI", "ML", "deep learning (DL)", "convolution neural network", "endoscopy (such as white light endoscopy (WLE), narrow band imaging (NBI) endoscopy, magnifying endoscopy with narrow band imaging (ME-NBI), chromoendoscopy, endocytoscopy (EC), and capsule endoscopy (CE))". Search results were assessed for relevance and then used for detailed discussion.

Conclusions: This review described the basic knowledge of AI, ML, and DL, and summarizes the application of AI in various endoscopes and gastrointestinal diseases. Finally, the challenges and directions of AI in clinical application were discussed. At present, the application of AI has solved some clinical problems, but more still needs to be done.
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http://dx.doi.org/10.21037/atm-21-3001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350704PMC
July 2021

Effect and quality of couple-based interventions of middle-aged and older adults with type 2 diabetes mellitus: a scoping review.

Fam Pract 2021 Aug 23. Epub 2021 Aug 23.

Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.

Background: Studies have shown the existence of health concordance between patients with type 2 diabetes mellitus (T2DM) and their spouses, and also that spouses could influence the effect of self-management, benefiting patients' health. However, these studies are heterogeneous and the evidence is inconclusive.

Objective: To synthesize evidence from published randomized controlled trials: the interventional effects and the quality of study performance, also to identify the research gap and the directions for future studies.

Methods: We performed the scoping review by following the PRISMA-ScR guidance. We searched and examined the reports from MEDLINE, EMBASE, PsychInfo, CINAHL Plus by the pre-specified criteria. Key characteristics and information of eligible reports were extracted, analysed and synthesized comprehensively, and the results were presented in the form of words and diagrams.

Results: We identified 5 reports from 4 studies out of 3479 records included. Qualified studies indicated a positive effect of couple-based interventions on couples' distress. Insufficient evidence on physiological health or health behaviours was identified owing to the small number of included studies and inconsistent assessment outcomes. The methodological quality across these studies was generally low due to inadequate reporting of study process and substantial biases.

Conclusions: Couple-based interventions for patients with T2DM showed small effects on the couple's distress while the effects of other outcomes were inconclusive. Future studies should strengthen methodologies by using standard measures of core diabetic outcomes, including detailed assessments of implementation process, and taking a dyadic approach to systematically examine the effects.
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http://dx.doi.org/10.1093/fampra/cmab093DOI Listing
August 2021

Heterogeneous graph attention networks for drug virus association prediction.

Methods 2021 Aug 20. Epub 2021 Aug 20.

Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), 138632, Singapore. Electronic address:

Coronavirus Disease-19 (COVID-19) has lead global epidemics with high morbidity and mortality. However, there are currently no proven effective drugs targeting COVID-19. Identifying drug-virus associations can not only provide insights into the understanding of drug-virus interaction mechanism, but also guide and facilitate the screening of compound candidates for antiviral drug discovery. Since conventional experiment methods are time-consuming, laborious and expensive, computational methods to identify potential drug candidates for viruses (e.g., COVID-19) provide an alternative strategy. In this work, we propose a novel framework of Heterogeneous Graph Attention Networks for Drug-Virus Association predictions, named HGATDVA. First, we fully incorporate multiple sources of biomedical data, e.g., drug chemical information, virus genome sequences and viral protein sequences, to construct abundant features for drugs and viruses. Second, we construct two drug-virus heterogeneous graphs. For each graph, we design a self-enhanced graph attention network (SGAT) to explicitly model the dependency between a node and its local neighbors and derive the graph-specific representations for nodes. Third, we further develop a neural network architecture with tri-aggregator to aggregate the graph-specific representations to generate the final node representations. Extensive experiments were conducted on two datasets, i.e., DrugVirus and MDAD, and the results demonstrated that our model outperformed 7 state-of-the-art methods. Case study on SARS-CoV-2 validated the effectiveness of our model in identifying potential drugs for viruses.
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http://dx.doi.org/10.1016/j.ymeth.2021.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376526PMC
August 2021

Treating unstable angina with detoxifying and blood-activating formulae: A randomized controlled trial.

J Ethnopharmacol 2021 Aug 17;281:114530. Epub 2021 Aug 17.

Department of Cardiovascular, Beijing Longfu Hospital, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Detoxifying and blood-activating Chinese medicine granule formula, which includes 15 g of Polygonum cuspidatum Sieb. et Zucc. (Polygonum cuspidatum) and 10 g of Crataegus pinnatifida Bunge (Hawthorn), can relieve the symptoms and serve as supplementary treatment for unstable angina.

Aim Of The Study: This study aimed to explore the role of detoxifying and blood-activating formulae in the treatment of unstable angina and the potential mechanism involved.

Materials And Methods: A total of 144 participants with unstable angina were randomly divided into experimental and control groups. Both groups were treated with standardized Western medicine; the experimental group was additionally treated with detoxifying and blood-activating Chinese medicine granules, which included 15 g of P. cuspidatum and 10 g of C. pinnatifida for 4 weeks. The primary endpoint was the frequency of weekly angina pectoris attacks before and after treatment. The secondary endpoints, also observed before and after treatment, included blood glucose, blood lipids, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10, and adiponectin levels, as well as the ratio of pro/anti-inflammatory factors and evaluation scales of symptoms and syndromes in Chinese and Western medicine.

Results: In both experimental and control groups, the frequency of weekly angina pectoris attacks was lower after treatment (P < 0.01), but with no significant intergroup difference (P = 0.10). After intervention, the hs-CRP, TNF-α, and IL-6 levels decreased, while the IL-10 and adiponectin levels significantly increased in the experimental group (P < 0.05 or 0.01). The ratios of the inflammatory factors significantly decreased after treatment, particularly in the experimental group (P < 0.01). Symptoms and syndromes were also ameliorated in the experimental group (P < 0.01), showing a significant difference from the control group (P < 0.01).

Conclusions: Detoxifying and blood-activating formulae can reduce the frequency and relieve symptoms of unstable angina, and this mechanism may be related to a regulation of the balance of pro- and anti-inflammatory factors.
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http://dx.doi.org/10.1016/j.jep.2021.114530DOI Listing
August 2021
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