Publications by authors named "Min Liu"

3,825 Publications

  • Page 1 of 1

Analysis of Clinical Features and Related Factors of Silent Aspiration in Hospitalized COPD Patients.

Altern Ther Health Med 2022 Aug 5. Epub 2022 Aug 5.

Context: Silent aspiration is a common complication of chronic obstructive pulmonary disease (COPD). COPD's acute-exacerbation phase may be associated with silent aspiration, impacting a patient's prognosis. Silent aspiration may be more likely to occur in patients in poor basic physical condition.

Objective: The study intended to explore the clinical features and other factors related to silent aspiration in patients hospitalized with COPD.

Design: The research team designed a retrospective study using data from medical records of patient's hospitalized with COPD.

Setting: The study took place at the Sixth Hospital of Wuhan at the Affiliated Hospital of Jianghan University in Wuhan, China.

Participants: Participants were 49 patients with acutely aggravated COPD who had been hospitalized between January 2019 and December 2019 at the hospital.

Intervention: Participants had all received a radionuclide salivary test at the hospital in the past for silent aspiration. Based on the test results, 15 patients were included in the positive group, and 34 patients were included in the negative group.

Outcome Measures: The study compared the two groups': (1) clinical features- respiratory difficulty on the modified Medical Research Council (mMRC) scale, rate of concomitant pneumonia, number of prior admissions to the intensive care unit (ICU), number of acute exacerbations within the year preceding the study, and proportion of patients with two or more acute exacerbations within the year preceding the study; (2) lung function-forced expiratory volume (FEV1), (FEV1%pre), and FEV1/ forced vital capacity (FVC %); (3) blood gases-partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2); and (4) laboratory parameters-white blood cell (WBC) counts, C-reactive protein (CRP), procalcitonin (PCT), and percentage of neutrophils. The research team used univariate and multivariate, logistic regression analysis to identify risk factors for silent aspiration in hospitalized COPD patients. All participants were followed for a mean duration of 18.98 ± 3.09 months, with a range 12 to 24 months.

Results: No patients died during the follow-up. No statistically significant differences existed between the groups in age, gender, course of illness, or other clinical variables (P > .05). The positive group had significantly lower scores on the mMRC than did the negative group. Some of the positive group's results were significantly higher than those of the negative group: (1) rate of concomitant pneumonia, (2) number of prior admissions to the ICU, (3) number of acute exacerbations within the year preceding the study, and (4) proportion of patients with two or more acute exacerbations within the year preceding the study (P < .05). No statistical differences existed between the groups in the FEV1, PaO2), PaCO2, WBCs, or percentage of neutrophils (P > .05). The FEV1%pre and FEV1/FVC%) were significantly lower and the CRP and PCT levels were significantly higher in the positive group than in the negative group (P < .05).

Conclusion: The mMRC scores, concomitant pneumonia, and prior admission to the ICU were risk factors for silent aspiration in hospitalized COPD patients. Hospital staff should pay more attention to patients with those risk factors during hospitalizations.
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August 2022

Analysis of the Influence of Serum MMP-2 and vWF Levels on the Predictive Value of Risk Grade and Prognosis of Patients with Acute Myeloid Leukemia.

Contrast Media Mol Imaging 2022 19;2022:1865189. Epub 2022 Jul 19.

Clinical Laboratory, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832003, China.

The expression of serum MMP-2 and von Willebrand factor (vWF) in patients with acute myeloid leukemia (AML) at different risks and their predictive value and prognostic impact were investigated. A total of 105 AML patients admitted to our hospital from February 2020 to February 2022 are divided into group A (32 cases), group B (46 cases), and group C (27 cases) according to risk stratification from low to high. The patients in the three groups are treated with induction chemotherapy according to the risk grade, and the expression of serum matrix metalloproteinase-2 (MMP-2) and vWF antigen in the three groups are detected before and after treatment. Pearson correlation is used to analyze the correlation between MMP-2 and vWF expression and prognosis of AML patients. ROC curve is used to analyze the predictive value of MMP-2 and vWF expression for risk grading of AML patients. MMP-2 and vWF are highly expressed in middle and high-risk patients, had high predictive value for the risk grade of AML patients, and are correlated with the prognosis of AML patients to a certain extent.
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http://dx.doi.org/10.1155/2022/1865189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325568PMC
August 2022

Evaluation of effect of robotic versus laparoscopic surgical technology on genitourinary function after total mesorectal excision for rectal cancer.

Int J Surg 2022 Aug 4:106800. Epub 2022 Aug 4.

Department of General Surgery, Third Xiangya Hospital, Central South University, 138 Tongzipo Street, Changsha, Hunan, People's Republic of China. Electronic address:

Objective: Because the recovery of genitourinary function after total mesorectal excision (TME) is affected by multiple factors, the role of robot-assisted TME technology in postoperative function in previous studies is still controversial. Our study aimed to evaluate the impact of robotic technology on the recovery of genitourinary function after TME for rectal cancer by analysing the correlations between influencing factors of genitourinary function and robotic surgery.

Methods: Between January 2017 and January 2020, patients with rectal cancer (cT1-3NxM0) were registered. Genitourinary function was assessed by the International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF) test, Female Sexual Function Index (FSFI) and urodynamic examination before surgery and 1, 3, 6, and 12 months postoperatively. Genitourinary function was compared between the laparoscopic total mesorectal excision(L-TME) and robotic total mesorectal excision(R-TME) groups, and the correlative factors associated with postoperative genitourinary function were analysed using the generalized estimated equation (GEE).

Results: Compared with L-TME, R-TME showed a superior IPSS, voiding volume, residual urine volume and IIEF score during the early postoperative period. According to the GEE analysis, postoperative genitourinary function was positively correlated with laparoscopic anterior resection/abdomen perineal resection(LAR/APR) but negatively correlated with tumour size, tumour distance to anus, TNM, adjuvant chemotherapy, adjuvant radiotherapy, complete TME, circumferential resection margin(CRM), blood loss, diverting stoma, conversion, and anastomotic leakage.

Conclusion: Due to the important role of robotic surgical technology on the influential factors of postoperative genitourinary function and the superiority of identifying and preserving autonomic nerves, robotic technology is conducive to the early recovery of postoperative urogenital function while adhering to oncological dissection principles. No significant difference was found between the da Vinci R-TME and MicroHand R-TME groups.
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http://dx.doi.org/10.1016/j.ijsu.2022.106800DOI Listing
August 2022

[The Tertiary Hospital's Medical Materials Supply in the Prevention of Public Health Emergencies].

Zhongguo Yi Liao Qi Xie Za Zhi 2022 Jul;46(4):469-472

Northern Jiangsu People's Hospital, Yangzhou, 225001.

Objective: To ensure the supply of prevention materials in the tertiary public hospitals in prefecturelevel cities, and to make the process of allocating prevention materials more scientific and reasonable.

Methods: Open the green passage, simplify the procurement process, carry out emergency procurement of related materials, ensure timely delivery of prevention materials, distribute them at different levels, and strengthen the warehouse management of prevention materials.

Results: The scheme of emergancy supplies was constantly improved, and the supply of prevention materials was completed with good quality.

Conclusions: Using scientific and efficient management methods, the supply of prevention materials in medical institutions has been guaranteed, which has experience and reference significance for the prevention and control of similar public health emergencies in the future.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2022.04.024DOI Listing
July 2022

Development of a series of flurbiprofen and zaltoprofen platinum(IV) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA.

Dalton Trans 2022 Aug 4. Epub 2022 Aug 4.

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P.R. China.

To develop new anti-metastasis chemotherapeutic drugs, a series of flurbiprofen (FLP) and zaltoprofen (ZTP) platinum(IV) complexes targeting COX-2, PD-L1 and DNA was prepared and investigated. Complex 2 with dual FLP ligands displays promising antitumor activities and exhibits much potential in overcoming drug resistance. More importantly, the antitumor evaluation demonstrates that complex 2 possesses promising inhibition of cancer growth and metastasis simultaneously. Further investigation of the mechanism revealed the multi-specific antitumor function of complex 2. It exerts remarkable DNA damage after reduction to platinum(II) complex, and up-regulates the expression of p53 and γ-H2AX. Then, complex 2 promotes mitochondria-mediated apoptosis effectively by activating the Bcl-2/Bax/caspase3 pathway. Furthermore, inflammation in tumor tissues is restrained by the suppression of enzymes COX-2, MMP-9, NLRP3 and caspase1, which would favor the inhibition of tumor metastasis. Moreover, compound 2 boosts T-cell immunity by restraining PD-L1 expression, and further improving the density of CD3 and CD8 T cells in tumor tissues.
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http://dx.doi.org/10.1039/d2dt00944gDOI Listing
August 2022

Oxalate-induced apoptosis through ERS-ROS-NF-κB signalling pathway in renal tubular epithelial cell.

Mol Med 2022 Aug 3;28(1):88. Epub 2022 Aug 3.

Department of Urology, Changhai Hospital of Shanghai, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, China.

Background: Kidney stones are composed of approximately 70-80% calcium oxalate. However, the exact mechanism of formation of calcium oxalate kidney stones remains unclear. In this study, we investigated the roles of endoplasmic reticulum stress (ERS), reactive oxygen species (ROS), and the NF-κB signalling pathway in the pathogenesis of oxalate-induced renal tubular epithelial cell injury and its possible molecular mechanisms.

Methods: We established a model to evaluate the formation of kidney stones by intraperitoneal injection of glyoxylic acid solution into mice and assessed cell morphology, apoptosis, and the expression levels of ERS, ROS, and NF-κB signalling pathway-related proteins in mouse renal tissues. Next, we treated HK-2 cells with potassium oxalate to construct a renal tubular epithelial cell injury model. We detected the changes in autophagy, apoptosis, and mitochondrial membrane potential and investigated the ultrastructure of the cells by transmission electron microscopy. Western blotting revealed the expression levels of apoptosis and autophagy proteins; mitochondrial structural and functional proteins; and ERS, ROS, and NF-κB (p65) proteins. Lastly, we studied the downregulation of NF-κB activity in HK-2 cells by lentivirus interference and confirmed the interaction between the NF-κB signalling and ERS/ROS pathways.

Results: We observed swelling of renal tissues, increased apoptosis of renal tubular epithelial cells, and activation of the ERS, ROS, and NF-κB signalling pathways in the oxalate group. We found that oxalate induced autophagy, apoptosis, and mitochondrial damage in HK-2 cells and activated the ERS/ROS/NF-κB pathways. Interestingly, when the NF-κB signalling pathway was inhibited, the ERS/ROS pathway was also inhibited.

Conclusion: Oxalate induces HK-2 cell injury through the interaction between the NF-κB signalling and ERS/ROS pathways.
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http://dx.doi.org/10.1186/s10020-022-00494-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347104PMC
August 2022

Identification of the Highly Active Co-N Coordination Motif for Selective Oxygen Reduction to Hydrogen Peroxide.

J Am Chem Soc 2022 Aug 3. Epub 2022 Aug 3.

Hunan Joint International Research Center for Carbon Dioxide Resource Utilization, State Key Laboratory of Powder Metallurgy, School of Physical and Electronics, Central South University, 410083 Changsha, China.

Electrosynthesis of hydrogen peroxide (HO) through oxygen reduction reaction (ORR) is an environment-friendly and sustainable route for obtaining a fundamental product in the chemical industry. Co-N single-atom catalysts (SAC) have sparkled attention for being highly active in both 2e ORR, leading to HO and 4e ORR, in which HO is the main product. However, there is still a lack of fundamental insights into the structure-function relationship between CoN and the ORR mechanism over this family of catalysts. Here, by combining theoretical simulation and experiments, we unveil that pyrrole-type CoN (Co-N SAC) is mainly responsible for the 2e ORR, while pyridine-type CoN catalyzes the 4e ORR. Indeed, Co-N SAC exhibits a remarkable HO selectivity of 94% and a superb HO yield of 2032 mg for 90 h in a flow cell, outperforming most reported catalysts in acid media. Theoretical analysis and experimental investigations confirm that Co-N SAC─with weakening O/HOO* interaction─boosts the HO production.
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http://dx.doi.org/10.1021/jacs.2c01194DOI Listing
August 2022

Clinical and imaging risk factors for the persistence of thromboembolism following acute pulmonary embolism.

Quant Imaging Med Surg 2022 Aug;12(8):4047-4058

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.

Background: Predicting the progression of acute pulmonary embolism to chronic pulmonary thromboembolism (CPTE) disease is essential to monitoring and improving the long-term prognosis of pulmonary embolism. We explored the risk factors for chronic persistence of thromboembolism after acute pulmonary embolism.

Methods: Cases with newly onset acute pulmonary embolism in the China-Japan Friendship Hospital from November 2016 to November 2019 were retrospectively analyzed. The clinical characteristics, serological examination results, and treatment strategies of acute pulmonary embolism patients were obtained through the electronic medical record system (Goodwill E-Health Info Co., Ltd.). Imaging parameters on computed tomography pulmonary angiography (CTPA) images at the onset of the acute pulmonary embolism were measured and counted. Notably, we propose a new parameter based on CTPA images: the ratio of S (sum of residual segmental pulmonary artery diameter) to MPA (the main pulmonary artery diameter) (S/MPA). After 3 months of regular treatment for acute pulmonary embolism, patients were classified into a CPTE group or a non-CPTE group based on the presence of residual embolus. All data were compared between the CPTE group and non-CPTE group. Furthermore, logistic regression analysis was used to investigate risk factors for the progression of acute pulmonary embolism to CPTE.

Results: A total of 77 cases (male:female = 1:1.26) were included in the study. There were 43 cases (55.84%) in the CPTE group and 34 cases in the non-CPTE group (44.16%). The results of univariate analysis showed that there were statistically significant differences between the 2 groups in risk stratification (χ=8.043; P=0.005), protein S activity (χ=5.551; P=0.018), the ratio of sum of residual segmental pulmonary artery diameter to the main pulmonary artery diameter (S/MPA; t=-2.103; P=0.039), Mastora score (U=362.500; P<0.001), and embolus location (χ=16.969; P<0.001). However, there were no statistically significant differences between the 2 groups in treatment options (P=0.381). According to multivariate logistic-regression analysis, protein S activity <55% (P=0.025), S/MPA ≥1.97 (P=0.011), and an embolus being located in the central pulmonary artery (P<0.001) were independent risk factors for chronic persistence of thromboembolism following acute pulmonary embolism.

Conclusions: The protein S activity, location of the embolus, and S/MPA on CTPA at the onset of acute pulmonary embolism may suggest the progression of acute pulmonary embolism to CPTE.
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http://dx.doi.org/10.21037/qims-21-753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338360PMC
August 2022

Three-dimensional ultrashort echo time magnetic resonance imaging in assessment of idiopathic pulmonary fibrosis, in comparison with high-resolution computed tomography.

Quant Imaging Med Surg 2022 Aug;12(8):4176-4189

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China.

Background: We aimed to evaluate the image quality, feasibility, and diagnostic performance of three-dimensional ultrashort echo time magnetic resonance imaging (3D UTE-MRI) to assess idiopathic pulmonary fibrosis (IPF) compared with high-resolution computed tomography (HRCT) and half-Fourier single-shot turbo spin-echo (HASTE) MRI.

Methods: A total of 36 patients with IPF (34 men; mean age: 62±8 years, age range: 43 to 78 years) were prospectively included and underwent HRCT and chest MRI on the same day. Chest MRI was performed with a free-breathing 3D spiral UTE pulse sequence and HASTE sequence on a 1.5 T MRI. Two radiologists independently evaluated the image quality of the HRCT, HASTE, and 3D UTE-MRI. They assessed the representative imaging features of IPF, including honeycombing, reticulation, traction bronchiectasis, and ground-glass opacities. Image quality of the 3D UTE-MRI, HASTE, and HRCT were assessed using a 5-point visual scoring method. Kappa and weighted kappa analysis were used to measure intra- and inter-observer and inter-method agreements. Sensitivity (SE), specificity (SP), and accuracy (AC) were used to assess the performance of 3D UTE-MRI for detecting image features of IPF and monitoring the extent of pulmonary fibrosis. Linear regressions and Bland-Altman plots were generated to assess the correlation and agreement between the assessment of the extent of pulmonary fibrosis made by the 2 observers.

Results: The image quality of HRCT was higher than that of HASTE and UTE-MRI (HRCT UTE-MRI HASTE: 4.9±0.3 4.1±0.7 3.0±0.3; P<0.001). Interobserver agreement of HRCT, HASTE, and 3D UTE-MRI when assessing pulmonary fibrosis was substantial and excellent (HRCT: 0.727≤ κ ≤1, P<0.001; HASTE: 0.654≤ κ ≤1, P<0.001; 3D UTE-MRI: 0.719≤ κ ≤0.824, P<0.001). In addition, reticulation (SE: 97.1%; SP: 100%; AC: 97.2%; κ =0.654), honeycombing (SE: 83.3%; SP: 100%; AC: 86.1%; κ =0.625) patterns, and traction bronchiectasis (SE: 94.1%; SP: 100%; AC: 94.4%, κ =0.640) were also well-visualized on 3D UTE-MRI, which was significantly superior to HASTE. Compared with HRCT, the sensitivity of 3D UTE-MRI to detect signs of pulmonary fibrosis (n=35) was 97.2%. The interobserver agreement in elevation of the extent of pulmonary fibrosis with HRCT and 3D UTE-MRI was R=0.84 (P<0.001) and R=0.84 (P<0.001), respectively. The extent of pulmonary fibrosis assessed with 3D UTE-MRI [median =9, interquartile range (IQR): 6.25 to 10.00] was lower than that from HRCT (median =12, IQR: 9.25 to 13.00; U=320.00, P<0.001); however, they had a positive correlation (R=0.72, P<0.001).

Conclusions: As a radiation-free non-contrast enhanced imaging method, although the image quality of 3D UTE-MRI is inferior to that of HRCT, it has high reproducibility to identify the imaging features of IPF and evaluate the extent of pulmonary fibrosis.
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http://dx.doi.org/10.21037/qims-21-1133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338383PMC
August 2022

TUBright: A Peptide Probe for Imaging Microtubules.

Anal Chem 2022 Aug 2. Epub 2022 Aug 2.

Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan 250014, China.

assays using reconstituted microtubules have provided molecular insights into the principles of microtubule dynamics and the roles of microtubule-associated proteins. Emerging questions that further uncover the complexity in microtubule dynamics, especially those on tubulin isotypes and post-translational modifications, raise new technical challenges on how to visualize microtubules composed of tubulin purified from limited sources, primarily due to the low efficiency of the conventional tubulin labeling protocol. Here, we develop a peptide probe, termed TUBright, that labels reconstituted microtubules. TUBright, when coupled with different fluorescent dyes, provides flexible labeling of microtubules with a high signal-to-noise ratio. TUBright does not interfere with the dynamic behaviors of microtubules and microtubule-associated proteins. Therefore, TUBright is a useful tool for imaging microtubules, making it feasible to use tubulin from limited sources for answering many open questions on microtubule dynamics.
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http://dx.doi.org/10.1021/acs.analchem.2c01285DOI Listing
August 2022

Epidemiological characteristics of all-cause mortality reviewing out-hospital death under the clouds of COVID-19.

Chin Med J (Engl) 2022 Aug 2. Epub 2022 Aug 2.

Department of Forensic Pathology, West China School of Basic Medical Sciences and Forensic Science, Sichuan University, Chengdu, Sichuan 610041, China.

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http://dx.doi.org/10.1097/CM9.0000000000002146DOI Listing
August 2022

Plasmonic Ag-decorated CuO nanowires for boosting photoelectrochemical CO reduction to multi-carbon products.

Chem Commun (Camb) 2022 Aug 2. Epub 2022 Aug 2.

School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.

The generation of multi-carbon products on the CuO photocathode remains a great challenge. Herein, effective charge separation and surface catalytic reaction are achieved for photoelectrochemical CO reduction through plasmon metal (Ag) decoration on CuO nanowires. The CuO/Ag composite photocathode achieves a 47.7% faradaic efficiency for CHCOOH and the generation rate is 212.7 μmol cm h under illumination, which is about five times that in dark (44.4 μmol cm h) at -0.7 V RHE.
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http://dx.doi.org/10.1039/d2cc03167aDOI Listing
August 2022

Ordered Ag Nanoneedle Arrays with Enhanced Electrocatalytic CO Reduction via Structure-Induced Inhibition of Hydrogen Evolution.

Nano Lett 2022 Aug 1;22(15):6276-6284. Epub 2022 Aug 1.

Hunan Joint International Research Center for Carbon Dioxide Resource Utilization, School of Physics and Electronics, Central South University, Changsha 410083, People's Republic of China.

Silver is an attractive catalyst for converting CO into CO. However, the high CO activation barrier and the hydrogen evolution side reaction seriously limit its practical application and industrial perspective. Here, an ordered Ag nanoneedle array (Ag-NNAs) was prepared by template-assisted vacuum thermal-evaporation for CO electroreduction into CO. The nanoneedle array structure induces a strong local electric field at the tips, which not only reduces the activation barrier for CO electroreduction but also increases the energy barrier for the hydrogen evolution reaction (HER). Moreover, the array structure endows a high surface hydrophobicity, which can regulate the adsorption of water molecules at the interface and thus dynamically inhibit the competitive HER. As a result, the optimal Ag-NNAs exhibits 91.4% Faradaic efficiency (FE) of CO for over 700 min at -1.0 V RHE. This work provides a new concept for the application of nanoneedle array structures in electrocatalytic CO reduction reactions.
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http://dx.doi.org/10.1021/acs.nanolett.2c01853DOI Listing
August 2022

Predicting Grade of Esophageal Squamous Carcinoma: Can Stretched Exponential Model-Based DWI Perform Better Than Bi-Exponential and Mono-Exponential Model?

Front Oncol 2022 14;12:904625. Epub 2022 Jul 14.

Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.

Background: To evaluate and compare the potential performance of various diffusion parameters obtained from mono-exponential model (MEM)-, bi-exponential model (BEM)-, and stretched exponential model (SEM)-based diffusion-weighted imaging (DWI) in grading of esophageal squamous carcinoma (ESC).

Methods: Eighty-two patients with pathologically confirmed ESC without treatment underwent multi-b-value DWI scan with 13 b values (0~12,00 s/mm). The apparent diffusion coefficient (ADC) deriving from the MEM; the pure molecular diffusion (ADC), pseudo-diffusion coefficient (ADC), perfusion, and fraction (f) deriving from the BEM; and the distributed diffusion coefficient (DDC) and water molecular diffusion heterogeneity index (α) deriving from the SEM were calculated and compared between poorly differentiated and well/moderately differentiated ESC, respectively. The prediction parameters and diagnostic efficiency were compared by drawing receiver operating characteristic (ROC) curves.

Results: The ADC, ADC, ADC, and DDC in poorly ESC were significantly lower than those in well/moderately differentiated ones. By using only one parameter, ADC, DDC had the moderate diagnostic efficiency and the areas under the curve (AUC) were 0.758 and 0.813 in differentiating ESC. The DDC had the maximum AUC with sensitivity (88.00%) and specificity (68.42%). Combining ADC with ADC, ADC, and DDC and combining ADC with ADC can provide a higher diagnostic accuracy with AUC ranging from 0.756, 0.771, 0.816, and 0.793, respectively.

Conclusion: Various parameters derived from different DWI models including MEM, BEM, and SEM were potentially helpful in grading ESC. DDC obtained from SEM was the most promising diffusion parameter for predicting the grade of ESC.
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http://dx.doi.org/10.3389/fonc.2022.904625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329622PMC
July 2022

Effects of High-Fat Diet During Childhood on Precocious Puberty and Gut Microbiota in Mice.

Front Microbiol 2022 14;13:930747. Epub 2022 Jul 14.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Precocious puberty mostly stems from endocrine disorders. However, more and more studies show that a high-fat diet (HFD) is closely related to precocious puberty, but its mechanism is unknown. Since gut microbiota is associated with hormone secretion and obesity, it inspires us to detect the mechanism of gut microbiota in triggering precocious puberty. The model of precocious puberty was established by feeding female mice with an HFD from 21 days old. After puberty, the serum hormone levels, gut microbiome sequencing, and metabolomics were collected. DNA was extracted from feces, and the V3-V4 region of the bacterial 16S rRNA gene was amplified, followed by microbial composition analysis. Subsequently, associations between precocious puberty and the microbiota were determined. We found that (1) HFD after weaning caused precocious puberty, increased serum estradiol, leptin, deoxycholic acid (DCA), and gonadotropin-releasing hormone (GnRH) in the hypothalamus; (2) Through correlation analysis, we found that GnRH was positively correlated with , and , suggesting that these bacteria may have a role in promoting sexual development. (3) "HFD-microbiota" transplantation promoted the precocious puberty of mice. (4) Estrogen changes the composition and proportion of gut microbiota and promotes precocious puberty. Therefore, the effect of HFD on precocious puberty is regulated by the interaction of gut microbiota and hormones.
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http://dx.doi.org/10.3389/fmicb.2022.930747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329965PMC
July 2022

A Review of Pharmaceutical Robot based on Hyperspectral Technology.

J Intell Robot Syst 2022 22;105(4):75. Epub 2022 Jul 22.

National Engineering Laboratory of Robot Visual Perception and Control Technology, Hunan University, Changsha, 410082 Hunan People's Republic of China.

The quality and safety of medicinal products are related to patients' lives and health. Therefore, quality inspection takes a key role in the pharmaceutical industry. Most of the previous solutions are based on machine vision, however, their performance is limited by the RGB sensor. The pharmaceutical visual inspection robot combined with hyperspectral imaging technology is becoming a new trend in the high-end medical quality inspection process since the hyperspectral data can provide spectral information with spatial knowledge. Yet, there is no comprehensive review about hyperspectral imaging-based medicinal products inspection. This paper focuses on the pivotal pharmaceutical applications, including counterfeit drugs detection, active component analysis of tables, and quality testing of herbal medicines and other medical materials. We discuss the technology and hardware of Raman spectroscopy and hyperspectral imaging, firstly. Furthermore, we review these technologies in pharmaceutical scenarios. Finally, the development tendency and prospect of hyperspectral imaging technology-based robots in the field of pharmaceutical quality inspection is summarized.
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http://dx.doi.org/10.1007/s10846-022-01602-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306415PMC
July 2022

The potential performance of serum albumin to globulin ratio, albumin and globulin in the diagnosis of periprosthetic joint infection and prediction of reinfection following reimplantation.

BMC Musculoskelet Disord 2022 Jul 30;23(1):730. Epub 2022 Jul 30.

Department of Orthopaedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, District Baiyun, Guangzhou, 510405, Guangdong, China.

Background: This study was conducted to evaluate the performance of serum albumin (ALB), globulin (GLO), and albumin to globulin ratio (AGR) in the diagnosis of PJI and prediction of reinfection following reimplantation in PJI patients who underwent two-stage revision.

Methods: We perform a retrospective data collection on identified patients who underwent revision arthroplasties in our institution from January 2010 to January 2020. A total of 241 patients were stratified into: group A (PJI), group B (aseptic loosening). Fifty-five patients who underwent two-stage revision in group A were assigned to group C. Group C was stratified into subgroup 1 (reinfection) and subgroup 2 (non-reinfection). Receiver operating characteristic curves were used to evaluate the utility of serum markers for diagnosing PJI and predicting reinfection following reimplantation.

Results: In the diagnosis of PJI, there were significant differences in the levels of ALB, GLO, and AGR between groups A and group B (P < 0.05). The AUC value of serum AGR (0.851) was similar to ESR (0.841) and CRP (0.866) (all p > 0.05). The AUC values of serum ALB and GLO were 0.757 and 0.753, respectively. As for predicting reinfection following reimplantation, the serum ALB in the non-reinfection group was higher than that in the reinfection group (p = 0.041). The AUC value of serum ALB was 0.7.

Conclusion: AGR was promising adjunct marker for the diagnosis of PJI, similar to CRP and ESR. ALB and GLO have an acceptable value for the diagnosis of PJI. ALB may be expected to be a kind of effective marker for predicting reinfection following reimplantation.
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http://dx.doi.org/10.1186/s12891-022-05533-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338558PMC
July 2022

Design and Analysis of a Novel Distributed Gradient Neural Network for Solving Consensus Problems in a Predefined Time.

IEEE Trans Neural Netw Learn Syst 2022 Jul 29;PP. Epub 2022 Jul 29.

In this article, a novel distributed gradient neural network (DGNN) with predefined-time convergence (PTC) is proposed to solve consensus problems widely existing in multiagent systems (MASs). Compared with previous gradient neural networks (GNNs) for optimization and computation, the proposed DGNN model works in a nonfully connected way, in which each neuron only needs the information of neighbor neurons to converge to the equilibrium point. The convergence and asymptotic stability of the DGNN model are proved according to the Lyapunov theory. In addition, based on a relatively loose condition, three novel nonlinear activation functions are designed to speedup the DGNN model to PTC, which is proved by rigorous theory. Computer numerical results further verify the effectiveness, especially the PTC, of the proposed nonlinearly activated DGNN model to solve various consensus problems of MASs. Finally, a practical case of the directional consensus is presented to show the feasibility of the DGNN model and a corresponding connectivity-testing example is given to verify the influence on the convergence speed.
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http://dx.doi.org/10.1109/TNNLS.2022.3193429DOI Listing
July 2022

Nanodrugs Manipulating Endoplasmic Reticulum Stress for Highly Effective Antitumor Therapy.

Front Pharmacol 2022 12;13:949001. Epub 2022 Jul 12.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.

Cancer is one of the leading causes of death worldwide due to high morbidity and mortality. Many attempts and efforts have been devoted to fighting cancer. Owing to the significant role of the endoplasmic reticulum (ER) in cell function, inducing ER stress can be promising for cancer treatment. However, the sustained activation of cytoprotective unfolded protein response (UPR) presents a tremendous obstacle for drugs in inducing unsolved ER stress in tumor cells, especially small-molecule drugs with poor bioavailability. Therefore, many emerging nanodrugs inducing and amplifying ER stress have been developed for efficient cancer treatment. More importantly, the novel discovery of ER stress in immunogenic cell death (ICD) makes it possible to repurpose antitumor drugs for immunotherapy through nanodrug-based strategies amplifying ER stress. Therefore, this mini-review aims to provide a comprehensive summary of the latest developments of the strategies underlying nanodrugs in the treatment of cancer manipulating ER stress. Meanwhile, the prospects of ER stress-inducing nanodrugs for cancer treatment are systematically discussed, which provide a sound platform for novel therapeutic insights and inspiration for the design of nanodrugs in treating cancer.
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http://dx.doi.org/10.3389/fphar.2022.949001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315921PMC
July 2022

Evaluation of cystoprostatectomy on patients with prostate cancer extending to bladder: a retrospective study from single center.

BMC Urol 2022 Jul 28;22(1):118. Epub 2022 Jul 28.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.

Background: This is an exploratory research of cystoprostatectomy (CP) in treating prostate cancer (PCa) extending to the bladder, which aimed to evaluate the effects of CP on survival outcomes and improving quality of life (QoL) in these patients.

Methods: A total of 27 PCa patients extending to the bladder were subjected to CP and followed up at regular intervals in our center. Prostate cancer-specific survival (PCSS) and prostate-specific antigen recurrence-free survival (PFS) were assessed by Kaplan-Meier analysis. Multivariate Cox regression was performed to evaluate clinical characteristics predicting survivals. QoL and pelvic symptoms were also evaluated.

Results: Median PCSS was not reached over the period of follow-up. 5-year PCSS rate was 82.1%. Median PFS was 66.0 months. 5-year PFS rate was 58.5%. Multivariate analysis showed Gleason score (≥ 8) (hazard ratio (HR) 2.55, 95% confidence interval (CI) 1.28-4.04, p = 0.033), positive local lymph node status (HR 3.52, 95% CI 1.57-7.38, p = 0.006) and bladder muscle-invasion (HR 4.75, 95% CI 1.37-7.53, p < 0.001) were independent predictors of worse PCSS. The number of patients suffering pelvic symptoms was significantly decreased, and QoL scores were significantly down-regulated after surgeries.

Conclusion: CP offered effective and durable palliation in patients of locally advanced prostate cancer with invasion of the bladder, providing better QoL and relieving local symptoms.
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http://dx.doi.org/10.1186/s12894-022-01068-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330683PMC
July 2022

Exploration of long afterglow luminescent materials composited with graphitized carbon nitride for photocatalytic degradation of basic fuchsin.

Environ Sci Pollut Res Int 2022 Jul 28. Epub 2022 Jul 28.

School of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha, Hunan, China.

The frequent exposure of the widely used dye, basic fuchsin (BF), is seriously threatening the health of human central nervous system. Thus, removing the environmental pollution caused by BF is crucial, and photocatalytic technology recently has been used to degrade the pollutions dye. In this study, the binary composite SrAlO:Eu, Dy/g-CN was prepared by high-temperature calcination and then applied in BF photodegradation. The results confirmed that the composite material had lower band gap value (Eg) and stronger visible light absorption ability. The photocatalytic capacity of the new composite materials was enhanced compared to that of the non-composite materials. By using the new binary-composited materials, 80% of BF could be degraded in 10 min, and the degradation ratio reached 100% in 30 min. More importantly, even the light source was removed, the photocatalytic reaction could continue due to the luminescence of SrAlO:Eu, Dy, and the degradation efficiency of BF could finally reach more than 90% within 3 h. By quenching experiments and electron spin resonance (ESR) spectra analysis, superoxide anion (·O) was verified to be the main active substance in this reaction process. Moreover, the excellent stability and recyclability of this catalyst was also proved. Furthermore, the new composite materials were utilized to degrade the BF aqueous solution and actual lake water, and the total organic matter contents (TOC) were measured. TOC values in these two systems decreased after photocatalytic reaction, which indicated that this catalyst has a great development prospect in the removal of organic matter in water. Our study confirmed a new kind of material of high performance with great significance for emergency treatment of water pollution in practical applications.
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http://dx.doi.org/10.1007/s11356-022-22097-7DOI Listing
July 2022

Research on the Identification Model of Medical Damage.

Fa Yi Xue Za Zhi 2022 Apr;38(2):158-165

West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.

Objectives: To understand the perceptions of doctors, patients and forensic examiners on the current situation of medical disputes and medical damage identification in China, and to explore the medical damage identification model that is more conducive for the resolution of medical disputes.

Methods: A questionnaire was designed, and in-service clinicians, forensic examiners and inpatients in Sichuan Province and Chongqing City were randomly selected from April to November 2019. SPSS 22.0 software was used to analyze the data of various survey results.

Results: Compared with patients (24.92%), doctors (61.72%) believed that the current doctor-patient relationship was more tense than before; both doctors and patients were more inclined to choose voluntary consultation and people's mediation to resolve medical disputes; forensic examiners have the highest level of cognition of medical and health-related laws and regulations, followed by doctors and patients; 66.72% of doctors and 78.41% of patients believed that medical damage identification was necessary, and they were more inclined to entrust forensic identification institutions; different groups all believed that forensic examiners and doctors should participate in the identification together, 80.94% of doctors believed that the appraisal institutions should be responsible for the forensic opinion, not the appraiser.

Conclusions: It is suggested that the Medical Association identification and forensic identification should learn from each other and formulate basic unified rules for the identification of medical damage. It is suggested to standardize the behavior of medical damage forensic identification institutions and appraisers, to improve their own appraisal level, actively invite clinical medical experts for consultation in identification, and promote the standardized, scientization of forensic identification.
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http://dx.doi.org/10.12116/j.issn.1004-5619.2022.220105DOI Listing
April 2022

Genetic Variants in Double-Strand Break Repair Pathway Genes to Predict Platinum-Based Chemotherapy Prognosis in Patients With Lung Cancer.

Front Pharmacol 2022 11;13:915822. Epub 2022 Jul 11.

Department of Pharmacy, Xinagya Hospital, Central South University, Changsha, China.

The purpose of this study was to investigate the associations of genetic variants in double-strand break (DSB) repair pathway genes with prognosis in patients with lung cancer treated with platinum-based chemotherapy. Three hundred ninety-nine patients with lung cancer who received platinum-based chemotherapy for at least two cycles were included in this study. A total of 35 single nucleotide polymorphisms (SNPs) in DSB repair, base excision repair (BER), and nucleotide excision repair (NER) repair pathway genes were genotyped, and were used to evaluate the overall survival (OS) and the progression-free survival (PFS) of patients who received platinum-based chemotherapy using Cox proportional hazard models. The PFS of patients who carried the rs746218 GG genotype was shorter than that in patients with the AG or AA genotypes (recessive model: = 0.039, OR = 5.31, 95% CI = 1.09-25.93). Patients with the TT or GT genotypes of rs4149570 had shorter OS times than those with the GG genotype (dominant model: = 0.030, OR = 0.57, 95% CI = 0.34-0.95). We also investigated the influence of age, gender, histology, smoking, stage, and metastasis in association between SNPs and OS or PFS in patients with lung cancer. DNA repair gene SNPs were significantly associated with PFS and OS in the subgroup analyses. Our study showed that variants in rs746218 and rs4149570 were associated with shorter PFS or OS in patients with lung cancer who received platinum-based chemotherapy. These variants may be novel biomarkers for the prediction of prognosis of patients with lung cancer who receive platinum-based chemotherapy.
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http://dx.doi.org/10.3389/fphar.2022.915822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309806PMC
July 2022

W-Band 4th Order Waveguide Filter Based on Double Layer SU8 Microfabrication.

Sensors (Basel) 2022 Jul 27;22(15). Epub 2022 Jul 27.

School of Information and Communications Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

This paper investigates the fabrication accuracy of the W-band SU-8 photoresist micromachined 4th order waveguide bandpass filters (BPF). The designed filter based on cylindrical resonators is excited in TM mode. It is ideally suitable for the layered SU-8 micromachining process as the height of the resonator is much smaller than one wavelength, the electromagnetic fields remain unchanged in the thickness direction. The filter is composed of three silver-coated SU-8 layers based on a double-layer overlay process. Excellent manufacturing tolerances can be controlled within 4 μm in the thickness direction, around 10 μm in double-layer stacking accuracy, and an average of 1° in vertical angle deviation. Various challenges encountered in the SU-8 process are investigated while corresponding general solutions are proposed for machining high-precision devices. The measured results show a return loss of 12.4 dB and a minimum insertion loss of 0.8 dB, which are in agreement with the simulated one. Stress and deformation analysis are also conducted to confirm the maximum pressure that the filter can withstand and maintain good transmission performance.
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http://dx.doi.org/10.3390/s22155604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332807PMC
July 2022

High grade acinic cell carcinoma of the breast with clear cytoplasm mimics clear cell carcinoma in a BRCA1 mutation carrier: a case report and review of the literature on the molecular analysis.

Histol Histopathol 2022 Jul 27:18501. Epub 2022 Jul 27.

Department of Pathology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

Acinic cell carcinoma of the breast is an extremely rare tumor. To the best of our knowledge, only one case is reported to have bilateral tumors and had both BRCA1 and TP53 mutation. Herein, we report another case of acinic cell carcinoma of the breast in a 29-years-old female carrying germline BRCA1 and TP53 mutation, and the tumor showed a complex combination of histological features which had not only the reported common features such as diffuse infiltrative small acinar or glandular structures mixed with solid nests, but also the uncommon widespread clear cells, high grade tumor cells. The immunohistochemical profile of the tumor cells was strongly positive for lysozyme and triple negative for ER, PR, HER2. Although she had bilateral high grade breast cancers, this patient refused postoperative adjuvant therapy this time and has been doing well in the past 12 months. As a rare form of triple-negative breast cancer with a relatively not so bad prognosis, more reports are needed to understand its biological characteristics.
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http://dx.doi.org/10.14670/HH-18-501DOI Listing
July 2022

The Association between Risk Perception and Hesitancy toward the Booster Dose of COVID-19 Vaccine among People Aged 60 Years and Older in China.

Vaccines (Basel) 2022 Jul 12;10(7). Epub 2022 Jul 12.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, China.

Background: Given the prevalence of the omicron variant and decreased immunity provided by vaccines, it is imperative to enhance resistance to COVID-19 in the old population. We planned to explore the hesitancy rate toward the booster dose of the COVID-19 vaccine and the association between risk perception and the abovementioned rate among people aged 60 and older.

Methods: This national cross-sectional study was conducted in mainland China from 25 May to 8 June 2022, targeting people who were 60 years old or above. Four dimensions were extracted from the Health Belief Model (HBM) to assess participants' perceived risk levels, including perceived susceptibility, perceived severity, perceived barriers, and perceived benefit. An independent Chi-square test was used to compare the vaccine hesitancy rates among different groups stratified by characteristics. Univariable and multivariable logistic regression models were performed to explore the associations between risk perception and hesitancy rate.

Results: Of 3321 participants, 17.2% (95% CI: 15.9-18.5%) were hesitant about booster shots of COVID-19 vaccines. Believing that they were ineligible for vaccination due to certain illnesses (38.3%), concern about vaccine safety (32.0%), believing the booster shots were unnecessary (33.1%), and their limitation on movements (28.0%) were the main reasons for vaccine hesitation. Adjusted by all the selected covariates, people with low perception level of susceptibility (aOR = 1.39, 95% CI: 1.00-1.92) and benefit (low: aOR = 3.31, 95% CI: 2.01-5.45; moderate: aOR = 2.23, 95% CI: 1.75-2.85) were less likely to receiving the booster dose, and the same results were found in people with higher perceived barriers (moderate: aOR = 2.67, 95% CI: 2.13-3.35; high: aOR = 2.04, 95% CI: 1.14-3.67). Our estimates were stable in all four models.

Conclusions: In total, 17.2% of the people aged 60 years and older in China were hesitant about booster dose of COVID-19 vaccines, and it was closely associated with a lower level of perceived susceptibility and benefit, as well as a higher level of perceived barriers. Concerns about contraindications, vaccine safety, and limited movements were the main reasons for vaccine hesitancy. Targeted public health measure is a priority to improve the understanding of the elderly on their own susceptibility and vulnerability and clear the obstacles to vaccination.
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http://dx.doi.org/10.3390/vaccines10071112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317690PMC
July 2022

Percentage of Asymptomatic Infections among SARS-CoV-2 Omicron Variant-Positive Individuals: A Systematic Review and Meta-Analysis.

Vaccines (Basel) 2022 Jun 30;10(7). Epub 2022 Jun 30.

School of Public Health, Peking University, Beijing 100191, China.

Background: Asymptomatic infections are potential sources of transmission for coronavirus disease 2019, especially during the epidemic of the SARS-CoV-2 Omicron variant. We aimed to assess the percentage of asymptomatic infections among SARS-CoV-2 Omicron variant-positive individuals detected by gene sequencing or specific polymerase chain reaction (PCR).

Methods: We searched PubMed, EMBASE, and Web of Science from 26 November 2021 to 13 April 2022. This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered with PROSPERO (CRD42022327894). Three researchers independently extracted data and two researchers assessed quality using pre-specified criteria. The pooled percentage with 95% confidence interval (CI) of asymptomatic infections of SARS-CoV-2 Omicron was estimated using random-effects models.

Results: Our meta-analysis included eight eligible studies, covering 7640 Omicron variant-positive individuals with 2190 asymptomatic infections. The pooled percentage of asymptomatic infections was 32.40% (95% CI: 25.30-39.51%) among SARS-CoV-2 Omicron variant-positive individuals, which was higher in the population in developing countries (38.93%; 95% CI: 19.75-58.11%), with vaccine coverage ≥ 80% (35.93%; 95% CI: 25.36-46.51%), with a travel history (40.05%; 95% CI: 7.59-72.51%), community infection (37.97%; 95% CI: 10.07-65.87%), and with a median age < 20 years (43.75%; 95% CI: 38.45-49.05%).

Conclusion: In this systematic review and meta-analysis, the pooled percentage of asymptomatic infections was 32.40% among SARS-CoV-2 Omicron variant-positive individuals. The people who were vaccinated, young (median age < 20 years), had a travel history, and were infected outside of a clinical setting (community infection) had higher percentages of asymptomatic infections. Screening is required to prevent clustered epidemics or sustained community transmission caused by asymptomatic infections of Omicron variants, especially for countries and regions that have successfully controlled SARS-CoV-2.
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http://dx.doi.org/10.3390/vaccines10071049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321237PMC
June 2022

Indoor MIMO-VLC Using Angle Diversity Transmitters.

Sensors (Basel) 2022 Jul 21;22(14). Epub 2022 Jul 21.

School of Microelectronics and Communication Engineering, Chongqing University, Chongqing 400044, China.

In this paper, we, for the first time, apply angle diversity transmitters (ADTs) to enhance the performance of multiple-input multiple-output visible light communication (MIMO-VLC) systems. The ADT is designed to consist of one center light emitting diode (LED) and multiple inclined side LEDs. We calculate the line-of-sight (LOS) channel gain of the MIMO-VLC system using ADTs and further derive the average achievable rate of the system. We show that the average achievable rate is related to both the inclination angle of the side LEDs and the spacing between two adjacent ADTs in the MIMO-VLC system. Simulations are conducted to verify that the average achievable rate of the ADT-enhanced MIMO-VLC system can be maximized by setting the optimal inclination angle of the side LEDs and the optimal spacing between adjacent ADTs. The obtained results further show that the average achievable rate of the ADT-enhanced MIMO-VLC system can be greatly improved when there are more LEDs in each ADT. Specifically, a substantial 42.9% average achievable rate improvement can be achieved by using the optimized ADT in comparison to using a conventional non-angle diversity transmitter.
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http://dx.doi.org/10.3390/s22145436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317698PMC
July 2022

LightFD: Real-Time Fault Diagnosis with Edge Intelligence for Power Transformers.

Sensors (Basel) 2022 Jul 15;22(14). Epub 2022 Jul 15.

Department of Computer Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.

Power fault monitoring based on acoustic waves has gained a great deal of attention in industry. Existing methods for fault diagnosis typically collect sound signals on site and transmit them to a back-end server for analysis, which may fail to provide a real-time response due to transmission packet loss and latency. However, the limited computing power of edge devices and the existing methods for feature extraction pose a significant challenge to performing diagnosis on the edge. In this paper, we propose a fast Lightweight Fault Diagnosis method for power transformers, referred to as LightFD, which integrates several technical components. Firstly, before feature extraction, we design an asymmetric Hamming-cosine window function to reduce signal spectrum leakage and ensure data integrity. Secondly, we design a multidimensional spatio-temporal feature extraction method to extract acoustic features. Finally, we design a parallel dual-layer, dual-channel lightweight neural network to realize the classification of different fault types on edge devices with limited computing power. Extensive simulation and experimental results show that the diagnostic precision and recall of LightFD reach 94.64% and 95.33%, which represent an improvement of 4% and 1.6% over the traditional SVM method, respectively.
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http://dx.doi.org/10.3390/s22145296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322841PMC
July 2022

Multi-Material Topology Optimization of Flexure Hinges Using Element Stacking Method.

Micromachines (Basel) 2022 Jun 24;13(7). Epub 2022 Jun 24.

School of Mechatronics & Vehicle Engineering, East China Jiaotong University, Nanchang 330013, China.

Traditional flexure hinges are designed by using a single material, and their performance is inadequate, compared to the ideal hinge. This paper presents a topology-optimization design method for multi-material flexure hinges based on the element stacking method. A topology optimization model for multi-material flexure hinges is constructed to find the optimal distribution of various materials, where the objective function is to maximize the compliance in the rotational direction, whilst minimizing the compliance in the axial direction. In order to ensure the rotation precision of the hinge, the position constraint of the rotation center is proposed. The gradient information of objective and constraint functions is derived by the adjoint method, and the method of moving asymptotes (MMA) is used to update the design variable. Several numerical examples are performed to verify the effectiveness of the proposed method, and the results show that the multi-material flexure hinge has a higher rotation ratio than the single-material flexure hinge.
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http://dx.doi.org/10.3390/mi13070993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315514PMC
June 2022
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