Publications by authors named "Min D"

982 Publications

The timing of targeted therapy initiation in metastatic sarcoma as an adjuvant to first-line chemotherapy or a second-line agent.

Am J Transl Res 2021 15;13(8):9095-9103. Epub 2021 Aug 15.

Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University No. 600, Yishan Road, Shanghai 200233, People's Republic of China.

58 cases of metastatic sarcoma were reviewed retrospectively in order to compare the efficacy and safety of concurrent (n=24, group A) versus sequential (n=34, group B) use of chemotherapy and targeted therapy in metastatic sarcoma. Progression-free survival (PFS) 1 was defined as the duration between initiation of first-line treatment to disease progression or recurrence. PFS' was defined as the duration between initiation of first-line treatment to the failure of chemotherapy and targeted therapy, and overall survival (OS) was defined as the duration between initiation of first-line treatment to the date of last follow-up or death. The results revealed that patients in group A possessed a higher tumor burden compared to those in group B (P=0.049). Survival curves revealed that the median PFS1 (15.2 vs. 5.4 months, P=0.000), median PFS' (15.2 vs. 10.8 months, P=0.049), and median OS (42.3 vs. 25.3 months, P=0.041) of subjects in group A were remarkably longer than those of group B. Subgroup analysis showed that patients in group A experienced more favorable PFS1 (15.2 vs. 3 months, P=0.000), PFS' (15.2 vs. 5.8 months, P=0.003), and OS (35.2 vs. 15.7 months, P=0.011) than those in group B, with findings especially prominent in patients with tumor burden ≥ 10 cm in comparison to patients with tumor burden < 10 cm (P ≥ 0.05). All grades of leukopenia, thrombocytopenia, fatigue, and oral mucositis were more frequently diagnosed in patients of group A compared to those of group B. However, there were no significant differences between the rates of Grade 3-4 adverse events between the two groups. This investigation suggests that the concurrent use of targeted therapy and chemotherapy may be useful and safe as a first-line treatment in patients with metastatic sarcoma who possess a high tumor burden.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430201PMC
August 2021

Conventional oxygen therapy versus CPAP as a ceiling of care in ward-based patients with COVID-19: a multi-centre cohort evaluation.

EClinicalMedicine 2021 Oct 8;40:101122. Epub 2021 Sep 8.

North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Background: Continuous positive airway pressure (CPAP) therapy is commonly used for respiratory failure due to severe COVID-19 pneumonitis, including in patients deemed not likely to benefit from invasive mechanical ventilation (nIMV). Little evidence exists demonstrating superiority over conventional oxygen therapy, whilst ward-level delivery of CPAP presents practical challenges. We sought to compare clinical outcomes of oxygen therapy versus CPAP therapy in patients with COVID-19 who were nIMV.

Methods: This retrospective multi-centre cohort evaluation included patients diagnosed with COVID-19 who were nIMV, had a treatment escalation plan of ward-level care and clinical frailty scale ≤ 6. Recruitment occurred during the first two waves of the UK COVID-19 pandemic in 2020; from 1 March to May 31, and from 1 September to 31 December. Patients given CPAP were compared to patients receiving oxygen therapy that required FiO ≥04 for more than 12 hours at hospitals not providing ward-level CPAP. Logistic regression modelling was performed to compare 30-day mortality between treatment groups, accounting for important confounders and within-hospital clustering.

Findings: Seven hospitals provided data for 479 patients during the UK COVID-19 pandemic in 2020. Overall 30-day mortality was 75.6% in the oxygen group (186/246 patients) and 77.7% in the CPAP group (181/233 patients). A lack of evidence for a treatment effect persisted in the adjusted model (adjusted odds ratio 0.84 95% CI 0.57-1.23, p=0.37). 49.8% of patients receiving CPAP-therapy (118/237) chose to discontinue it.

Interpretation: No survival difference was found between using oxygen alone or CPAP to treat patients with severe COVID-19 who were nIMV. A high patient-initiated discontinuation rate for CPAP suggests a significant treatment burden. Further reflection is warranted on the current treatment guidance and widespread application of CPAP in this setting.

Funding: L Pearmain is supported by the MRC (MR/R00191X/1). TW Felton is supported by the NIHR Manchester Biomedical Research Centre.
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http://dx.doi.org/10.1016/j.eclinm.2021.101122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424135PMC
October 2021

Osmium-Tellurium Nanozymes for Pentamodal Combinatorial Cancer Therapy.

ACS Appl Mater Interfaces 2021 Sep 8;13(37):44124-44135. Epub 2021 Sep 8.

Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.

Although nanoparticles based on Group 8 elements such as Fe and Ru have been developed, not much is known about Os nanoparticles. However, Os-based nanostructures might have potential in various applications including biomedical fields. Therefore, in this study, we synthesized Os-Te nanorods (OsTeNRs) by solvothermal galvanic replacement with Te nanotemplates. We explored the nanozymatic activity of the synthesized OsTeNRs and found that they exhibited superior photothermal conversion and photocatalytic activity. Along with chemotherapy (regorafenib) and immunotherapy, the nanozymatic, photothermal, and photodynamic activities of OsTeNRs were harnessed to develop a pentamodal treatment for hepatocellular carcinoma (HCC); and studies demonstrated that the pentamodal therapy could alleviate hypoxia in HCC cells by generating oxygen and reduced unintended drug accumulation in organs. Moreover, bone-marrow toxicity due to regorafenib could be reduced as the drug was released in a sustained manner. Thus, OsTeNRs can be considered as suitable nanotemplates for combinatorial cancer therapy.
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http://dx.doi.org/10.1021/acsami.1c14201DOI Listing
September 2021

Graphene oxide-based fluorescent biosensors and their biomedical applications in diagnosis and drug discovery.

Chem Commun (Camb) 2021 Sep 28;57(77):9820-9833. Epub 2021 Sep 28.

Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.

Graphene oxide (GO), an oxidized derivative of graphene, has received much attention for developing novel fluorescent bioanalytic platforms due to its remarkable optical properties and biocompatibility. The reliable performance and robustness of GO-based biosensors have enabled various applications in the biomedical field including diagnosis and drug discovery. Here, recent advances in the development of GO-based fluorescent biosensors are overviewed, particularly nucleic acid detection and enzyme activity assay. In addition, practical applications in biomarker detection and high-throughput screening are also examined. Lastly, basic design principles and remaining challenges of these types of biosensors are discussed for further progress.
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http://dx.doi.org/10.1039/d1cc02157eDOI Listing
September 2021

Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1.

Exp Mol Med 2021 09 1;53(9):1287-1297. Epub 2021 Sep 1.

College of Pharmacy, Yonsei University, Incheon, 21983, South Korea.

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is known about the regulation of SIRT1 activity. Here, we show that phospholipase D2 (PLD2), but not PLD1, selectively interacts with SIRT1 and increases the deacetylase activity of SIRT1. PLD2 does not interact with the other isozymes of SIRT (SIRT2-7). Two leucine residues in the LXXLL motif (L173 and L174) in the phox domain of PLD2 interact with the region essential for SIRT1 activity. PLD2 stimulates the SIRT1-mediated deacetylation of p53 independent of its lipase activity. In our study, mutagenesis of the LXXLL motif suppressed the interaction of PLD2 with SIRT1 and inhibited SIRT1-mediated p53 deacetylation and p53-induced transactivation of proapoptotic genes. Ultimately, overexpression of wild-type PLD2 but not that of LXXLL-mutant PLD2 protected cells against etoposide-induced apoptosis. Moreover, PLD2 did not protect against apoptosis induced by SIRT1 depletion under genotoxic stress. Collectively, our results suggest that PLD2 is a positive regulator of SIRT1 and modulates p53-mediated apoptosis via SIRT1.
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http://dx.doi.org/10.1038/s12276-021-00659-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492672PMC
September 2021

IoT Sensor Networks in Smart Buildings: A Performance Assessment Using Queuing Models.

Sensors (Basel) 2021 Aug 23;21(16). Epub 2021 Aug 23.

Programa de Pós-Graduação em Ciência da Computação, Universidade Federal do Piauí (UFPI), Teresina-Piauí 64049-550, Brazil.

Smart buildings in big cities are now equipped with an internet of things (IoT) infrastructure to constantly monitor different aspects of people's daily lives via IoT devices and sensor networks. The malfunction and low quality of service (QoS) of such devices and networks can severely cause property damage and perhaps loss of life. Therefore, it is important to quantify different metrics related to the operational performance of the systems that make up such computational architecture even in advance of the building construction. Previous studies used analytical models considering different aspects to assess the performance of building monitoring systems. However, some critical points are still missing in the literature, such as (i) analyzing the capacity of computational resources adequate to the data demand, (ii) representing the number of cores per machine, and (iii) the clustering of sensors by location. This work proposes a queuing network based message exchange architecture to evaluate the performance of an intelligent building infrastructure associated with multiple processing layers: edge and fog. We consider an architecture of a building that has several floors and several rooms in each of them, where all rooms are equipped with sensors and an edge device. A comprehensive sensitivity analysis of the model was performed using the Design of Experiments (DoE) method to identify bottlenecks in the proposal. A series of case studies were conducted based on the DoE results. The DoE results allowed us to conclude, for example, that the number of cores can have more impact on the response time than the number of nodes. Simulations of scenarios defined through DoE allow observing the behavior of the following metrics: average response time, resource utilization rate, flow rate, discard rate, and the number of messages in the system. Three scenarios were explored: (i) scenario A (varying the number of cores), (ii) scenario B (varying the number of fog nodes), and (iii) scenario C (varying the nodes and cores simultaneously). Depending on the number of resources (nodes or cores), the system can become so overloaded that no new requests are supported. The queuing network based message exchange architecture and the analyses carried out can help system designers optimize their computational architectures before building construction.
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http://dx.doi.org/10.3390/s21165660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402539PMC
August 2021

Association between self-reported physical activity and indicators of cardiovascular risk in community-dwelling older adults with hypertension in Korea: A cohort study.

Medicine (Baltimore) 2021 Aug;100(34):e27074

Department of Nursing, College of Medicine, Wonkwang University, Iksan, Republic of Korea.

Abstract: The prevalence of hypertension has increased with the rise in the elderly population, and high blood pressure is a major cause of cardiovascular disease. Physical activity is an important strategy for preventing cardiovascular disease. The study aimed to explore the association between physical activity and cardiovascular risk indicators in community-dwelling older adults with hypertension.This study is a secondary data analysis of a prospective longitudinal study using data from the Elderly Cohort Database of the National Health Insurance Service in South Korea between 2002 and 2013. Participants included 10,588 older adults (≥60 years) with hypertension. Data assessing self-reported physical activity and directly measured blood pressure, fasting blood glucose, body mass index, and total cholesterol levels throughout the 12-year study were extracted from the original database and analyzed. Participants were categorized into 4 groups based on the reported changes in physical activity over time: Group I (Maintaining No Physical Activity Group), II (Changing from No Physical Activity to Physical Activity Group), III (Changing from Physical Activity to No Physical Activity Group), and IV (Maintaining Physical Activity Group). Cox proportional hazard model was used to confirm the risk of cardiovascular indicators over time in each group.Participants' mean age was 64.2 years in the initial year of 2002. The number of participants in Groups I, II, III, and IV was 4032, 2697, 1919, and 1940, respectively. Group IV showed a significant decline in risk for uncontrolled hypertension compared to Group I (hazard ratio = 0.87, 95% confidence interval [0.800-0.948]). Group II showed a significant decrease in risk for uncontrolled diabetes compared to Group I (hazard ratio = 0.94, 95% confidence interval [0.888-0.999]).The findings indicated that physical activity is a significant factor associated with indicators of cardiovascular risk in older people with high blood pressure. Healthcare providers should be aware of the importance of older adults' physical activity and encourage them to perform and maintain it steadily for better long-term cardio-metabolic outcomes.
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http://dx.doi.org/10.1097/MD.0000000000027074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389870PMC
August 2021

Effect of a fall cut on dry matter yield, nutritive value, and stand persistence of alfalfa.

J Anim Sci Technol 2021 Jul 31;63(4):799-814. Epub 2021 Jul 31.

Department of Agronomy, Kansa State University, Manhattan, KS 66506, USA.

Information is lacking about the effect of date of a fall cut of alfalfa ( L.) on dry matter yield (DMY), forage nutritive value, and stands persistence. The objective of this study was to determine the effect of timing of a fall cut on DMY, forage nutritive value and stand persistence of three alfalfa varieties: low-lignin Hi-Gest 360, Roundup Ready Tonica, and conventional Gunner in Northeastern Kansas in the United States. The field study was carried out by splitting plot in randomized complete block design with four replications. The harvesting data of different maturity stages were collected in each year from 2015 to 2018. Three cuts were harvested based on the stage of maturity, and the last (fourth) cut was done on September 15, September 30, October 15, and October 30 of each year. The persistence of the alfalfa stands was determined each fall after the last cut, and each spring after the first cut, by counting the number of live plants in a randomly placed quadrat in each plot. Alfalfa cut on September 15 and September 30 had a higher stand persistence compared to alfalfa cut on October 15 and October 30. The DMY of the first cut in 2016 was significantly higher in roundup ready than the low-lignin alfalfa variety. In the second cut, DMY was significantly higher in conventional alfalfa than the roundup ready. There were no significant differences in DMY between alfalfa varieties in the rest of seasonal cuttings in 2016 and 2017 and annual total yield in both years. In general, low lignin alfalfa variety had higher crude protein and relative feed value and lower acid detergent fiber and neutral detergent fiber contents than those in roundup ready and conventional alfalfa varieties. On average, nutritive value of alfalfa was generally affected by last cutting dates in 2017. Based on 3-year data the last cutting of alfalfa in the fall could be done by September 30-October 15 without harmful effect on DMY.
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http://dx.doi.org/10.5187/jast.2021.e65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367415PMC
July 2021

Factors Influencing Early Readmission after Discharge against Medical Advice from the Emergency Department.

Healthcare (Basel) 2021 Aug 3;9(8). Epub 2021 Aug 3.

College of Nursing, Dongguk University, Gyeongju 38066, Korea.

Discharge against medical advice (DAMA) and readmissions are important issues worldwide and can lead to adverse clinical outcomes, financial burden, and exposure of healthcare workers to unintended medical disputes. This study aimed to identify factors that affect readmissions within 48 h after DAMA. This retrospective study utilized the medical records of patients who visited an emergency medical center in Korea for treatment and were readmitted during a 10-year period. Factors predicting readmission after being DAMA were identified using logistic regression analysis. The total number of patients who were DAMA during the study period was 5445, of which 351 were readmitted to the emergency department within 48 h (6.4%). Factors influencing readmission included medical aid (odds ratio (OR) = 2.02, 95% confidence interval (CI): 1.46-2.83) and foreign worker insurance (OR = 2.07, 95% CI: 1.04-4.09) as their health insurance, as well as presenting for readmission by car (OR = 1.41, 95% CI: 1.08-1.82). Healthcare workers should treat patients who are DAMA and those who are likely to return with a more careful and preventative management strategy so that potential clinical, legal, and economic impacts of DAMA can be mitigated.
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http://dx.doi.org/10.3390/healthcare9080986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393729PMC
August 2021

Enhanced Bioreduction of Radionuclides by Driving Microbial Extracellular Electron Pumping with an Engineered CRISPR Platform.

Environ Sci Technol 2021 09 11;55(17):11997-12008. Epub 2021 Aug 11.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Technology, University of Science and Technology of China, Hefei 230026, China.

Dissimilatory metal-reducing bacteria (DMRB) with extracellular electron transfer (EET) capability show great potential in bioremediating the subsurface environments contaminated by uranium through bioreduction and precipitation of hexavalent uranium [U(VI)]. However, the low EET efficiency of DMRB remains a bottleneck for their applications. Herein, we develop an engineered CRISPR platform to drive the extracellular electron pumping of , a representative DMRB species widely present in aquatic environments. The CRISPR platform allows for highly efficient and multiplex genome editing and rapid platform elimination post-editing in . Enabled by such a platform, a genomic promoter engineering strategy (GPS) for genome-widely engineering the EET-encoding gene network was established. The production of electron conductive Mtr complex, synthesis of electron shuttle flavin, and generation of NADH as intracellular electron carrier are globally optimized and promoted, leading to a significantly enhanced EET ability. Applied to U(VI) bioreduction, the edited strains achieve up to 3.62-fold higher reduction capacity over the control. Our work endows DMRB with an enhanced ability to remediate the radionuclides-contaminated environments and provides a gene editing approach to handle the growing environmental challenges of radionuclide contaminations.
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http://dx.doi.org/10.1021/acs.est.1c03713DOI Listing
September 2021

Effects of Functional Fitness Enhancement through Taekwondo Training on Physical Characteristics and Risk Factors of Dementia in Elderly Women with Depression.

Int J Environ Res Public Health 2021 07 28;18(15). Epub 2021 Jul 28.

College of Arts and Sports, Dong-A University, 37, Nakdong-Daero, 550, Sahagu, Busan 49315, Korea.

The purpose of this research is to identify the correlations between functional fitness enhancement through a long-term Taekwondo training program and the physical characteristics and risk factors of dementia among elderly women with depression. The study has found that conducting three 60-min Taekwondo training sessions a week for the duration of 12 weeks has enhanced a number of functional fitness indexes, including hand grip strength/weight ( < 0.01), 4-m gait speed ( < 0.001), 3-m timed up and go ( < 0.05), and figure-of-eight track ( < 0.05), and significantly improved general health condition indexes as well, including percent fat ( < 0.05), appendicular skeletal muscle mass index ( < 0.01), systolic blood pressure ( < 0.01), and diastolic blood pressure ( < 0.001). Furthermore, the arteriosclerosis index and cognitive function have been found to be improved with an increase of brain-derived neurotrophic factor (BDNF; which prevents dementia) and a significant decrease of β-amyloid-a risk factor of dementia-as a result of enhancements in serum lipids and adiponectin, confirming the positive effects of functional fitness enhancement on fighting depression, promoting physical characteristics, and reducing the risk factors of dementia.
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http://dx.doi.org/10.3390/ijerph18157961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345697PMC
July 2021

Genome-Wide Analysis of Genes in Foxtail Millet ( L.) and Functional Assessment of the Role of in the Drought Stress Response.

Front Plant Sci 2021 28;12:659474. Epub 2021 Jun 28.

College of Agronomy, Northwest A&F University/State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling, China.

MADS-box transcription factors play vital roles in multiple biological processes in plants. At present, a comprehensive investigation into the genome-wide identification and classification of genes in foxtail millet ( L.) has not been reported. In this study, we identified 72 genes in the foxtail millet genome and give an overview of the phylogeny, chromosomal location, gene structures, and potential functions of the proteins encoded by these genes. We also found that the expression of 10 MIKC-type genes was induced by abiotic stresses (PEG-6000 and NaCl) and exogenous hormones (ABA and GA), which suggests that these genes may play important regulatory roles in response to different stresses. Further studies showed that transgenic and rice ( L.) plants overexpressing had reduced drought stress tolerance as revealed by lower survival rates and poorer growth performance under drought stress conditions, which demonstrated that is a negative regulator of drought stress tolerance in plants. Moreover, expression of some stress-related genes were down-regulated in the -overexpressing plants. The results of our study provide an overall picture of the gene family in foxtail millet and establish a foundation for further research on the mechanisms of action of MADS-box proteins with respect to abiotic stresses.
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http://dx.doi.org/10.3389/fpls.2021.659474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273297PMC
June 2021

Case Report: Sequential Chemotherapy and Immunotherapy Produce Sustained Response in Osteosarcoma With High Tumor Mutational Burden.

Front Endocrinol (Lausanne) 2021 18;12:625226. Epub 2021 Jun 18.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: Immunotherapy has provided an effective method for the treatment of many cancers. However, its efficacy in osteosarcoma is not satisfactory so far.

Case Presentation: Here, we presented a case of osteosarcoma treated with sequential chemotherapy and immunotherapy and showed promising therapeutic potential. The 29-year-old female patient presented 9 rib osteosarcoma with suspected right lung lower lobe metastasis. Surgery was performed to remove the primary lesion, and a series of chemotherapies were given afterward in consideration of the response and tolerance. The right lung lower lobe metastasis was under control first but progressed (PD) 9 months after the initiation of therapy. The lesion was surgically removed and subsequent chemotherapy was implemented. The patient had good tolerance with chemotherapy and maintained well for approximately 11 months before the discovery of 11 rib and right lung upper lobe metastases. Surgery was then performed on both lesions and achieved complete response. Post-surgical brief chemotherapy and subsequent long-term immunotherapy (pembrolizumab) maintained continuous remission for 33 months. The patient survived for 60 months with well-controlled disease from the time of confirmed diagnosis. Genetic alterations of all primary and metastatic lesions were investigated by whole-exome sequencing (WES). Substantial similarity in mutational landscape between the primary lesion and 11 rib metastasis and between the two lung metastases were revealed, while substantial heterogeneity was found between the rib lesions and lung metastases. The tumor mutational burden (TMB) for the 9 rib primary lesion, the metastatic 11 rib lesion, and the metastatic right upper and lower lobe nodule tissues was 8.02, 2.38, 4.61, and 0.14 mutations/Mb, respectively. The primary lesion exhibited the most diverse copy number variation (CNV) changes among all lesions. Furthermore, pathway enrichment analysis also suggested significant heterogeneity among the lesions.

Conclusions: Surgery with sequential chemotherapy and maintenance immunotherapy was shown to have good response for the first time on osteosarcoma patient who had high TMB tumor lesions and good tolerance for chemotherapy and immunotherapy.
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http://dx.doi.org/10.3389/fendo.2021.625226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249865PMC
December 2021

Level of Decoy Receptor 3 for Monitoring Clinical Progression of Severe Burn Patients.

J Burn Care Res 2021 09;42(5):925-933

First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

The clinical value of Decoy receptor 3 (DcR3) in severe burn is investigated. Ten patients with severe burns were monitored for DcR3, PCT, CRP, IL6, SOFA score, white blood cell (WBC), and platelet. The correlations were analyzed. DcR3 increased on day 1. The nonsurvivors had a steady high level of DcR3 while the survivors had a relatively low level of DcR3. The peak magnitude of DcR3 was high in five nonsurvivors and low in five survivors without overlap. Three patients had a continuously increasing DcR3 level and then died. In the other two nonsurvivors, DcR3 reached the peak and then decreased before death. DcR3 correlated well with PCT (ρ = 0.4469, P < .0001), less with CRP, platelet, IL6, SOFA score and WBC (ρ = 0.4369, 0.4078, 0.3995, 0.2631, 0.1504, respectively, all P < .001). To explore the mechanisms, the HaCaT or THP-1 cells were stimulated by the plasma of burn patients, 45°C, LPS or stimulators of TLRs or NOD2 (PGN, CL264, MDP, iE-DAP, Gardiquimod), and their DcR3 was increased, which could be reduced by GDC-0941 or BEZ235 (inhibitors of PI3K and mTOR). The levels of DcR3 appeared to be a useful biomarker for monitoring the clinical severity and a predictor of mortality of severe burns.
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http://dx.doi.org/10.1093/jbcr/irz170DOI Listing
September 2021

Effects of cultivar and harvest days after planting on dry matter yield and nutritive value of teff.

J Anim Sci Technol 2021 May 31;63(3):510-519. Epub 2021 May 31.

Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.

One of the most pressing issues facing the dairy industry is drought. In areas where annual precipitation is low, irrigation for growing feed presents the greatest water-utilization challenge for dairy producers. Here, we investigated the effects of cultivar and harvest days after planting (DAP) on dry matter (DM) yield and nutritive value of teff (), a warm-season annual grass native to Ethiopia that is well adapted to drought conditions. Eighty pots were blocked by location in a greenhouse and randomly assigned to four teff cultivars (Tiffany, Moxie, Corvallis, and Dessie) and to five harvest times (40, 45, 50, 55, or 60 DAP). Cultivars had no effect on DM yield and nutritive value. As harvest time increased from 40 to 60 DAP, DM yield and ash-free neutral detergent fiber (aNDFom) concentrations increased, while crude protein (CP) concentrations and NDF digestibility decreased. To assess carryover effects of time of harvest on yield and nutritive value, two additional cuttings were taken from each pot. Increasing first-cutting harvest time decreased CP concentrations in the second cutting and reduced DM yields in the second and third cutting. Harvesting teff between 45 and 50 DAP best optimized forage yield and nutritive value in the first and subsequent cuttings.
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http://dx.doi.org/10.5187/jast.2021.e56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204008PMC
May 2021

Aberrant expression of HDL-bound microRNA induced by a high-fat diet in a pig model: implications in the pathogenesis of dyslipidaemia.

BMC Cardiovasc Disord 2021 06 6;21(1):280. Epub 2021 Jun 6.

Key Laboratory of Ministry of Education for Traditional Chinese Medicine Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People's Republic of China.

Background: A high-fat diet can affect lipid metabolism and trigger cardiovascular diseases. A growing body of studies has revealed the HDL-bound miRNA profiles in familial hypercholesterolaemia; in sharp contrast, relevant studies on high-fat diet-induced dyslipidaemia are lacking. In the current study, HDL-bound miRNAs altered by a high-fat diet were explored to offer some clues for elucidating their effects on the pathogenesis of dyslipidaemia.

Methods: Six pigs were randomly divided into two groups of three pigs each, namely, the high-fat diet and the balanced diet groups, which were fed a high-fat diet and balanced diet separately for six months. HDL was separated from plasma, which was followed by dissociation of the miRNA bound to HDL. miRNA sequencing of the isolated miRNA was performed to identify the differential expression profiles between the two groups, which was validated by real-time PCR. TargetScan, miRDB, and miRWalk were used for the prediction of genes targeted by the differential miRNAs.

Results: Compared with the balanced diet group, the high-fat diet group had significantly higher levels of TG, TC, LDL-C and HDL-C at six months. miRNA sequencing revealed 6 upregulated and 14 downregulated HDL-bound miRNAs in the high-fat diet group compared to the balanced diet group, which was validated by real-time PCR. GO enrichment analysis showed that dysregulated miRNAs in the high-fat diet group were associated with the positive regulation of lipid metabolic processes, positive regulation of lipid biosynthetic processes, and positive regulation of Ras protein signal transduction. Insulin resistance and the Ras signalling pathway were enriched in the KEGG pathway enrichment analysis.

Conclusions: Twenty HDL-bound miRNAs are significantly dysregulated in high-fat diet-induced dyslipidaemia. This study presents an analysis of a new set of HDL-bound miRNAs that are altered by a high-fat diet and offers some valuable clues for novel mechanistic insights into high-fat diet-induced dyslipidaemia. Further functional verification study using a larger sample size will be required.
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http://dx.doi.org/10.1186/s12872-021-02084-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180175PMC
June 2021

Factors Associated with the Need for Breastfeeding Information Among Women with Gestational Diabetes Mellitus: A Cross-sectional Study.

Asian Nurs Res (Korean Soc Nurs Sci) 2021 Aug 26;15(3):210-214. Epub 2021 May 26.

Department of Nursing, College of Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea. Electronic address:

Purpose: Analyzing information based on individual needs can maximize the effectiveness of education, leading to changes in personal health behaviors. This cross-sectional descriptive survey study aimed to identify the characteristics of mothers who experienced gestational diabetes mellitus and correlate the factors associated with their information needs.

Methods: The participants were 298 women between the ages of 20 and 49 years who were pregnant and diagnosed with gestational diabetes at the time of the study, or who were diagnosed with gestational diabetes mellitus within five years after delivery. The average age of the participants was 34.28 years. After comparing participants' demographics, diabetes, and breastfeeding-related characteristics according to their need for information on breastfeeding, a multiple logistic regression analysis was performed.

Results: Factors associated with participants' need for information on breastfeeding were economic conditions, usual body mass index, current pregnancy, and experience of breastfeeding.

Conclusion: The findings can be used to implement programs that meet the needs of these women and help improve maternal and pediatric health and quality of life.
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http://dx.doi.org/10.1016/j.anr.2021.05.002DOI Listing
August 2021

Identification of a Direct-Acting Antiviral Agent Targeting RNA Helicase via a Graphene Oxide Nanobiosensor.

ACS Appl Mater Interfaces 2021 Jun 26;13(22):25715-25726. Epub 2021 May 26.

Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.

Dengue virus (DENV), an arbovirus transmitted by mosquitoes, causes infectious diseases such as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Despite the dangers posed by DENV, there are no approved antiviral drugs for treatment of DENV infection. Considering the potential for a global dengue outbreak, rapid development of antiviral agents against DENV infections is crucial as a preemptive measure; thus, the selection of apparent drug targets, such as the viral enzymes involved in the viral life cycle, is recommended. Helicase, a potential drug target in DENV, is a crucial viral enzyme that unwinds double-stranded viral RNA, releasing single-stranded RNA genomes during viral replication. Therefore, an inhibitor of helicase activity could serve as a direct-acting antiviral agent. Here, we introduce an RNA helicase assay based on graphene oxide, which enables fluorescence-based analysis of RNA substrate-specific helicase enzyme activity. This assay demonstrated high reliability and ability for high-throughput screening, identifying a new helicase inhibitor candidate, micafungin (MCFG), from an FDA-approved drug library. As a direct-acting antiviral agent targeting RNA helicase, MCFG inhibits DENV proliferation in cells and an animal model. Notably, , MCFG treatment reduced viremia, inflammatory cytokine levels, and viral loads in several tissues and improved survival rates by up to 40% in a lethal mouse model. Therefore, we suggest MCFG as a potential direct-acting antiviral drug candidate.
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http://dx.doi.org/10.1021/acsami.1c04641DOI Listing
June 2021

Genome-wide analysis of the serine carboxypeptidase-like protein family in Triticum aestivum reveals TaSCPL184-6D is involved in abiotic stress response.

BMC Genomics 2021 May 15;22(1):350. Epub 2021 May 15.

State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, China.

Background: The serine carboxypeptidase-like protein (SCPL) family plays a vital role in stress response, growth, development and pathogen defense. However, the identification and functional analysis of SCPL gene family members have not yet been performed in wheat.

Results: In this study, we identified a total of 210 candidate genes encoding SCPL proteins in wheat. According to their structural characteristics, it is possible to divide these members into three subfamilies: CPI, CPII and CPIII. We uncovered a total of 209 TaSCPL genes unevenly distributed across 21 wheat chromosomes, of which 65.7% are present in triads. Gene duplication analysis showed that ~ 10.5% and ~ 64.8% of the TaSCPL genes are derived from tandem and segmental duplication events, respectively. Moreover, the Ka/Ks ratios between duplicated TaSCPL gene pairs were lower than 0.6, which suggests the action of strong purifying selection. Gene structure analysis showed that most of the TaSCPL genes contain multiple introns and that the motifs present in each subfamily are relatively conserved. Our analysis on cis-acting elements showed that the promoter sequences of TaSCPL genes are enriched in drought-, ABA- and MeJA-responsive elements. In addition, we studied the expression profiles of TaSCPL genes in different tissues at different developmental stages. We then evaluated the expression levels of four TaSCPL genes by qRT-PCR, and selected TaSCPL184-6D for further downstream analysis. The results showed an enhanced drought and salt tolerance among TaSCPL184-6D transgenic Arabidopsis plants, and that the overexpression of the gene increased proline and decreased malondialdehyde levels, which might help plants adapting to adverse environments. Our results provide comprehensive analyses of wheat SCPL genes that might work as a reference for future studies aimed at improving drought and salt tolerance in wheat.

Conclusions: We conducte a comprehensive bioinformatic analysis of the TaSCPL gene family in wheat, which revealing the potential roles of TaSCPL genes in abiotic stress. Our analysis also provides useful resources for improving the resistance of wheat.
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http://dx.doi.org/10.1186/s12864-021-07647-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126144PMC
May 2021

Effects of alfalfa and alfalfa-grass mixtures with nitrogen fertilization on dry matter yield and forage nutritive value.

J Anim Sci Technol 2021 Mar 31;63(2):305-318. Epub 2021 Mar 31.

Department of Agronomy, Kansas State University, Manhattan, KS 66506, USA.

Alfalfa ( L.) is an important forage legume grown in Kansas, USA and its productivity with cool-season grasses however is unknown. The objective of this study was to determine the dry matter yield (DMY) and forage nutritive value of alfalfa-grass mixtures compared to those of alfalfa and grasses grown in monoculture with and without nitrogen fertilization. Three different alfalfa varieties were planted (reduced-lignin alfalfa, Roundup Ready, and conventional alfalfa) and two kinds of cool-season grasses (smooth brome, Leyss, and tall fescue, Schreb) were planted as a monoculture or in alfalfa-grass mixtures. Nitrogen fertilizer (urea) was applied at green-up at a rate of 56 kg/ha and after the second cutting at a rate of 56 kg/ha in 2016 and 2017, respectively. and control treatments received no nitrogen. DMY was significantly higher in monoculture alfalfa and alfalfa-grass mixtures than in grass monocultures. Between alfalfa monoculture and alfalfa-grass mixtures, no significant differences in DMY were found. For all treatments, nitrogen application significantly increased DMY compared to the control. In 2016 and 2017, the low-lignin alfalfa monoculture had the lowest acid detergent fiber (ADF) and the grass monocultures had the highest ADF. In 2016 and 2017, neutral detergent fiber (NDF) in smooth bromegrass and tall fescue was higher than in other species treatments. A low-lignin alfalfa monoculture had significantly lower NDF concentration compared to alfalfa-grass mixtures. When averaged over 2016 and 2017, relative feed value (RFV) was highest in low-lignin alfalfa and lowest in the grass monocultures. In both years, nitrogen fertilizer application did not affect nutritive values.
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http://dx.doi.org/10.5187/jast.2021.e33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071749PMC
March 2021

Helical carbon nanofibers modified with FeO as a high performance anode material for lithium-ion batteries.

Dalton Trans 2021 May;50(17):5819-5827

School of Materials Science and Engineering, Sichuan University of Science & Engineering, Zigong 643000, China.

Helical carbon nanofibers (HCNFs) modified with Fe2O3 (Fe2O3/HCNFs) with a particle size of about 10-20 nm were first introduced for potential use as a novel anode material for lithium-ion batteries (LIBs). Fe2O3/HCNFs were successfully prepared via a chemical liquid deposition (CLPD) method in this study. HCNFs with a special three-dimensional helical structure improve the conductivity and also provide a strong supporting network space for stress and strain during the volume expansion of Fe2O3 nanoparticles. The Fe2O3/HCNF anode still retains its capacity of 816.3 mA h g-1 after 100 cycles at the current density of 200 mA g-1, which is significantly better than those of contrast samples (only 144.2 mA h g-1 for the bare Fe2O3, 241.2 mA h g-1 for HCNFs and 486.4 mA h g-1 for Fe2O3-HCNFs). These superior properties and facile preparation represent the potential of Fe2O3/HCNF anode materials for LIB application.
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http://dx.doi.org/10.1039/d1dt00275aDOI Listing
May 2021

Regulation of Cardiac Conduction and Arrhythmias by Ankyrin/Spectrin-Based Macromolecular Complexes.

J Cardiovasc Dev Dis 2021 Apr 29;8(5). Epub 2021 Apr 29.

The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart. The fidelity of this system depends on the proper spatio-temporal regulation of ion channels in myocytes throughout the conduction system. Importantly, inherited or acquired defects in a wide class of ion channels has been linked to dysfunction at various stages of the conduction system resulting in life-threatening cardiac arrhythmia. There is growing appreciation of the role that adapter and cytoskeletal proteins play in organizing ion channel macromolecular complexes critical for proper function of the cardiac conduction system. In particular, members of the ankyrin and spectrin families have emerged as important nodes for normal expression and regulation of ion channels in myocytes throughout the conduction system. Human variants impacting ankyrin/spectrin function give rise to a broad constellation of cardiac arrhythmias. Furthermore, chronic neurohumoral and biomechanical stress promotes ankyrin/spectrin loss of function that likely contributes to conduction disturbances in the setting of acquired cardiac disease. Collectively, this review seeks to bring attention to the significance of these cytoskeletal players and emphasize the potential therapeutic role they represent in a myriad of cardiac disease states.
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http://dx.doi.org/10.3390/jcdd8050048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146975PMC
April 2021

Factors Associated With the Presenteeism of Single-Person Household Employees in Korea: The 5th Korean Working Conditions Survey (KWCS).

J Occup Environ Med 2021 09;63(9):808-812

Department of Nursing, College of Medicine, Wonkwang University, Iksan, Korea (Dr Min), Division of Nursing, Hyejeon College, Chungcheongnam-do, Korea (Dr Lee).

Objective: The number of single-person households is rapidly increasing worldwide. Many workers from these households have to work even when they are sick, leading to presenteeism. The study aimed to identify factors affecting presenteeism in workers from single-person households.

Methods: This study is a retrospective survey, a secondary data analysis using data from the 5th Korean Working Conditions Survey of 2017.

Results: Of 2156 workers, 366 (17%) showed presenteeism and 1790 (83%) did not. Multiple logistic regression analysis showed that being a woman, subjective health status being moderate or good, presence of disease, longer commuting hours, and longer working hours per week are related to presenteeism.

Conclusions: To reduce the presenteeism of workers from single-person households, specific programs and organizational policies can be developed.
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http://dx.doi.org/10.1097/JOM.0000000000002247DOI Listing
September 2021

A graphene oxide-based fluorescent nanosensor to identify antiviral agents via a drug repurposing screen.

Biosens Bioelectron 2021 Jul 1;183:113208. Epub 2021 Apr 1.

Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea; Department of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea; Institute of Biotherapeutics Convergence Technology, Lemonex Inc., Seoul, 08826, Republic of Korea. Electronic address:

Currently, there are no approved therapeutics for Dengue virus (DENV) infection, even though it can cause fatal complications. Understanding DENV infection and its propagation process in host cells is necessary to develop specific antiviral therapeutics. Here, we developed a graphene oxide-based fluorescent system (Graphene Oxide-based Viral RNA Analysis system, GOViRA) that enables sensitive and quantitative real-time monitoring of the intracellular viral RNA level in living cells. The GOViRA system consists of a fluorescent dye-labeled peptide nucleic acid (PNA) with a complementary sequence to the DENV genome and a dextran-coated reduced graphene oxide nanocolloid (DRGON). When the dye labeled PNA is adsorbed onto DRGON, the fluorescence of the dye is effectively quenched. The quenched fluorescence signal is recovered when the dye labeled PNA forms interaction with intracellular viral RNA in DENV infected host cells. We demonstrated the successful use of the GOViRA platform for high-throughput screening to discover novel antiviral compounds. Through a cell-based high-throughput screening of FDA-approved small-molecule drugs, we identified ulipristal, a selective progesterone receptor modulator (SPRM), as a potent inhibitor against DENV infection. The anti-DENV activity of ulipristal was confirmed both in vitro and in vivo. Moreover, we suggest that the mode of action of ulipristal is mediated by inhibiting viral entry into the host cells.
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http://dx.doi.org/10.1016/j.bios.2021.113208DOI Listing
July 2021

Negative-pressure wound therapy in skin grafts: A systematic review and meta-analysis of randomized controlled trials.

Burns 2021 06 23;47(4):747-755. Epub 2021 Feb 23.

The Department of Burn, The First Affiliated Hospital of Nanchang University, No. 17 Yong Wai Street, Nanchang 330006, Jiangxi, PR China. Electronic address:

Introduction: Although skin grafts are widely used in reconstruction of large skin defect and complex wounds, many factors lead to suboptimal graft take. Negative-pressure wound therapy (NPWT) reportedly increases the graft take rates when added to skin grafting, but a summary analysis of the data of randomized controlled trials has yet to be performed. We conducted this systematic review and meta-analysis of randomized controlled trials to compare the effectiveness and safety of NPWT and non-NPWT for patients with skin grafts.

Methods: We searched PubMed, Embase, Cochrane Library, and CNKI for relevant trials based on predetermined eligibility criteria from database establishment to February 2020. Two reviewers screened citations and extracted data independently. The quality of the included studies was evaluated according to the Cochrane Handbook, whereas statistical heterogeneity was assessed using chi-square tests and I2 statistics. Review Manager 5.3 was used for statistical analysis.

Results: Ten randomized controlled trials with 488 patients who underwent NPWT or non-NPWT were included. Compared with non-NPWT, NPWT yielded an improved the percentage of graft take, a reduction in days from grafting to discharge, with lower relative risk of re-operation, and no increased relative risk of adverse event. Further, the subgroup analysis showed an improved the percentage of graft take in negative pressure of 80 mmHg, and no improved the percentage of graft take in negative pressure of 125 mmHg.

Conclusion: NPWT is more effective than non-NPWT for the integration of skin grafts, and the negative pressure of 80 mmHg can be recommended. Data on adverse events and negative pressure are, however, limited. A better understanding of complications after NPWT and the ideal negative pressure for the integration of skin grafts is imperative.
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http://dx.doi.org/10.1016/j.burns.2021.02.012DOI Listing
June 2021

On the confidence of stereo matching in a deep-learning era: a quantitative evaluation.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 2;PP. Epub 2021 Apr 2.

Stereo matching is one of the most popular techniques to estimate dense depth maps by finding the disparity between matching pixels on two, synchronized and rectified images. Alongside with the development of more accurate algorithms, the research community focused on finding good strategies to estimate the reliability, i.e. the confidence, of estimated disparity maps. This information proves to be a powerful cue to naively find wrong matches as well as to improve the overall effectiveness of a variety of stereo algorithms according to different strategies. In this paper, we review more than ten years of developments in the field of confidence estimation for stereo matching. We extensively discuss and evaluate existing confidence measures and their variants, from hand-crafted ones to the most recent, state-of-the-art learning based methods. We study the different behaviors of each measure when applied to a pool of different stereo algorithms and, for the first time in literature, when paired with a state-of-the-art deep stereo network. Our experiments, carried out on five different standard datasets, provide a comprehensive overview of the field, highlighting in particular both strengths and limitations of learning-based strategies.
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http://dx.doi.org/10.1109/TPAMI.2021.3069706DOI Listing
April 2021

The complete chloroplast genome of (Lamiaceae), a traditional Tibetan medicinal herb.

Mitochondrial DNA B Resour 2021 Mar 24;6(3):1186-1188. Epub 2021 Mar 24.

Research Centre of Ecological Sciences, College of Agronomy, Jiangxi Agricultural University, Nanchang, PR China.

The species is a medicinal herb mainly distributed in southwest China. The first complete plastid genome sequence of reported here was 151,747 bp long, with the large single copy (LSC) region of 83,181 bp, the small single copy (SSC) region of 17,372 bp and two inverted repeats (IRa and IRb) of 25,597 bp. The plastome contained 114 genes, including 80 protein-coding genes, four encoding rRNAs, and 30 encoding tRNAs. The overall GC content was 38.5%. Phylogenetic analysis of Lamiaceae based on a whole plastome matrix suggested that is closely related to the genus as members of subfamily Lamioideae.
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http://dx.doi.org/10.1080/23802359.2021.1902413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995819PMC
March 2021

Cellular and subcellular localization of endogenous phospholipase D6 in seminiferous tubules of mouse testes.

Cell Tissue Res 2021 Jul 30;385(1):191-205. Epub 2021 Mar 30.

College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea.

Phospholipase D6 (PLD6) plays pivotal roles in mitochondrial dynamics and spermatogenesis, but the cellular and subcellular localization of endogenous PLD6 in testis germ cells is poorly defined. We examined the distribution and subcellular localization of PLD6 in mouse testes using validated specific anti-PLD6 antibodies. Ectopically expressed PLD6 protein was detected in the mitochondria of PLD6-transfected cells, but endogenous PLD6 expression in mouse testes was localized to the perinuclear region of pachytene spermatocytes, and more prominently, to the round (Golgi and cap phases) and elongating spermatids (acrosomal phase); these results suggest that PLD6 is localized to the Golgi apparatus. The distribution of PLD6 in the round spermatids partially overlapped with that of the cis-Golgi marker GM130, indicating that the PLD6 expression corresponded to the GM130-positive subdomains of the Golgi apparatus. Correlative light and electron microscopy revealed that PLD6 expression in developing spermatids was localized almost exclusively to several flattened cisternae, and these structures might correspond to the medial Golgi subcompartment; neither the trans-Golgi networks nor the developing acrosomal system expressed PLD6. Further, we observed that PLD6 interacted with tesmin, a testis-specific transcript necessary for successful spermatogenesis in mouse testes. To our knowledge, these results provide the first evidence of PLD6 as a Golgi-localized protein of pachytene spermatocytes and developing spermatids and suggest that its subcompartment-specific distribution within the Golgi apparatus may be related to the specific functions of this organelle during spermatogenesis.
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http://dx.doi.org/10.1007/s00441-021-03442-7DOI Listing
July 2021

Suggestion for a new deterministic model coupled with machine learning techniques for landslide susceptibility mapping.

Sci Rep 2021 03 23;11(1):6594. Epub 2021 Mar 23.

Department of Construction and Disaster Prevention Engineering, Daejeon University, Daejeon, 300-716, Korea.

Deterministic models have been widely applied in landslide risk assessment (LRA), but they have limitations in obtaining various geotechnical and hydraulic properties. The objective of this study is to suggest a new deterministic method based on machine learning (ML) algorithms. Eight crucial variables of LRA are selected with reference to expert opinions, and the output value is set to the safety factor derived by Mohr-Coulomb failure theory in infinite slope. Linear regression and a neural network based on ML are applied to find the best model between independent and dependent variables. To increase the reliability of linear regression and the neural network, the results of back propagation, including gradient descent, Levenberg-Marquardt (LM), and Bayesian regularization (BR) methods, are compared. An 1800-item dataset is constructed through measured data and artificial data by using a geostatistical technique, which can provide the information of an unknown area based on measured data. The results of linear regression and the neural network show that the special LM and BR back propagation methods demonstrate a high determination of coefficient. The important variables are also investigated though random forest (RF) to overcome the number of various input variables. Only four variables-shear strength, soil thickness, elastic modulus, and fine content-demonstrate a high reliability for LRA. The results show that it is possible to perform LRA with ML, and four variables are enough when it is difficult to obtain various variables.
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http://dx.doi.org/10.1038/s41598-021-86137-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988100PMC
March 2021

Compact in-line floating display system using a dihedral corner reflector array.

Opt Express 2021 Jan;29(2):1188-1209

We propose a compact type floating display system using a dihedral corner reflector array. Conventional floating displays using the dihedral corner reflector array usually have a folded configuration which makes the system bulky. The proposed technique achieves the compact in-line configuration using a pair of decentered lenses. The decentered lenses make the effective incident angle to the dihedral corner reflector array be tilted while maintaining the display panel and the dihedral corner reflector array in parallel. The ghost images are also refracted largely by the decentered lenses, being separated from the desired floating images. The proposed technique is verified by optical experiments.
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http://dx.doi.org/10.1364/OE.413544DOI Listing
January 2021
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