Miles D Houslay

Miles D Houslay

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Miles D Houslay

Publications by authors named "Miles D Houslay"

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Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).

Clin Sci (Lond) 2019 Jan 25;133(2):269-286. Epub 2019 Jan 25.

Philips Research Europe, High Tech Campus 34, 5656AE Eindhoven, The Netherlands

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http://dx.doi.org/10.1042/CS20180519DOI Listing
January 2019

Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

Eur Urol Focus 2018 04 13;4(3):376-384. Epub 2017 Jun 13.

Philips Research Europe, High Tech Campus, Eindhoven, The Netherlands; Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.05.010DOI Listing
April 2018

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

Biochem J 2017 02 19;474(4):597-609. Epub 2016 Dec 19.

Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.

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http://biochemj.org/lookup/doi/10.1042/BCJ20160849
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http://dx.doi.org/10.1042/BCJ20160849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290487PMC
February 2017

Melanoma, Viagra, and PDE5 Inhibitors: Proliferation and Metastasis.

Authors:
Miles D Houslay

Trends Cancer 2016 04 17;2(4):163-165. Epub 2016 Mar 17.

Institute of Pharmaceutical Sciences, 5th Floor Franklin-Wilkins Building, King's College London, London SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.02.007DOI Listing
April 2016

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Cell Rep 2016 Jan 31;14(2):255-68. Epub 2015 Dec 31.

Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831919PMC
January 2016

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.

Nat Neurosci 2015 Aug 29;18(8):1077-80. Epub 2015 Jun 29.

1] Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nn.4054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404PMC
August 2015

The role of ventral striatal cAMP signaling in stress-induced behaviors.

Nat Neurosci 2015 Aug 20;18(8):1094-100. Epub 2015 Jul 20.

1] Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. [3] Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/nn.4066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519694PMC
August 2015

Editorial: Reflections on being 'founding' Editor-in-Chief of Cellular Signalling.

Authors:
Miles D Houslay

Cell Signal 2015 Mar 18;27(3):A1-2. Epub 2014 Dec 18.

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http://dx.doi.org/10.1016/j.cellsig.2014.12.007DOI Listing
March 2015

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding.

Biochim Biophys Acta 2014 Nov 7;1843(11):2765-74. Epub 2014 Aug 7.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.07.021DOI Listing
November 2014

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

Cell Signal 2014 Sep 9;26(9):1958-74. Epub 2014 May 9.

Institute of Pharmaceutical Science, King's College London, 5th Floor, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.04.023DOI Listing
September 2014

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

Biochem Pharmacol 2013 May 5;85(9):1297-305. Epub 2013 Mar 5.

Institute of Cardiovascular and Medical Sciences, CMVLS, Glasgow University, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.bcp.2013.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625111PMC
May 2013

Phosphodiesterase-8A binds to and regulates Raf-1 kinase.

Proc Natl Acad Sci U S A 2013 Apr 18;110(16):E1533-42. Epub 2013 Mar 18.

Institute of Cardiovascular and Medical Science, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://www.pnas.org/content/110/16/E1533.full.pdf
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http://researchrepository.ucd.ie/bitstream/handle/10197/5062
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http://www.pnas.org/cgi/doi/10.1073/pnas.1303004110
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http://dx.doi.org/10.1073/pnas.1303004110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631629PMC
April 2013

Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway.

Mol Cell Biol 2012 Jan 24;32(1):88-95. Epub 2011 Oct 24.

Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1128/MCB.05770-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255715PMC
January 2012

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

Mol Cell 2011 Nov;44(3):476-90

Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212815PMC
November 2011

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action.

Handb Exp Pharmacol 2011 (204):47-84

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.

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http://dx.doi.org/10.1007/978-3-642-17969-3_2DOI Listing
September 2011

The cyclic nucleotides.

Handb Exp Pharmacol 2011 (204):v-vii

Molecular Phamarcology Group, Institute of Neuroscience and Psychology, CMVLS, University of G;asgow, Scotland, UK.

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September 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.

J Cell Sci 2011 Jul 7;124(Pt 13):2253-66. Epub 2011 Jun 7.

Molecular Pharmacology Group, Davidson/Wolfson Link Bldgs, Institute of Neuroscience and Psychology, University of Glasgow, University Avenue, Glasgow G128QQ, UK.

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http://dx.doi.org/10.1242/jcs.082982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113672PMC
July 2011

Arresting times for PTEN.

Authors:
Miles D Houslay

EMBO J 2011 Jul 6;30(13):2513-5. Epub 2011 Jul 6.

Molecular Pharmacology Group, Wolfson Link and Davidson Buildings, Institute for Psychology and Neurosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1038/emboj.2011.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155314PMC
July 2011

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

Biochem J 2011 May;435(3):755-69

Molecular Pharmacology Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, Wolfson Link and Davidson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20101184DOI Listing
May 2011

Hard times for oncogenic BRAF-expressing melanoma cells.

Authors:
Miles D Houslay

Cancer Cell 2011 Jan;19(1):3-4

Molecular Pharmacology Group, Institute of Neuroscience and Psychology, CMVLS, Wolfson Link and Davidson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/j.ccr.2011.01.004DOI Listing
January 2011

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors.

Mol Ther 2010 Dec 26;18(12):2139-45. Epub 2010 Oct 26.

British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1038/mt.2010.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997595PMC
December 2010

Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.

Mol Cell Biol 2010 Nov 13;30(22):5406-20. Epub 2010 Sep 13.

Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbook 790-784, South Korea.

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http://dx.doi.org/10.1128/MCB.00217-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976372PMC
November 2010

p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4.

Autophagy 2010 Nov 16;6(8):1198-200. Epub 2010 Nov 16.

Molecular Pharmacology Group, Wolfson Link and Davidson Buildings, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotand, UK.

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http://dx.doi.org/10.4161/auto.6.8.13479DOI Listing
November 2010

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Cell Signal 2010 Oct 19;22(10):1576-96. Epub 2010 Jun 19.

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.cellsig.2010.06.003DOI Listing
October 2010

Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo.

Arterioscler Thromb Vasc Biol 2010 Jul 29;30(7):1389-97. Epub 2010 Apr 29.

British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.

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http://dx.doi.org/10.1161/ATVBAHA.110.204800DOI Listing
July 2010

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Curr Biol 2010 Jun 20;20(12):1086-92. Epub 2010 May 20.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1016/j.cub.2010.04.042DOI Listing
June 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

Biochem J 2010 Apr 28;428(1):55-65. Epub 2010 Apr 28.

Neuroscience and Molecular Pharmacology, Division of Integrative Biology, IBLS, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20091672DOI Listing
April 2010

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown.

Authors:
Miles D Houslay

Trends Biochem Sci 2010 Feb 26;35(2):91-100. Epub 2009 Oct 26.

Neuroscience and Molecular Pharmacology, FBLS, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/j.tibs.2009.09.007DOI Listing
February 2010

Putting the lid on phosphodiesterase 4.

Nat Biotechnol 2010 Jan;28(1):38-40

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http://dx.doi.org/10.1038/nbt0110-38DOI Listing
January 2010

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

FEBS Lett 2009 Oct 24;583(20):3310-6. Epub 2009 Sep 24.

Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, Wolfson Building, Glasgow University, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2009.09.035DOI Listing
October 2009

Disrupting specific PDZ domain-mediated interactions for therapeutic benefit.

Authors:
Miles D Houslay

Br J Pharmacol 2009 Sep;158(2):483-5

Neuroscience and Molecular Pharmacology, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00359.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757687PMC
September 2009

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

J Biol Chem 2009 Jul 7;284(30):20263-74. Epub 2009 May 7.

From the Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland.

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http://dx.doi.org/10.1074/jbc.M109.017640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740452PMC
July 2009

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.

J Biol Chem 2009 Jun 16;284(24):16170-82. Epub 2009 Apr 16.

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.008078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713507PMC
June 2009

MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.

J Biol Chem 2009 Apr 19;284(17):11425-35. Epub 2009 Jan 19.

Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M806395200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670148PMC
April 2009

The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.

J Biol Chem 2009 Apr 13;284(14):9140-6. Epub 2009 Feb 13.

Department of Pharmacology, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M805366200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666564PMC
April 2009

Arrestin times for developing antipsychotics and beta-blockers.

Authors:
Miles D Houslay

Sci Signal 2009 Apr 14;2(66):pe22. Epub 2009 Apr 14.

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1126/scisignal.266pe22DOI Listing
April 2009

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

Cell Signal 2008 Dec 2;20(12):2356-69. Epub 2008 Oct 2.

Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, Wolfson Link and Davidson Buildings, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/j.cellsig.2008.09.017DOI Listing
December 2008

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

Cell Signal 2008 Nov 5;20(11):2071-83. Epub 2008 Aug 5.

Neuroscience and Molecular Pharmacology, Wolfson Link and Davidson Buildings, Faculty of Biomedical & Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/j.cellsig.2008.07.017DOI Listing
November 2008

Protein kinase A type I and type II define distinct intracellular signaling compartments.

Circ Res 2008 Oct 28;103(8):836-44. Epub 2008 Aug 28.

Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.174813DOI Listing
October 2008

Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.

Biochem J 2008 Sep;414(3):363-74

Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20080560DOI Listing
September 2008

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

Proc Natl Acad Sci U S A 2008 Sep 26;105(35):12791-6. Epub 2008 Aug 26.

Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1073/pnas.0805167105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529053PMC
September 2008

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

J Biol Chem 2008 Aug 19;283(34):22952-61. Epub 2008 Jun 19.

Department of Biochemistry, BioSciences Institute, University College Cork, Ireland.

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http://dx.doi.org/10.1074/jbc.M800802200DOI Listing
August 2008

Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.

Biochem J 2008 Jul;413(1):51-60

Sir Henry Welcome Functional Genomics Facility, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20080685DOI Listing
July 2008

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.

Bioorg Med Chem Lett 2008 Feb 14;18(4):1530-3. Epub 2007 Dec 14.

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268889PMC
February 2008

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

Biochem J 2007 Dec;408(2):193-201

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7260, USA.

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http://dx.doi.org/10.1042/BJ20070970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267353PMC
December 2007

Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.

J Biol Chem 2007 Nov 13;282(47):34235-49. Epub 2007 Sep 13.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M706765200
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http://dx.doi.org/10.1074/jbc.M706765200DOI Listing
November 2007

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.

J Physiol 2007 Oct 6;584(Pt 2):401-5. Epub 2007 Sep 6.

University of Edinburgh, Medical Genetics Section, Molecular Medicine Centre, Crewe Road, Edinburgh EH4 2XU, Scotland, UK.

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http://dx.doi.org/10.1113/jphysiol.2007.140210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277141PMC
October 2007

PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

J Pharmacol Exp Ther 2007 Aug 22;322(2):600-9. Epub 2007 May 22.

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

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http://dx.doi.org/10.1124/jpet.107.122218DOI Listing
August 2007

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

J Neurosci 2007 Aug;27(35):9513-24

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.1493-07.2007DOI Listing
August 2007

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.

Biochem J 2007 May;404(1):71-80

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20070005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868836PMC
May 2007

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.

Circ Res 2007 Apr;100(7):950-66

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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https://www.ahajournals.org/doi/10.1161/01.RES.0000261934.56
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http://dx.doi.org/10.1161/01.RES.0000261934.56938.38DOI Listing
April 2007

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

Cell Signal 2006 Nov 1;18(11):2056-69. Epub 2006 Aug 1.

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/j.cellsig.2006.07.018DOI Listing
November 2006

Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling.

Curr Top Dev Biol 2006 ;75:225-59

Division of Biochemistry and Molecular Biology, IBLS, Wolfson Building University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/S0070-2153(06)75007-4DOI Listing
October 2006

Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.

J Cell Sci 2006 Sep 29;119(Pt 18):3799-810. Epub 2006 Aug 29.

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK.

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http://dx.doi.org/10.1242/jcs.03106DOI Listing
September 2006

A RSK(y) relationship with promiscuous PKA.

Authors:
Miles D Houslay

Sci STKE 2006 Aug 22;2006(349):pe32. Epub 2006 Aug 22.

Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1126/stke.3492006pe32DOI Listing
August 2006

Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.

Eur J Cell Biol 2006 Jul 3;85(7):679-91. Epub 2006 Feb 3.

Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S017193350600008
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http://dx.doi.org/10.1016/j.ejcb.2006.01.006DOI Listing
July 2006

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.

Eur J Cell Biol 2006 Jul 28;85(7):673-8. Epub 2006 Feb 28.

Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin-Buch, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2006.01.005DOI Listing
July 2006

Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice.

FEBS Lett 2006 Jul 30;580(17):4126-30. Epub 2006 Jun 30.

Biotechnology Centre of Oslo, University of Oslo, P.O. Box 1125 Blindern, 0317 Oslo, Norway.

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http://dx.doi.org/10.1016/j.febslet.2006.06.058DOI Listing
July 2006

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

Biochem J 2006 Mar;394(Pt 2):427-35

Molecular Pharmacology Group, Division of Biochemistry & Molecular Biology, IBLS, Wolfson Link Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20051560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408673PMC
March 2006

A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP.

Biochem J 2006 Jan;393(Pt 2):481-8

Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK.

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http://dx.doi.org/10.1042/BJ20051505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360698PMC
January 2006

Keynote review: phosphodiesterase-4 as a therapeutic target.

Drug Discov Today 2005 Nov;10(22):1503-19

Division of Biochemistry and Molecular Biology, IBLS, Wolfson Link Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1016/S1359-6446(05)03622-6DOI Listing
November 2005

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

J Biol Chem 2005 Sep 19;280(39):33178-89. Epub 2005 Jul 19.

Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414316200
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http://dx.doi.org/10.1074/jbc.M414316200DOI Listing
September 2005