Mildred Cho

Mildred Cho

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Mildred Cho

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Partial Entrustment in Pragmatic Clinical Trials.

Am J Bioeth 2020 01;20(1):24-26

Stanford University.

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http://dx.doi.org/10.1080/15265161.2019.1687791DOI Listing
January 2020

Informed Consent in the Genomics Era.

Cold Spring Harb Perspect Med 2019 Sep 30. Epub 2019 Sep 30.

Stanford Center for Biomedical Ethics, Stanford, California 94305, USA.

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http://dx.doi.org/10.1101/cshperspect.a036582DOI Listing
September 2019

Disposition toward privacy and information disclosure in the context of emerging health technologies.

J Am Med Inform Assoc 2019 Jul;26(7):610-619

Department of Psychiatry, School of Medicine, University of California, San Diego, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1093/jamia/ocz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562158PMC
July 2019

Using Korean Dramas as a Precision Mental Health Education Tool for Asian Americans: A Pilot Study.

Int J Environ Res Public Health 2019 06 18;16(12). Epub 2019 Jun 18.

Department of Primary Care and Population Health, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.3390/ijerph16122151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617237PMC
June 2019

Anticipating uncertainty and irrevocable decisions: provider perspectives on implementing whole-genome sequencing in critically ill children with heart disease.

Genet Med 2018 11 1;20(11):1455-1461. Epub 2018 Mar 1.

Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/gim.2018.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119522PMC
November 2018

Metaphors matter: from biobank to a library of medical information.

Genet Med 2018 08 21;20(8):802-805. Epub 2017 Dec 21.

Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/gim.2017.204DOI Listing
August 2018

Consent and engagement, security, and authentic living using wearable and mobile health technology.

Nat Biotechnol 2017 07;35(7):617-620

Stanford Center for Biomedical Ethics, Department of Medicine, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.3887DOI Listing
July 2017

Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study.

JAMA Cardiol 2017 01;2(1):67-76

Department of Medicine, Stanford University, Stanford, California2Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California4Department of Genetics, Stanford University, Stanford, California.

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http://dx.doi.org/10.1001/jamacardio.2016.4395DOI Listing
January 2017

Toward a Predictive Understanding of Earth's Microbiomes to Address 21st Century Challenges.

mBio 2016 05 13;7(3). Epub 2016 May 13.

Earth and Environmental Sciences, Lawrence Berkeley National Lab, Berkeley, California, USA Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA

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http://dx.doi.org/10.1128/mBio.00714-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895116PMC
May 2016

"This lifetime commitment": Public conceptions of disability and noninvasive prenatal genetic screening.

Am J Med Genet A 2016 Feb 14;170A(2):363-374. Epub 2015 Nov 14.

Stanford Center for Biomedical Ethics, Stanford, California.

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http://dx.doi.org/10.1002/ajmg.a.37459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948186PMC
February 2016

Informed Consent for Research on Medical Practices.

Ann Intern Med 2015 Nov;163(9):725-6

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http://dx.doi.org/10.7326/L15-5152-2DOI Listing
November 2015

Reporting Race and Ethnicity in Genetics Research: Do Journal Recommendations or Resources Matter?

Sci Eng Ethics 2015 Oct 19;21(5):1353-66. Epub 2014 Nov 19.

Jefferson Medical College, 1025 Walnut Street, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1007/s11948-014-9596-yDOI Listing
October 2015

Impact of Psychiatric Information on Potential Jurors in Evaluating High-Functioning Autism Spectrum Disorder (hfASD).

J Ment Health Res Intellect Disabil 2015 Jul 28;8(3-4):140-167. Epub 2015 May 28.

Stanford Center for Biomedical Ethics Stanford University, and Department of Pediatrics Stanford School of Medicine.

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http://dx.doi.org/10.1080/19315864.2015.1040176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733480PMC
July 2015

Research ethics consultation: ethical and professional practice challenges and recommendations.

Acad Med 2015 May;90(5):615-20

R.R. Sharp is director, Biomedical Ethics Program, Mayo Clinic, Rochester, Minnesota. H.A. Taylor is associate professor, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, and core faculty, Johns Hopkins Berman Institute of Bioethics, Baltimore, Maryland. M.A. Brinich is editor-in-chief, Lakewood Observer, Lakewood, Ohio. M.M. Boyle is clinical research coordinator, MDS/MPN Group, Transplantation Biology Department, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. M. Cho is professor, Stanford Department of Pediatrics, and associate director, Stanford Center for Biomedical Ethics, Stanford University, Stanford, California. M. Coors is associate professor, Department of Psychiatry, Center for Bioethics and Humanities, Anschutz Medical Campus, Aurora, Colorado. M. Danis is section head, Ethics and Health Policy, Department of Bioethics, National Institutes of Health Clinical Center, Bethesda, Maryland. M. Havard is a medical student, University of Cincinnati College of Medicine, Cincinnati, Ohio. D. Magnus is professor of medicine and biomedical ethics, professor of pediatrics, and director, Stanford Center for Biomedical Ethics, Stanford University, Stanford, California. B. Wilfond is director, Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, and professor and chief, Division of Bioethics, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1097/ACM.0000000000000640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414686PMC
May 2015

Whole genome sequencing in critically ill children.

Lancet Respir Med 2015 Apr 20;3(4):264-6. Epub 2015 Feb 20.

Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/S2213-2600(15)00006-5DOI Listing
April 2015

Demographic and experiential correlates of public attitudes towards cell-free fetal DNA screening.

J Genet Couns 2014 Dec 9;23(6):957-67. Epub 2014 Apr 9.

Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1007/s10897-014-9704-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192103PMC
December 2014

Ethics and empiricism in the formation of professional guidelines.

Authors:
Mildred K Cho

Am J Bioeth 2014 ;14(3):1-2

a Stanford University.

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http://dx.doi.org/10.1080/15265161.2014.890426DOI Listing
October 2014

Open-label extension studies: are they really research?

Authors:
Mildred K Cho

Am J Bioeth 2014 ;14(4):60-1

a Stanford University.

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http://dx.doi.org/10.1080/15265161.2014.889958DOI Listing
October 2014

Views of genetics health professionals on the return of genomic results.

J Genet Couns 2014 Aug 2;23(4):531-8. Epub 2013 Jun 2.

Department of Genetics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s10897-013-9611-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809025PMC
August 2014

Genetic testing of children for predisposition to mood disorders: anticipating the clinical issues.

J Genet Couns 2014 Aug 22;23(4):566-77. Epub 2014 Mar 22.

Center for the Integration of Research on Genetics and Ethics of the Stanford Center for Biomedical Ethics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s10897-014-9710-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090807PMC
August 2014

Integrating stakeholder perspectives into the translation of cell-free fetal DNA testing for aneuploidy.

Genome Med 2012 21;4(6):49. Epub 2012 Jun 21.

Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road Modular A, Stanford, California, 94301, USA ; Department of Pediatrics, Division of Genetics, Stanford University, 1215 Welch Road Modular A, Stanford, California, 94301, USA.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm3
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http://dx.doi.org/10.1186/gm348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738226PMC
May 2014

Focusing on Cause or Cure?: Priorities and Stakeholder Presence in Childhood Psychiatry Research.

AJOB Prim Res 2014 Jan;5(1):44-55

Center for the Integration of Research on Genetics and Ethics (CIRGE), Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road, Modular A, Stanford, CA 94305, Tel: (650) 725-7993,

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http://dx.doi.org/10.1080/21507716.2013.811315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979560PMC
January 2014

Translating personalized medicine using new genetic technologies in clinical practice: the ethical issues.

Per Med 2014 ;11(2):211-222

Stanford Center for Biomedical Ethics, 1215 Welch Road, Modular A, Stanford, CA 94305-5417, USA ; Department of Pediatrics, 300 Pasteur Drive, Stanford, CA 94305-5208, USA.

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https://www.futuremedicine.com/doi/10.2217/pme.13.104
Publisher Site
http://dx.doi.org/10.2217/pme.13.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160120PMC
January 2014

Ethical, legal, social, and policy implications of behavioral genetics.

Annu Rev Genomics Hum Genet 2013 28;14:515-34. Epub 2013 Feb 28.

Stanford Center for Biomedical Ethics and.

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http://dx.doi.org/10.1146/annurev-genom-090711-163743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371728PMC
December 2013

The Henrietta Lacks legacy grows.

EMBO Rep 2013 Oct 13;14(10):849. Epub 2013 Sep 13.

Centre for Law and the Biosciences, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/embor.2013.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807222PMC
October 2013

Awareness and Acceptable Practices: IRB and Researcher Reflections on the Havasupai Lawsuit.

AJOB Prim Res 2013 Oct;4(4):55-63

Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road, Modular A, Stanford, CA, USA 94305-5417.

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http://dx.doi.org/10.1080/21507716.2013.770104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786163PMC
October 2013

Interest, rationale, and potential clinical applications of genetic testing for mood disorders: a survey of stakeholders.

J Affect Disord 2013 Feb 28;145(2):240-5. Epub 2012 Sep 28.

Stanford Center for Biomedical Ethics Center for Integration of Research on Genetics and Ethics, CA 94305, USA.

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http://dx.doi.org/10.1016/j.jad.2012.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612530PMC
February 2013

Translating cell-free fetal DNA technology: structural lessons from non-invasive RhD blood typing.

Trends Biotechnol 2013 Jan 3;31(1):7-9. Epub 2012 Oct 3.

Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road, Modular A, Stanford, CA 94301, USA.

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http://dx.doi.org/10.1016/j.tibtech.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309969PMC
January 2013

Genetic counseling for prenatal testing: where is the discussion about disability?

J Genet Couns 2012 Dec 17;21(6):814-24. Epub 2012 Aug 17.

Department of Genetics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s10897-012-9484-zDOI Listing
December 2012

Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration challenges in the US context.

Hum Reprod 2012 Nov 3;27(11):3123-31. Epub 2012 Aug 3.

Stanford Center for Biomedical Ethics, Stanford, CA 94305-5417, USA.

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http://dx.doi.org/10.1093/humrep/des286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472618PMC
November 2012

Customers or research participants? Guidance for research practices in commercialization of personal genomics.

Genet Med 2012 Oct 14;14(10):833-5. Epub 2012 Jun 14.

Center for Biomedical Ethics, School of Medicine, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/gim.2012.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289753PMC
October 2012

Informational risk, institutional review, and autonomy in the proposed changes to the common rule.

IRB 2012 May-Jun;34(3):17-9

Stanford Center for the Integration of Research on Genetics and Ethics, Stanford University, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824263PMC
August 2012

In the public interest?

Sci Transl Med 2012 Jul;4(144):144fs23

Stanford Center for Biomedical Ethics, Stanford University, Stanford, CA 94301, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003612DOI Listing
July 2012

Secondary researchers' duties to return incidental findings and individual research results: a partial-entrustment account.

Genet Med 2012 Apr 23;14(4):467-72. Epub 2012 Feb 23.

Department of Philosophy, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1038/gim.2012.12DOI Listing
April 2012

Human evolutionary genomics: ethical and interpretive issues.

Trends Genet 2012 Mar 20;28(3):137-45. Epub 2012 Jan 20.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.tig.2011.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210170PMC
March 2012

Triggers for research ethics consultation.

Sci Transl Med 2012 Jan;4(118):118cm1

Center for Biomedical Ethics, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002734DOI Listing
January 2012

Cell-free fetal DNA testing: a pilot study of obstetric healthcare provider attitudes toward clinical implementation.

Prenat Diagn 2011 Nov 27;31(11):1070-6. Epub 2011 Jul 27.

Stanford Center for Biomedical Ethics, Stanford University, Stanford, CA 94301, USA.

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http://dx.doi.org/10.1002/pd.2835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200428PMC
November 2011

Ethics watch: the G.I. genome: ethical implications of genome sequencing in the military.

Nat Rev Genet 2011 Aug 2;12(9):589. Epub 2011 Aug 2.

Center for the Integration of Research on Genetics and Ethics, Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road, Modular A, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nrg3063DOI Listing
August 2011

Cell-free fetal nucleic acid testing: a review of the technology and its applications.

Obstet Gynecol Surv 2011 Jul;66(7):431-42

Stanford Center for Biomedical Ethics, Department of Pediatrics, Division of Genetics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1097/OGX.0b013e31822dfbe2DOI Listing
July 2011

Medical and graduate students' attitudes toward personal genomics.

Genet Med 2011 May;13(5):400-8

Department of Genetics, Stanford Center for Biomedical Ethics, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1097/GIM.0b013e31820562f6DOI Listing
May 2011

Research ethics in the era of personalized medicine: updating science's contract with society.

Public Health Genomics 2010 31;13(6):378-84. Epub 2010 Aug 31.

Indiana University Center for Bioethics, IU School of Medicine, Indianapolis, Ind. 46202, USA.

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http://dx.doi.org/10.1159/000319473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951727PMC
December 2010

Patently unpatentable: implications of the Myriad court decision on genetic diagnostics.

Authors:
Mildred Cho

Trends Biotechnol 2010 Nov;28(11):548-51

Stanford Center for Biomedical Ethics, 1215 Welch Road, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.tibtech.2010.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955823PMC
November 2010

Not yet in sequence: Clinical, technical, ethical questions linger over personal genomics.

Mod Healthc 2010 Nov;40(47):24

Center for Integration of Research on Genetics and Ethics, Stanford University School of Medicine, Palo Alto, Calif., USA.

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November 2010

Genetic technologies. Synthetic "life," ethics, national security, and public discourse.

Science 2010 Jul;329(5987):38-9

Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.1193749DOI Listing
July 2010

Direct-to-consumer genetic tests: beyond medical regulation?

Genome Med 2009 Feb 2;1(2):17. Epub 2009 Feb 2.

Stanford Center for Biomedical Ethics, 701A Welch Road, Suite 1105, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1186/gm17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664950PMC
February 2009

Research ethics consultation: the Stanford experience.

IRB 2008 Nov-Dec;30(6):1-6

Stanford Center for Biomedical Ethics, Stanford University, Palo Alto, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931698PMC
January 2009

Translating genomics into the clinic: moving to the post-Mendelian world.

Authors:
Mildred K Cho

Genome Med 2009 Jan 20;1(1). Epub 2009 Jan 20.

Stanford Center for Biomedical Ethics, Center for Integration of Research on Genetics and Ethics, Department of Pediatrics, Division of Genetics, Welch Road, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1186/gm7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651588PMC
January 2009

Understanding incidental findings in the context of genetics and genomics.

Authors:
Mildred K Cho

J Law Med Ethics 2008 ;36(2):280-5, 212

Department of Pediatrics at Stanford University, CA, USA.

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http://dx.doi.org/10.1111/j.1748-720X.2008.00270.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581745PMC
July 2008

Strangers at the benchside: research ethics consultation.

Am J Bioeth 2008 Mar;8(3):4-13

Stanford Center for Biomedical Ethics, Center for Integration of Research on Geneticsand Ethics, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1080/15265160802132951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585006PMC
March 2008

Research ethics and the challenge of whole-genome sequencing.

Nat Rev Genet 2008 02;9(2):152-6

Amy L. McGuire is at the Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nrg2302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225443PMC
February 2008

Ethical implications of array comparative genomic hybridization in complex phenotypes: points to consider in research.

Genet Med 2007 Sep;9(9):626-31

Stanford Center for Biomedical Ethics, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.

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http://dx.doi.org/10.1097/gim.0b013e3181485688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220022PMC
September 2007

Medicine. The future of personal genomics.

Science 2007 Sep;317(5845):1687

Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1147475
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http://dx.doi.org/10.1126/science.1147475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220016PMC
September 2007

Race and ethnicity in genetic research.

Am J Med Genet A 2007 May;143A(9):961-70

Department of Medical Ethics; Center for Bioethics; Leonard Davis Institute for Health Economics, University of Pennsylvania, Philadelphia, PA 19130, USA.

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http://dx.doi.org/10.1002/ajmg.a.31575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271134PMC
May 2007

Response to open peer commentaries on "Thinking about the human neuron mouse".

Am J Bioeth 2007 May;7(5):W4-6

Stanford University, CA, USA.

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http://dx.doi.org/10.1080/15265160701372674DOI Listing
May 2007

How do women decide? Accepting or declining BRCA1/2 testing in a nationwide clinical sample in the United States.

Community Genet 2006 ;9(2):78-86

Center for Bioethics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1159/000091484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317096PMC
September 2006

A commentary on oocyte donation for stem cell research in South Korea.

Am J Bioeth 2006 Jan-Feb;6(1):W23-4

Stanford University.

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http://dx.doi.org/10.1080/15265160500496666DOI Listing
February 2006

Research conduct. Lessons of the stem cell scandal.

Science 2006 Feb;311(5761):614-5

Stanford Center for Biomedical Ethics, Department of Pediatrics; Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/science.1124948DOI Listing
February 2006

What are gene patents and why are people worried about them?

Community Genet 2005 ;8(4):203-8

Department of Medical Ethics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-3308, USA.

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http://dx.doi.org/10.1159/000087956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220018PMC
January 2006

What is in a cause? Exploring the relationship between genetic cause and felt stigma.

Genet Med 2006 Jan;8(1):33-42

Center for Bioethics, University of Pennsylvania, 3401 Market Street, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271135PMC
http://dx.doi.org/10.1097/01.gim.0000195894.67756.8bDOI Listing
January 2006

Ethics. Issues in oocyte donation for stem cell research.

Science 2005 Jun 19;308(5729):1747-8. Epub 2005 May 19.

Stanford Center for Biomedical Ethics and Department of Pediatrics, Stanford University, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1126/science.1114454DOI Listing
June 2005

Forensic genetics and ethical, legal and social implications beyond the clinic.

Nat Genet 2004 Nov;36(11 Suppl):S8-12

Stanford Center for Biomedical Ethics, 701A Welch Road, Suite 1105, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1038/ng1594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271138PMC
November 2004