Dr Milad Bastami, PhD - Assistant Professor at Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences - Dr

Dr Milad Bastami

PhD

Assistant Professor at Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences

Dr

Tabriz | Iran (Islamic Republic of)

Main Specialties: Medical Genetics

Additional Specialties: Medical genetics

ORCID logohttps://orcid.org/0000-0002-7686-4505

Dr Milad Bastami, PhD - Assistant Professor at Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences - Dr

Dr Milad Bastami

PhD

Introduction

Primary Affiliation: Assistant Professor at Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences - Tabriz , Iran (Islamic Republic of)

Specialties:

Additional Specialties:

Research Interests:

Education

Jan 2012 - Jan 2016
Shahid Beheshti University of Medical Sciences
PhD candidate
Medical Genetics
Jan 2009 - Jan 2011
University of Social Welfare and Rehabilitation Science
MSc student
Genetics Research Center
Jan 2004 - Jan 2008
Urmia University
BSc
Department of Biology

Experience

Jul 2016
Tabriz University of Medical Sciences
Assistant Professor
Medical Genetics

Publications

30Publications

639Reads

484Profile Views

27PubMed Central Citations

Breast cancer-linked lncRNA u-Eleanor is upregulated in breast of healthy women with lack or short duration of breastfeeding.

J Cell Biochem 2019 Jun 11;120(6):9869-9876. Epub 2018 Dec 11.

Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

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http://dx.doi.org/10.1002/jcb.28269DOI Listing
June 2019
9 Reads
3.263 Impact Factor

Cell-free microRNA-148a is associated with renal allograft dysfunction: Implication for biomarker discovery.

J Cell Biochem 2019 Apr 15;120(4):5737-5746. Epub 2018 Oct 15.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1002/jcb.27860DOI Listing
April 2019
6 Reads
3.263 Impact Factor

Association of mir-196a-2 rs11614913 and mir-149 rs2292832 Polymorphisms With Risk of Cancer: An Updated Meta-Analysis

Front. Genet., 15 March 2019. https://doi.org/10.3389/fgene.2019.00186

Frontiers in Genetics

Background: Accumulating evidence suggests that functional dysregulations of miRNAs, especially miR-196a-2 and miR-149, in cancers could be attributed to polymorphisms in miRNA sequences. This study was aimed at clarifying the association of mir-196a-2 rs11614913 and mir-149 rs2292832 with cancer risk by performing an updated meta-analysis of genetic association studies.

Methods: PubMed, Embase, Scopus, and ScienceDirect databases were searched until 9 April 2018 to identify eligible studies. Studies should meet the following criteria to be included in the meta-analysis: evaluation of genetic association between rs11614913 and/or rs2292832 and susceptibility to cancer; A case-control design; Written in English; Availability of sufficient data for estimating odds ratio (OR) and its 95% confidence interval (95%CI). Studies that met the following criteria were excluded: review articles, meta-analysis, abstracts or conference papers; duplicate publications; studies on animals or cell-lines; studies without a case-control design; studies that did not report genotype frequencies. Pooled ORs and 95% CIs were estimated using a total of 111 studies (41,673 cases and 49,570 controls) for mir-196a rs11614913 and 44 studies (15,954 cases and 19,594 controls) for mir-149 rs2292832. Stratified analysis according to quality scores, genotyping method, ethnicity, broad cancer category and cancer type was also performed.

Results: Mir-196a-2 rs11614913 T allele was associated with decreased cancer risk in overall population. The association was only significant in Asians but not Caucasians. In subgroup analysis, significant associations were found in high quality studies, gynecological cancers, ovarian, breast, and hepatocellular cancer. Mir-149 rs2292832 was not associated with cancer risk in overall population and there were no differences between Asians and Caucasians. However, the T allele was associated with a decrease risk of gastrointestinal tract cancers under the heterozygote model and an increased risk of colorectal cancer under the recessive model.

Conclusions: The present meta-analysis suggests that mir-196a-2 rs11614913 may contribute to the risk of cancer especially in Asians. Mir-149 rs2292832 may modulate the risk of gastrointestinal tract cancers especially colorectal cancer. This study had some limitations such as significant heterogeneity in most contrasts, limited number of studies enrolling Africans or Caucasians ancestry and lack of adjustment for covariates and environmental interactions.

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March 2019

Impact Factor 4.180

The intricate role of miR-155 in carcinogenesis: potential implications for esophageal cancer research.

Biomark Med 2019 Feb 23;13(2):147-159. Epub 2019 Jan 23.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.2217/bmm-2018-0127DOI Listing
February 2019
61 Reads
2.858 Impact Factor

Methylation of progesterone receptor isoform A promoter in normal breast tissue: An epigenetic link between early age at menarche and risk of breast cancer?

J Cell Biochem 2019 Feb 28. Epub 2019 Feb 28.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform ? is a crucial regulator of breast hormone responsiveness and its hypermethylation plays an important role in the initiation and development of breast tumors. However, such a methylation change in healthy women and its link with the different risk factors has not yet been investigated. In the present study, we aimed to examine the relationship of possible methylation changes within a critical region in the promoter CpG island of PGR-? (progesterone receptor ?) gene in the healthy women with a set of reproductive and nonreproductive BC risk factors. The breast tissues were collected from 120 cancer-free women who had undergone cosmetic mammoplasty. The genomic DNA was extracted from the breast tissues and the methylation level of PGR-? promoter CpG island was determined by using MeDIP-qPCR assay. Using regression analysis, we found that increasing menarche age is inversely associated with the high methylation of PGR-? promoter ( ??=?-0.790, SE?=?0.362; P?=?0.031). Although lactating women had more methylation than nonlactating women (P?=?0.026, the t test), this result was not confirmed by regression models. Such an observation may be helpful in better understanding of the underlying mechanisms by which early age at menarche increases the risk of BC. However, this perspective requires further validations in larger studies of more subjects as well as the inclusion of other related genes.

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http://dx.doi.org/10.1002/jcb.28505DOI Listing
February 2019
2 Reads
3.263 Impact Factor

miRNA Polymorphisms and Risk of Cardio-Cerebrovascular Diseases: A Systematic Review and Meta-Analysis.

Int J Mol Sci 2019 Jan 12;20(2). Epub 2019 Jan 12.

Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz 5138663134, Iran.

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http://dx.doi.org/10.3390/ijms20020293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359604PMC
January 2019
65 Reads
2.862 Impact Factor

The role of microbiota in the pathogenesis of lupus: Dose it impact lupus nephritis?

Pharmacol Res 2019 01 22;139:191-198. Epub 2018 Nov 22.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.11.023DOI Listing
January 2019
29 Reads
4.408 Impact Factor

An Association and Meta-Analysis of Esophageal Squamous Cell Carcinoma Risk Associated with PLCE1 rs2274223, C20orf54 rs13042395 and RUNX1 rs2014300 Polymorphisms.

Pathol Oncol Res 2019 Jan 21. Epub 2019 Jan 21.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1007/s12253-019-00579-3DOI Listing
January 2019
53 Reads
1.806 Impact Factor

Expression levels of breast cancer-related GAS5 and LSINCT5 lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity.

Breast J 2018 Nov 21;24(6):876-882. Epub 2018 May 21.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/tbj.13067DOI Listing
November 2018
12 Reads
1.433 Impact Factor

Simultaneous downregulation of miR-21 and miR-155 through oleuropein for breast cancer prevention and therapy.

J Cell Biochem 2018 Sep 15;119(9):7151-7165. Epub 2018 Jun 15.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1002/jcb.26754DOI Listing
September 2018
9 Reads
3.263 Impact Factor

Aberrant miRNA promoter methylation and EMT-involving miRNAs in breast cancer metastasis: Diagnosis and therapeutic implications.

J Cell Physiol 2018 05 7;233(5):3729-3744. Epub 2017 Sep 7.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1002/jcp.26116DOI Listing
May 2018
39 Reads
4 Citations
3.840 Impact Factor

Overexpression of serum MicroRNA-140-3p in premenopausal women with newly diagnosed breast cancer.

Gene 2018 May 21;655:25-29. Epub 2018 Feb 21.

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2018.02.032DOI Listing
May 2018
7 Reads
2.140 Impact Factor

A link between expression level of long-non-coding RNA ZFAS1 in breast tissue of healthy women and obesity.

Int J Biol Markers 2018 Apr 1:1724600818762258. Epub 2018 Apr 1.

1 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1177/1724600818762258DOI Listing
April 2018
14 Reads
1.360 Impact Factor

Epigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?

Genet Test Mol Biomarkers 2017 Aug 14;21(8):464-470. Epub 2017 Jul 14.

1 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran .

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http://dx.doi.org/10.1089/gtmb.2017.0028DOI Listing
August 2017
18 Reads

The miRNA targetome of coronary artery disease is perturbed by functional polymorphisms identified and prioritized by in-depth bioinformatics analyses exploiting genome-wide association studies.

Gene 2016 Dec 2;594(1):74-81. Epub 2016 Sep 2.

Bambino Gesù Children's Hospital-IRCCS, Gene Expression - Microarrays Laboratory, Viale di San Paolo 15, 00146 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2016.08.054DOI Listing
December 2016
49 Reads
2 Citations
2.140 Impact Factor

In silico dissection of miRNA targetome polymorphisms and their role in regulating miRNA-mediated gene expression in esophageal cancer.

Cell Biochem Biophys 2016 Dec 12;74(4):483-497. Epub 2016 Aug 12.

Bambino Gesù Children's Hospital-IRCCS, Gene Expression - Microarrays Laboratory, Viale di San Paolo 15, Rome, 00146, Italy.

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http://dx.doi.org/10.1007/s12013-016-0754-5DOI Listing
December 2016
19 Reads
2 Citations
1.680 Impact Factor

A Bioinformatics Approach to Prioritize Single Nucleotide Polymorphisms in TLRs Signaling Pathway Genes.

Int J Mol Cell Med 2016 1;5(2):65-79. Epub 2016 May 1.

Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947211PMC
August 2016
13 Reads

MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population.

Int J Mol Cell Med 2016 21;5(3):134-140. Epub 2016 Aug 21.

Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125365PMC
August 2016
48 Reads

A Bioinformatics Approach to the Identification of Variants Associated with Type 1 and Type 2 Diabetes Mellitus that Reside in Functionally Validated miRNAs Binding Sites.

Biochem Genet 2016 Jun 28;54(3):211-21. Epub 2016 Jan 28.

Gene Expression - Microarrays Laboratory, Bambino Gesù Children's Hospital, IRCCS, Polo di Ricerca - V.le di San Paolo 15, 00146, Rome, Italy.

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http://dx.doi.org/10.1007/s10528-016-9713-5DOI Listing
June 2016
37 Reads
2 Citations
0.865 Impact Factor

MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population.

Genet Test Mol Biomarkers 2016 May 24;20(5):241-8. Epub 2016 Feb 24.

5 Bambino Gesù Children's Hospital-IRCCS , Gene Expression - Microarrays Laboratory, Rome, Italy .

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http://dx.doi.org/10.1089/gtmb.2015.0253DOI Listing
May 2016
23 Reads
5 Citations

Bioinformatics prioritization of SNPs perturbing microRNA regulation of hematological malignancy-implicated genes.

Genomics 2015 Dec 29;106(6):360-6. Epub 2015 Oct 29.

Bambino Gesù Children's Hospital-IRCCS, Gene Expression - Microarrays Laboratory, V.le San Paolo 15, 00146 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2015.10.004DOI Listing
December 2015
21 Reads
2 Citations
2.284 Impact Factor

Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.

Cell Mol Biol (Noisy-le-grand) 2015 Nov 20;61(7):50-4. Epub 2015 Nov 20.

Bambino Gesù Children's Hospital—IRCCS Gene Expression—Microarrays Laboratory Rome Italy.

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November 2015
9 Reads
1 Citation
1.234 Impact Factor

Mutational screening of the NR5A1 in azoospermia.

Andrologia 2015 May 20;47(4):395-401. Epub 2014 Apr 20.

Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/and.12274DOI Listing
May 2015
11 Reads
1 Citation
1.172 Impact Factor

Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers.

Iran Red Crescent Med J 2014 Jul 5;16(7):e16659. Epub 2014 Jul 5.

Medical Genetics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

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http://dx.doi.org/10.5812/ircmj.16659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166088PMC
July 2014
12 Reads
6 Citations
0.504 Impact Factor

Mutational screening of the NR5A1 in azoospermia

Andrologia. 2014 Apr 20. doi: 10.1111/and.12274

Andrologia

Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes a nuclear receptor that regulates transcription of multiple genes involved in adrenal and gonadal development, steroidogenesis and the reproductive axis. Human mutations in NR5A1were initially found in two 46, XY female patients suffering from severe gonadal dysgenesis and primary adrenal failure. However, more recent case reports have suggested that heterozygous mutations in NR5A1 may also contribute to the male infertility aetiology. We have analysed the coding sequence of NR5A1 in a cohort of 90 well-characterised idiopathic Iranian azoospermic infertile men versus 112 fertile men. Heterozygous NR5A1 mutations were found in 2 of 90 (2.2%) of cases. These two patients harboured missense mutations within the hinge region (p.P97T) and ligand-binding domain (p.E237K) of the NR5A1 protein. In silico analysis of the mutations showed that founded mutations could be detrimental. In conclusion, findings of the current and previous studies suggest that mutations in the NR5A1 gene are not common in azoospermia, and male infertility and inclusion of NR5A1 mutation screening in the diagnostic workup of male infertility may seem unnecessary.

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April 2014
14 Reads

Top co-authors

Abdolreza Daraei
Abdolreza Daraei

Isfahan University of Medical Sciences

8
Yaser Mansoori
Yaser Mansoori

School of Medicine

8
Zahra Saadatian
Zahra Saadatian

International Branch of Tabriz University of Medical Sciences (Aras)

8
Andrea Masotti
Andrea Masotti

Bambino Gesù Children's Hospital

7
Hamid Ghaedi
Hamid Ghaedi

Shahid Beheshti University of Medical Sciences

6
Mir Davood Omrani
Mir Davood Omrani

Shahid Beheshti University of Medical Sciences

6
Sepideh Zununi Vahed
Sepideh Zununi Vahed

Tabriz University of Medical Sciences

4
Mohammad Mehdi Naghizadeh
Mohammad Mehdi Naghizadeh

Noncommunicable Diseases Research Center

4