Publications by authors named "Mikhail V Blagosklonny"

100Publications

From causes of aging to death from COVID-19.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2020 06 12;12(11):10004-10021. Epub 2020 Jun 12.

Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
June 2020

Rapamycin for the aging skin.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2019 12 27;11(24):12822-12826. Epub 2019 Dec 27.

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2019

Rapamycin for longevity: opinion article.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2019 10 4;11(19):8048-8067. Epub 2019 Oct 4.

Cell Stress Biology Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
October 2019

Fasting and rapamycin: diabetes versus benevolent glucose intolerance.

Authors:
Mikhail V Blagosklonny

Cell Death Dis 2019 08 13;10(8):607. Epub 2019 Aug 13.

Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY, 14263, USA.

View Article and Find Full Text PDF
August 2019

The mystery of the ketogenic diet: benevolent pseudo-diabetes.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2019 09 1;18(18):2157-2163. Epub 2019 Aug 1.

Cell Stress Biology, Roswell Park Cancer Institute , Buffalo , NY , USA.

View Article and Find Full Text PDF
September 2019

Paradoxes of senolytics.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2018 12;10(12):4289-4293

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2018

Rapamycin, proliferation and geroconversion to senescence.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2018 12;17(24):2655-2665. Epub 2018 Dec 12.

a Cell Stress Biology , Roswell Park Cancer Institute , Buffalo , NY , USA.

View Article and Find Full Text PDF
November 2019

Disease or not, aging is easily treatable.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2018 11;10(11):3067-3078

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
November 2018

Does rapamycin slow down time?

Authors:
Mikhail V Blagosklonny

Oncotarget 2018 Jul 13;9(54):30210-30212. Epub 2018 Jul 13.

Mikhail V. Blagosklonny: Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
July 2018

Correction: Librarians against scientists: Oncotarget's lesson.

Authors:
Mikhail V Blagosklonny

Oncotarget 2018 03 13;9(19):15167. Epub 2018 Mar 13.

View Article and Find Full Text PDF
March 2018

Librarians against scientists: Oncotarget's lesson.

Authors:
Mikhail V Blagosklonny

Oncotarget 2018 Jan 19;9(5):5515-5516. Epub 2018 Jan 19.

View Article and Find Full Text PDF
January 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

View Article and Find Full Text PDF
March 2018

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Oncotarget 2017 Dec 11;8(65):109848-109856. Epub 2017 May 11.

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2017

From rapalogs to anti-aging formula.

Authors:
Mikhail V Blagosklonny

Oncotarget 2017 May;8(22):35492-35507

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
May 2017

Gerosuppression by pan-mTOR inhibitors.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Aging (Albany NY) 2016 12;8(12):3535-3551

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elms and Carlson Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2016

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).

Authors:
Olga V Leontieva Zoya N Demidenko Mikhail V Blagosklonny

Oncotarget 2015 Sep;6(27):23238-48

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
September 2015

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.

Authors:
Ekaterina A Lesovaya Kirill I Kirsanov Elena E Antoshina Lubov S Trukhanova Tatiana G Gorkova Elena V Shipaeva Ramiz M Salimov Gennady A Belitsky Mikhail V Blagosklonny Marianna G Yakubovskaya Olga B Chernova

Oncotarget 2015 ;6(12):9718-27

Everon Biosciences, Inc., Buffalo, NY, USA.

View Article and Find Full Text PDF
April 2016

Rejuvenating immunity: "anti-aging drug today" eight years later.

Authors:
Mikhail V Blagosklonny

Oncotarget 2015 Aug;6(23):19405-12

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
August 2015

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Oncotarget 2014 Dec;5(24):12715-27

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2014

Gerosuppression in confluent cells.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Aging (Albany NY) 2014 Dec;6(12):1010-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elms and Carlson Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2014

Fasting levels of hepatic p-S6 are increased in old mice.

Authors:
Olga V Leontieva Geraldine M Paszkiewicz Mikhail V Blagosklonny

Cell Cycle 2014 ;13(17):2656-9

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

View Article and Find Full Text PDF
July 2015

Comparison of rapamycin schedules in mice on high-fat diet.

Authors:
Olga V Leontieva Geraldine M Paszkiewicz Mikhail V Blagosklonny

Cell Cycle 2014 ;13(21):3350-6

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

View Article and Find Full Text PDF
July 2015

Geroconversion: irreversible step to cellular senescence.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2014 ;13(23):3628-35

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

View Article and Find Full Text PDF
September 2015

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.

Authors:
Olga V Leontieva Zoya N Demidenko Mikhail V Blagosklonny

Proc Natl Acad Sci U S A 2014 Jun 2;111(24):8832-7. Epub 2014 Jun 2.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263

View Article and Find Full Text PDF
June 2014

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.

Authors:
Olga V Leontieva Geraldine M Paszkiewicz Mikhail V Blagosklonny

Aging Cell 2014 Aug 22;13(4):616-22. Epub 2014 Mar 22.

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA.

View Article and Find Full Text PDF
August 2014

Immunosuppressants in cancer prevention and therapy.

Authors:
Mikhail V Blagosklonny

Oncoimmunology 2013 Dec 6;2(12):e26961. Epub 2013 Nov 6.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
December 2013

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.

Authors:
Irina G Popovich Vladimir N Anisimov Mark A Zabezhinski Anna V Semenchenko Margarita L Tyndyk Maria N Yurova Mikhail V Blagosklonny

Cancer Biol Ther 2014 May 20;15(5):586-92. Epub 2014 Feb 20.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
May 2014

M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Cell Cycle 2014 23;13(4):509-15. Epub 2014 Jan 23.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
April 2015

Selective anti-cancer agents as anti-aging drugs.

Authors:
Mikhail V Blagosklonny

Cancer Biol Ther 2013 Dec 27;14(12):1092-7. Epub 2013 Nov 27.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
December 2013

Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2013 Dec 15;12(24):3736-42. Epub 2013 Nov 15.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
December 2013

Dysregulation of the mTOR pathway in p53-deficient mice.

Authors:
Olga V Leontieva Liliya R Novototskaya Geraldine M Paszkiewicz Elena A Komarova Andrei V Gudkov Mikhail V Blagosklonny

Cancer Biol Ther 2013 Dec 1;14(12):1182-8. Epub 2013 Nov 1.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
December 2013

S6K in geroconversion.

Authors:
Olga V Leontieva Zoya N Demidenko Mikhail V Blagosklonny

Cell Cycle 2013 Oct 9;12(20):3249-52. Epub 2013 Sep 9.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
October 2013

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Cell Cycle 2013 Sep 22;12(18):3063-9. Epub 2013 Aug 22.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Elm & Carlton Streets; Buffalo, NY USA.

View Article and Find Full Text PDF
September 2013

Damage-induced aging and perpetual motion.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2013 Sep 5;12(17):2709-10. Epub 2013 Aug 5.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

View Article and Find Full Text PDF
September 2013

Rapamycin extends life- and health span because it slows aging.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2013 Aug;5(8):592-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

View Article and Find Full Text PDF
August 2013

M(o)TOR of aging: MTOR as a universal molecular hypothalamus.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2013 Jul;5(7):490-4

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
July 2013

Rapamycin suppresses brain aging in senescence-accelerated OXYS rats.

Authors:
Nataliya G Kolosova Anton O Vitovtov Natalia A Muraleva Andrey E Akulov Natalia A Stefanova Mikhail V Blagosklonny

Aging (Albany NY) 2013 Jun;5(6):474-84

Institute of Cytology and Genetics SB RAS, Acad. , 630090, Novosibirsk, Russia.

View Article and Find Full Text PDF
June 2013

MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2013 Jun 12;12(12):1842-7. Epub 2013 Jun 12.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
June 2013

Big mice die young but large animals live longer.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2013 Apr;5(4):227-33

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
April 2013

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.

Authors:
Mikhail V Blagosklonny

Oncotarget 2012 Dec;3(12):1711-24

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2012

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.

Authors:
Olga V Leontieva Geraldine M Paszkiewicz Mikhail V Blagosklonny

Aging (Albany NY) 2012 Dec;4(12):899-916

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2012

Answering the ultimate question "what is the proximal cause of aging?".

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2012 Dec;4(12):861-77

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2012

Hypoxia, MTOR and autophagy: converging on senescence or quiescence.

Authors:
Mikhail V Blagosklonny

Autophagy 2013 Feb 28;9(2):260-2. Epub 2012 Nov 28.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
February 2013

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells.

Authors:
Olga V Leontieva Felicia Lenzo Zoya N Demidenko Mikhail V Blagosklonny

Cell Cycle 2012 Dec 27;11(24):4642-9. Epub 2012 Nov 27.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2012

Rapalogs in cancer prevention: anti-aging or anticancer?

Authors:
Mikhail V Blagosklonny

Cancer Biol Ther 2012 Dec 14;13(14):1349-54. Epub 2012 Nov 14.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2012

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.

Authors:
Elena A Komarova Marina P Antoch Liliya R Novototskaya Olga B Chernova Geraldine Paszkiewicz Olga V Leontieva Mikhail V Blagosklonny Andrei V Gudkov

Aging (Albany NY) 2012 Oct;4(10):709-14

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
October 2012

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Authors:
Maria Comas Ilia Toshkov Karen K Kuropatwinski Olga B Chernova Alexander Polinsky Mikhail V Blagosklonny Andrei V Gudkov Marina P Antoch

Aging (Albany NY) 2012 Oct;4(10):715-22

Departments of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
October 2012

Hypoxia and gerosuppression: the mTOR saga continues.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Cell Cycle 2012 Nov 17;11(21):3926-31. Epub 2012 Sep 17.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
November 2012

How to save Medicare: the anti-aging remedy.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2012 Aug;4(8):547-52

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
August 2012

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2012 Jul;4(7):450-5

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
July 2012

Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

Authors:
Olga V Leontieva Venkatesh Natarajan Zoya N Demidenko Lyudmila G Burdelya Andrei V Gudkov Mikhail V Blagosklonny

Proc Natl Acad Sci U S A 2012 Aug 30;109(33):13314-8. Epub 2012 Jul 30.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
August 2012

Prospective treatment of age-related diseases by slowing down aging.

Authors:
Mikhail V Blagosklonny

Am J Pathol 2012 Oct 27;181(4):1142-6. Epub 2012 Jul 27.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

View Article and Find Full Text PDF
October 2012

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells.

Authors:
Mikhail V Blagosklonny

Oncotarget 2012 Jun;3(6):601-7

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
June 2012

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug.

Authors:
Isabelle Mercier Jeanette Camacho Kanani Titchen Donna M Gonzales Kevin Quann Kelly G Bryant Alexander Molchansky Janet N Milliman Diana Whitaker-Menezes Federica Sotgia Jean-François Jasmin Roland Schwarting Richard G Pestell Mikhail V Blagosklonny Michael P Lisanti

Am J Pathol 2012 Jul 13;181(1):278-93. Epub 2012 Jun 13.

Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

View Article and Find Full Text PDF
July 2012

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2012 May;4(5):350-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
May 2012

Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats.

Authors:
Nataliya G Kolosova Natalia A Muraleva Anna A Zhdankina Natalia A Stefanova Anzhela Z Fursova Mikhail V Blagosklonny

Am J Pathol 2012 Aug 7;181(2):472-7. Epub 2012 Jun 7.

Institute of Cytology and Genetics, The Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

View Article and Find Full Text PDF
August 2012

Suppression of replicative senescence by rapamycin in rodent embryonic cells.

Authors:
Tatiana V Pospelova Olga V Leontieva Tatiana V Bykova Svetlana G Zubova Valery A Pospelov Mikhail V Blagosklonny

Cell Cycle 2012 Jun 15;11(12):2402-7. Epub 2012 Jun 15.

Institute of Cytology, St. Petersburg, Russia.

View Article and Find Full Text PDF
June 2012

The second international conference "genetics of aging and longevity".

Authors:
Vladimir N Anisimov Andrzej Bartke Nir Barzilai Mikhail A Batin Mikhail V Blagosklonny Holly Brown-Borg Yelena Budovskaya Judith Campisi Bertrand Friguet Vadim Fraifeld Claudio Franceschi David Gems Vadim Gladyshev Vera Gorbunova Andrei V Gudkov Brian Kennedy Maria Konovalenko Brian Kraemer Alexey Moskalev Isabelle Petropoulos Elena Pasyukova Suresh Rattan Blanka Rogina Andrei Seluanov Mikhail Shaposhnikov Robert Shmookler Reis Nektarios Tavernarakis Jan Vijg Anatoli Yashin Piotr Zimniak

Aging (Albany NY) 2012 May;4(5):305-17

N.N. Petrov Research Institute of Oncology, St-Petersburg, Russia.

View Article and Find Full Text PDF
May 2012

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2012 Mar;4(3):159-65

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
March 2012

NCI's provocative questions on cancer: some answers to ignite discussion.

Authors:
Mikhail V Blagosklonny

Oncotarget 2011 Dec;2(12):1352-67

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2011

Molecular damage in cancer: an argument for mTOR-driven aging.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2011 Dec;3(12):1130-41

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2011

Hormesis does not make sense except in the light of TOR-driven aging.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2011 Nov;3(11):1051-62

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
November 2011

Rapamycin-induced glucose intolerance: hunger or starvation diabetes.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2011 Dec 15;10(24):4217-24. Epub 2011 Dec 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2011

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Aging (Albany NY) 2011 Nov;3(11):1078-91

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
November 2011

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

Authors:
Vladimir N Anisimov Mark A Zabezhinski Irina G Popovich Tatiana S Piskunova Anna V Semenchenko Margarita L Tyndyk Maria N Yurova Svetlana V Rosenfeld Mikhail V Blagosklonny

Cell Cycle 2011 Dec 15;10(24):4230-6. Epub 2011 Dec 15.

Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, St. Petersburg, Russia.

View Article and Find Full Text PDF
December 2011

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.

Authors:
Olga V Leontieva Zoya N Demidenko Andrei V Gudkov Mikhail V Blagosklonny

PLoS One 2011 11;6(10):e26126. Epub 2011 Oct 11.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.

View Article and Find Full Text PDF
February 2012

Progeria, rapamycin and normal aging: recent breakthrough.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2011 Jul;3(7):685-91

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
July 2011

The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2011 Jul 15;10(14):2295-8. Epub 2011 Jul 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
July 2011

The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.

Authors:
Zoya N Demidenko Mikhail V Blagosklonny

Cell Cycle 2011 May 15;10(10):1557-62. Epub 2011 May 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute; Buffalo NY, USA.

View Article and Find Full Text PDF
May 2011

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture.

Authors:
Pasha Apontes Olga V Leontieva Zoya N Demidenko Fengzhi Li Mikhail V Blagosklonny

Oncotarget 2011 Mar;2(3):222-33

Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
March 2011

Cell cycle arrest is not senescence.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2011 Feb;3(2):94-101

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
February 2011

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.

Authors:
Olga V Leontieva Mikhail V Blagosklonny

Aging (Albany NY) 2010 Dec;2(12):924-35

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2010

Metformin and sex: Why suppression of aging may be harmful to young male mice.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2010 Dec;2(12):897-9

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2010

Why the disposable soma theory cannot explain why women live longer and why we age.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2010 Dec;2(12):884-7

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2010

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2010 Dec 15;9(24):4788-94. Epub 2010 Dec 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2010

Weak p53 permits senescence during cell cycle arrest.

Authors:
Olga V Leontieva Andrei V Gudkov Mikhail V Blagosklonny

Cell Cycle 2010 Nov 10;9(21):4323-7. Epub 2010 Nov 10.

Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
November 2010

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2010 Aug 20;9(16):3151-6. Epub 2010 Aug 20.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
August 2010

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.

Authors:
Lioubov G Korotchkina Olga V Leontieva Elena I Bukreeva Zoya N Demidenko Andrei V Gudkov Mikhail V Blagosklonny

Aging (Albany NY) 2010 Jun;2(6):344-52

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
June 2010

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2010 May;2(5):265-73

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
May 2010

Paradoxical suppression of cellular senescence by p53.

Authors:
Zoya N Demidenko Lioubov G Korotchkina Andrei V Gudkov Mikhail V Blagosklonny

Proc Natl Acad Sci U S A 2010 May 10;107(21):9660-4. Epub 2010 May 10.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
May 2010

Rapamycin and quasi-programmed aging: four years later.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2010 May 15;9(10):1859-62. Epub 2010 May 15.

Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
May 2010

Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2010 Apr 18;2(4):177-82. Epub 2010 Apr 18.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
April 2010

Rapamycin extends maximal lifespan in cancer-prone mice.

Authors:
Vladimir N Anisimov Mark A Zabezhinski Irina G Popovich Tatiana S Piskunova Anna V Semenchenko Margarita L Tyndyk Maria N Yurova Marina P Antoch Mikhail V Blagosklonny

Am J Pathol 2010 May 2;176(5):2092-7. Epub 2010 Apr 2.

Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.

View Article and Find Full Text PDF
May 2010

Impact papers on aging in 2009.

Authors:
Mikhail V Blagosklonny Judy Campisi David A Sinclair Andrzej Bartke Maria A Blasco William M Bonner Vilhelm A Bohr Robert M Brosh Anne Brunet Ronald A Depinho Lawrence A Donehower Caleb E Finch Toren Finkel Myriam Gorospe Andrei V Gudkov Michael N Hall Siegfried Hekimi Stephen L Helfand Jan Karlseder Cynthia Kenyon Guido Kroemer Valter Longo Andre Nussenzweig Heinz D Osiewacz Daniel S Peeper Thomas A Rando K Lenhard Rudolph Paolo Sassone-Corsi Manuel Serrano Norman E Sharpless Vladimir P Skulachev Jonathan L Tilly John Tower Eric Verdin Jan Vijg

Aging (Albany NY) 2010 Mar 23;2(3):111-21. Epub 2010 Mar 23.

Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
March 2010

Aging: past, present and future.

Authors:
Mikhail V Blagosklonny Judith Campisi David A Sinclair

Aging (Albany NY) 2009 Jan 7;1(1):1-5. Epub 2009 Jan 7.

View Article and Find Full Text PDF
January 2009

Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential.

Authors:
Zoya N Demidenko Mikhail V Blagosklonny

Aging (Albany NY) 2009 Dec 31;1(12):1008-16. Epub 2009 Dec 31.

Oncotarget, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
December 2009

Inhibition of S6K by resveratrol: in search of the purpose.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2009 Jun 29;1(6):511-4. Epub 2009 Jun 29.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
June 2009

Growth and aging: a common molecular mechanism.

Authors:
Mikhail V Blagosklonny Michael N Hall

Aging (Albany NY) 2009 Apr 20;1(4):357-62. Epub 2009 Apr 20.

Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
April 2009

Validation of anti-aging drugs by treating age-related diseases.

Authors:
Mikhail V Blagosklonny

Aging (Albany NY) 2009 Mar 28;1(3):281-8. Epub 2009 Mar 28.

Cancer Center, Ordway Research Institute, Albany, NY 12208, USA.

View Article and Find Full Text PDF
March 2009

Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

Authors:
Mikhail V Blagosklonny

Cell Cycle 2010 Feb 2;9(4):683-8. Epub 2010 Mar 2.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

View Article and Find Full Text PDF
February 2010

Pseudo-DNA damage response in senescent cells.

Authors:
Tatyana V Pospelova Zoya N Demidenko Elena I Bukreeva Valery A Pospelov Andrei V Gudkov Mikhail V Blagosklonny

Cell Cycle 2009 Dec 1;8(24):4112-8. Epub 2009 Dec 1.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

View Article and Find Full Text PDF
December 2009

TOR-driven aging: speeding car without brakes.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2009 Dec 9;8(24):4055-9. Epub 2009 Dec 9.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA.

View Article and Find Full Text PDF
December 2009

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.

Authors:
Lioubov G Korotchkina Zoya N Demidenko Andrei V Gudkov Mikhail V Blagosklonny

Cell Cycle 2009 Nov 23;8(22):3777-81. Epub 2009 Nov 23.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA.

View Article and Find Full Text PDF
November 2009

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.

Authors:
Zoya N Demidenko Michael Shtutman Mikhail V Blagosklonny

Cell Cycle 2009 Jun 21;8(12):1896-900. Epub 2009 Jun 21.

Oncotarget, Albany, NY, USA.

View Article and Find Full Text PDF
June 2009

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence.

Authors:
Zoya N Demidenko Mikhail V Blagosklonny

Cell Cycle 2009 Jun 21;8(12):1901-4. Epub 2009 Jun 21.

Oncotarget, Albany, NY, USA.

View Article and Find Full Text PDF
June 2009

Rapamycin decelerates cellular senescence.

Authors:
Zoya N Demidenko Svetlana G Zubova Elena I Bukreeva Valery A Pospelov Tatiana V Pospelova Mikhail V Blagosklonny

Cell Cycle 2009 Jun 1;8(12):1888-95. Epub 2009 Jun 1.

Oncotarget, Albany, NY, USA.

View Article and Find Full Text PDF
June 2009

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2009 Jun 21;8(12):1883-7. Epub 2009 Jun 21.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

View Article and Find Full Text PDF
June 2009

Aging: ROS or TOR.

Authors:
Mikhail V Blagosklonny

Cell Cycle 2008 Nov 11;7(21):3344-54. Epub 2008 Nov 11.

Ordway Research Institute, and Oncotarget, Albany, New York 12208, USA.

View Article and Find Full Text PDF
November 2008

Growth stimulation leads to cellular senescence when the cell cycle is blocked.

Authors:
Zoya N Demidenko Mikhail V Blagosklonny

Cell Cycle 2008 Nov 12;7(21):3355-61. Epub 2008 Nov 12.

Oncotarget, Albany, New York, USA.

View Article and Find Full Text PDF
November 2008

Prevention of cancer by inhibiting aging.

Authors:
Mikhail V Blagosklonny

Cancer Biol Ther 2008 Oct 21;7(10):1520-4. Epub 2008 Oct 21.

Cancer Center, Ordway Research Institute, and Oncotarget, Albany, NY 12208, USA.

View Article and Find Full Text PDF
October 2008