Mikhail V Blagosklonny

Mikhail V Blagosklonny

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Mikhail V Blagosklonny

Mikhail V Blagosklonny

Publications by authors named "Mikhail V Blagosklonny"

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Rapamycin for longevity: opinion article.

Aging (Albany NY) 2019 Oct 4. Epub 2019 Oct 4.

Cell Stress Biology Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.102355DOI Listing
October 2019

The mystery of the ketogenic diet: benevolent pseudo-diabetes.

Cell Cycle 2019 Sep 1;18(18):2157-2163. Epub 2019 Aug 1.

Cell Stress Biology, Roswell Park Cancer Institute , Buffalo , NY , USA.

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http://dx.doi.org/10.1080/15384101.2019.1644765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738531PMC
September 2019

Fasting and rapamycin: diabetes versus benevolent glucose intolerance.

Cell Death Dis 2019 Aug 13;10(8):607. Epub 2019 Aug 13.

Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY, 14263, USA.

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http://dx.doi.org/10.1038/s41419-019-1822-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690951PMC
August 2019

Rapamycin, proliferation and geroconversion to senescence.

Cell Cycle 2018 12;17(24):2655-2665. Epub 2018 Dec 12.

a Cell Stress Biology , Roswell Park Cancer Institute , Buffalo , NY , USA.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2018.1
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http://dx.doi.org/10.1080/15384101.2018.1554781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343718PMC
December 2018

Paradoxes of senolytics.

Aging (Albany NY) 2018 12;10(12):4289-4293

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/101750/text
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http://dx.doi.org/10.18632/aging.101750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326665PMC
December 2018

Disease or not, aging is easily treatable.

Aging (Albany NY) 2018 11;10(11):3067-3078

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/101647/text
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http://dx.doi.org/10.18632/aging.101647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286826PMC
November 2018

Does rapamycin slow down time?

Oncotarget 2018 Jul 13;9(54):30210-30212. Epub 2018 Jul 13.

Mikhail V. Blagosklonny: Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.oncotarget.com/fulltext/25788
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http://dx.doi.org/10.18632/oncotarget.25788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084391PMC
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Librarians against scientists: Oncotarget's lesson.

Oncotarget 2018 Jan 19;9(5):5515-5516. Epub 2018 Jan 19.

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http://dx.doi.org/10.18632/oncotarget.24272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814154PMC
January 2018

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts.

Oncotarget 2017 Dec 11;8(65):109848-109856. Epub 2017 May 11.

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.17827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752566PMC
December 2017

From rapalogs to anti-aging formula.

Oncotarget 2017 May;8(22):35492-35507

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.18033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482593PMC
May 2017

Gerosuppression by pan-mTOR inhibitors.

Aging (Albany NY) 2016 12;8(12):3535-3551

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elms and Carlson Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.101155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270685PMC
December 2016

Geroconversion: irreversible step to cellular senescence.

Cell Cycle 2014 ;13(23):3628-35

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

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http://dx.doi.org/10.4161/15384101.2014.985507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614001PMC
September 2015

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).

Oncotarget 2015 Sep;6(27):23238-48

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.4836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695114PMC
September 2015

Rejuvenating immunity: "anti-aging drug today" eight years later.

Oncotarget 2015 Aug;6(23):19405-12

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637294PMC
http://dx.doi.org/10.18632/oncotarget.3740DOI Listing
August 2015

Comparison of rapamycin schedules in mice on high-fat diet.

Cell Cycle 2014 ;13(21):3350-6

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

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http://dx.doi.org/10.4161/15384101.2014.970491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614913PMC
July 2015

Fasting levels of hepatic p-S6 are increased in old mice.

Cell Cycle 2014 ;13(17):2656-9

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

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http://dx.doi.org/10.4161/15384101.2014.949150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612665PMC
July 2015

M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.

Cell Cycle 2014 23;13(4):509-15. Epub 2014 Jan 23.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cc.27973DOI Listing
April 2015

Gerosuppression in confluent cells.

Aging (Albany NY) 2014 Dec;6(12):1010-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elms and Carlson Streets, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298362PMC
http://dx.doi.org/10.18632/aging.100714DOI Listing
December 2014

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.

Oncotarget 2014 Dec;5(24):12715-27

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350340PMC
http://dx.doi.org/10.18632/oncotarget.3011DOI Listing
December 2014

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.

Aging Cell 2014 Aug 22;13(4):616-22. Epub 2014 Mar 22.

Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA.

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http://dx.doi.org/10.1111/acel.12211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326934PMC
August 2014

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.

Proc Natl Acad Sci U S A 2014 Jun 2;111(24):8832-7. Epub 2014 Jun 2.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263

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http://www.pnas.org/cgi/doi/10.1073/pnas.1405723111
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http://dx.doi.org/10.1073/pnas.1405723111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066505PMC
June 2014

Dysregulation of the mTOR pathway in p53-deficient mice.

Cancer Biol Ther 2013 Dec 1;14(12):1182-8. Epub 2013 Nov 1.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cbt.26947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912042PMC
December 2013

Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.

Cell Cycle 2013 Dec 15;12(24):3736-42. Epub 2013 Nov 15.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cc.27188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905065PMC
December 2013

Selective anti-cancer agents as anti-aging drugs.

Cancer Biol Ther 2013 Dec 27;14(12):1092-7. Epub 2013 Nov 27.

Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cbt.27350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912031PMC
December 2013

Immunosuppressants in cancer prevention and therapy.

Oncoimmunology 2013 Dec 6;2(12):e26961. Epub 2013 Nov 6.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://www.tandfonline.com/doi/abs/10.4161/onci.26961
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http://dx.doi.org/10.4161/onci.26961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926869PMC
December 2013

S6K in geroconversion.

Cell Cycle 2013 Oct 9;12(20):3249-52. Epub 2013 Sep 9.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cc.26248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885635PMC
October 2013

Damage-induced aging and perpetual motion.

Cell Cycle 2013 Sep 5;12(17):2709-10. Epub 2013 Aug 5.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.26015
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http://dx.doi.org/10.4161/cc.26015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899178PMC
September 2013

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.

Cell Cycle 2013 Sep 22;12(18):3063-9. Epub 2013 Aug 22.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Elm & Carlton Streets; Buffalo, NY USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.26130
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http://dx.doi.org/10.4161/cc.26130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875680PMC
September 2013

Rapamycin extends life- and health span because it slows aging.

Aging (Albany NY) 2013 Aug;5(8):592-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796212PMC
http://dx.doi.org/10.18632/aging.100591DOI Listing
August 2013

M(o)TOR of aging: MTOR as a universal molecular hypothalamus.

Aging (Albany NY) 2013 Jul;5(7):490-4

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765577PMC
http://dx.doi.org/10.18632/aging.100580DOI Listing
July 2013

MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer.

Cell Cycle 2013 Jun 12;12(12):1842-7. Epub 2013 Jun 12.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.25062
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http://dx.doi.org/10.4161/cc.25062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735698PMC
June 2013

Rapamycin suppresses brain aging in senescence-accelerated OXYS rats.

Aging (Albany NY) 2013 Jun;5(6):474-84

Institute of Cytology and Genetics SB RAS, Acad. , 630090, Novosibirsk, Russia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824413PMC
http://dx.doi.org/10.18632/aging.100573DOI Listing
June 2013

Big mice die young but large animals live longer.

Aging (Albany NY) 2013 Apr;5(4):227-33

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/100551
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651517PMC
http://dx.doi.org/10.18632/aging.100551DOI Listing
April 2013

Hypoxia, MTOR and autophagy: converging on senescence or quiescence.

Autophagy 2013 Feb 28;9(2):260-2. Epub 2012 Nov 28.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.tandfonline.com/doi/abs/10.4161/auto.22783
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http://dx.doi.org/10.4161/auto.22783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552896PMC
February 2013

Rapalogs in cancer prevention: anti-aging or anticancer?

Cancer Biol Ther 2012 Dec 14;13(14):1349-54. Epub 2012 Nov 14.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cbt.22859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542224PMC
December 2012

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells.

Cell Cycle 2012 Dec 27;11(24):4642-9. Epub 2012 Nov 27.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cc.22937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562309PMC
December 2012

Answering the ultimate question "what is the proximal cause of aging?".

Aging (Albany NY) 2012 Dec;4(12):861-77

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/100525
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615154PMC
http://dx.doi.org/10.18632/aging.100525DOI Listing
December 2012

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.

Aging (Albany NY) 2012 Dec;4(12):899-916

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615157PMC
http://dx.doi.org/10.18632/aging.100528DOI Listing
December 2012

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.

Oncotarget 2012 Dec;3(12):1711-24

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681506PMC
http://dx.doi.org/10.18632/oncotarget.890DOI Listing
December 2012

Hypoxia and gerosuppression: the mTOR saga continues.

Cell Cycle 2012 Nov 17;11(21):3926-31. Epub 2012 Sep 17.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cc.21908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507487PMC
November 2012

Prospective treatment of age-related diseases by slowing down aging.

Am J Pathol 2012 Oct 27;181(4):1142-6. Epub 2012 Jul 27.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.06.024DOI Listing
October 2012

Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats.

Am J Pathol 2012 Aug 7;181(2):472-7. Epub 2012 Jun 7.

Institute of Cytology and Genetics, The Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

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http://dx.doi.org/10.1016/j.ajpath.2012.04.018DOI Listing
August 2012

Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

Proc Natl Acad Sci U S A 2012 Aug 30;109(33):13314-8. Epub 2012 Jul 30.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.1205690109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421205PMC
August 2012

How to save Medicare: the anti-aging remedy.

Aging (Albany NY) 2012 Aug;4(8):547-52

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461342PMC
http://dx.doi.org/10.18632/aging.100479DOI Listing
August 2012

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Aging (Albany NY) 2012 Jul;4(7):450-5

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433931PMC
http://dx.doi.org/10.18632/aging.100475DOI Listing
July 2012

Suppression of replicative senescence by rapamycin in rodent embryonic cells.

Cell Cycle 2012 Jun 15;11(12):2402-7. Epub 2012 Jun 15.

Institute of Cytology, St. Petersburg, Russia.

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http://dx.doi.org/10.4161/cc.20882DOI Listing
June 2012

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells.

Oncotarget 2012 Jun;3(6):601-7

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.oncotarget.com/fulltext/548
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442293PMC
http://dx.doi.org/10.18632/oncotarget.548DOI Listing
June 2012

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

Aging (Albany NY) 2012 May;4(5):350-8

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384435PMC
http://dx.doi.org/10.18632/aging.100461DOI Listing
May 2012

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.

Aging (Albany NY) 2012 Mar;4(3):159-65

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/100443
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348476PMC
http://dx.doi.org/10.18632/aging.100443DOI Listing
March 2012

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.

PLoS One 2011 11;6(10):e26126. Epub 2011 Oct 11.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191182PMC
February 2012

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

Cell Cycle 2011 Dec 15;10(24):4230-6. Epub 2011 Dec 15.

Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, St. Petersburg, Russia.

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http://dx.doi.org/10.4161/cc.10.24.18486DOI Listing
December 2011

Rapamycin-induced glucose intolerance: hunger or starvation diabetes.

Cell Cycle 2011 Dec 15;10(24):4217-24. Epub 2011 Dec 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cc.10.24.18595DOI Listing
December 2011

Molecular damage in cancer: an argument for mTOR-driven aging.

Aging (Albany NY) 2011 Dec;3(12):1130-41

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273893PMC
http://dx.doi.org/10.18632/aging.100422DOI Listing
December 2011

NCI's provocative questions on cancer: some answers to ignite discussion.

Oncotarget 2011 Dec;2(12):1352-67

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/oncotarget.432DOI Listing
December 2011

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.

Aging (Albany NY) 2011 Nov;3(11):1078-91

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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November 2011

Hormesis does not make sense except in the light of TOR-driven aging.

Aging (Albany NY) 2011 Nov;3(11):1051-62

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.100411DOI Listing
November 2011

The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors.

Cell Cycle 2011 Jul 15;10(14):2295-8. Epub 2011 Jul 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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July 2011

Progeria, rapamycin and normal aging: recent breakthrough.

Aging (Albany NY) 2011 Jul;3(7):685-91

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.100352DOI Listing
July 2011

The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.

Cell Cycle 2011 May 15;10(10):1557-62. Epub 2011 May 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute; Buffalo NY, USA.

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May 2011

Cell cycle arrest is not senescence.

Aging (Albany NY) 2011 Feb;3(2):94-101

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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February 2011

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal.

Cell Cycle 2010 Dec 15;9(24):4788-94. Epub 2010 Dec 15.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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December 2010

Why the disposable soma theory cannot explain why women live longer and why we age.

Aging (Albany NY) 2010 Dec;2(12):884-7

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.100253DOI Listing
December 2010

Metformin and sex: Why suppression of aging may be harmful to young male mice.

Aging (Albany NY) 2010 Dec;2(12):897-9

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/100264
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December 2010

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.

Aging (Albany NY) 2010 Dec;2(12):924-35

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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December 2010

Weak p53 permits senescence during cell cycle arrest.

Cell Cycle 2010 Nov 10;9(21):4323-7. Epub 2010 Nov 10.

Roswell Park Cancer Institute, Buffalo, NY, USA.

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November 2010

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program.

Cell Cycle 2010 Aug 20;9(16):3151-6. Epub 2010 Aug 20.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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August 2010

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.

Aging (Albany NY) 2010 Jun;2(6):344-52

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.100160DOI Listing
June 2010

Rapamycin extends maximal lifespan in cancer-prone mice.

Am J Pathol 2010 May 2;176(5):2092-7. Epub 2010 Apr 2.

Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.

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http://dx.doi.org/10.2353/ajpath.2010.091050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861075PMC
May 2010

Rapamycin and quasi-programmed aging: four years later.

Cell Cycle 2010 May 15;9(10):1859-62. Epub 2010 May 15.

Roswell Park Cancer Institute, Buffalo, NY, USA.

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May 2010

Paradoxical suppression of cellular senescence by p53.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9660-4. Epub 2010 May 10.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.1002298107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906905PMC
May 2010

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives.

Aging (Albany NY) 2010 May;2(5):265-73

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.aging-us.com/article/100149
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May 2010

Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.

Aging (Albany NY) 2010 Apr 18;2(4):177-82. Epub 2010 Apr 18.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.18632/aging.100139DOI Listing
April 2010

Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

Cell Cycle 2010 Feb 2;9(4):683-8. Epub 2010 Mar 2.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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February 2010

TOR-driven aging: speeding car without brakes.

Cell Cycle 2009 Dec 9;8(24):4055-9. Epub 2009 Dec 9.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA.

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December 2009

Pseudo-DNA damage response in senescent cells.

Cell Cycle 2009 Dec 1;8(24):4112-8. Epub 2009 Dec 1.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970747PMC
December 2009

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.

Cell Cycle 2009 Nov 23;8(22):3777-81. Epub 2009 Nov 23.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cc.8.22.10121DOI Listing
November 2009

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

Cell Cycle 2009 Jun 21;8(12):1883-7. Epub 2009 Jun 21.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.4161/cc.8.12.8815DOI Listing
June 2009

Rapamycin decelerates cellular senescence.

Cell Cycle 2009 Jun 1;8(12):1888-95. Epub 2009 Jun 1.

Oncotarget, Albany, NY, USA.

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http://dx.doi.org/10.4161/cc.8.12.8606DOI Listing
June 2009

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence.

Cell Cycle 2009 Jun 21;8(12):1901-4. Epub 2009 Jun 21.

Oncotarget, Albany, NY, USA.

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June 2009

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.

Cell Cycle 2009 Jun 21;8(12):1896-900. Epub 2009 Jun 21.

Oncotarget, Albany, NY, USA.

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http://dx.doi.org/10.4161/cc.8.12.8809DOI Listing
June 2009

Inhibition of S6K by resveratrol: in search of the purpose.

Aging (Albany NY) 2009 Jun 29;1(6):511-4. Epub 2009 Jun 29.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806036PMC
http://dx.doi.org/10.18632/aging.100059DOI Listing
June 2009

Growth and aging: a common molecular mechanism.

Aging (Albany NY) 2009 Apr 20;1(4):357-62. Epub 2009 Apr 20.

Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806018PMC
http://dx.doi.org/10.18632/aging.100040DOI Listing
April 2009

Validation of anti-aging drugs by treating age-related diseases.

Aging (Albany NY) 2009 Mar 28;1(3):281-8. Epub 2009 Mar 28.

Cancer Center, Ordway Research Institute, Albany, NY 12208, USA.

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http://www.aging-us.com/article/100034
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http://dx.doi.org/10.18632/aging.100034DOI Listing
March 2009

Aging: past, present and future.

Aging (Albany NY) 2009 Jan 7;1(1):1-5. Epub 2009 Jan 7.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815757PMC
http://dx.doi.org/10.18632/aging.100009DOI Listing
January 2009

Growth stimulation leads to cellular senescence when the cell cycle is blocked.

Cell Cycle 2008 Nov 12;7(21):3355-61. Epub 2008 Nov 12.

Oncotarget, Albany, New York, USA.

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http://dx.doi.org/10.4161/cc.7.21.6919DOI Listing
November 2008

Aging: ROS or TOR.

Cell Cycle 2008 Nov 11;7(21):3344-54. Epub 2008 Nov 11.

Ordway Research Institute, and Oncotarget, Albany, New York 12208, USA.

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http://dx.doi.org/10.4161/cc.7.21.6965DOI Listing
November 2008

Prevention of cancer by inhibiting aging.

Cancer Biol Ther 2008 Oct 21;7(10):1520-4. Epub 2008 Oct 21.

Cancer Center, Ordway Research Institute, and Oncotarget, Albany, NY 12208, USA.

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http://dx.doi.org/10.4161/cbt.7.10.6663DOI Listing
October 2008

Cancer and aging: more puzzles, more promises?

Cell Cycle 2008 Sep 16;7(17):2615-8. Epub 2008 Sep 16.

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http://dx.doi.org/10.4161/cc.7.17.6626DOI Listing
September 2008

Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells.

Rejuvenation Res 2008 Aug;11(4):801-8

Cancer Center, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA.

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http://dx.doi.org/10.1089/rej.2008.0722DOI Listing
August 2008