Mikael Pittet

Mikael Pittet

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Mikael Pittet

Publications by authors named "Mikael Pittet"

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Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Theranostics 2018 12;8(21):5842-5854. Epub 2018 Nov 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://www.thno.org/v08p5842.htm
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http://dx.doi.org/10.7150/thno.26888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299430PMC
September 2019

Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.

Oncogenesis 2019 Apr 1;8(4):24. Epub 2019 Apr 1.

Department of Cancer Biology, University of Pennsylvania, 421 Curie Blvd., 751 BRB II/III, Philadelphia, PA, 19104-6160, USA.

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http://dx.doi.org/10.1038/s41389-019-0133-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443683PMC
April 2019

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using Cu-Labeled Macrin.

ACS Nano 2018 12 11;12(12):12015-12029. Epub 2018 Dec 11.

Center for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acsnano.8b04338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482841PMC
December 2018

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Immunity 2018 12 11;49(6):1148-1161.e7. Epub 2018 Dec 11.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301092PMC
December 2018

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

JCI Insight 2018 11 2;3(21). Epub 2018 Nov 2.

Center for Systems Biology, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.

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https://insight.jci.org/articles/view/122961
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http://dx.doi.org/10.1172/jci.insight.122961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238736PMC
November 2018

Recording the wild lives of immune cells.

Sci Immunol 2018 09;3(27)

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aaq0491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771424PMC
September 2018

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Nat Biomed Eng 2018 08 21;2(8):578-588. Epub 2018 May 21.

Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41551-018-0236-8DOI Listing
August 2018

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Nat Biomed Eng 2018 21;2:578-588. Epub 2018 May 21.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192054PMC
May 2018

Tumor Microenvironment: No Effector T Cells without Dendritic Cells.

Cancer Cell 2017 05;31(5):614-615

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.007DOI Listing
May 2017

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.

Nat Commun 2017 02 8;8:14293. Epub 2017 Feb 8.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms14293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309815PMC
February 2017

Gal3 Links Inflammation and Insulin Resistance.

Cell Metab 2016 11;24(5):655-656

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.014DOI Listing
November 2016

PF4 Promotes Platelet Production and Lung Cancer Growth.

Cell Rep 2016 11;17(7):1764-1772

Center for Systems Biology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108525PMC
November 2016

The role of myeloid cells in cancer therapies.

Nat Rev Cancer 2016 07;16(7):447-62

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrc.2016.54DOI Listing
July 2016

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.

Cancer Discov 2016 06 12;6(6):630-49. Epub 2016 Apr 12.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Massachusetts Institute of Technology Ludwig Center for Molecular Oncology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918202PMC
June 2016

Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor.

PLoS One 2015 23;10(3):e0121419. Epub 2015 Mar 23.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America; Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121419PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370445PMC
February 2016

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.

Proc Natl Acad Sci U S A 2016 Feb 1;113(7):1871-6. Epub 2016 Feb 1.

Department of Pediatrics, Divisions of Medical Genetics and Pediatric Hematology/Oncology, MassGeneral Hospital for Children, Center for Human Genetics Research and MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1511380113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763742PMC
February 2016

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Sci Transl Med 2015 Nov;7(314):314ra183

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.aac6522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462466PMC
November 2015

ER Stress in Dendritic Cells Promotes Cancer.

Cell 2015 Jun;161(7):1492-3

Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.006DOI Listing
June 2015

Common TLR5 mutations control cancer progression.

Cancer Cell 2015 Jan;27(1):1-3

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.12.008DOI Listing
January 2015

The journey from stem cell to macrophage.

Ann N Y Acad Sci 2014 Jun 27;1319:1-18. Epub 2014 Mar 27.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.12393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074243PMC
June 2014

Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis.

Biol Reprod 2014 May 1;90(5):90. Epub 2014 May 1.

Division of Nephrology/Program in Membrane Biology, Massachusetts General Hospital (MGH) and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1095/biolreprod.113.116681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076373PMC
May 2014

Imaging macrophages with nanoparticles.

Nat Mater 2014 Feb;13(2):125-38

1] Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA [2] Department of Radiology, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nmat3780DOI Listing
February 2014

The spleen in local and systemic regulation of immunity.

Immunity 2013 Nov;39(5):806-18

Verona University Hospital and Department of Pathology, 37134 Verona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912742PMC
November 2013

Therapeutically reeducating macrophages to treat GBM.

Nat Med 2013 Oct;19(10):1207-8

1] Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Graduate Program in Immunology, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nm.3355
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http://dx.doi.org/10.1038/nm.3355DOI Listing
October 2013

MicroRNA-mediated control of macrophages and its implications for cancer.

Trends Immunol 2013 Jul 13;34(7):350-9. Epub 2013 Mar 13.

The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.it.2013.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700601PMC
July 2013

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

PLoS Biol 2012 25;10(9):e1001393. Epub 2012 Sep 25.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463506PMC
June 2013

Molecular pathways: tumor-derived microvesicles and their interactions with immune cells in vivo.

Clin Cancer Res 2013 May 20;19(10):2598-604. Epub 2013 Feb 20.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655093PMC
May 2013

Remote control of macrophage production by cancer.

Oncoimmunology 2013 May;2(5):e24183

Center for Systems Biology; Massachusetts General Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/onci.24183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667905PMC
May 2013

Regulation of macrophage and dendritic cell responses by their lineage precursors.

J Innate Immun 2012 16;4(5-6):411-23. Epub 2012 Mar 16.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1159/000335733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498093PMC
January 2013

89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.

Bioconjug Chem 2011 Dec 7;22(12):2383-9. Epub 2011 Nov 7.

Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.

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https://pubs.acs.org/doi/10.1021/bc200405d
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http://dx.doi.org/10.1021/bc200405dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244512PMC
December 2011

Intravital imaging.

Cell 2011 Nov;147(5):983-91

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674110133
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http://dx.doi.org/10.1016/j.cell.2011.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824153PMC
November 2011

Monocytes link atherosclerosis and cancer.

Eur J Immunol 2011 Sep;41(9):2519-22

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://doi.wiley.com/10.1002/eji.201141727
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http://dx.doi.org/10.1002/eji.201141727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817567PMC
September 2011

A dense network of dendritic cells populates the murine epididymis.

Reproduction 2011 May 10;141(5):653-63. Epub 2011 Feb 10.

Program in Membrane Biology and Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, CPZN 8.206, Boston, Massachusetts 02114-2790, USA.

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http://dx.doi.org/10.1530/REP-10-0493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657760PMC
May 2011

Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.

J Immunol 2011 Feb 27;186(3):1369-76. Epub 2010 Dec 27.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.1002047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670585PMC
February 2011

Self-assembled magnetic filter for highly efficient immunomagnetic separation.

Lab Chip 2011 Jan 14;11(1):147-51. Epub 2010 Oct 14.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c0lc00149jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005961PMC
January 2011

Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.

Circulation 2010 Jun;121(22):2437-45

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.9
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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.916346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892474PMC
June 2010

Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.

Opt Lett 2010 Apr;35(7):1088-90

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900933PMC
http://dx.doi.org/10.1364/OL.35.001088DOI Listing
April 2010

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

J Am Coll Cardiol 2010 Apr;55(15):1629-38

Center for Systems Biology, Simches Research Building, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.jacc.2009.08.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852892PMC
April 2010

Hybrid PET-optical imaging using targeted probes.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7910-5. Epub 2010 Apr 12.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0915163107
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http://dx.doi.org/10.1073/pnas.0915163107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867879PMC
April 2010

Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis.

Arterioscler Thromb Vasc Biol 2009 Oct 16;29(10):1424-32. Epub 2009 Apr 16.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.180521
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http://dx.doi.org/10.1161/ATVBAHA.108.180521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746262PMC
October 2009

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

Arterioscler Thromb Vasc Biol 2009 Oct 16;29(10):1444-51. Epub 2009 Jul 16.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.193086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746251PMC
October 2009

Behavior of immune players in the tumor microenvironment.

Authors:
Mikael J Pittet

Curr Opin Oncol 2009 Jan;21(1):53-9

Center for Systems Biology and Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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https://insights.ovid.com/crossref?an=00001622-200901000-000
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http://dx.doi.org/10.1097/CCO.0b013e32831bc38aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901856PMC
January 2009

Perturbational profiling of nanomaterial biologic activity.

Proc Natl Acad Sci U S A 2008 May 20;105(21):7387-92. Epub 2008 May 20.

Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0802878105
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http://dx.doi.org/10.1073/pnas.0802878105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396702PMC
May 2008

Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.

Mol Imaging 2007 Jul-Aug;6(4):269-76

Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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April 2008

Imaging in the era of molecular oncology.

Nature 2008 Apr;452(7187):580-9

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://www.nature.com/articles/nature06917
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http://dx.doi.org/10.1038/nature06917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708079PMC
April 2008

Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.

Gastroenterology 2008 Apr 30;134(4):1028-37. Epub 2008 Jan 30.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.01.070DOI Listing
April 2008

Regulation of T-cell migration and effector functions: insights from in vivo imaging studies.

Immunol Rev 2008 Feb;221:107-29

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02129, USA.

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http://doi.wiley.com/10.1111/j.1600-065X.2008.00584.x
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http://dx.doi.org/10.1111/j.1600-065X.2008.00584.xDOI Listing
February 2008

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

J Exp Med 2007 Nov 19;204(12):3037-47. Epub 2007 Nov 19.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1084/jem.20070885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118517PMC
November 2007

A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.

PLoS One 2007 Oct 24;2(10):e1075. Epub 2007 Oct 24.

Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America. fswirski@ mgh.harvard.edu

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001075PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034600PMC
October 2007

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.

Proc Natl Acad Sci U S A 2007 Jul 18;104(30):12457-61. Epub 2007 Jul 18.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

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http://www.pnas.org/content/104/30/12457.full.pdf
Web Search
http://www.pnas.org/cgi/doi/10.1073/pnas.0704460104
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http://dx.doi.org/10.1073/pnas.0704460104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941490PMC
July 2007

Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles.

Nat Protoc 2006 ;1(1):73-9

Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nprot.2006.11DOI Listing
June 2007

Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.

J Immunol 2007 Apr;178(7):4112-9

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research-Lausanne Branch, University Hospital of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.178.7.4112DOI Listing
April 2007

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.

J Clin Invest 2007 Jan;117(1):195-205

Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI29950
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http://dx.doi.org/10.1172/JCI29950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716211PMC
January 2007

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.

Proc Natl Acad Sci U S A 2006 Jul 26;103(27):10340-10345. Epub 2006 Jun 26.

*Center for Molecular Imaging Research and Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129; and

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http://dx.doi.org/10.1073/pnas.0604260103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502459PMC
July 2006

Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation.

Immunity 2006 Jul;25(1):129-41

CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130600302
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http://dx.doi.org/10.1016/j.immuni.2006.04.015DOI Listing
July 2006

Fluorescent nanoparticle uptake for brain tumor visualization.

Neoplasia 2006 Apr;8(4):302-11

Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1593/neo.05751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1600680PMC
April 2006

Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.

J Immunol 2006 Feb;176(4):2330-6

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.176.4.2330DOI Listing
February 2006

Ex vivo analysis of human antigen-specific CD8+ T-cell responses: quality assessment of fluorescent HLA-A2 multimer and interferon-gamma ELISPOT assays for patient immune monitoring.

J Immunother 2004 Jul-Aug;27(4):298-308

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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March 2005

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.

Proc Natl Acad Sci U S A 2005 Jan 27;102(2):419-24. Epub 2004 Dec 27.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0408197102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544311PMC
January 2005

Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.

Cancer Res 2004 Apr;64(8):2865-73

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research and Multidisciplinary Oncology Center, University Hospital (Centre Hospitalier Universitaire Vaudois), Lausanne, Switzerland.

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April 2004

Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.

J Immunol 2004 Mar;172(5):2773-7

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, University Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.172.5.2773DOI Listing
March 2004

Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.

Cancer Res 2004 Mar;64(6):2192-8

Immunology/Institut National de la Santé et de la Recherche Médicale ERM0208 and Immunotherapy Unit, Department of Pathology, Dermatology Unit, Institut Gustave-Roussy, 94805 Villejuif Cedex, France.

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March 2004

Evaluation of melanoma vaccines with molecularly defined antigens by ex vivo monitoring of tumor-specific T cells.

Semin Cancer Biol 2003 Dec;13(6):461-72

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Hôpital Orthopédique, Centre Hospitalier Universitaire Vaudois, Niveau 5, Aile Est, Av. Pierre-Decker 4, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.semcancer.2003.09.010DOI Listing
December 2003