Mikael Knip

Mikael Knip

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Mikael Knip

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Pediatr Diabetes 2019 Dec;20(8):1045-1046

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http://dx.doi.org/10.1111/pedi.12933DOI Listing
December 2019

Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia.

Acta Paediatr 2019 Nov 23;108(11):2075-2082. Epub 2019 Jun 23.

Pediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/apa.14874DOI Listing
November 2019

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

J Clin Endocrinol Metab 2019 Nov;104(11):5585-5594

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2019-01069DOI Listing
November 2019

Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis.

Diabetologia 2019 Nov 25;62(11):2025-2039. Epub 2019 Jul 25.

Children's Hospital, University of Helsinki, P.O. Box 22, (Stenbäckinkatu 11), FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-019-4952-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805821PMC
November 2019

Circulating CXCR5PD-1 peripheral T helper cells are associated with progression to type 1 diabetes.

Diabetologia 2019 Sep 3;62(9):1681-1688. Epub 2019 Jul 3.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland.

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http://dx.doi.org/10.1007/s00125-019-4936-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677711PMC
September 2019

Coeliac disease and HLA-conferred susceptibility to autoimmunity are associated with IgE sensitization in young children.

Allergy 2019 Sep 17. Epub 2019 Sep 17.

Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/all.14055DOI Listing
September 2019

Rhinoviruses in infancy and risk of immunoglobulin E sensitization.

J Med Virol 2019 Aug 25;91(8):1470-1478. Epub 2019 Mar 25.

Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere University, Tampere, Finland.

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http://doi.wiley.com/10.1002/jmv.25455
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http://dx.doi.org/10.1002/jmv.25455DOI Listing
August 2019

Microbiome and type 1 diabetes.

EBioMedicine 2019 Aug 27;46:512-521. Epub 2019 Jun 27.

Children's Hospital, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, 33520 Tampere, Finland; Folkhälsan Research Center, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710855PMC
August 2019

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Diabetologia 2019 Aug 23. Epub 2019 Aug 23.

Turku Bioscience, University of Turku and Åbo Akademi University, Tykistokatu 6, FI-20520, Turku, Finland.

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http://dx.doi.org/10.1007/s00125-019-04980-0DOI Listing
August 2019

Development of atopic sensitization in Finnish and Estonian children: A latent class analysis in a multicenter cohort.

J Allergy Clin Immunol 2019 May 23;143(5):1904-1913.e9. Epub 2019 Jan 23.

Dr. von Hauner Children's Hospital, LMU Munich, Munich, Germany; German Center for Lung Research (DZL). Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.12.1014DOI Listing
May 2019

Development of T cell immunity to norovirus and rotavirus in children under five years of age.

Sci Rep 2019 Mar 1;9(1):3199. Epub 2019 Mar 1.

Vaccine Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-019-39840-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397277PMC
March 2019

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Pediatr Diabetes 2019 02 19;20(1):73-77. Epub 2018 Nov 19.

Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://doi.wiley.com/10.1111/pedi.12788
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http://dx.doi.org/10.1111/pedi.12788DOI Listing
February 2019

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.

Environ Sci Pollut Res Int 2019 Jan 13;26(2):1370-1378. Epub 2018 Nov 13.

Scientific Laboratory, Clinicum, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland.

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http://link.springer.com/10.1007/s11356-018-3659-6
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http://dx.doi.org/10.1007/s11356-018-3659-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331740PMC
January 2019

Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe.

Pediatr Diabetes 2018 12 25;19(8):1400-1406. Epub 2018 Sep 25.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/pedi.12756
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http://dx.doi.org/10.1111/pedi.12756DOI Listing
December 2018

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Clin Exp Allergy 2018 12 16;48(12):1698-1704. Epub 2018 Oct 16.

Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1111/cea.13280DOI Listing
December 2018

Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes.

Diabetologia 2018 12 20;61(12):2668-2670. Epub 2018 Sep 20.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-018-4738-4DOI Listing
December 2018

Developing a vaccine for type 1 diabetes by targeting coxsackievirus B.

Expert Rev Vaccines 2018 12 29;17(12):1071-1083. Epub 2018 Nov 29.

d Children's Hospital , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

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http://dx.doi.org/10.1080/14760584.2018.1548281DOI Listing
December 2018

Sex as a determinant of type 1 diabetes at diagnosis.

Pediatr Diabetes 2018 11 17;19(7):1221-1228. Epub 2018 Jun 17.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pedi.12697DOI Listing
November 2018

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents.

Pediatr Diabetes 2018 10;19 Suppl 27:20-27

Department of Diabetes and Endocrinology, The Children's Hospital at Westmead, Sydney, Australia.

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http://dx.doi.org/10.1111/pedi.12734DOI Listing
October 2018

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

J Clin Endocrinol Metab 2018 08;103(8):2870-2878

Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1210/jc.2017-02040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097602PMC
August 2018

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

J Immunol 2018 08 13;201(4):1144-1153. Epub 2018 Jul 13.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland;

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http://dx.doi.org/10.4049/jimmunol.1701199DOI Listing
August 2018

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Cell Host Microbe 2018 07;24(1):146-154.e4

The Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091882PMC
July 2018

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Pediatr Diabetes 2018 05 17;19(3):398-402. Epub 2017 Oct 17.

Department of Virology, School of Medicine, University of Tampere, Tampere, Finland.

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http://doi.wiley.com/10.1111/pedi.12592
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http://dx.doi.org/10.1111/pedi.12592DOI Listing
May 2018

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

Pediatr Diabetes 2018 03 23;19(2):314-319. Epub 2017 May 23.

Department of Pediatrics, MRC Oulu, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1111/pedi.12541DOI Listing
March 2018

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Pediatr Diabetes 2018 03 9;19(2):284-292. Epub 2017 Jun 9.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pedi.12545DOI Listing
March 2018

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members.

Pediatr Diabetes 2018 03 26;19(2):305-313. Epub 2017 Jul 26.

Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/pedi.12563
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http://dx.doi.org/10.1111/pedi.12563DOI Listing
March 2018

Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study.

Pediatr Allergy Immunol 2017 Nov 8;28(7):641-648. Epub 2017 Sep 8.

Faculty of Social Sciences/Health, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1111/pai.12773DOI Listing
November 2017

Early life origin of type 1 diabetes.

Semin Immunopathol 2017 11 23;39(6):653-667. Epub 2017 Nov 23.

Children's Hospital, University of Helsinki and Helsinki University Hospital, P.O. Box 22, (Stenbäckinkatu 11), FI -00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00281-017-0665-6DOI Listing
November 2017

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Gastroenterology 2017 10 5;153(4):961-970.e3. Epub 2017 Jul 5.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.049DOI Listing
October 2017

Type 1 diabetes mellitus is a heterogeneous disease.

Authors:
Mikael Knip

Nat Rev Endocrinol 2017 09 7;13(9). Epub 2017 Jul 7.

Children's Hospital, Department of Paediatrics, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrendo.2017.84DOI Listing
September 2017

Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome.

Curr Diab Rep 2017 Sep 23;17(11):105. Epub 2017 Sep 23.

Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s11892-017-0933-9DOI Listing
September 2017

Metabolically inactive insulin: friend or foe in the prevention of autoimmune diabetes?

Authors:
Mikael Knip

Diabetologia 2017 08 3;60(8):1382-1384. Epub 2017 Jun 3.

Children's Hospital, University of Helsinki, and Helsinki University Hospital, P.O. Box 22, (Stenbäckinkatu 11), 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4319-yDOI Listing
August 2017

Lipidomics of human umbilical cord serum: identification of unique sterol sulfates.

Future Sci OA 2017 Aug 5;3(3):FSO193. Epub 2017 Apr 5.

Children's Hospital, University of Helsinki & Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.4155/fsoa-2017-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583693PMC
August 2017

Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies.

Acta Paediatr 2017 Jul 25;106(7):1142-1149. Epub 2017 Apr 25.

Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1111/apa.13846DOI Listing
July 2017

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.

Diabetologia 2017 07 31;60(7):1284-1293. Epub 2017 Mar 31.

Children's Hospital, University of Helsinki and Helsinki University Hospital, P.O. Box 22, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4258-7DOI Listing
July 2017

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Diabetologia 2017 07 4;60(7):1223-1233. Epub 2017 May 4.

Department of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, FI-00271, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4280-9DOI Listing
July 2017

Diabetes: Loss of β-cell mass - an acute event before T1DM presentation?

Authors:
Mikael Knip

Nat Rev Endocrinol 2017 05 31;13(5):253-254. Epub 2017 Mar 31.

Children's Hospital, Department of Paediatrics, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrendo.2017.33DOI Listing
May 2017

Reclassification of asymptomatic beta cell autoimmunity: a critical perspective.

Diabetologia 2017 01 27;60(1):39-42. Epub 2016 Oct 27.

Department of Pediatrics, PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1007/s00125-016-4147-5DOI Listing
January 2017

Reply to "Antibiotics, intestinal dysbiosis and risk of celiac disease" by Hakim Rahmoune et al. [Digestive and Liver Disease].

Dig Liver Dis 2017 01 25;49(1):106-107. Epub 2016 Oct 25.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15908658163077
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http://dx.doi.org/10.1016/j.dld.2016.10.009DOI Listing
January 2017

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.

J Clin Virol 2016 12 20;85:1-6. Epub 2016 Oct 20.

School of Medicine, University of Tampere, Lääkärinkatu 1, FIN-33520, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.

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http://dx.doi.org/10.1016/j.jcv.2016.10.010DOI Listing
December 2016

Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study.

Dig Liver Dis 2016 Nov 6;48(11):1296-1301. Epub 2016 Jul 6.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2016.06.029DOI Listing
November 2016

Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus.

Diabetes Res Clin Pract 2016 Oct 6;120:89-96. Epub 2016 Aug 6.

Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.diabres.2016.07.027DOI Listing
October 2016

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population.

J Clin Endocrinol Metab 2016 08 11;101(8):3018-26. Epub 2016 May 11.

Department of Pediatrics (H.H., J.M.), University of Eastern Finland, and Kuopio University Hospital, Kuopio, Finland; Children's Hospital (P.J.M., M.K., T.O.), University of Helsinki, and Helsinki University Hospital, Helsinki, Finland; Immunogenetics Laboratory (J.I.), University of Turku, and Turku University Hospital, Turku, Finland; Department of Pediatrics (P.N.), Mikkeli Central Hospital, Mikkeli, Finland; Department of Pediatrics (R.V.), Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Pediatrics (P.K.), Tampere University Hospital, Tampere, Finland; Department of Pediatrics (K.N.-S.), Turku University Hospital, Turku, Finland; Institute of Clinical Medicine (J.V., J.R., A.S., T.K., M.L.), Internal Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine (M.L.), Internal Medicine, University of Eastern Finland, and Kuopio University Hospital, Kuopio, Finland.

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http://dx.doi.org/10.1210/jc.2015-4296DOI Listing
August 2016

Role of humoral beta-cell autoimmunity in type 1 diabetes.

Pediatr Diabetes 2016 07;17 Suppl 22:17-24

Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://doi.wiley.com/10.1111/pedi.12386
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http://dx.doi.org/10.1111/pedi.12386DOI Listing
July 2016

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.

Sci Transl Med 2016 06;8(343):343ra81

Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA. Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032909PMC
June 2016

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Cell 2016 May 28;165(4):842-53. Epub 2016 Apr 28.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950857PMC
May 2016

Development and maturation of norovirus antibodies in childhood.

Microbes Infect 2016 Apr 25;18(4):263-9. Epub 2015 Dec 25.

Vaccine Research Center, University of Tampere Medical School, Tampere, Finland.

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http://dx.doi.org/10.1016/j.micinf.2015.12.004DOI Listing
April 2016

Reduced β-cell function in early preclinical type 1 diabetes.

Eur J Endocrinol 2016 Mar 30;174(3):251-9. Epub 2015 Nov 30.

Department of PaediatricsUniversity of Turku and Turku University Hospital, Turku, FinlandMediCity LaboratoriesDepartment of Clinical Medicine, University of Turku, Lemminkäisenkatu 3, 20520 Turku, FinlandPEDEGO Research UnitDepartment of Paediatrics, Medical Research Centre Oulu, University of Oulu, Oulu, FinlandDepartment of Children and AdolescentsOulu University Hospital, Oulu, FinlandClinical Research CentreTurku University Hospital, Turku, FinlandDepartment of PaediatricsTampere University Hospital, Tampere, FinlandNovo Nordisk Farma OyCMR Department, Espoo, FinlandDiabetes Outpatient ClinicTampere, FinlandDepartment of PaediatricsTurku University Hospital, Turku, FinlandResearch Centre of Applied and Preventive Cardiovascular MedicineUniversity of Turku, Turku, FinlandImmunogenetics LaboratoryUniversity of Turku, Turku, FinlandDepartment of Clinical MicrobiologyUniversity of Eastern Finland, Kuopio, FinlandChildren's HospitalUniversity of Helsinki and Helsinki University Hospital, Helsinki, FinlandResearch Programs UnitDiabetes and Obesity, University of Helsinki, Helsinki, FinlandFolkhälsan Research CentreUniversity of Helsinki, Helsinki, FinlandDepartment of PhysiologyInstitute of Biomedicine, University of Turku, Turku, Finland Department of PaediatricsUniversity of Turku and Turku University Hospital, Turku, FinlandMediCity LaboratoriesDepartment of Clinical Medicine, University of Turku, Lemminkäisenkatu 3, 20520 Turku, FinlandPEDEGO Research UnitDepartment of Paediatrics, Medical Research Centre Oulu, University of Oulu, Oulu, FinlandDepartment of Children and AdolescentsOulu University Hospital, Oulu, FinlandClinical Research CentreTurku University Hospital, Turku, FinlandDepartment of PaediatricsTampere University Hospital, Tampere, FinlandNovo Nordisk Farma OyCMR Department, Espoo, FinlandDiabetes Outpatient ClinicTampere, FinlandDepartment of PaediatricsTurku University Hospital, Turku, FinlandResearch Centre of Applied and Preventive Cardiovascu

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http://dx.doi.org/10.1530/EJE-15-0674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712442PMC
March 2016

The role of the intestinal microbiota in type 1 diabetes mellitus.

Nat Rev Endocrinol 2016 Mar 4;12(3):154-67. Epub 2016 Jan 4.

Children's Hospital, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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http://www.nature.com/articles/nrendo.2015.218
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http://dx.doi.org/10.1038/nrendo.2015.218DOI Listing
March 2016

Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes.

J Clin Endocrinol Metab 2016 Feb 22;101(2):723-9. Epub 2015 Dec 22.

Medicity (M.M., M.Ko., V.S.), Department of Pediatrics (M.M., J.M., M.Ko., J.T.), Immunogenetics Laboratory (J.I.), University of Turku and Turku University Hospital, and Research Center of Applied and Preventive Cardiovascular Medicine (O.S.), and Department of Physiology (J.T.), Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland; Department of Pediatrics (R.V.), Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Medical Research Center Oulu, University of Oulu, FI 90014 Oulu, Finland; Department of Children and Adolescents (R.V.), Oulu University Hospital, FI 90029 Oulu, Finland; Department of Virology (H.H.), School of Medicine, University of Tampere, and Department of Pediatrics (M.Kn.), Tampere University Hospital, FI-33520 Tampere, Finland; Fimlab Laboratories (H.H.), Pirkanmaa Hospital District, FI-33014 Tampere, Finland; Children's Hospital (M.Kn.), University of Helsinki and Helsinki University Hospital, Research Programs Unit (M.Kn.), Diabetes and Obesity, University of Helsinki, and Folkhälsan Research Center (M.Kn.), FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2015-3504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880127PMC
February 2016

Environmental Trigger(s) of Type 1 Diabetes: Why Is It So Difficult to Identify?

Biomed Res Int 2015 30;2015:847906. Epub 2015 Mar 30.

Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1155/2015/847906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396126PMC
January 2016

Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes.

Diabetes Care 2016 Jan 30;39(1):118-21. Epub 2015 Oct 30.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland Folkhälsan Research Center, University of Helsinki, Helsinki, Finland Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland

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http://dx.doi.org/10.2337/dc15-1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876730PMC
January 2016

MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential.

Autoimmun Rev 2015 Nov 8;14(11):1029-37. Epub 2015 Jul 8.

Children`s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2015.07.005DOI Listing
November 2015

ConStrains identifies microbial strains in metagenomic datasets.

Nat Biotechnol 2015 Oct 7;33(10):1045-52. Epub 2015 Sep 7.

Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676274PMC
October 2015

Circulating IGF1 and IGFBP3 in relation to the development of β-cell autoimmunity in young children.

Eur J Endocrinol 2015 Aug 6;173(2):129-37. Epub 2015 May 6.

Department of PediatricsUniversity of Tartu, N. Lunini 6 51014 Tartu, EstoniaChildren's Clinic of Tartu University HospitalN. Lunini 6, Tartu, EstoniaChildren's Hospital and Jorvi HospitalUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, FinlandImmunogenetics LaboratoryUniversity of Turku, Turku, FinlandDepartment of Clinical MicrobiologyUniversity of Eastern Finland, Kuopio, FinlandDiabetes and Obesity Research ProgramUniversity of Helsinki, Helsinki, FinlandFolkhälsan Research CenterHelsinki, Finland andDepartment of PediatricsTampere University Hospital, Tampere, Finland Department of PediatricsUniversity of Tartu, N. Lunini 6 51014 Tartu, EstoniaChildren's Clinic of Tartu University HospitalN. Lunini 6, Tartu, EstoniaChildren's Hospital and Jorvi HospitalUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, FinlandImmunogenetics LaboratoryUniversity of Turku, Turku, FinlandDepartment of Clinical MicrobiologyUniversity of Eastern Finland, Kuopio, FinlandDiabetes and Obesity Research ProgramUniversity of Helsinki, Helsinki, FinlandFolkhälsan Research CenterHelsinki, Finland andDepartment of PediatricsTampere University Hospital, Tampere, Finland.

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https://eje.bioscientifica.com/view/journals/eje/173/2/129.x
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http://dx.doi.org/10.1530/EJE-14-1078DOI Listing
August 2015

OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis.

Diabetologia 2015 Aug 19;58(8):1787-96. Epub 2015 May 19.

Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University Hospital and University of Oulu, PO Box 5000, FIN-90014, Oulu, Finland,

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http://link.springer.com/10.1007/s00125-015-3621-9
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http://dx.doi.org/10.1007/s00125-015-3621-9DOI Listing
August 2015

Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran.

Immunol Lett 2015 Aug 5;166(2):134-9. Epub 2015 Jun 5.

Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1016/j.imlet.2015.05.021DOI Listing
August 2015

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

J Autoimmun 2015 Jul 12;61:45-53. Epub 2015 Jun 12.

Immunogenetics Laboratory, University of Turku, Turku, Finland; Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jaut.2015.05.005DOI Listing
July 2015

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

N Engl J Med 2015 Jun;372(25):2409-22

From the Division of Immunology (K.D., J.C., S.K., M.J.M., K.C., K.F., T.A.C., R.S.G., L.D.N.) and Manton Center for Orphan Disease Research (L.D.N.), Boston Children's Hospital, and Department of Molecular Biology, Massachusetts General Hospital (T.K.O.), Boston, Harvard Stem Cell Institute, Harvard University, Cambridge (L.D.N.), and Department of Pediatrics, University of Massachusetts Medical School, Worcester (A.M.C.) - all in Massachusetts; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (C.D.C., I.B., N.K.S., M.S., C.B., K.B.), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna (K.B.), and CeRUD Vienna Center for Rare and Undiagnosed Diseases (K.B.) - all in Vienna; St. Giles Laboratory of Human Genetics of Infectious Disease, Rockefeller Branch, Rockefeller University (S.-Y.Z., M.A., S.O., B.B., Y.I., L.A., J.-L.C.), and Institute for Genomic Medicine, Columbia University (S. Petrovski, D.B.G.) - both in New York; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (S.-Y.Z., V.P., L.A., J.-L.C.), Paris Descartes University, Sorbonne Paris Cité, Imagine Institute (S.-Y.Z., F.R., P.L., L.A., J.-L.C.), and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children (J.-L.C.) - all in Paris; Howard Hughes Medical Institute, Chevy Chase, MD (J.-L.C.); Department of Molecular and Translational Medicine, University of Brescia, Brescia (S. Parolini, O.P., G.T.), and Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa (A.M.) - both in Italy; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology (E.H.), Institute for Molecular Medicine Finland (J.S.), Children's Hospital (M.K.), Research Programs Unit, Diabetes and Obesity Research Program (M.K.), and Folkhälsan Research Center (M.K.), University of Helsinki and Helsinki University Central Hospital, Helsinki, Tampere Center

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http://dx.doi.org/10.1056/NEJMoa1413462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480434PMC
June 2015