Publications by authors named "Mikael Knip"

100Publications

Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.

Diabetologia 2020 Oct 7. Epub 2020 Oct 7.

Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-020-05287-1DOI Listing
October 2020

Decreased Incidence of Type 1 Diabetes in Young Finnish Children.

Diabetes Care 2020 Dec 30;43(12):2953-2958. Epub 2020 Sep 30.

Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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http://dx.doi.org/10.2337/dc20-0604DOI Listing
December 2020

Maternal antioxidant intake during pregnancy and the development of cows' milk allergy in the offspring.

Br J Nutr 2020 Sep 18:1-8. Epub 2020 Sep 18.

Department of Public Health Solutions, Finnish Institute for Health and Welfare, 00271Helsinki, Finland.

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http://dx.doi.org/10.1017/S0007114520003633DOI Listing
September 2020

Extended family history of type 1 diabetes in HLA-predisposed children with and without islet autoantibodies.

Pediatr Diabetes 2020 Dec 1;21(8):1447-1456. Epub 2020 Oct 1.

Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1111/pedi.13122DOI Listing
December 2020

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years.

J Clin Endocrinol Metab 2020 Dec;105(12)

Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1210/clinem/dgaa624DOI Listing
December 2020

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes.

Diabetologia 2020 Nov 3;63(11):2396-2409. Epub 2020 Sep 3.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1007/s00125-020-05257-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527319PMC
November 2020

Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease.

Environ Res 2020 09 30;188:109864. Epub 2020 Jun 30.

School of Science and Technology, Örebro University, Örebro, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.envres.2020.109864DOI Listing
September 2020

Type 1 and type 2 diabetes after gestational diabetes: a 23 year cohort study.

Diabetologia 2020 Oct 29;63(10):2123-2128. Epub 2020 Jul 29.

Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1007/s00125-020-05215-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476985PMC
October 2020

HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity.

Pediatr Diabetes 2020 Jul 1. Epub 2020 Jul 1.

Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1111/pedi.13073DOI Listing
July 2020

Multiplexed High-Throughput Serological Assay for Human Enteroviruses.

Microorganisms 2020 Jun 26;8(6). Epub 2020 Jun 26.

Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.

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http://dx.doi.org/10.3390/microorganisms8060963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355947PMC
June 2020

Association of diabetes-related autoantibodies with the incidence of asthma, eczema and allergic rhinitis in the TRIGR randomised clinical trial.

Diabetologia 2020 Sep 17;63(9):1796-1807. Epub 2020 Jun 17.

Unit of Public Health Promotion, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-020-05188-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416479PMC
September 2020

Type 1 diabetes-origins and epidemiology.

Lancet Diabetes Endocrinol 2020 05;8(5):368-369

Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland.

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http://dx.doi.org/10.1016/S2213-8587(20)30121-2DOI Listing
May 2020

The role of vitamin D in the aetiology of type 1 diabetes. Reply to Korsgren O [letter].

Diabetologia 2020 06 31;63(6):1281-1282. Epub 2020 Mar 31.

Department of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-020-05135-2DOI Listing
June 2020

Contrasting microbiotas between Finnish and Estonian infants: Exposure to Acinetobacter may contribute to the allergy gap.

Allergy 2020 09 17;75(9):2342-2351. Epub 2020 Mar 17.

Pediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/all.14250DOI Listing
September 2020

Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy.

Pediatr Allergy Immunol 2020 04 11;31(3):265-272. Epub 2020 Jan 11.

Faculty of Social Sciences/Health Sciences, Tampere University, Tampere, Finland.

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http://dx.doi.org/10.1111/pai.13186DOI Listing
April 2020

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.

Eur J Immunol 2020 04 19;50(4):581-588. Epub 2019 Dec 19.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1002/eji.201948378DOI Listing
April 2020

Coeliac disease and HLA-conferred susceptibility to autoimmunity are associated with IgE sensitization in young children.

Allergy 2020 03 2;75(3):692-694. Epub 2019 Oct 2.

Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/all.14055DOI Listing
March 2020

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Diabetologia 2019 12 23;62(12):2287-2297. Epub 2019 Aug 23.

Turku Bioscience, University of Turku and Åbo Akademi University, Tykistokatu 6, FI-20520, Turku, Finland.

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http://dx.doi.org/10.1007/s00125-019-04980-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861356PMC
December 2019

Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis.

Diabetologia 2019 11 25;62(11):2025-2039. Epub 2019 Jul 25.

Children's Hospital, University of Helsinki, P.O. Box 22, (Stenbäckinkatu 11), FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-019-4952-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805821PMC
November 2019

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

J Clin Endocrinol Metab 2019 11;104(11):5585-5594

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2019-01069DOI Listing
November 2019

Circulating CXCR5PD-1 peripheral T helper cells are associated with progression to type 1 diabetes.

Diabetologia 2019 09 3;62(9):1681-1688. Epub 2019 Jul 3.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1 C, FIN-70210, Kuopio, Finland.

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http://dx.doi.org/10.1007/s00125-019-4936-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677711PMC
September 2019

Microbiome and type 1 diabetes.

EBioMedicine 2019 Aug 27;46:512-521. Epub 2019 Jun 27.

Children's Hospital, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, 33520 Tampere, Finland; Folkhälsan Research Center, 00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710855PMC
August 2019

Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia.

Acta Paediatr 2019 11 23;108(11):2075-2082. Epub 2019 Jun 23.

Pediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/apa.14874DOI Listing
November 2019

Rhinoviruses in infancy and risk of immunoglobulin E sensitization.

J Med Virol 2019 08 25;91(8):1470-1478. Epub 2019 Mar 25.

Department of Virology, Faculty of Medical Sciences and Biotechnology, Tampere University, Tampere, Finland.

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http://doi.wiley.com/10.1002/jmv.25455
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http://dx.doi.org/10.1002/jmv.25455DOI Listing
August 2019

Development of T cell immunity to norovirus and rotavirus in children under five years of age.

Sci Rep 2019 03 1;9(1):3199. Epub 2019 Mar 1.

Vaccine Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-019-39840-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397277PMC
March 2019

Development of atopic sensitization in Finnish and Estonian children: A latent class analysis in a multicenter cohort.

J Allergy Clin Immunol 2019 05 23;143(5):1904-1913.e9. Epub 2019 Jan 23.

Dr. von Hauner Children's Hospital, LMU Munich, Munich, Germany; German Center for Lung Research (DZL). Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.12.1014DOI Listing
May 2019

Developing a vaccine for type 1 diabetes by targeting coxsackievirus B.

Expert Rev Vaccines 2018 12 29;17(12):1071-1083. Epub 2018 Nov 29.

d Children's Hospital , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

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http://dx.doi.org/10.1080/14760584.2018.1548281DOI Listing
December 2018

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.

Environ Sci Pollut Res Int 2019 Jan 13;26(2):1370-1378. Epub 2018 Nov 13.

Scientific Laboratory, Clinicum, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland.

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http://link.springer.com/10.1007/s11356-018-3659-6
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http://dx.doi.org/10.1007/s11356-018-3659-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331740PMC
January 2019

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Pediatr Diabetes 2019 02 19;20(1):73-77. Epub 2018 Nov 19.

Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://doi.wiley.com/10.1111/pedi.12788
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http://dx.doi.org/10.1111/pedi.12788DOI Listing
February 2019

Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes.

Diabetologia 2018 12 20;61(12):2668-2670. Epub 2018 Sep 20.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-018-4738-4DOI Listing
December 2018

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Clin Exp Allergy 2018 12 16;48(12):1698-1704. Epub 2018 Oct 16.

Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1111/cea.13280DOI Listing
December 2018

Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe.

Pediatr Diabetes 2018 12 25;19(8):1400-1406. Epub 2018 Sep 25.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/pedi.12756
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http://dx.doi.org/10.1111/pedi.12756DOI Listing
December 2018

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents.

Pediatr Diabetes 2018 10;19 Suppl 27:20-27

Department of Diabetes and Endocrinology, The Children's Hospital at Westmead, Sydney, Australia.

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http://dx.doi.org/10.1111/pedi.12734DOI Listing
October 2018

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

J Immunol 2018 08 13;201(4):1144-1153. Epub 2018 Jul 13.

Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland;

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http://dx.doi.org/10.4049/jimmunol.1701199DOI Listing
August 2018

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Cell Host Microbe 2018 07;24(1):146-154.e4

The Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091882PMC
July 2018

Sex as a determinant of type 1 diabetes at diagnosis.

Pediatr Diabetes 2018 11 17;19(7):1221-1228. Epub 2018 Jun 17.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pedi.12697DOI Listing
November 2018

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

J Clin Endocrinol Metab 2018 08;103(8):2870-2878

Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1210/jc.2017-02040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097602PMC
August 2018

Early life origin of type 1 diabetes.

Semin Immunopathol 2017 11 23;39(6):653-667. Epub 2017 Nov 23.

Children's Hospital, University of Helsinki and Helsinki University Hospital, P.O. Box 22, (Stenbäckinkatu 11), FI -00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00281-017-0665-6DOI Listing
November 2017

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Pediatr Diabetes 2018 05 17;19(3):398-402. Epub 2017 Oct 17.

Department of Virology, School of Medicine, University of Tampere, Tampere, Finland.

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http://doi.wiley.com/10.1111/pedi.12592
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http://dx.doi.org/10.1111/pedi.12592DOI Listing
May 2018

Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome.

Curr Diab Rep 2017 Sep 23;17(11):105. Epub 2017 Sep 23.

Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s11892-017-0933-9DOI Listing
September 2017

Lipidomics of human umbilical cord serum: identification of unique sterol sulfates.

Future Sci OA 2017 Aug 5;3(3):FSO193. Epub 2017 Apr 5.

Children's Hospital, University of Helsinki & Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.4155/fsoa-2017-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583693PMC
August 2017

Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study.

Pediatr Allergy Immunol 2017 Nov 8;28(7):641-648. Epub 2017 Sep 8.

Faculty of Social Sciences/Health, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1111/pai.12773DOI Listing
November 2017

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members.

Pediatr Diabetes 2018 03 26;19(2):305-313. Epub 2017 Jul 26.

Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/pedi.12563
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http://dx.doi.org/10.1111/pedi.12563DOI Listing
March 2018

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Gastroenterology 2017 10 5;153(4):961-970.e3. Epub 2017 Jul 5.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.049DOI Listing
October 2017

Type 1 diabetes mellitus is a heterogeneous disease.

Authors:
Mikael Knip

Nat Rev Endocrinol 2017 09 7;13(9). Epub 2017 Jul 7.

Children's Hospital, Department of Paediatrics, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrendo.2017.84DOI Listing
September 2017

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Pediatr Diabetes 2018 03 9;19(2):284-292. Epub 2017 Jun 9.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pedi.12545DOI Listing
March 2018

Metabolically inactive insulin: friend or foe in the prevention of autoimmune diabetes?

Authors:
Mikael Knip

Diabetologia 2017 08 3;60(8):1382-1384. Epub 2017 Jun 3.

Children's Hospital, University of Helsinki, and Helsinki University Hospital, P.O. Box 22, (Stenbäckinkatu 11), 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4319-yDOI Listing
August 2017

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

Pediatr Diabetes 2018 03 23;19(2):314-319. Epub 2017 May 23.

Department of Pediatrics, MRC Oulu, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1111/pedi.12541DOI Listing
March 2018

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Diabetologia 2017 07 4;60(7):1223-1233. Epub 2017 May 4.

Department of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, FI-00271, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4280-9DOI Listing
July 2017

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.

Diabetologia 2017 07 31;60(7):1284-1293. Epub 2017 Mar 31.

Children's Hospital, University of Helsinki and Helsinki University Hospital, P.O. Box 22, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4258-7DOI Listing
July 2017

Diabetes: Loss of β-cell mass - an acute event before T1DM presentation?

Authors:
Mikael Knip

Nat Rev Endocrinol 2017 05 31;13(5):253-254. Epub 2017 Mar 31.

Children's Hospital, Department of Paediatrics, University of Helsinki and Helsinki University Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrendo.2017.33DOI Listing
May 2017

Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies.

Acta Paediatr 2017 Jul 25;106(7):1142-1149. Epub 2017 Apr 25.

Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1111/apa.13846DOI Listing
July 2017

Reply to "Antibiotics, intestinal dysbiosis and risk of celiac disease" by Hakim Rahmoune et al. [Digestive and Liver Disease].

Dig Liver Dis 2017 01 25;49(1):106-107. Epub 2016 Oct 25.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15908658163077
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http://dx.doi.org/10.1016/j.dld.2016.10.009DOI Listing
January 2017

Reclassification of asymptomatic beta cell autoimmunity: a critical perspective.

Diabetologia 2017 01 27;60(1):39-42. Epub 2016 Oct 27.

Department of Pediatrics, PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1007/s00125-016-4147-5DOI Listing
January 2017

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.

J Clin Virol 2016 12 20;85:1-6. Epub 2016 Oct 20.

School of Medicine, University of Tampere, Lääkärinkatu 1, FIN-33520, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.

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http://dx.doi.org/10.1016/j.jcv.2016.10.010DOI Listing
December 2016

Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study.

Dig Liver Dis 2016 Nov 6;48(11):1296-1301. Epub 2016 Jul 6.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2016.06.029DOI Listing
November 2016