Mika Scheinin

Mika Scheinin

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Mika Scheinin

Mika Scheinin

Publications by authors named "Mika Scheinin"

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Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study.

Anesthesiology 2019 Aug 9. Epub 2019 Aug 9.

From the Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, and the Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden (A.L., L.I.E., M.J.F.) the West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia (K.J.M., P.R.E., D.R.H., J.H.W.) the Centre for Sleep Science, School of Human Sciences (K.J.M., P.R.E., D.R.H., J.H.W.) the Department of Anaesthesia, Sir Charles Gairdner Hospital (B.K.L.), Nedlands, Western Australia, Australia the Institute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland (M.S.).

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http://dx.doi.org/10.1097/ALN.0000000000002883DOI Listing
August 2019

Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression.

EBioMedicine 2019 Aug 26. Epub 2019 Aug 26.

Institute of Biomedicine, University of Turku, Finland; Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.08.035DOI Listing
August 2019

Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients.

Anesth Analg 2019 Jun 12. Epub 2019 Jun 12.

From the Department of Anesthesiology and Intensive Care, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1213/ANE.0000000000004264DOI Listing
June 2019

Premedication with intranasal dexmedetomidine decreases barbiturate requirement in pediatric patients sedated for magnetic resonance imaging: a retrospective study.

BMC Anesthesiol 2019 02 13;19(1):22. Epub 2019 Feb 13.

Department of Anaesthesiology and Intensive Care, University of Turku, P.O. Box 51, Kiinamyllynkatu 4-8, FI-20521, Turku, Finland.

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http://dx.doi.org/10.1186/s12871-019-0690-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374898PMC
February 2019

Peripheral α-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs.

Vet Anaesth Analg 2018 Jul 3;45(4):405-413. Epub 2018 Feb 3.

Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.vaa.2018.01.008DOI Listing
July 2018

Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors.

Neuroendocrinology 2018 24;107(4):324-339. Epub 2018 Jul 24.

Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1159/000492387DOI Listing
July 2018

Safety, Tolerability, and Antihypertensive Effect of SER100, an Opiate Receptor-Like 1 (ORL-1) Partial Agonist, in Patients With Isolated Systolic Hypertension.

Clin Pharmacol Drug Dev 2017 Nov 29;6(6):584-591. Epub 2016 Dec 29.

Smerud Medical Research International AS, Karenslyst alle, Oslo, Norway.

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http://dx.doi.org/10.1002/cpdd.330DOI Listing
November 2017

The role of active transport in the transcellular movement of the peripheral α-adrenoceptor antagonist, MK-467: An pilot study.

Can J Vet Res 2017 Oct;81(4):318-320

Equine and Small Animal Medicine, University of Helsinki, Koetilantie 2 Helsinki 00790, Finland (Bennett, Palviainen, Peltoniemi, Vuorilehto, Scheinin, Raekallio, Vainio).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644448PMC
October 2017

Gene expression profiles and signaling mechanisms in α-adrenoceptor-evoked proliferation of vascular smooth muscle cells.

BMC Syst Biol 2017 Jun 28;11(1):65. Epub 2017 Jun 28.

Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.

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http://dx.doi.org/10.1186/s12918-017-0439-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490158PMC
June 2017

Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha-antagonist MK-467 in dogs.

Vet Anaesth Analg 2017 May 11;44(3):417-426. Epub 2017 Jan 11.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.vaa.2016.04.006DOI Listing
May 2017

Clinical effects and pharmacokinetic variables of romifidine and the peripheral α -adrenoceptor antagonist MK-467 in horses.

Vet Anaesth Analg 2016 Nov 26;43(6):599-610. Epub 2016 Feb 26.

Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/vaa.12354DOI Listing
November 2016

Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study.

Anesthesiology 2016 10;125(4):700-15

From the Department of Anesthesiology, Surgical Services and Intensive Care, Karolinska University Hospital, Stockholm, Sweden (Å.L., E.C., J.U., L.I.E., M.J.F.); Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology (Å.L., A.E., A.H.C., S.M., E.C., J.U., L.I.E., M.J.F.) and Medical Statistics Unit, Department of Learning, Informatics, Managements and Ethics (E.H.), Karolinska Institutet, Stockholm, Sweden; Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland (M.S.); and Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland (M.S.).

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http://dx.doi.org/10.1097/ALN.0000000000001236DOI Listing
October 2016

A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.

Bioorg Med Chem 2016 07 24;24(14):3174-83. Epub 2016 May 24.

Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, POB 522, Mihaila Petrovica Alasa 14, 11001 Belgrade, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.05.043DOI Listing
July 2016

Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies.

Eur J Med Chem 2016 Jun 14;115:406-15. Epub 2016 Mar 14.

Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK.

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http://dx.doi.org/10.1016/j.ejmech.2016.03.026DOI Listing
June 2016

Comparison of simultaneous measurement of mouse locomotor activity by radiotelemetry and photobeam methods.

J Pharmacol Toxicol Methods 2015 Jan-Feb;71:90-4. Epub 2014 Sep 16.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, FI-20014 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.vascn.2014.09.003DOI Listing
April 2016

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

J Biol Chem 2016 Mar 19;291(11):5634-51. Epub 2016 Jan 19.

From the Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute 18.6, University of Copenhagen, DK-2200 Copenhagen, Denmark,

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http://dx.doi.org/10.1074/jbc.M115.702050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786704PMC
March 2016

Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [11C]ORM-13070.

Synapse 2016 Feb 26;70(2):57-65. Epub 2015 Nov 26.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1002/syn.21872DOI Listing
February 2016

Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist.

Basic Clin Pharmacol Toxicol 2015 Dec 30;117(6):392-8. Epub 2015 Jul 30.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://doi.wiley.com/10.1111/bcpt.12440
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http://dx.doi.org/10.1111/bcpt.12440DOI Listing
December 2015

Sensitivity of [(11)C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects.

Psychopharmacology (Berl) 2015 Nov 29;232(21-22):4169-78. Epub 2015 Apr 29.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1007/s00213-015-3941-yDOI Listing
November 2015

Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

Eur J Clin Pharmacol 2015 Oct 2;71(10):1197-207. Epub 2015 Aug 2.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 404 Kapoor Hall, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s00228-015-1913-0DOI Listing
October 2015

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane.

Vet Anaesth Analg 2015 Sep 22;42(5):527-36. Epub 2014 Dec 22.

Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/vaa.12238DOI Listing
September 2015

Quantitative determination of α(2B)-adrenoceptor-evoked myosin light chain phosphorylation in vascular smooth muscle cells.

J Pharmacol Toxicol Methods 2014 Sep-Oct;70(2):152-62. Epub 2014 Aug 7.

Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1016/j.vascn.2014.07.004DOI Listing
June 2015

Validation of [(11) C]ORM-13070 as a PET tracer for alpha2c -adrenoceptors in the human brain.

Synapse 2015 Mar 8;69(3):172-81. Epub 2015 Jan 8.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland; Clinical Research Services Turku CRST, Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1002/syn.21798DOI Listing
March 2015

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.

Eur J Clin Pharmacol 2015 Mar 6;71(3):321-7. Epub 2015 Jan 6.

Department of Anaesthesiology, Intensive Care, Emergency Care, and Pain Medicine, Turku University Hospital, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland,

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http://dx.doi.org/10.1007/s00228-014-1799-2DOI Listing
March 2015

Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.

Int J Neuropsychopharmacol 2014 Dec 13;18(3). Epub 2014 Dec 13.

Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden (Drs Finnema, Stepanov, Nakao, Varnäs, Varrone, Farde, and Halldin); Pfizer, Neuroscience Research Unit, Cambridge, MA (Drs Hughes, Babalola, and Grimwood); University of Turku, Turku PET Centre, Turku, Finland (Drs Haaparanta-Solin, Arponen, Marjamäki, and Solin); University of Turku, Department of Pharmacology, Drug Development and Therapeutics, and Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland (Drs Pohjanoksa, Vuorilehto, and Scheinin); Orion Corporation, Orion Pharma, Research and Development, Turku, Finland (Dr Sallinen); AstraZeneca, Translational Science Center at Karolinska Institutet, Stockholm, Sweden (Dr Farde).

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http://dx.doi.org/10.1093/ijnp/pyu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360244PMC
December 2014

Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.

Eur J Med Chem 2014 Nov 28;87:386-97. Epub 2014 Sep 28.

Department of Pathophysiology, Medical University of Gdańsk, Dębinki 7, Building 27, 80-211 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.ejmech.2014.09.083DOI Listing
November 2014

A PET Tracer for Brain α2C Adrenoceptors, (11)C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice.

J Nucl Med 2014 Jul 5;55(7):1171-7. Epub 2014 May 5.

Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland Accelerator Laboratory, Åbo Akademi University, Turku, Finland

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http://dx.doi.org/10.2967/jnumed.113.135574DOI Listing
July 2014

Reply to "Letter to the editor: 'Deconstructing the dogma of sympathetic restraint and its role in the cardiovascular response to exercise'".

Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H464

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland;

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http://dx.doi.org/10.1152/ajpheart.00935.2013DOI Listing
February 2014

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

Biopharm Drug Dispos 2013 Oct 15;34(7):387-95. Epub 2013 Aug 15.

Clinical Research Services Turku, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1002/bdd.1853DOI Listing
October 2013

Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose.

Pharmacogenet Genomics 2013 Sep;23(9):479-86

Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283642f93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787837PMC
September 2013

Inhibition of α-adrenergic tone disturbs the distribution of blood flow in the exercising human limb.

Am J Physiol Heart Circ Physiol 2013 Jul 10;305(2):H163-72. Epub 2013 May 10.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1152/ajpheart.00925.2012DOI Listing
July 2013

Rifampicin markedly decreases the exposure to oral and intravenous tramadol.

Eur J Clin Pharmacol 2013 Jun 15;69(6):1293-301. Epub 2012 Dec 15.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20520 Turku, Finland.

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http://dx.doi.org/10.1007/s00228-012-1460-xDOI Listing
June 2013

Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine.

Vet Anaesth Analg 2013 May 31;40(3):257-64. Epub 2013 Jan 31.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/vaa.12012DOI Listing
May 2013

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

Eur J Clin Pharmacol 2013 Apr 26;69(4):867-75. Epub 2012 Oct 26.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku, Kiinamyllynkatu 4-8, P.O. Box 52, FI-20520 Turku, Finland.

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http://link.springer.com/10.1007/s00228-012-1433-0
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http://dx.doi.org/10.1007/s00228-012-1433-0DOI Listing
April 2013

Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia.

Neuroendocrinology 2012 7;96(1):51-9. Epub 2012 Feb 7.

Department of Pharmacology, Drug Development and Therapeutics and Turku Center for Disease Modeling, University of Turku, Finland.

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https://www.karger.com/Article/FullText/334629
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http://dx.doi.org/10.1159/000334629DOI Listing
December 2012

High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors.

Eur J Pharm Sci 2012 Dec 12;47(5):941-51. Epub 2012 Sep 12.

Pharmaceutical Sciences, Department of Biosciences, Abo Akademi University, BioCity, Turku, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S092809871200344
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http://dx.doi.org/10.1016/j.ejps.2012.08.021DOI Listing
December 2012

Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2012 Nov 17;39(11):1784-95. Epub 2012 Jul 17.

MediCity/PET Preclinical Laboratory, Turku PET Centre, University of Turku, Tykistökatu 6A, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1007/s00259-012-2178-9DOI Listing
November 2012

CYP2A6 genetic variation and dexmedetomidine disposition.

Eur J Clin Pharmacol 2012 Jun 21;68(6):937-42. Epub 2012 Jan 21.

Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s00228-011-1208-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352974PMC
June 2012

Influence of MK-467, a peripherally acting α2-adrenoceptor antagonist on the disposition of intravenous dexmedetomidine in dogs.

Drug Metab Dispos 2012 Mar 23;40(3):445-9. Epub 2011 Nov 23.

Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1124/dmd.111.042671DOI Listing
March 2012

Might the observed α(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

Bioorg Med Chem 2012 Mar 31;20(6):2082-90. Epub 2012 Jan 31.

Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università degli Studi di Camerino, via S. Agostino 1, 62032 Camerino, Italy.

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http://dx.doi.org/10.1016/j.bmc.2012.01.035DOI Listing
March 2012

Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines.

Bioorg Med Chem 2012 Jan 25;20(1):108-16. Epub 2011 Nov 25.

Department of Chemical Technology of Drugs, Medical University of Gdańsk, Al. Gen. J. Hallera 107, Gdańsk 80-416, Poland.

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http://dx.doi.org/10.1016/j.bmc.2011.11.025DOI Listing
January 2012

Bioavailability of dexmedetomidine after intranasal administration.

Eur J Clin Pharmacol 2011 Aug 12;67(8):825-31. Epub 2011 Feb 12.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, P.O. Box 52, FI-20521, Turku, Finland.

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http://link.springer.com/content/pdf/10.1007/s00228-011-1002
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http://link.springer.com/10.1007/s00228-011-1002-y
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http://dx.doi.org/10.1007/s00228-011-1002-yDOI Listing
August 2011

α2-adrenoceptor regulation of blood glucose homeostasis.

Basic Clin Pharmacol Toxicol 2011 Jun 11;108(6):365-70. Epub 2011 Apr 11.

Turku PET Centre, University of Turku, Finland.

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http://dx.doi.org/10.1111/j.1742-7843.2011.00699.xDOI Listing
June 2011

Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease.

Q J Nucl Med Mol Imaging 2011 Jun;55(3):265-79

Turku PET Centre, University of Turku, Turku University Hospital, Turku, Finland.

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June 2011

Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves.

Am J Physiol Regul Integr Comp Physiol 2011 Feb 24;300(2):R298-310. Epub 2010 Nov 24.

Dept. of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg. 41, Highway 6W, Iowa City, IA 52246, USA.

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http://dx.doi.org/10.1152/ajpregu.00469.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043795PMC
February 2011

Dorsal hand vein responses to the α₁-adrenoceptor agonist phenylephrine do not predict responses to the α₂-adrenoceptor agonist dexmedetomidine.

Eur J Pharmacol 2011 Feb 11;653(1-3):70-4. Epub 2010 Dec 11.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.ejphar.2010.11.024DOI Listing
February 2011

3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor.

Bioorg Med Chem 2011 Jan 11;19(1):321-9. Epub 2010 Nov 11.

Department of Chemical Technology of Drugs, Medical University of Gdańsk, 80-416 Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.bmc.2010.11.020DOI Listing
January 2011

Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.

Basic Clin Pharmacol Toxicol 2010 Aug 28;107(2):690-7. Epub 2010 Mar 28.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1111/j.1742-7843.2010.00563.xDOI Listing
August 2010

Homogeneous GTP binding assay employing QRET technology.

J Biomol Screen 2010 Mar 26;15(3):261-7. Epub 2010 Jan 26.

Laboratory of Biophysics, Institute of Biomedicine, University of Turku, Finland.

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http://dx.doi.org/10.1177/1087057109358921DOI Listing
March 2010

Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.

Eur J Pain 2010 Feb 6;14(2):154-9. Epub 2009 May 6.

Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1016/j.ejpain.2009.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815116PMC
February 2010

Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report.

J Med Case Rep 2010 Feb 25;4:73. Epub 2010 Feb 25.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku and Turku University Hospital, FIN-20521, Turku, Finland.

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http://dx.doi.org/10.1186/1752-1947-4-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848065PMC
February 2010

Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data.

Eur J Nucl Med Mol Imaging 2009 Oct 4;36(10):1651-60. Epub 2009 Jun 4.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

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http://link.springer.com/10.1007/s00259-009-1174-1
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http://dx.doi.org/10.1007/s00259-009-1174-1DOI Listing
October 2009

Blood pressure regulation and cardiac autonomic control in mice overexpressing alpha- and gamma-melanocyte stimulating hormone.

Peptides 2008 Nov 28;29(11):1943-52. Epub 2008 Jun 28.

Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.peptides.2008.06.012DOI Listing
November 2008

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.

J Med Chem 2008 Jul 25;51(14):4289-99. Epub 2008 Jun 25.

Dipartimento di Scienze Chimiche, Università degli Studi di Camerino, via S. Agostino 1, 62032 Camerino, Italy.

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http://dx.doi.org/10.1021/jm800250zDOI Listing
July 2008

Expression and characterization of the human alpha 2B-adrenoceptor in a vascular smooth muscle cell line.

Eur J Pharmacol 2008 Jun 4;587(1-3):48-56. Epub 2008 Apr 4.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.ejphar.2008.03.049DOI Listing
June 2008

Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine.

Hypertension 2008 Feb 10;51(2):406-11. Epub 2007 Dec 10.

Department of Medicine, Division of Clinical Pharmacology, 542 RRB, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.098939DOI Listing
February 2008

Reduced blood glucose levels, increased insulin levels and improved glucose tolerance in alpha2A-adrenoceptor knockout mice.

Eur J Pharmacol 2008 Jan 2;578(2-3):359-64. Epub 2007 Oct 2.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Clinical Pharmacology, TYKSLAB, Hospital District of Southwest Finland, Itäinen Pitkäkatu 4B, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.ejphar.2007.09.015DOI Listing
January 2008

Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects.

Anesthesiology 2006 Nov;105(5):902-10; quiz 1069-70

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1097/00000542-200611000-00010DOI Listing
November 2006

Determinants of coronary flow velocity reserve in healthy young men.

Am J Physiol Heart Circ Physiol 2006 Aug 24;291(2):H564-9. Epub 2006 Feb 24.

Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1152/ajpheart.00915.2005DOI Listing
August 2006

The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene.

Eur J Pharmacol 2006 Jan 2;529(1-3):105-13. Epub 2005 Dec 2.

Department of Pharmacology and Clinical Pharmacology, University of Turku, FI-20520 Turku, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S001429990501095
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http://dx.doi.org/10.1016/j.ejphar.2005.10.029DOI Listing
January 2006

Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies.

J Recept Signal Transduct Res 2005 ;25(2):99-124

Institute of Biotechnology, Biocenter 3, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1081/RRS-200068745 DOI Listing
October 2005

Expression and function of alpha-adrenoceptors in zebrafish: drug effects, mRNA and receptor distributions.

J Neurochem 2005 Sep 5;94(6):1559-69. Epub 2005 Jul 5.

Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03305.xDOI Listing
September 2005

Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells.

Brain Res Mol Brain Res 2005 Aug;138(2):116-23

Turku Centre for Biotechnology, University of Turku/Abo Akademi University, Tykistökatu 6 B, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.molbrainres.2005.04.003DOI Listing
August 2005

alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice.

Eur J Pharmacol 2005 Jul;517(1-2):74-83

Department of Pharmacology and Clinical Pharmacology, University of Turku, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.ejphar.2005.05.022DOI Listing
July 2005

Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction.

Pharmacogenet Genomics 2005 May;15(5):357-63

Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143-0648, USA.

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May 2005

Uneven cellular expression of recombinant alpha2A-adrenoceptors in transfected CHO cells results in loss of response in adenylyl cyclase inhibition.

Biochim Biophys Acta 2005 May 2;1744(1):38-46. Epub 2004 Dec 2.

Department of Pharmacology and Clinical Pharmacology, University of Turku, Itäinen Pitkäkatu 4, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.bbamcr.2004.11.006DOI Listing
May 2005

Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers.

Anesthesiology 2005 Mar;102(3):536-42

Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143-0648, USA.

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http://dx.doi.org/10.1097/00000542-200503000-00010DOI Listing
March 2005

Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases.

Int J Cardiol 2004 Dec;97(3):367-72

Department of Pharmacology, School of Medicine, University of Patras, Rio Patras, Greece.

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http://dx.doi.org/10.1016/j.ijcard.2003.10.014DOI Listing
December 2004