Mika Leinonen

Continuous Subcutaneous Levodopa Delivery for Parkinson's Disease: A Randomized Study.

Authors:

C Warren Olanow Alberto J Espay Fabrizio Stocchi Aaron L Ellenbogen Mika Leinonen Liat Adar Ryan J Case Shir Fuchs Orenbach Tami Yardeni Sheila Oren Werner Poewe

J Parkinsons Dis 2020 Nov 4. Epub 2020 Nov 4.

Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

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November 2020

Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study.

Authors:

Andrew McGarry Mika Leinonen Karl Kieburtz Michal Geva C Warren Olanow Michael Hayden

J Huntingtons Dis 2020 ;9(4):371-380

Prilenia Therapeutics, Herzliya, Israel.

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January 2020

Idebenone does not inhibit disability progression in primary progressive MS.

Authors:

Peter Kosa Tianxia Wu Jonathan Phillips Mika Leinonen Ruturaj Masvekar Mika Komori Alison Wichman Mary Sandford Bibiana Bielekova

Mult Scler Relat Disord 2020 Oct 5;45:102434. Epub 2020 Aug 5.

Neuroimmunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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October 2020

Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.

Authors:

John G Nutt Carolin Curtze Amie Hiller Shannon Anderson Paul S Larson Amber D Van Laar R Mark Richardson Marin E Thompson Alexander Sedkov Mika Leinonen Bernard Ravina Krystof S Bankiewicz Chadwick W Christine

Mov Disord 2020 05 9;35(5):851-858. Epub 2020 Mar 9.

Department of Neurology, University of California San Francisco, San Francisco, California, USA.

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May 2020

Apomorphine sublingual film for off episodes in Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 study.

Authors:

C Warren Olanow Stewart A Factor Alberto J Espay Robert A Hauser Holly A Shill Stuart Isaacson Rajesh Pahwa Mika Leinonen Parul Bhargava Ken Sciarappa Bradford Navia David Blum

Lancet Neurol 2020 02 7;19(2):135-144. Epub 2019 Dec 7.

Sunovion, Marlborough, MA, USA.

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February 2020

Long-term data with idebenone on respiratory function outcomes in patients with Duchenne muscular dystrophy.

Authors:

Laurent Servais Chiara S M Straathof Ulrike Schara Andrea Klein Mika Leinonen Shabir Hasham Thomas Meier Liesbeth De Waele Heather Gordish-Dressman Craig M McDonald Oscar H Mayer Thomas Voit Eugenio Mercuri Gunnar M Buyse

Neuromuscul Disord 2020 01 5;30(1):5-16. Epub 2019 Nov 5.

Pediatric Neurology, University Hospitals Leuven, Herestraat 49, B - 3000 Leuven, Belgium. Electronic address:

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January 2020

Continuous versus intermittent oral administration of levodopa in Parkinson's disease patients with motor fluctuations: A pharmacokinetics, safety, and efficacy study.

Authors:

C Warren Olanow Margherita Torti Karl Kieburtz Mika Leinonen Laura Vacca Paola Grassini Adam Heller Ephraim Heller Fabrizio Stocchi

Mov Disord 2019 03 17;34(3):425-429. Epub 2019 Jan 17.

Institute for Research and Medical Care, IRCCS, San Raffaele, Rome, Italy.

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March 2019

Longitudinal pulmonary function testing outcome measures in Duchenne muscular dystrophy: Long-term natural history with and without glucocorticoids.

Authors:

Craig M McDonald Heather Gordish-Dressman Erik K Henricson Tina Duong Nanette C Joyce Sanjay Jhawar Mika Leinonen Fengming Hsu Anne M Connolly Avital Cnaan Richard T Abresch

Neuromuscul Disord 2018 11 29;28(11):897-909. Epub 2018 Aug 29.

University of California Davis Health, Sacramento, CA, USA.

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November 2018

Home-Based Monitoring of Pulmonary Function in Patients with Duchenne Muscular Dystroph.

Authors:

Gunnar M Buyse Christian Rummey Thomas Meier Mika Leinonen Thomas Voit Craig M McDonald Oscar H Mayer

J Neuromuscul Dis 2018 ;5(4):419-430

The Children's Hospital of Philadelphia, Philadelphia, USA.

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January 2019

Efficacy of Idebenone to Preserve Respiratory Function above Clinically Meaningful Thresholds for Forced Vital Capacity (FVC) in Patients with Duchenne Muscular Dystrophy.

Authors:

Oscar H Mayer Mika Leinonen Christian Rummey Thomas Meier Gunnar M Buyse

J Neuromuscul Dis 2017;4(3):189-198

University Hospitals Leuven, Leuven, Belgium.

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April 2018

A randomized trial of a low-dose Rasagiline and Pramipexole combination (P2B001) in early Parkinson's disease.

Authors:

C Warren Olanow Karl Kieburtz Mika Leinonen Lawrence Elmer Nir Giladi Robert A Hauser Olga S Klepiskaya David L Kreitzman Mark F Lew David S Russell Shaul Kadosh Pninit Litman Hadas Friedman Nurit Linvah For The P B Study Group

Mov Disord 2017 05 3;32(5):783-789. Epub 2017 Apr 3.

Clintrex LLC, Rye, New York, USA.

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May 2017

Characterization of pulmonary function in 10-18 year old patients with Duchenne muscular dystrophy.

Authors:

Thomas Meier Christian Rummey Mika Leinonen Paolo Spagnolo Oscar H Mayer Gunnar M Buyse

Neuromuscul Disord 2017 Apr 6;27(4):307-314. Epub 2017 Jan 6.

University Hospitals Leuven, Leuven, Belgium. Electronic address:

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April 2017

Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson's disease.

Authors:

Michael M Lipp Richard Batycky Jerome Moore Mika Leinonen Martin I Freed

Sci Transl Med 2016 10;8(360):360ra136

Acorda Therapeutics, Chelsea, MA 02150, USA.

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October 2016

Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy.

Authors:

Gunnar M Buyse Thomas Voit Ulrike Schara Chiara S M Straathof Maria Grazia D'Angelo Günther Bernert Jean-Marie Cuisset Richard S Finkel Nathalie Goemans Christian Rummey Mika Leinonen Oscar H Mayer Paolo Spagnolo Thomas Meier Craig M McDonald

Pediatr Pulmonol 2017 04 29;52(4):508-515. Epub 2016 Aug 29.

University Hospitals Leuven, Leuven, Belgium.

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April 2017

Prospective evaluation of pulmonary function in Parkinson's disease patients with motor fluctuations.

Authors:

Neil B Hampson Karl D Kieburtz Peter A LeWitt Mika Leinonen Martin I Freed

Int J Neurosci 2017 Mar 27;127(3):276-284. Epub 2016 Jun 27.

e Acorda Therapeutics , Chelsea , MA , USA.

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March 2017

Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy.

Authors:

Craig M McDonald Thomas Meier Thomas Voit Ulrike Schara Chiara S M Straathof M Grazia D'Angelo Günther Bernert Jean-Marie Cuisset Richard S Finkel Nathalie Goemans Christian Rummey Mika Leinonen Paolo Spagnolo Gunnar M Buyse

Neuromuscul Disord 2016 08 12;26(8):473-80. Epub 2016 May 12.

University Hospitals Leuven, Leuven, Belgium. Electronic address:

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August 2016

Long-term safety profile of anakinra in patients with severe cryopyrin-associated periodic syndromes.

Authors:

Torbjörn Kullenberg Malin Löfqvist Mika Leinonen Raphaela Goldbach-Mansky Hans Olivecrona

Rheumatology (Oxford) 2016 08 3;55(8):1499-506. Epub 2016 May 3.

Development & Medical, Sobi.

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August 2016

A randomized trial of inhaled levodopa (CVT-301) for motor fluctuations in Parkinson's disease.

Authors:

Peter A LeWitt Robert A Hauser Donald G Grosset Fabrizio Stocchi Marie-Helene Saint-Hilaire Aaron Ellenbogen Mika Leinonen Neil B Hampson Tia DeFeo-Fraulini Martin I Freed Karl D Kieburtz

Mov Disord 2016 09 19;31(9):1356-65. Epub 2016 Apr 19.

Clintrex LLC, Rye, New York, USA.

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September 2016

Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?

Authors:

Mikael Eriksson Peter Reichardt Kirsten Sundby Hall Jochen Schütte Silke Cameron Peter Hohenberger Sebastian Bauer Mika Leinonen Annette Reichardt Maria Rejmyr Davis Thor Alvegård Heikki Joensuu

Eur J Cancer 2016 05 28;59:128-133. Epub 2016 Mar 28.

Department of Oncology, University of Helsinki, and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.

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May 2016

Efficacy and safety of entacapone in levodopa/carbidopa versus levodopa/benserazide treated Parkinson's disease patients with wearing-off.

Authors:

Mikko Kuoppamäki Mika Leinonen Werner Poewe

J Neural Transm (Vienna) 2015 Dec 7;122(12):1709-14. Epub 2015 Sep 7.

Universitätsklinik für Neurologie, Leopold-Franzens-Universität, Innsbruck, Austria.

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December 2015

Long-Term Safety Outcomes in Patients with Hematological Malignancies Undergoing Autologous Hematopoietic Stem Cell Transplantation Treated with Palifermin to Prevent Oral Mucositis.

Authors:

Patrick J Stiff Mika Leinonen Torbjörn Kullenberg Mattias Rudebeck Maarten de Chateau Ricardo Spielberger

Biol Blood Marrow Transplant 2016 Jan 22;22(1):164-9. Epub 2015 Aug 22.

City of Hope Department of Hematology and Hematopoietic Cell Transplantation, Los Angeles, California; Southern California Permanente Medical Group, Los Angeles, California.

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January 2016

Risk factors for gastrointestinal stromal tumor recurrence in patients treated with adjuvant imatinib.

Cancer 2014 Aug 15;120(15):2325-33. Epub 2014 Apr 15.

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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August 2014

Outcome of patients with HER2-positive breast cancer treated with or without adjuvant trastuzumab in the Finland Capecitabine Trial (FinXX).

Authors:

Heikki Joensuu Pirkko-Liisa Kellokumpu-Lehtinen Riikka Huovinen Arja Jukkola-Vuorinen Minna Tanner Riitta Kokko Johan Ahlgren Päivi Auvinen Outi Saarni Leena Helle Kenneth Villman Paul Nyandoto Greger Nilsson Mika Leinonen Vesa Kataja Petri Bono Henrik Lindman

Acta Oncol 2014 Feb 19;53(2):186-94. Epub 2013 Aug 19.

Department of Oncology, Helsinki University Central Hospital , Helsinki , Finland.

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February 2014

Factors predictive of the development of Levodopa-induced dyskinesia and wearing-off in Parkinson's disease.

Authors:

C Warren Olanow Karl Kieburtz Olivier Rascol Werner Poewe Anthony H Schapira Murat Emre Helena Nissinen Mika Leinonen Fabrizio Stocchi

Mov Disord 2013 Jul 29;28(8):1064-71. Epub 2013 Apr 29.

Department of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

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July 2013

Effects of idebenone on color vision in patients with leber hereditary optic neuropathy.

Authors:

Guenther Rudolph Konstantinos Dimitriadis Boriana Büchner Suzette Heck Jasmina Al-Tamami Florian Seidensticker Christian Rummey Mika Leinonen Thomas Meier Thomas Klopstock

J Neuroophthalmol 2013 Mar;33(1):30-6

Department of Ophthalmology (GR, FS), Ludwig-Maximilians-University, Munich, Germany.

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March 2013

Randomized clinical trial of fipamezole for dyskinesia in Parkinson disease (FJORD study).

Authors:

Peter A Lewitt Robert A Hauser Mei Lu Anthony P Nicholas William Weiner Nicholas Coppard Mika Leinonen Juha-Matti Savola

Neurology 2012 Jul 27;79(2):163-9. Epub 2012 Jun 27.

Departments of Neurology, Henry Ford Hospital, Detroit, MI, USA.

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July 2012

Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects.

Authors:

Eftyhia Vardas Ioana Stanescu Mika Leinonen Kim Ellefsen Giuseppe Pantaleo Minna Valtavaara Mart Ustav Kalevi Reijonen

Vaccine 2012 Jun 28;30(27):4046-54. Epub 2012 Apr 28.

Lancet Laboratories, Richmond, Johannesburg, South Africa.

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June 2012

One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial.

JAMA 2012 Mar;307(12):1265-72

Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 180, FIN-00029 Helsinki, Finland.

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March 2012

Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: final analysis of the randomized FinXX trial.

J Clin Oncol 2012 Jan 21;30(1):11-8. Epub 2011 Nov 21.

Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 180, FIN-00029 Helsinki, Finland.

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January 2012

Meta-analysis of the prevalence of Leber hereditary optic neuropathy mtDNA mutations in Europe.

Authors:

Barbara Mascialino Mika Leinonen Thomas Meier

Eur J Ophthalmol 2012 May-Jun;22(3):461-5

Stockholm University, Stockholm, Sweden.

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July 2012

A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy.

Authors:

Thomas Klopstock Patrick Yu-Wai-Man Konstantinos Dimitriadis Jacinthe Rouleau Suzette Heck Maura Bailie Alaa Atawan Sandip Chattopadhyay Marion Schubert Aylin Garip Marcus Kernt Diana Petraki Christian Rummey Mika Leinonen Günther Metz Philip G Griffiths Thomas Meier Patrick F Chinnery

Brain 2011 Sep 25;134(Pt 9):2677-86. Epub 2011 Jul 25.

Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.

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September 2011

Direct switch from levodopa/benserazide or levodopa/carbidopa to levodopa/carbidopa/entacapone in Parkinson's disease patients with wearing-off: efficacy, safety and feasibility--an open-label, 6-week study.

Authors:

Karla Eggert Orjan Skogar Khaled Amar Liisa Luotonen Mikko Kuoppamäki Mika Leinonen Helena Nissinen Wolfgang Oertel

J Neural Transm (Vienna) 2010 Mar 15;117(3):333-42. Epub 2009 Dec 15.

Department of Neurology, Philipps-University Marburg, Marburg, Germany.

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March 2010

Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for breast cancer: an open-label, randomised controlled trial.

Lancet Oncol 2009 Dec 10;10(12):1145-51. Epub 2009 Nov 10.

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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December 2009

Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial.

J Clin Oncol 2009 Dec 2;27(34):5685-92. Epub 2009 Nov 2.

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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December 2009

Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data.

Authors:

Sargo Aalto Noora M Scheinin Nina M Kemppainen Kjell Någren Marita Kailajärvi Mika Leinonen Mika Scheinin Juha O Rinne

Eur J Nucl Med Mol Imaging 2009 Oct 4;36(10):1651-60. Epub 2009 Jun 4.

Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.

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October 2009

Five-year efficacy and safety of levodopa/DDCI and entacapone in patients with Parkinson's disease.

Authors:

David J Brooks Mika Leinonen Mikko Kuoppamäki Helena Nissinen

J Neural Transm (Vienna) 2008 Jun 8;115(6):843-9. Epub 2008 Feb 8.

Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.

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June 2008

Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer.

N Engl J Med 2006 Feb;354(8):809-20

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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February 2006

Entacapone increases levodopa exposure and reduces plasma levodopa variability when used with Sinemet CR.

Authors:

Outi Paija Kari Laine Eeva-Riitta Kultalahti Mika Leinonen Risto Huupponen Ariel Gordin Kari Reinikainen

Clin Neuropharmacol 2005 May-Jun;28(3):115-9

Clinical Research Services Turku, Finland.

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October 2005

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