Publications by authors named "Mika Ala-Korpela"

100Publications

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.

Nat Metab 2020 Oct 16;2(10):1135-1148. Epub 2020 Oct 16.

Department of Medicine, Karolinska Institute, Solna, Sweden.

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http://dx.doi.org/10.1038/s42255-020-00287-2DOI Listing
October 2020

The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study.

J Bone Miner Res 2020 Jul 12;35(7):1224-1235. Epub 2020 Mar 12.

Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3989DOI Listing
July 2020

Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study.

Atherosclerosis 2020 04 14;299:56-63. Epub 2020 Feb 14.

Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; National Institute for Health and Welfare, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.02.002DOI Listing
April 2020

Commentary: The unbelievable impediment to understanding causality of risk factors: case prostate cancer.

Int J Epidemiol 2020 04;49(2):597-598

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.

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http://dx.doi.org/10.1093/ije/dyaa011DOI Listing
April 2020

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease.

Atherosclerosis 2020 02 13;294:10-15. Epub 2019 Dec 13.

Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.12.009DOI Listing
February 2020

Polygenic risk scores and the prediction of common diseases.

Int J Epidemiol 2020 02;49(1):1-3

Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/ije/dyz254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261205PMC
February 2020

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.

Liver Int 2019 10 8;39(10):1895-1905. Epub 2019 Jul 8.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1111/liv.14174DOI Listing
October 2019

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum.

Clin Chem 2019 08 17;65(8):1042-1050. Epub 2019 Apr 17.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.299
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http://dx.doi.org/10.1373/clinchem.2018.299222DOI Listing
August 2019

The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease.

Authors:
Mika Ala-Korpela

Int J Epidemiol 2019 10;48(5):1389-1392

Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1093/ije/dyz068DOI Listing
October 2019

A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density.

J Bone Miner Res 2019 07 18;34(7):1306-1313. Epub 2019 Mar 18.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3697DOI Listing
July 2019

Commentary: Data-driven subgrouping in epidemiology and medicine.

Authors:
Mika Ala-Korpela

Int J Epidemiol 2019 04;48(2):374-376

Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1093/ije/dyz040DOI Listing
April 2019

What is 'LDL cholesterol'?

Nat Rev Cardiol 2019 04;16(4):197-198

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41569-019-0157-6DOI Listing
April 2019

The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.

Sci Rep 2019 01 24;9(1):458. Epub 2019 Jan 24.

Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-018-36450-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346097PMC
January 2019

Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts - CORRIGENDUM.

Psychol Med 2018 11 30;48(15):2628. Epub 2018 Aug 30.

Department of Psychiatry,Research Unit of Clinical Neuroscience, University of Oulu,Oulu,Finland.

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http://dx.doi.org/10.1017/S0033291718002192DOI Listing
November 2018

Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.

Psychol Med 2018 11 24;48(15):2609-2623. Epub 2018 Jul 24.

Department of Psychiatry,Research Unit of Clinical Neuroscience, University of Oulu,Oulu,Finland.

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http://dx.doi.org/10.1017/S0033291718001794DOI Listing
November 2018

Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial.

Diabetologia 2018 07 4;61(7):1581-1591. Epub 2018 May 4.

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1007/s00125-018-4619-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445481PMC
July 2018

Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.

J Am Coll Cardiol 2018 02;71(6):620-632

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811927PMC
February 2018

Metabolic characterization of menopause: cross-sectional and longitudinal evidence.

BMC Med 2018 02 6;16(1):17. Epub 2018 Feb 6.

MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1186/s12916-018-1008-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800033PMC
February 2018

Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood.

J Pediatr 2018 04 1;195:190-198.e3. Epub 2018 Feb 1.

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1016/j.jpeds.2017.11.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864506PMC
April 2018

DHA mediates the protective effect of fish consumption on new episodes of depression among women.

Br J Nutr 2017 Nov;118(9):743-749

1Menzies Institute for Medical Research,University of Tasmania,Private Bag 23, Hobart, Tasmania 7000,Australia.

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https://www.cambridge.org/core/product/identifier/S000711451
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http://dx.doi.org/10.1017/S0007114517002768DOI Listing
November 2017

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.

Diabetes Care 2017 12 18;40(12):1779-1786. Epub 2017 Oct 18.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland

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http://dx.doi.org/10.2337/dc17-1642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701741PMC
December 2017

Objective Metabolomics Research.

Authors:
Mika Ala-Korpela

Clin Chem 2018 01 16;64(1):30-33. Epub 2017 Oct 16.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;

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http://dx.doi.org/10.1373/clinchem.2017.274852DOI Listing
January 2018

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.

Nat Rev Cardiol 2017 Oct 1;14(10):577-590. Epub 2017 Jun 1.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1038/nrcardio.2017.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600813PMC
October 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge?

Int J Epidemiol 2016 10 27;45(5):1311-1318. Epub 2016 Oct 27.

Medical Research Council Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyw305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100630PMC
October 2016

Metabolomics in cardiovascular medicine: Not personalised, not diagnostic.

Authors:
Mika Ala-Korpela

Eur J Prev Cardiol 2016 11 11;23(17):1821-1822. Epub 2016 Aug 11.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland

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http://dx.doi.org/10.1177/2047487316664443DOI Listing
November 2016

Metabolomics of aging requires large-scale longitudinal studies with replication.

Proc Natl Acad Sci U S A 2016 06 14;113(25):E3470. Epub 2016 Jun 14.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, 90014, Oulu, Finland; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, United Kingdom; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1607062113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922179PMC
June 2016

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection.

Cell Syst 2015 Oct 22;1(4):293-301. Epub 2015 Oct 22.

Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria, Australia; Department of Pathology, The University of Melbourne, Parkville, 3010 Victoria, Australia; Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2015.09.007DOI Listing
October 2015

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.

Circ Cardiovasc Genet 2016 Jun 25;9(3):231-9. Epub 2016 Apr 25.

From the MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol (F.D., G.D.S., M.A.-K., D.A.L., T.R.G., N.J.T.); Institute of Cardiovascular Science, University College London, London, United Kingdom (F.D., C.D., J.-P.C.); Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, Oulu (M.A.-K., J.K., P.W., P.S., A.J.K.); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio (M.A.-K., J.K., P.S.); Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (J.K.); and Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom (C.D., J.-P.C.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920206PMC
June 2016

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase.

J Am Coll Cardiol 2016 Mar;67(10):1200-1210

Computational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.12.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783625PMC
March 2016

Abdominal obesity and circulating metabolites: A twin study approach.

Metabolism 2016 Mar 31;65(3):111-21. Epub 2015 Oct 31.

Obesity Research Unit, Research programs unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.metabol.2015.10.027DOI Listing
March 2016

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.

Lancet Diabetes Endocrinol 2015 Jul 18;3(7):526-534. Epub 2015 Jun 18.

​ (J C Chambers PhD, M Loh PhD, B Lehne PhD, W R Scott MRCP, W Zhang PhD, G Campanella MSc, M Chadeau-Hyam PhD, U Afzal MRCP, Prof P Froguel PhD, Prof P Vineis MD, Prof M-R Jarvelin PhD, Prof P Elliott PhD) (J C Chambers, Prof M-R Jarvelin, Prof P Elliott, Prof J S Kooner FRCP) (W R Scott, S-T Tan MRCP, Prof J Scott PhD, Prof J S Kooner) (J Abbott PhD) (J C Chambers, W Zhang, S-T Tan, U Afzal, Prof J S Kooner) (J C Chambers, P Punjabi FRCS, Prof J S Kooner) (M Loh) (C Blancher PhD) (A Drong PhD, Prof M I McCarthy MD) (Prof M I McCarthy) (J Kriebel PhD, S Wahl MSc, C Gieger PhD, H Grallert PhD) (C Gieger) (J Kriebel, S Wahl, C Gieger, B Thorand PhD, H Grallert) (H Prokisch PhD) (J Kriebel, S Wahl, B Thorand, H Grallert) (V Motta PhD, F Rota PhD, L Tarantini PhD, B Albetti PhD, Prof P A Bertazzi MD, V Bollati PhD) (Prof M Ala-Korpela PhD) (H R Elliott Dip Biol, R C Richmond BA, R Caiazzo PhD, T R Gaunt FRCP, Prof C L Relton PhD) (L Yengo PhD, Prof F Pattou PhD, R Caiazzo, S Cauchi PhD, Prof P Froguel) (L Yengo, S Cauchi, Prof P Froguel) (L Yengo, Prof F Pattou, S Cauchi, Prof P Froguel) (M Adamowicz-Brice PhD, Prof T J Aitman PhD) (K Bozaoglu PhD, R Caiazzo, J Jowett PhD) (Z Y Mok BSc, H K Ng BSc, M A Rozario BSc, R Soong PhD) (E-S Tai PhD) (E-S Tai) (Prof F Pattou) (H Prokisch) (Prof M Ala-Korpela, A J Kangas MSc, P Soininen PhD) (M Loh, Prof M-R Jarvelin) (Prof M-R Jarvelin) (Prof M Ala-Korpela, P Soininen) (Prof M-R Jarvelin) (Prof M Ala-Korpela) (Prof O Ammerpohl PhD) (Prof C Schafmayer MD) (Prof J Danesh FRCP) (Prof S de Lusignan PhD, Prof S Jones PhD) (Prof T Illig PhD) (S Jha MRCP) (A Kasturiratne MD, Prof A R Wickremasinghe PhD) (N Kato PhD) (N Kotea PhD) (S Kowlessur Dip Pub Health Admin) (J Pitkäniemi PhD) (Prof J Tuomilehto PhD) (J Pitkäniemi) (D Saleheen PhD) (D Saleheen) (D Saleheen) (E-S Tai) (Prof S A Kyrtopoulos PhD) (C Herder PhD) (C Herder) (Prof J Hampe MD) (R Soong) (Prof P Vineis) (Prof M I McCarthy).

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http://dx.doi.org/10.1016/S2213-8587(15)00127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724884PMC
July 2015

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates.

Int J Epidemiol 2015 Apr 6;44(2):623-37. Epub 2015 Jun 6.

Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, NordLab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland, Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland, Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland, Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland, National Institute for Health and Welfare, Helsinki, Finland, Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Estonian Genome Center, University of Tartu, Tartu, Estonia, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK, Institute of Health Sciences & Biocenter Oulu, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Oulu, Finland, Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland, Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, UK and Computational Medicine, Oulu University Hospital, Oulu, Finland. Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, F

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http://dx.doi.org/10.1093/ije/dyv093DOI Listing
April 2015

Novel methodologies for biomarker discovery in atherosclerosis.

Eur Heart J 2015 Oct 5;36(39):2635-42. Epub 2015 Jun 5.

Ludwig-Maximilians-University, G02.523, Heidelberglaan 100, 3584CX Munich, Germany German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.

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http://eurheartj.oxfordjournals.org/content/ehj/36/39/2635.f
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http://eurheartj.oxfordjournals.org/lookup/doi/10.1093/eurhe
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http://dx.doi.org/10.1093/eurheartj/ehv236DOI Listing
October 2015

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men.

Atherosclerosis 2015 May 23;240(1):272-7. Epub 2015 Mar 23.

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.03.034DOI Listing
May 2015

Serum Nuclear Magnetic Resonance Spectroscopy: One More Step toward Clinical Utility.

Authors:
Mika Ala-Korpela

Clin Chem 2015 May 10;61(5):681-3. Epub 2015 Mar 10.

Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine and Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1373/clinchem.2015.238279DOI Listing
May 2015

Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics.

Circ Cardiovasc Genet 2015 Feb;8(1):192-206

From the Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland (P.S., A.J.K., P.W., T.S., M.A.-K.); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (P.S., M.A.-K.); Oulu University Hospital, Oulu, Finland (M.A.-K.); and Computational Medicine, School of Social and Community Medicine and Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (M.A.-K.).

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.114.000
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http://dx.doi.org/10.1161/CIRCGENETICS.114.000216DOI Listing
February 2015

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.

Circulation 2015 Mar 8;131(9):774-85. Epub 2015 Jan 8.

From Computational Medicine, Institute of Health Sciences, University of Oulu, Finland (P.W., P.S., T. Tynkkynen, Q.W., M.T., A.J.K., J. Kettunen, M.A.-K.); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Finland (P.W., A.S.H., J. Kettunen, A.J., M.P., V.S.); Institute for Molecular Medicine Finland, University of Helsinki (P.W., A.S.H., M.P., S.P.); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio (P.S., T. Tynkkynen, Q.W., M.T., M.A.-K.); Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, United Kingdom (D.P.-M., J.-P.C.); Institute of Cardiovascular Science, University College London, United Kingdom (T. Tillin, A.D.H., J.-P.C., N.C.); Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, MA (A.G., R.S.V.); Genome Analysis Center, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany (A.A., J.A.); Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (J. Kaikkonen, V.M., O.T.R.); Department of Food and Environmental Sciences, University of Helsinki, Finland (V.M.,); Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Finland (M.K.); Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Finland (T.L.); Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom (D.A.L., T.R.G., M.A.-K.); School of Social and Community Medicine, University of Bristol, United Kingdom (D.A.L., T.R.G., M.A.-K.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (N.S.); Hannover Medical School, Hannover Unified Biobank, Germany (T.I.); Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351161PMC
March 2015

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.

PLoS Med 2014 Dec 9;11(12):e1001765. Epub 2014 Dec 9.

Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260795PMC
December 2014

Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children.

Am J Clin Nutr 2014 Dec 8;100(6):1569-77. Epub 2014 Oct 8.

From the Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland (AVA-O, NP, MKO, VM, KP, and TR); the Department of Food and Environmental Sciences (VM) and the Institute for Molecular Medicine Finland (FIMM) (JK), University of Helsinki, Helsinki, Finland; the Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, Tampere, Finland (TL); the Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland (MK); Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland (KP); the Department of Pediatrics, Turku University Hospital, Turku, Finland (HN and OS); Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland (AJK, PS, and MA-K); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (PS and MA-K); Oulu University Hospital, Oulu, Finland (MA-K); Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (MA-K); the Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland (JSV and TR); and the Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland (OTR).

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http://dx.doi.org/10.3945/ajcn.114.085027DOI Listing
December 2014

Lipoprotein subclass metabolism in nonalcoholic steatohepatitis.

J Lipid Res 2014 Dec 24;55(12):2676-84. Epub 2014 Oct 24.

Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P054387
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http://dx.doi.org/10.1194/jlr.P054387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242459PMC
December 2014

A metabolic view on menopause and ageing.

Nat Commun 2014 Aug 21;5:4708. Epub 2014 Aug 21.

1] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland [2] Institute for Molecular Medicine (FIMM), University of Helsinki, Biomedicum 2, Tukholmankatu 8, Helsinki 00290, Finland [3] Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.

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http://dx.doi.org/10.1038/ncomms5708DOI Listing
August 2014

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals.

Nutr Metab (Lond) 2014 13;11:28. Epub 2014 Jun 13.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, Helsinki, Finland ; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland ; Diabetes & Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1743-7075-11-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067102PMC
June 2014