Publications by authors named "Mihalis I Panayiotidis"

75Publications

Mitochondrial Metabolism in Astrocytes Regulates Brain Bioenergetics, Neurotransmission and Redox Balance.

Front Neurosci 2020 5;14:536682. Epub 2020 Nov 5.

Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, United States.

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http://dx.doi.org/10.3389/fnins.2020.536682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674659PMC
November 2020

Repurposing denosumab in breast cancer beyond prevention of skeletal related events: Could nonclinical data be translated into clinical practice?

Expert Rev Clin Pharmacol 2020 Nov 4;13(11):1235-1252. Epub 2020 Nov 4.

Department of Pharmacology, Clinical Pharmacology Unit, Faculty of Medicine, National and Kapodistrian University of Athens , Athens, Greece.

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http://dx.doi.org/10.1080/17512433.2020.1839416DOI Listing
November 2020

3,6-Disubstituted 1,2,4-Triazolo[3,4-]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha.

Onco Targets Ther 2020 28;13:7369-7386. Epub 2020 Jul 28.

Laboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.

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http://dx.doi.org/10.2147/OTT.S254856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395825PMC
July 2020

Prophylactic lymph node dissection in clinically N0 differentiated thyroid carcinoma: example of personalized treatment.

Per Med 2020 07 26;17(4):317-338. Epub 2020 Jun 26.

Department of Pharmacology - Clinical Pharmacology Unit, National & Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens, Greece.

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http://dx.doi.org/10.2217/pme-2019-0119DOI Listing
July 2020

Endocrine adverse events related with immune checkpoint inhibitors: an update for clinicians.

Immunotherapy 2020 05 29;12(7):481-510. Epub 2020 Apr 29.

Department of Pharmacology - Clinical Pharmacology Unit, National & Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor: 75 Mikras Asias, 11527-Goudi, Athens, Greece.

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http://dx.doi.org/10.2217/imt-2019-0132DOI Listing
May 2020

Combining immune checkpoint inhibitors with denosumab: a new era in repurposing denosumab in oncology?

J BUON 2020 Jan-Feb;25(1):1-14

Department of Pharmacology - Clinical Pharmacology Unit, National and Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens, Greece.

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April 2020

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.

Eur J Nutr 2020 Mar 25. Epub 2020 Mar 25.

Faculty of Health and Life Sciences, Department of Applied Sciences, Group of Translational Biosciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.

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http://dx.doi.org/10.1007/s00394-020-02227-yDOI Listing
March 2020

Aldehyde dehydrogenase 3A1 confers oxidative stress resistance accompanied by altered DNA damage response in human corneal epithelial cells.

Free Radic Biol Med 2020 04 30;150:66-74. Epub 2020 Jan 30.

Department of Molecular Biology & Genetics, Democritus University of Thrace, University Campus Dragana, 68100, Alexandroupolis, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.01.183DOI Listing
April 2020

Redox homeostasis, oxidative stress and mitophagy.

Mitochondrion 2020 03 20;51:105-117. Epub 2020 Jan 20.

Redox Biology Center and School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2020.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062406PMC
March 2020

Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and Example of Statins.

Curr Med Chem 2020 Jan 23. Epub 2020 Jan 23.

Department of Pharmacology - Clinical Pharmacology Unit, National and Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens. Greece.

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http://dx.doi.org/10.2174/0929867327666200123151132DOI Listing
January 2020

Survival Mechanisms and Xenobiotic Susceptibility of Keratinocytes Exposed to Metal-Derived Nanoparticles.

Chem Res Toxicol 2020 02 30;33(2):536-552. Epub 2020 Jan 30.

Departamento de Toxicologı́a , CINVESTAV-IPN , México City 07360 , México.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00398DOI Listing
February 2020

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Cell Rep 2019 12;29(11):3367-3373.e4

Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str., Athens 11527, Greece; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Athens 11527, Greece; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Manchester Cancer Research Centre, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester M20 4GJ, UK; 1st Department of Propaedeutic Internal Medicine, Medical School, Laikon Hospital, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Athens 11527, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.017DOI Listing
December 2019

Arsenic-induced neurotoxicity: a mechanistic appraisal.

J Biol Inorg Chem 2019 12 21;24(8):1305-1316. Epub 2019 Nov 21.

Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.

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http://dx.doi.org/10.1007/s00775-019-01740-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903391PMC
December 2019

Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes.

Chem Commun (Camb) 2019 Nov;55(95):14283-14286

Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.

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http://dx.doi.org/10.1039/c9cc06828gDOI Listing
November 2019

Parathyroid hormone related protein (PTHrP)-mediated hypercalcemia in malignancy associated with anti-PD-1 immune checkpoint inhibitor treatment and related inflammatory reactions.

Int Immunopharmacol 2019 Dec 4;77:105942. Epub 2019 Nov 4.

Department of Pharmacology - Clinical Pharmacology Unit, National and Kapodistrian University of Athens, Faculty of Medicine, Building 16, 1st Floor, 75 Mikras Asias, 11527-Goudi, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2019.105942DOI Listing
December 2019

Harnessing the versatile role of OPG in bone oncology: counterbalancing RANKL and TRAIL signaling and beyond.

Clin Exp Metastasis 2020 02 1;37(1):13-30. Epub 2019 Oct 1.

Clinical Pharmacology Unit, Laboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str, Goudi, 11527, Athens, Greece.

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http://dx.doi.org/10.1007/s10585-019-09997-8DOI Listing
February 2020

Mitochondrial Homeostasis and Cellular Senescence.

Cells 2019 07 6;8(7). Epub 2019 Jul 6.

Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.

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http://dx.doi.org/10.3390/cells8070686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678662PMC
July 2019

Probiotics in Extraintestinal Diseases: Current Trends and New Directions.

Nutrients 2019 Apr 5;11(4). Epub 2019 Apr 5.

Department of Molecular Biology and Genetics, Faculty of Health Sciences, Democritus University of Thrace, Alexandroupolis 68100, Greece.

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http://dx.doi.org/10.3390/nu11040788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521300PMC
April 2019

Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma.

Eur J Nutr 2020 Mar 14;59(2):557-569. Epub 2019 Feb 14.

Department of Applied Sciences, Translational Biosciences Group, Northumbria University, Ellison Building, Newcastle Upon Tyne, NE1 8ST, UK.

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http://dx.doi.org/10.1007/s00394-019-01925-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058602PMC
March 2020

Production of a Novel Functional Fruit Beverage Consisting of Cornelian Cherry Juice and Probiotic Bacteria.

Antioxidants (Basel) 2018 Nov 12;7(11). Epub 2018 Nov 12.

Laboratory of Microbiology, Biotechnology and Hygiene, Faculty of Agriculture Development, Democritus University of Thrace, 68200 Orestiada, Greece.

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http://www.mdpi.com/2076-3921/7/11/163
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http://dx.doi.org/10.3390/antiox7110163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262609PMC
November 2018

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention.

Pharmacol Ther 2018 10 8;190:187-201. Epub 2018 Jun 8.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.06.001DOI Listing
October 2018

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival.

Toxicology 2017 11 26;391:109-115. Epub 2017 Jun 26.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681369PMC
November 2017

Human aldehyde dehydrogenase 3A1 (ALDH3A1) exhibits chaperone-like function.

Int J Biochem Cell Biol 2017 08 16;89:16-24. Epub 2017 May 16.

Department of Molecular Biology & Genetics, Democritus University of Thrace, University Campus, Dragana, Alexandroupolis 68100, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.05.017DOI Listing
August 2017

Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.

Brain Res Bull 2017 Jul 21;133:12-30. Epub 2017 Mar 21.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68516, United States; Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68503, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555796PMC
July 2017

A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma.

Molecules 2016 Dec 31;22(1). Epub 2016 Dec 31.

Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, 68100 Alexandroupolis, Greece.

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http://dx.doi.org/10.3390/molecules22010062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155798PMC
December 2016

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss.

Pharmacol Ther 2016 09 8;165:153-63. Epub 2016 Jun 8.

Heriot-Watt University, School of Life Sciences, John Muir Building, Riccarton Campus, Edinburgh EH14 4AS, Scotland, UK.

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http://dx.doi.org/10.1016/j.pharmthera.2016.06.005DOI Listing
September 2016

Aldehyde dehydrogenase 3A1 promotes multi-modality resistance and alters gene expression profile in human breast adenocarcinoma MCF-7 cells.

Int J Biochem Cell Biol 2016 08 6;77(Pt A):120-128. Epub 2016 Jun 6.

Departments of Molecular Biology & Genetics, School of Health Sciences, Democritus University of Thrace, Alexandroupolis 68100, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.06.004DOI Listing
August 2016

Epigenetic therapy as a novel approach in hepatocellular carcinoma.

Pharmacol Ther 2015 Jan 7;145:103-19. Epub 2014 Sep 7.

School of Life Sciences, Heriot Watt University, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.09.005DOI Listing
January 2015

Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology.

Cancer Lett 2015 Jan 13;356(1):34-42. Epub 2013 Dec 13.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou 15780, Athens, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835130082
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http://dx.doi.org/10.1016/j.canlet.2013.11.018DOI Listing
January 2015

Cancer epigenetics as biomarkers of clinical significance.

Cancer Lett 2014 Jan 29;342(2):168-9. Epub 2013 Oct 29.

School of Life Sciences, Heriot Watt University, John Muir Building, Riccarton Campus, Edinburgh, EH14 4AS, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.10.027DOI Listing
January 2014

Efficient E. coli expression strategies for production of soluble human crystallin ALDH3A1.

PLoS One 2013 22;8(2):e56582. Epub 2013 Feb 22.

Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, Alexandroupolis, Greece.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579847PMC
September 2013

Molecular markers for cancer prognosis and treatment: have we struck gold?

Cancer Lett 2012 Dec 25;327(1-2):142-52. Epub 2011 Nov 25.

Department of Radiation Oncology, University of Alabama at Birmingham Comprehensive Cancer Center, 35294, USA.

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http://dx.doi.org/10.1016/j.canlet.2011.11.022DOI Listing
December 2012

DNA damage and autophagy.

Mutat Res 2011 Jun 17;711(1-2):158-66. Epub 2011 Mar 17.

Redox Biology Center and School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, United States.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105359PMC
June 2011

Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis.

Mutat Res 2011 Jun 16;711(1-2):167-73. Epub 2011 Mar 16.

Department of Student Success Services, University of Nevada, Reno, NV 89557, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.02.015DOI Listing
June 2011

DNA damage induced by endogenous aldehydes: current state of knowledge.

Mutat Res 2011 Jun 16;711(1-2):13-27. Epub 2011 Mar 16.

Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, 68100, Greece.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.03.006DOI Listing
June 2011

The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development.

Chem Biol Interact 2010 Nov 15;188(2):334-9. Epub 2010 Jul 15.

Nevada Center for Ethics & Health Policy, University of Nevada, Reno, 89557, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.07.010DOI Listing
November 2010

The role of epigenetics in environmental and occupational carcinogenesis.

Chem Biol Interact 2010 Nov 1;188(2):340-9. Epub 2010 Jul 1.

Nevada Center for Ethics and Health Policy, University of Nevada, Reno, 89557, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.06.012DOI Listing
November 2010

Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease.

Chem Biol Interact 2010 Nov 11;188(2):289-300. Epub 2010 Jun 11.

Redox Biology Center, University of Nebraska-Lincoln, 68583, United States.

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http://dx.doi.org/10.1016/j.cbi.2010.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942983PMC
November 2010

Viral-induced human carcinogenesis: an oxidative stress perspective.

Mol Biosyst 2010 Jul 30;6(7):1162-72. Epub 2010 Apr 30.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1039/b923958hDOI Listing
July 2010

Ouabain-induced perturbations in intracellular ionic homeostasis regulate death receptor-mediated apoptosis.

Apoptosis 2010 Jul;15(7):834-49

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/s10495-010-0494-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399447PMC
July 2010

BRCA1 involvement in toxicological responses and human cancer etiology.

Toxicol Lett 2009 Jul 16;188(2):77-83. Epub 2009 Apr 16.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.toxlet.2009.04.006DOI Listing
July 2009

Environmental toxicity, oxidative stress and apoptosis: ménage à trois.

Mutat Res 2009 Mar 9;674(1-2):3-22. Epub 2008 Dec 9.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, P. O. Box 12233, 111. T.W. Alexander Drive, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.mrgentox.2008.11.012DOI Listing
March 2009

Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells.

Mutat Res 2009 Mar 25;674(1-2):23-30. Epub 2008 Oct 25.

School of Community Health Sciences, University of Nevada, Reno, NV 89557, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138357180800303
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http://dx.doi.org/10.1016/j.mrgentox.2008.10.006DOI Listing
March 2009

Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells.

Mutat Res 2009 Mar 7;674(1-2):123-30. Epub 2008 Oct 7.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://ac.els-cdn.com/S1383571808002751/1-s2.0-S138357180800
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http://linkinghub.elsevier.com/retrieve/pii/S138357180800275
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http://dx.doi.org/10.1016/j.mrgentox.2008.09.014DOI Listing
March 2009

Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues.

Mutat Res 2009 Mar 2;674(1-2):131-6. Epub 2008 Oct 2.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2008.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944316PMC
March 2009

Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.

Cancer Lett 2008 Sep 11;269(1):174-83. Epub 2008 Jun 11.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Howell Science Complex, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.04.049DOI Listing
September 2008

Oxidative stress, DNA methylation and carcinogenesis.

Cancer Lett 2008 Jul 26;266(1):6-11. Epub 2008 Mar 26.

Laboratory of Cell Biology and Signal Transduction, Biomedical Research Unit, FES-Iztacala, UNAM, Mexico, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.02.026DOI Listing
July 2008

Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors.

J Cell Physiol 2008 Jul;216(1):14-28

Laboratory of Cell Biology and Signal Transduction, Biomedical Research Unit, FES-Iztacala, UNAM, Mexico.

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http://doi.wiley.com/10.1002/jcp.21406
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http://dx.doi.org/10.1002/jcp.21406DOI Listing
July 2008

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation.

J Biol Chem 2007 Oct 27;282(42):30452-65. Epub 2007 Aug 27.

Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M703091200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267748PMC
October 2007

Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cells.

In Vivo 2006 Nov-Dec;20(6B):861-5

Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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February 2007

Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.

Chem Biol Interact 2004 Jan;147(1):87-97

Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.cbi.2003.10.009DOI Listing
January 2004

Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells.

Antioxid Redox Signal 2004 Feb;6(1):129-36

Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://www.liebertpub.com/doi/10.1089/152308604771978435
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http://dx.doi.org/10.1089/152308604771978435DOI Listing
February 2004