Mihai Gheorghiade

Mihai Gheorghiade

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Mihai Gheorghiade

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Assessment and management of coronary artery disease in kidney and pancreas transplant candidates.

J Cardiovasc Med (Hagerstown) 2019 Feb;20(2):51-58

Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.2459/JCM.0000000000000742DOI Listing
February 2019

A Critical Appraisal of Short-Term End Points in Acute Heart Failure Clinical Trials.

J Card Fail 2018 11 11;24(11):783-792. Epub 2018 Sep 11.

Cardiology Division, Stony Brook University, Stony Brook, New York, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183096
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http://dx.doi.org/10.1016/j.cardfail.2018.08.007DOI Listing
November 2018

Mobile health applications in cardiovascular research.

Int J Cardiol 2018 Oct 12;269:265-271. Epub 2018 Jun 12.

Cardiology Division, Stony Brook University, Stony Brook, New York, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.06.039DOI Listing
October 2018

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

N Engl J Med 2018 10 27;379(14):1332-1342. Epub 2018 Aug 27.

From the Université de Lorraine, INSERM Unité 1116 and Clinical Investigation Center 1433, French Clinical Research Infrastructure Network, Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional et Universitaire de Nancy, Vandoeuvre lès Nancy, France (F.Z.); the Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin Berlin, Berlin (S.D.A.); Janssen Research and Development, Raritan (W.M.B., C.C.N.), and Bayer U.S., Research and Development, Pharmaceuticals, Thrombosis and Hematology Therapeutic Area, Whippany (T.E.S.) - both in New Jersey; Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College London, London - both in the United Kingdom (J.G.F.C.); Janssen Research and Development, Spring House, PA (M.F.); Northwestern University, Chicago (M.G.); National Heart Centre Singapore and Duke-National University of Singapore, Singapore (C.S.P.L.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (C.S.P.L., D.J.V.); Brigham and Women's Hospital and Harvard Medical School, Boston (M.R.M.); the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (J.D.N.); and the Department of Medicine, Cardiology Division, University of California, San Diego, San Diego (B.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808848
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http://dx.doi.org/10.1056/NEJMoa1808848DOI Listing
October 2018

Expanded algorithm for managing patients with acute decompensated heart failure.

Heart Fail Rev 2018 07;23(4):597-607

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s10741-018-9697-9DOI Listing
July 2018

Past, present, and future of acute heart failure clinical trials-a high-risk population in search of a strategy.

Eur J Heart Fail 2018 05 18;20(5):839-841. Epub 2017 Sep 18.

Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.987DOI Listing
May 2018

Lessons learned in acute heart failure.

Eur J Heart Fail 2018 04 29;20(4):630-641. Epub 2017 Oct 29.

Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.1042DOI Listing
April 2018

Acute Dyspnea and Decompensated Heart Failure.

Cardiol Clin 2018 Feb;36(1):63-72

Department of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1016/j.ccl.2017.09.003DOI Listing
February 2018

Dual Vasopressin V1a/V2 Antagonism: The Next Step in Neurohormonal Modulation in Patients With Heart Failure?

J Card Fail 2018 02 9;24(2):112-114. Epub 2018 Jan 9.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.cardfail.2017.12.011DOI Listing
February 2018

Clinical trials in acute heart failure: beginning of the end or end of the beginning?

Eur J Heart Fail 2017 11 28;19(11):1358-1360. Epub 2017 Jun 28.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.925DOI Listing
November 2017

Real-world dosing of evidence-based medications for heart failure: embracing guideline recommendations and clinical judgement.

Eur J Heart Fail 2017 11 8;19(11):1424-1426. Epub 2017 Aug 8.

Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://doi.wiley.com/10.1002/ejhf.915
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http://dx.doi.org/10.1002/ejhf.915DOI Listing
November 2017

Regional Validation and Recalibration of Clinical Predictive Models for Patients With Acute Heart Failure.

J Am Heart Assoc 2017 Nov 18;6(11). Epub 2017 Nov 18.

Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1161/JAHA.117.006121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721739PMC
November 2017

Partial Adenosine A1 Agonist in Heart Failure.

Handb Exp Pharmacol 2017 ;243:177-203

Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Hospital, Detroit, MI, USA.

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http://dx.doi.org/10.1007/164_2016_83DOI Listing
October 2017

Clinical profiles in acute heart failure: one size fits all or not at all?

Eur J Heart Fail 2017 10 8;19(10):1255-1257. Epub 2017 Aug 8.

Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.907DOI Listing
October 2017

Protein turnover in the failing heart: an ever-changing landscape.

Eur J Heart Fail 2017 10 14;19(10):1218-1221. Epub 2017 Aug 14.

Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.905DOI Listing
October 2017

Novel Endpoints for Heart Failure Clinical Trials.

Curr Heart Fail Rep 2017 08;14(4):210-216

Department of Medicine, Division of Cardiology, Stony Brook University, T-16, Room 080, Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1007/s11897-017-0334-zDOI Listing
August 2017

Dose of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Outcomes in Heart Failure: A Meta-Analysis.

Circ Heart Fail 2017 Aug;10(8)

From the John H. Stroger Jr Hospital of Cook County, Chicago, IL (M.S.K.); University of California Los Angeles (G.C.F.); Veterans Affairs Medical Center and George Washington University, DC (A.A.); Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, NC (S.J.G.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.V.); Emory University, Atlanta, GA (H.K.); University of Georgia, Athens (C.M.); Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.); and Stony Brook University, NY (J.B.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.003956DOI Listing
August 2017

Finding the road to recovery: therapeutic and clinical trial implications of dysfunctional viable myocardium in heart failure with reduced ejection fraction.

Eur J Heart Fail 2017 07 2;19(7):870-872. Epub 2017 May 2.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.842DOI Listing
July 2017

Employing Extracellular Volume Cardiovascular Magnetic Resonance Measures of Myocardial Fibrosis to Foster Novel Therapeutics.

Circ Cardiovasc Imaging 2017 Jun;10(6)

From the Department of Medicine, University of Pittsburgh School of Medicine, PA (E.B.S.); UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, PA (E.B.S.); Clinical and Translational Science Institute, University of Pittsburgh, PA (E.B.S.); Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Health System, Detroit, MI (H.N.S.); Cardiology Division, Department of Medicine, Stony Brook University, NY (J.B.); and Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/CIRCIMAGING.116.005619DOI Listing
June 2017

Drug Development for Heart Failure With Preserved Ejection Fraction: What Pieces Are Missing From the Puzzle?

Can J Cardiol 2017 06 25;33(6):768-776. Epub 2017 Mar 25.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.03.013DOI Listing
June 2017

Patient-reported outcomes in the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED ejection fraction (SOCRATES-PRESERVED) study.

Eur J Heart Fail 2017 06;19(6):782-791

Department of Internal Medicine and Cardiology, Campus Virchow Klinikum; Charité University Medicine Berlin, and Department of Internal Medicine and Cardiology, German Heart Center Berlin, and DZHK (German Center for Cardiovascular Research), Berlin, Germany.

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http://dx.doi.org/10.1002/ejhf.800DOI Listing
June 2017

Redefining the role of biomarkers in heart failure trials: expert consensus document.

Heart Fail Rev 2017 05;22(3):263-277

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 201 East Huron, Galter 3-150, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s10741-017-9608-5DOI Listing
May 2017

Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy.

J Cardiovasc Med (Hagerstown) 2017 Apr;18(4):283-290

aDivision of Cardiology, Duke University Medical Center, Durham, North Carolina bMedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, District of Columbia cDivision of Cardiology, Emory University, Atlanta, Georgia dDivision of Cardiology, Northwestern University Feinberg School of Medicine eDivision of Cardiology, Stony Brook University, Stony Brook, New York fCardioCell LLC gStemedica Cell Technologies Inc, San Diego, California hCenter for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.2459/JCM.0000000000000303DOI Listing
April 2017

Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.

Nat Rev Cardiol 2017 04 22;14(4):238-250. Epub 2016 Dec 22.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 201 East Huron, Galter 3-150, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/nrcardio.2016.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350035PMC
April 2017

Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations.

Circ Heart Fail 2017 Apr;10(4)

From the Department of Medicine, Stony Brook University, NY (J.B., C.E.H.); Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Division of Cardiology, Inova Heart & Vascular Institute, Falls Church, VA (C.O'C.); Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI (H.N.S.); Division of Cardiology, University of Brescia and Civil Hospital, Italy (M.M.); Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S., C.Y.); Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Division of Cardiology, University of California San Francisco (J.R.T.); Merck & Co., Kenilworth, NJ (H.S.B., J.K.); Gilead Sciences, Foster City, CA (G.B., J.H., C.S.); Amgen Inc., Thousand Oaks, CA (C.D., M.K.); Bristol-Myers Squibb, Princeton, NJ (M.M.D., M.D., R.J.F., P.M., S.M., C.R.); Bayer, Wuppertal, Germany (W.D., M.v.d.L.); Department of Cardiology, HELIOS Clinic Wuppertal, University Hospital Witten/Herdecke, Germany (W.D.); AstraZeneca, Gaithersburg, MD (R.F.-D., J.H., L.-M.G.); AstraZeneca, Gothenburg, Sweden (R.F.-D., J.H., L.-M.G.); Relypsa Inc., Redwood City, CA (D.G., M.M.); Vifor Pharma, Opfikon, Switzerland (U.-M.G.); Department of Cardiology, Nippon Medical School Musashi-Kosugi Hospital, Kawasaki, Japan (S.I.); Novartis Pharmaceuticals Inc., East Hanover, NJ (P.K.-M., V.S.); Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (C.J.L.); Bayer Pharma AG, Wuppertal, Germany (L.R.); Cardiology Division, Columbia University Medical Center, New York, NY (C.R.); Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT (A.S.); Moderna Therapeutics, Cambridge, MA (B.T.); Division of Cardiovascular and Renal Products, United States Food and Drug Administration, Silver Spring, MD (N.S.); Center for Cardiovascular Innovation, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400283PMC
April 2017

Mode of Death in Heart Failure With Preserved Ejection Fraction.

J Am Coll Cardiol 2017 Feb;69(5):556-569

Division of Cardiology, Stony Brook University, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.10.078DOI Listing
February 2017

Intravenous Allogeneic Mesenchymal Stem Cells for Nonischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial.

Circ Res 2017 Jan 16;120(2):332-340. Epub 2016 Nov 16.

From the Division of Cardiology, Department of Medicine, Stony Brook University, NY (J.B., H.A.S.); MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC (S.E.E., M.J.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.J.G., R.J.K.); Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA (A.A.Q., R.T.C.); CardioCell LLC, San Diego, CA (S.S.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (A.S.A., J.E.W.); Stemedica Cell Technologies Inc, San Diego, CA (N.I.T.); Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA (Y.-A.K.); Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.B.M.); and Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309717DOI Listing
January 2017

The impact of coronary artery disease on outcomes after liver transplantation.

J Cardiovasc Med (Hagerstown) 2016 Dec;17(12):875-885

aComprehensive Transplant Center, Northwestern Medicine, Chicago, Illinois, USA bNorthwestern Univeristy Transplant Outcomes Research Collaborative, Northwestern Medicine, Chicago, Illinois, USA cUT Transplant Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA dDepartment of Preventive Medicine, Northwestern Medicine, Chicago, Illinois, USA eDepartment of Anesthesia, Northwestern Medicine, Chicago, Illinois, USA fDepartment of Medicine, Division of Cardiology gDepartment of Medicine, Division of Gastroenterology and Hepatology hCenter for Cardiovascular Innovation, Northwestern Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.2459/JCM.0000000000000207DOI Listing
December 2016

Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction.

Circ Heart Fail 2016 Nov;9(11)

From the Department of Medicine, Stony Brook University, NY (J.B., C.E.H.); Division of Cardiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (J.E.U.); Division of Cardiology, University of Michigan School of Medicine, Ann Arbor (B.P.); Division of Cardiology (C.Y., S.J.S.) and Center for Cardiovascular Innovation (M.G.), Feinberg School of Medicine, Northwestern University, Chicago, IL; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.D.-N); Merck & Co, Kenilworth, NJ (H.S.B.); Medtronic, Mounds View, MN (R.L.C., J.J.S.); Amgen Inc, Thousand Oaks, CA (C.D., A.H., J.M.); Bayer Pharma AG, Wuppertal, Germany (W.D., F.K., K.L., L.R., S.R.); Department of Cardiology, HELIOS Clinic Wuppertal, University Hospital Witten/Herdecke, Germany (W.D.); Novartis Pharmaceuticals Inc, East Hanover, NJ (P.K.-M., M.L., S.M.); Clinical Research in Cardiovascular Disease Division, Merck Research Laboratories, Rahway, NJ (M.J.P.); AstraZeneca Global Medicines Development, Gaithersburg, MD (P.S.P.); Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT (A.S.); Dipartimento Cardiovascolare, Azienda Ospedaliera Papa Giovannni XXIII, Bergamo, Italy (M.S.); Department of Medical Sciences, IRCCS San Raffaele Pisana, Roma, Italy (G.R.); Cardiovascular and Cell Science Institute, St George's University of London, United Kingdom (G.R.); Division of Cardiovascular and Renal Products, the United States Food and Drug Administration, Silver Spring, MD (P.D., N.S.); Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG), Germany (S.D.A.); and Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston (M.R.Z.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003358DOI Listing
November 2016

Hyperkalemia in Heart Failure.

J Am Coll Cardiol 2016 10;68(14):1575-89

Cardiology Division, Stony Brook University, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.06.060DOI Listing
October 2016

Transforming Drug Development in Heart Failure: Navigating the Regulatory Crossroads.

Circ Heart Fail 2016 10;9(10)

From the Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA (M.V.); Division of Cardiology, Stony Brook University, NY (J.B.); and Center for Cardiovascular Innovation, Northwestern University, Feinberg School of Medicine, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003192DOI Listing
October 2016

Targeting the vulnerable phase of heart failure: initiate novel therapies in stable patients prior to hospitalization.

Eur J Heart Fail 2016 09 23;18(9):1190-2. Epub 2016 Jun 23.

Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.598DOI Listing
September 2016

Natriuretic peptide-guided management in heart failure.

J Cardiovasc Med (Hagerstown) 2016 Aug;17(8):556-68

aInstitute of Emergency for Cardiovascular Diseases 'Professor C.C. Iliescu', University of Medicine and Pharmacy Carol Davila, Bucuresti, Romania bDepartment of Emergency Medicine, Vanderbilt University, Nashville, Tennessee cDivision of Cardiology, Duke University Medical Center, Durham, North Carolina dBrigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, Massachusetts eDivision of Cardiology, Health Sciences Center, Stony Brook University, SUNY at Stony Brook, New York fCenter for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.2459/JCM.0000000000000329DOI Listing
August 2016

Targeting digoxin dosing to serum concentration: is the bullseye too small?

Eur J Heart Fail 2016 08;18(8):1082-4

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.589DOI Listing
August 2016

Cardiovascular clinical trials with noninferiority or equivalence designs from 2001 to 2012.

Int J Cardiol 2016 Jul 26;214:16-8. Epub 2016 Mar 26.

Division of Cardiology, Stony Brook University, Stony Brook, NY, United States.

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http://dx.doi.org/10.1016/j.ijcard.2016.03.157DOI Listing
July 2016

Trends in Utilization of Surrogate Endpoints in Contemporary Cardiovascular Clinical Trials.

Am J Cardiol 2016 Jun 19;117(11):1845-50. Epub 2016 Mar 19.

Division of Cardiology, Stony Brook University, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.03.021DOI Listing
June 2016

Serum chloride in heart failure: a salty prognosis.

Eur J Heart Fail 2016 06 27;18(6):669-71. Epub 2016 Apr 27.

Center for Cardiovascular Innovation, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.546DOI Listing
June 2016

Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure.

Circ Heart Fail 2016 06;9(6)

From the Departments of Cardiology (J.M.t.M., M.A.E.V., K.D., D.J.v.V., P.v.d.M., H.L.H., A.A.V.) and Epidemiology (H.L.H.), University of Groningen, University Medical Center Groningen, The Netherlands; University of Hull, Kingston Upon Hull, United Kingdom (J.G.C.); Brigham and Women's Hospital, Boston, MA (M.M.G.); University of Brescia, Italy (M.M.); Inova Heart and Vascular Institute, Falls Church, VA (C.M.O.C.); University of California at San Francisco, San Francisco Veterans Affairs Medical Center, CA (J.R.T.); Medical University, Clinical Military Hospital, Wroclaw, Poland (P.P.); Merck Research Laboratories, Rahway, NJ (D.M.B.); Momentum Research, Durham, NC (G.C., B.D.); University of Iowa Carver College of Medicine Cardiovascular Research Center Iowa City, IA (H.S., M.G.); and Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (H.S., M.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002845DOI Listing
June 2016

Digoxin for Worsening Chronic Heart Failure: Underutilized and Underrated.

JACC Heart Fail 2016 05;4(5):365-7

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2016.03.005DOI Listing
May 2016

Changes in Dyspnea Status During Hospitalization and Postdischarge Health-Related Quality of Life in Patients Hospitalized for Heart Failure: Findings From the EVEREST Trial.

Circ Heart Fail 2016 05;9(5)

From the Duke University Medical Center, Durham, NC (A.P.A., R.J.M., S.J.G.); Department of Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Division of Cardiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (J.E.U., M.A.K.); Duke Clinical Research Institute, Durham, NC (R.J.M.); Institute of Emergency for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine and Pharmacy Carol Davila, Bucuresti, Romania (O.C.); Division of Cardiology, Brigham and Women's Hospital, Boston, MA (M.V.); Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (H.P.S., M.G.); Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (K.S.); Department of Cardiology, INSERM, Nancy University, University de Lorraine, Nancy, France (F.Z.); Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy (A.P.M.); and Stony Brook Heart Institute, Stony Brook, NY (J.B.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002458DOI Listing
May 2016

Developing New Treatments for Heart Failure: Focus on the Heart.

Circ Heart Fail 2016 05;9(5)

From the Center for Cardiovascular Innovation (M.G.) and Division of Cardiology (S.J.S.), Northwestern Feinberg School of Medicine, Northwestern University, Chicago, IL; Cardiovascular & Metabolic Diseases Drug Discovery Unit, Takeda Pharmaceuticals, Chicago, IL (C.J.L., S.O.); Division of Cardiology, Duke University Medical Center, Durham, NC (S.J.G., R.J.K.); National Heart & Lung Institute, Imperial College, London, United Kingdom (J.G.F.C.); Cardiovascular Medicine Section, Boston University School of Medicine and Boston Medical Center, MA (W.S.C.); Division of Cardiovascular and Renal Products, the United States Food and Drug Administration, Silver Spring, MD (P.D., N.S.); MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington DC (S.E.E.); Psychiatry Department (R.V.P.) and Cardiology Division (J.B.), Stony Brook University, NY; Stealth Bio Therapeutics, Philadelphia, PA (J.C.); Global Drug Discovery, Bayer HealthCare AG, Wuppertal, Germany (W.D., T.K., F.K.); Department of Cardiology, Witten University, Witten, Germany (W.D.); Astra Zeneca Research and Development, Gothenburg, Sweden (K.W.); CSL Behring, Philadelphia, PA (L.I.D.); Sunovion Pharmaceuticals Inc, Marlborough, MA (D.C.); Dipartimento Cardiovascolare, Azienda Ospedaliera Papa Giovannni XXIII, Bergamo, Italy (M.S.); Cardiocell Inc, San Diego, CA (S.S.); and Cardiology Division, Henry Ford Hospital, Detroit, MI (H.N.S.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002727DOI Listing
May 2016

Utility of positron emission tomography for drug development for heart failure.

Am Heart J 2016 05 27;175:142-52. Epub 2016 Feb 27.

Cardiology Division, Stony Brook University, Stony Brook, NY. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2016.02.016DOI Listing
May 2016

Moving away from symptoms-based heart failure treatment: misperceptions and real risks for patients with heart failure.

Eur J Heart Fail 2016 04 17;18(4):350-2. Epub 2016 Mar 17.

Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1002/ejhf.507DOI Listing
April 2016

Trends in Heart Failure Clinical Trials From 2001-2012.

J Card Fail 2016 Mar 21;22(3):171-9. Epub 2015 Jun 21.

Division of Cardiology, Stony Brook University, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2015.06.014DOI Listing
March 2016

Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.

Expert Rev Cardiovasc Ther 2015 ;13(7):799-809

Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1586/14779072.2015.1053872DOI Listing
February 2016

Contrasting acute and chronic effects of tolvaptan on serum osmolality in the EVEREST trial.

Eur J Heart Fail 2016 Feb 7;18(2):185-91. Epub 2015 Oct 7.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.415DOI Listing
February 2016

Temporal Changes in Postdischarge Mortality Risk After Hospitalization for Heart Failure (from the EVEREST Trial).

Am J Cardiol 2016 Feb 8;117(4):611-616. Epub 2015 Dec 8.

Division of Cardiology, Stony Brook University, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.11.050DOI Listing
February 2016

Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 2: Prevention, Treatment, Guidelines, and Future Directions.

Circ Heart Fail 2016 Feb;9(2):e002843

From the Cardiology Division (C.E.H., M.W.B, H.S., J.B.) and Oncology Division, Stony Brook University, NY (L.B.); Oncology Division, European Institute of Oncology, Milan, Italy (D.C.); Cardiology Division, University of Pennsylvania, Philadelphia (B.K.); Cardiology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.N.); Cardiology Division, Vanderbilt University, Nashville, TN (D.J.L.); Cardiology Division, Center for Cardiovascular Innovation, Northwestern Feinberg School of Medicine, Chicago, IL (M.G.); and Cardiovascular Division, NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College London, London, United Kingdom (A.R.L.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743885PMC
February 2016

Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review.

Eur J Heart Fail 2016 Jan 3;18(1):54-65. Epub 2015 Dec 3.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 201 East Huron, Galter 3-150, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.442DOI Listing
January 2016

Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure.

Heart Fail Rev 2016 Jan;21(1):95-102

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 201 East Huron, Galter 3-150, Chicago, IL, 60601, USA.

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http://dx.doi.org/10.1007/s10741-015-9522-7DOI Listing
January 2016

Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 1: Definitions, Pathophysiology, Risk Factors, and Imaging.

Circ Heart Fail 2016 Jan;9(1):e002661

From the Cardiology Division (M.W.B., C.E.H., H.S., J.B.) and Oncology Division (L.B.), Stony Brook University, NY; Oncology Division, European Institute of Oncology, Milan, Italy (D.C.); Cardiology Division, University of Pennsylvania, Philadelphia (B.K.); Cardiology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.N.); Cardiology Division, Vanderbilt University, Nashville, TN (D.J.L.); Cardiovascular Division, Center for Cardiovascular Innovation, Northwestern Feinberg School of Medicine, Chicago, IL (M.G.); and Cardiovascular Division, NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College London, London, United Kingdom (A.R.L.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709035PMC
January 2016

Acute heart failure: the role of focused emergency cardiopulmonary ultrasound in identification and early management.

Eur J Heart Fail 2015 Dec 14;17(12):1223-7. Epub 2015 Oct 14.

Department of Emergency Medicine, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1002/ejhf.421DOI Listing
December 2015

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.

JAMA 2015 Dec;314(21):2251-62

Department of Internal Medicine and Cardiology, Charité University Medicine Berlin-Campus Virchow Klinikum, Berlin, Germany13Department of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.

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http://dx.doi.org/10.1001/jama.2015.15734DOI Listing
December 2015

Myocardial Fibrosis Quantified by Extracellular Volume Is Associated With Subsequent Hospitalization for Heart Failure, Death, or Both Across the Spectrum of Ejection Fraction and Heart Failure Stage.

J Am Heart Assoc 2015 Dec 18;4(12). Epub 2015 Dec 18.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA (E.B.S., K.M.Z., C.C.H.C., T.C.W.) UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, PA (E.B.S., K.M.P., K.M.Z., T.C.W.) Clinical and Translational Science Institute, University of Pittsburgh, PA (E.B.S., T.C.W.).

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http://dx.doi.org/10.1161/JAHA.115.002613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845263PMC
December 2015

Length of hospital stay and 30-day readmission following heart failure hospitalization: insights from the EVEREST trial.

Eur J Heart Fail 2015 Oct 9;17(10):1022-31. Epub 2015 May 9.

Division of Cardiology, Stony Brook University, Health Sciences Center, T-16, Room 080, SUNY at Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1002/ejhf.282DOI Listing
October 2015

Using Natriuretic Peptides for Selection of Patients in Acute Heart Failure Clinical Trials.

Am J Cardiol 2015 Oct 29;116(8):1304-10. Epub 2015 Jul 29.

Department of Cardiology/Heart Failure and Transplantation, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1016/j.amjcard.2015.07.049DOI Listing
October 2015

Same protocol, different continents, different patients: should we continue to conduct global heart failure trials?

Eur J Heart Fail 2015 Sep 20;17(9):875-8. Epub 2015 Aug 20.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 201 East Huron, Galter 3-150, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1002/ejhf.335DOI Listing
September 2015

"Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction.

JACC Heart Fail 2015 Sep;3(9):661-9

Northwestern University Division of Cardiology, Feinberg School of Medicine, Chicago, Illinois; Northwestern University Center for Cardiovascular Innovation, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2015.04.011DOI Listing
September 2015

Think Small and Examine the Constituents of Left Ventricular Hypertrophy and Heart Failure: Cardiomyocytes Versus Fibroblasts, Collagen, and Capillaries in the Interstitium.

J Am Heart Assoc 2015 Sep 15;4(9):e002491. Epub 2015 Sep 15.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/JAHA.115.002491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599514PMC
September 2015

Heart failure at the crossroads: moving beyond blaming stakeholders to targeting the heart.

Eur J Heart Fail 2015 Aug 15;17(8):760-3. Epub 2015 Jul 15.

Cardiology Division, Stony Brook University, Stony Brook, NY, USA.

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http://dx.doi.org/10.1002/ejhf.315DOI Listing
August 2015

Trends in characteristics of cardiovascular clinical trials 2001-2012.

Am Heart J 2015 Aug 14;170(2):263-72. Epub 2015 May 14.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL.

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https://linkinghub.elsevier.com/retrieve/pii/S00028703150031
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http://dx.doi.org/10.1016/j.ahj.2015.05.006DOI Listing
August 2015

Agents with vasodilator properties in acute heart failure: how to design successful trials.

Eur J Heart Fail 2015 Jul 4;17(7):652-64. Epub 2015 Jun 4.

INSERM, Centre d'Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, and the Department of Cardiology, Nancy University, Université de Lorraine, Nancy, France.

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http://dx.doi.org/10.1002/ejhf.294DOI Listing
July 2015

Contemporary Drug Development in Heart Failure: Call for Hemodynamically Neutral Therapies.

Circ Heart Fail 2015 Jul;8(4):826-31

From the Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.V.); Division of Cardiology, Stony Brook University, NY (J.B.); University of Michigan School of Medicine, Ann Arbor (B.P.); and Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL (M.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002271DOI Listing
July 2015

Digoxin use in atrial fibrillation: a critical reappraisal.

Lancet 2015 Jun 6;385(9985):2330-2. Epub 2015 Mar 6.

Center for Cardiovascular Innovation, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(14)62301-1DOI Listing
June 2015

Global variation in clinical profile, management, and post-discharge outcomes among patients hospitalized for worsening chronic heart failure: findings from the ASTRONAUT trial.

Eur J Heart Fail 2015 Jun 30;17(6):591-600. Epub 2015 Apr 30.

Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1002/ejhf.280DOI Listing
June 2015

Population risk prediction models for incident heart failure: a systematic review.

Circ Heart Fail 2015 May 3;8(3):438-47. Epub 2015 Mar 3.

From the Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA (J.B.E.-T.); Center for Cardiovascular Innovation, Department of Medicine (S.J.G., M.G.) and Department of Cardiology (C.W.Y.), Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiology, Department of Medicine, Stony Brook University, NY (L.P., J.B.); and CHU Nancy, Department of Cardiology, Institute of Lorraine Heart and Blood Vessels, Nancy, France (F.Z.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001896DOI Listing
May 2015

Pulmonary Oedema-Therapeutic Targets.

Card Fail Rev 2015 Apr;1(1):38-45

Athens University Hospital, Attikon, Athens, Greece.

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http://dx.doi.org/10.15420/CFR.2015.01.01.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491006PMC
April 2015

Reply: considerations for drug development for heart failure.

J Am Coll Cardiol 2015 Mar;65(10):1061-2

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http://dx.doi.org/10.1016/j.jacc.2014.11.064DOI Listing
March 2015