Publications by authors named "Miguel Ruiz"

148 Publications

Electronic Structure and Donor Ability of an Unsaturated Triphosphorus-Bridged Dimolybdenum Complex.

Inorg Chem 2021 Aug 19;60(15):11548-11561. Epub 2021 Jul 19.

Departamento de Química Orgánica e Inorgánica/IUQOEM, Universidad de Oviedo, E-33071 Oviedo, Spain.

The triphosphorus complex [MoCp(μ-η:η-P)(μ-PBu)] was prepared in 83% yield by reacting the methyl complex [MoCp(μ-κ:η-CH)(μ-PBu)(μ-CO)] with P at 333 K, a process also giving small amounts of the methyldiphosphenyl complex [MoCp(μ-η:η-PMe)(μ-PBu)(CO)]. The latter could be better prepared by first reacting the anionic complex Na[MoCp(μ-PBu)(μ-CO)] with P to give the diphosphorus derivative Na[MoCp(μ-η:η-P)(μ-PBu)(CO)] and further reaction of the latter with MeI. Density functional theory calculations on the title complex revealed that its triphosphorus group can be viewed as an allylic-like P ligand acting as a six-electron donor via the external P atoms, while coordination of the internal P atom involves donation from the π orbital of the ligand and back-donation to its π* orbital, both interactions having a weakening effect on the Mo-Mo and P-P connections. The reactivity of the title compound is dominated by the electron-donor ability associated with the lone pairs located at the P atoms. Its reaction with CFSOMe gave [MoCp(μ-η:η-PMe)(μ-PBu)](CFSO) as a result of methylation at an external atom of the P ligand, while its reaction with [Fe(CO)] enabled the addition of one, two, or three Fe(CO) fragments at these P atoms, but only the diiron derivative [MoFeCp(μ-η:η:κ:κ-P)(μ-PBu)(CO)] could be isolated. This complex bears a Fe(CO) fragment at each of the external atoms of the P ligand, and the central P atom of the latter displays the lowest P chemical shift reported to date (δ -721.8 ppm). The related complexes [MoMCp(μ-η:η:κ:κ-P)(μ-PBu)(CO)] (M = Mo, W) were prepared by reacting the title compound with the corresponding [M(CO)(THF)] complexes in toluene, while reaction with [Mo(CO)(THF)] also enabled the formation of the heptanuclear derivative [MoCp(μ-η:η:κ:κ-P)(μ-PBu)(CO)]. The interatomic distances in the above compounds indicate that the central MoP skeleton of these molecules is little modified by the attachment of 16-electron M(CO) fragments at the external atoms of the P ligand.
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http://dx.doi.org/10.1021/acs.inorgchem.1c01552DOI Listing
August 2021

Are doctors accurate when diagnosing themselves with migraine? A study on migraine prevalence among doctors in a tertiary care hospital.

Acta Neurol Belg 2021 Aug 3;121(4):1045-1051. Epub 2021 Jul 3.

Department of Neurology, La Princesa University Hospital, Madrid, Spain.

Migraine is considered an underdiagnosed disease in general population. Different studies show a higher prevalence in neurologists. However, there are few studies about its prevalence in doctors of other specialties, where it could also be superior than in general population. Our aim was to define migraine lifetime prevalence among doctors according to three parameters (previous diagnosis, self-diagnosis and positivity of a screening test). Single-center, descriptive, cross-sectional study based on online surveys with collection of sociodemographic and clinical variables, addressed to doctors of a tertiary hospital. Participants who reported 5 or more headaches throughout their lives were considered "headache sufferers" and were divided in different groups according to their position (specialists or trainees) and their specialty (medical, medical-surgical and surgical or specialties with no direct contact with the patient). The Spanish validated version of the Migraine Screen Questionnaire (MS-Q) was used as screening test. There were 217 participants (response rate of 29%), 72% were women and 56% trainees, mean age 34 years (SD10). 77% were "headache sufferers" Among all participants, migraine lifetime prevalence according to diagnosis by another physician was 15.2%, self-diagnosis 38.2% and positivity of the MS-Q 20.3%; those categories were not mutually exclusive Greater but not statistically significant coexistence of self-diagnosis and positive MS-Q was seen in specialists compared to trainees and in medical specialties. Migraine prevalence among doctors in a tertiary care hospital was higher than in general population, according to all three parameters analyzed. Self-diagnosis was the highest which could reflect an overdiagnosis; further studies are needed to determine this possibility.
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http://dx.doi.org/10.1007/s13760-021-01727-wDOI Listing
August 2021

Financial impact of the hospital pharmacy's participation in clinical trials.

Eur J Hosp Pharm 2021 Jun 8. Epub 2021 Jun 8.

Pharmacy Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain.

Objectives: To estimate the cost of the hospital pharmacy's participation in clinical trials (CTs) and to compare it to the amount received in compensation from sponsors.To analyse the financial impact of CTs that end without recruiting any patients and without any financial compensation from promoters.

Methods: This retrospective observational study analysed data from 5 years (2014-2018) at a tertiary university hospital.We established an allocation formula taking into account direct costs related to the pharmacy department's CT area's activity (reception, safekeeping, preparation, devolution, and destruction of medication, as well as patient monitoring) and indirect costs (facilities, resources, support staff). We calculated the costs to the department and the compensation received both overall and based on the type of promoter, clinical department involved in the trial, and the number of patients included.

Results: We included 134 trials. Costs added up to €207 372.95 and the compensation to €149 128.93 (€58 244.02 loss for the department). Trials ending without recruiting patients (33.6%) and without compensation accounted for 57.45% of the deficit. The mean cost of trials ending without recruiting patients was €875. We plan to charge a reimbursable setup fee for opening CTs to safeguard against these losses (€875 for trials in all departments except oncology; €1100 for oncology because 38% of their trials end without recruiting patients) and to compensate for the costs incurred in participating in trials for cooperative groups without financial compensation (20%).

Conclusions: Billing sponsors based on costs incurred for each trial would be a fairer system than the current approach based on the number of patients included. Establishing an initial fee would make up for losses from trials that fail to recruit any patients.
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http://dx.doi.org/10.1136/ejhpharm-2020-002601DOI Listing
June 2021

Predictive and criterion validity of the Cervantes-SF menopause quality of life questionnaire.

Menopause 2021 05 10;28(8):935-942. Epub 2021 May 10.

Faculty of Psychology, Autonoma University of Madrid, Madrid, Spain.

Objectives: To determine the predictive and criterion-based validity of the Cervantes-SF scale that measures the impact of menopause on Health-Related Quality of Life.

Methods: We recruited a noninstitutionalized sample of peri/postmenopausal women aged 40 to 65 years, who had their last menstrual cycle 12+ months prior to inclusion in the study of the psychometric validity of the Cervantes-SF scale. Predictive validity of the scale was confirmed for various health outcome measures administered concomitantly (years of disability-free life expectancy, work productivity and impact on daily activities, economic impact arising from loss of work productivity, hours of undisturbed sleep each day, and the utilization of healthcare facilities), whilst criterion validity was determined by the likelihood of identifying a moderate-to-severe vasomotor or genital syndrome requiring specific treatment.

Results: A sample of 308 peri/postmenopausal women with a mean age of 55.7 years (SD: 5.3 y) was analyzed in this study. A score >25 points on the dimension of vasomotor problems (or menopausal health) showed values of sensitivity and specificity > 80% for identifying women with moderate-severe vasomotor syndrome requiring pharmacological treatment. Predictive validity was confirmed for menopause-related health outcomes. A change of 6.7 points in the scale score, equivalent to the value of its minimal difference, is indicative of a significant increase in the degree of disability regarding work/day-to-day activities, greater economic loss due to decreased work productivity, fewer years of life expectancy without disability, fewer hours of undisturbed sleep, and more visits to the physician per year due to menopausal symptoms.

Conclusions: These results confirm the criterion and predictive validity of the Cervantes-SF scale in peri/postmenopausal women.
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http://dx.doi.org/10.1097/GME.0000000000001790DOI Listing
May 2021

Population-based norms for the Cervantes-SF short-form questionnaire assessing health-related quality of life in menopause.

Maturitas 2021 Apr 30;146:34-41. Epub 2021 Jan 30.

Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain.

Objectives: To develop the population-based norms for the Cervantes-SF scale, which measures the impact of menopause on the health-related quality of life (HRQOL) of women in Spain.

Methods: We used a sample obtained from representative studies of the Spanish population according to geographic density and autonomous community. This sample was composed of 5,237 non- institutionalized peri- and post-menopausal women, aged 40-75 years. Measures of central tendency, dispersion and percentiles were calculated for the total score and its dimensions, in 11 three-year age categories. Construct validity was analyzed based on a comparison with known groups to confirm the validity of the normative scales.

Results: The norms show a monotonic gradient, with an incremental impact on HRQOL as age increases, as shown by an increase in the total score and each of the dimensions. Fifty percent of women showed that peri-/post-menopausal symptomatology interfered with HRQOL > 39 %, ranging from 25 % (40-44 years) to 47 % (72-75 years). The population norms showed significant differences between groups according to generic HRQOL, number of comorbidities, history of osteoporotic fracture, educational level, and presence of obesity.

Conclusions: These results support the validity of the population-based norms for the Cervantes-SF scale, a valid instrument for measuring the impact of menopause on HRQOL in Spain. The norms obtained facilitate the interpretation of these scores in clinical practice, research, and health management.
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http://dx.doi.org/10.1016/j.maturitas.2021.01.004DOI Listing
April 2021

Pericardial agenesis.

Ann Pediatr Cardiol 2021 Jan-Mar;14(1):119-121. Epub 2020 Sep 23.

Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.

Congenital pericardial defect is a rare and usually asymptomatic condition which is classified incomplete or partial. Up to 70% of cases consist of complete absence of left pericardium. The diagnosis may be challenging due to its low frequency and absence of correlation with any specific finding on the clinical examination. Cardiac magnetic resonance imaging is the gold standard imaging technique for the diagnosis confirming the absence of pericardium, although other indirect signs may be seen. In partial defects, surgery is the treatment option. We present an incidental finding of total agenesis of the left pericardium in an asymptomatic 16-year-old male diagnosed in a preoperative assessment of a bone fracture.
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http://dx.doi.org/10.4103/apc.APC_152_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918029PMC
September 2020

Postoperative Psychosocial Factors in Health Functioning and Health-Related Quality of Life After Knee Arthroplasty: A 6-Month Follow up Prospective Observational Study.

Pain Med 2021 Sep;22(9):1905-1915

Faculty of Health Sciences and Welfare, University of Vic-Central University of Catalonia, Vic, Spain.

Objective: Knee arthroplasty (KA) is an effective and cost-effective treatment for end-stage knee osteoarthritis. Despite high surgical success rates, as many as 25% of patients report compromised postoperative functioning, persistent pain, and reduced quality of life. The purpose of this study was to assess the predictive value of psychological factors in health functioning and quality of life, during a 6-month period after KA.

Design: A prospective observational study.

Setting: Surgery at two hospitals and follow-up was carried out through the domiciliary rehabilitation service.

Subjects: In total, 89 patients (age 70.27 ± 7.99 years) met the inclusion criteria.

Method: A test battery composed of Health functioning associated with osteoarthritis (WOMAC), Health-related quality of life (EQ-5D-5L), Anxiety and Depression (HADS), Pain attitudes (SOPA-B), Pain catastrophizing (PCS), and Fear of Movement (TSK-11) was assessed at 1 week, and 1, 3, and 6 months after surgery. A mixed effects linear model was used to estimate the effect of time and covariates. An exploratory factor analysis was used to identify the number of dimensions underlying the group of psychological measurements.

Results: In WOMAC model, anxiety level (F = 120.8), PCS (F = 103.9), depression level (F = 93.6) and pain score (F = 72.8) were the most influential variables. Regarding EQ-5D-5L model, anxiety level (F = 98.5), PCS (F = 79.8), depression level (F = 78.3) and pain score (F = 45) were the most influential variables. Pain score and the psychosocial variables of PCS, TSK, HADS-A, HADS-D, SOPA-B Emotion, SOPA-B Harm and SOPA-B Disability loaded in one single dimension.

Conclusions: Postoperative acute pain and psychosocial factors of pain catastrophizing, anxiety, depression, and pain attitudes might influence health functioning and quality of life during KA rehabilitation. Such factors could be gathered into one single dimension defined as pain-related psychologic distress.
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http://dx.doi.org/10.1093/pm/pnab025DOI Listing
September 2021

A Mobile App-Based Intervention Program for Nonprofessional Caregivers to Promote Positive Mental Health: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 01 22;9(1):e21708. Epub 2021 Jan 22.

Department of Nursing, Universitat Rovira i Virgili, Tortosa, Spain.

Background: While nonprofessional caregivers often experience a sense of fulfillment when they provide care, there is also a significant risk of emotional and physical burnout. Consequently, this can negatively affect both the caregiver and the person being cared for. Intervention programs can help empower nonprofessional caregivers of people with chronic diseases and develop solutions to decrease the physical and psychological consequences resulting from caregiving. However, most clinically tested intervention programs for nonprofessional caregivers require face-to-face training, and many caregivers encounter obstacles that hinder their participation in such programs. Consequently, it is necessary to design internet-based intervention programs for nonprofessional caregivers that address their needs and test the efficacy of the programs.

Objective: The aim of this study was to evaluate the effectiveness of a smartphone app-based intervention program to increase positive mental health for nonprofessional caregivers.

Methods: This study was a randomized controlled trial of 3 months' duration. A total of 152 caregivers over 18 years of age with a minimum of 4 months' experience as nonprofessional caregivers were recruited from primary health care institutions. Nonprofessional caregivers were randomized into two groups. In the intervention group, each caregiver installed a smartphone app and used it for 28 days. This app offered them daily activities that were based on 10 recommendations to promote positive mental health. The level of positive mental health, measured using the Positive Mental Health Questionnaire (PMHQ), and caregiver burden, measured using the 7-item short-form version of the Zarit Caregiver Burden Interview (ZBI-7), were the primary outcomes. Users' satisfaction was also measured.

Results: In all, 113 caregivers completed the study. After the first month of the intervention, only one factor of the PMHQ, F1-Personal satisfaction, showed a significant difference between the groups, but it was not clinically relevant (0.96; P=.03). However, the intervention group obtained a higher mean change for the overall PMHQ score (mean change between groups: 1.40; P=.24). The results after the third month of the intervention showed an increment of PMHQ scores. The mean difference of change in the PMHQ score showed a significant difference between the groups (11.43; P<.001; d=0.82). Significant changes were reported in 5 of the 6 factors, especially F5-Problem solving and self-actualization (5.69; P<.001; d=0.71), F2-Prosocial attitude (2.47; P<.001; d=1.18), and F3-Self-control (0.76; P=.03; d=0.50). The results of the ZBI-7 showed a decrease in caregiver burden in the intervention group, although the results were inconclusive. Approximately 93.9% (46/49) of the app users indicated that they would recommend the app to other caregivers and 56.3% (27/49) agreed that an extension of the program's duration would be beneficial.

Conclusions: The app-based intervention program analyzed in this study was effective in promoting positive mental health and decreasing the burden of caregivers and achieved a high range of user satisfaction. This study provides evidence that mobile phone app-based intervention programs may be useful tools for increasing nonprofessional caregivers' well-being. The assessment of the effectiveness of intervention programs through clinical trials should be a focus to promote internet-based programs in health policies.

Trial Registration: ISRCTN Registry ISRCTN14818443; http://www.isrctn.com/ISRCTN14818443.

International Registered Report Identifier (irrid): RR2-10.1186/s12889-019-7264-5.
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http://dx.doi.org/10.2196/21708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864775PMC
January 2021

[Usefulness of laser Holmium Lumenis Pulse 120 H® in the treatment of renal lithiasis through RIRS: Preliminary experience.]

Arch Esp Urol 2020 Nov;73(9):803-812

Servicio de Urología. Hospital Clínico San Carlos. Instituto de Investigación Sanitaria (IdISSC). Universidad Complutense. Madrid. España.

Introduction: The Holmium laser is the most used energy source in flexible ureterrenoscopy (URSf). The Lumenis Pulse 120H® laser has a higher system energy, a higher energy per pulse and a higher repetition frequency in relation to other types of lasers, which offers advantages in the treatment of lithiasis.

Objective: To analyze the results that we have obtained with the use of the Lumenis Pulse120H® laser in patients treated by intrarenal retrograde surgery (RIRS). As secondary objectives there are: the study of the demographic variables of the patients, the characteristics of the stones and the complications associated with the procedure.

Material And Methods: An observational, retrospective study of the first 26 patients treated by RIRS and Lumenis Pulse 120H® laser has been performed in our Service between August 2018 and February 2019. The size of the lithiasis was measured on the simple radiography and the CT, in addition, the volume of the lithiasis was calculated. For the realization of RIRS, 8.5Fr digital flexible ureterorenoscope (Olympus®) and the Holmium Lumenis 120H® laser with 200 micron laser fibers from Lumenis® were used. Statistical analysis was performed with the SPSSv21 system.

Results: A total of 26 patients with renal lithiasis have been analyzed. The median age was 55.15 years (40.67-67.05). 57.7% of the patients had prior surgical treatment of lithiasis. Thirteen patients presented the litiasis in the renal pelvis, ten in the Upper Calicial Group (GCS), fifteen in the Middle Calicial Group (GCM) and eighteen in the Lower Calicial Group (GCI). The median of the lithiasic volume was 1826.41 mm3. Our overall success rate was 80.8% (100% success in lithiasis less than 2 cm and 85.7% in lithiasis between 2-3 cm). Five patients presented complications, of which 4 were ClavienII and 1 Clavien IIIb. No significant results were found between the lithiasic size and the presence of complications (p = 0.128).

Conclusions: The use of the Lumenis Pulse 120H®laser is an useful tool for the treatment of kidney stones by RIRS, due to his efficiency in the fragmentation and dusting, taking into account that very large lithiasic masses require, in a high percentage of cases, more than one treatment session.
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November 2020

Differential activities of maize plant elicitor peptides as mediators of immune signaling and herbivore resistance.

Plant J 2020 12 2;104(6):1582-1602. Epub 2020 Dec 2.

Division of Biology, University of California San Diego, La Jolla, CA, USA.

Plant elicitor peptides (Peps) are conserved regulators of defense responses and models for the study of damage-associated molecular pattern-induced immunity. Although present as multigene families in most species, the functional relevance of these multigene families remains largely undefined. While Arabidopsis Peps appear largely redundant in function, previous work examining Pep-induced responses in maize (Zm) implied specificity of function. To better define the function of individual ZmPeps and their cognate receptors (ZmPEPRs), activities were examined by assessing changes in defense-associated phytohormones, specialized metabolites and global gene expression patterns, in combination with heterologous expression assays and analyses of CRISPR/Cas9-generated knockout plants. Beyond simply delineating individual ZmPep and ZmPEPR activities, these experiments led to a number of new insights into Pep signaling mechanisms. ZmPROPEP and other poaceous precursors were found to contain multiple active Peps, a phenomenon not previously observed for this family. In all, seven new ZmPeps were identified and the peptides were found to have specific activities defined by the relative magnitude of their response output rather than by uniqueness. A striking correlation was observed between individual ZmPep-elicited changes in levels of jasmonic acid and ethylene and the magnitude of induced defense responses, indicating that ZmPeps may collectively regulate immune output through rheostat-like tuning of phytohormone levels. Peptide structure-function studies and ligand-receptor modeling revealed structural features critical to the function of ZmPeps and led to the identification of ZmPep5a as a potential antagonist peptide able to competitively inhibit the activity of other ZmPeps, a regulatory mechanism not previously observed for this family.
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http://dx.doi.org/10.1111/tpj.15022DOI Listing
December 2020

Efficient Synthesis and Multisite Reactivity of a Phosphinidene-Bridged Mo-Re Complex. A Platform Combining Nucleophilic and Electrophilic Features.

Inorg Chem 2020 Jul 6;59(14):9481-9485. Epub 2020 Jul 6.

Departamento de Química Orgánica e Inorgánica, Instituto de Quı́mica Organometálica Enrique Moles, Universidad de Oviedo, E33071 Oviedo, Spain.

The heterometallic complex [MoReCp(μ-PR*)(CO)] () was prepared in 60% overall yield from -[MoCp(PHR*)(CO)] via a three-step procedure involving complexes -[MoCp(PClR*)(CO)] and [MoReCp(μ-PR*)(CO)] as intermediate species (R* = 2,4,6-CHBu). The PR* ligand in displays a novel asymmetric interaction with the dimetal center, involving a double bond with one atom (Mo) and a dative single bond with the other one (Re). Compound underwent thermal isomerization involving a C-H bond cleavage to yield the hydride [MoReCp(μ-H){μ-P(CHCMe)CHBu}(CO)] and reacted with I to give [MoReCpI(μ-PR*)(CO)], which displays a symmetrical phosphinidene bridge. Its reaction with methyl propiolate at 293 K proceeded with [2 + 2] cycloaddition of the alkyne and decarbonylation to yield the phosphapropenylidene-bridged complex [MoReCp{μ-κ:η-PR*CHC(COMe)}(CO)] as the major product, whereas its reaction with excess CN(4-CHOMe) at 273 K proceeded with formal [2 + 1] cycloaddition of the isocyanide and further isocyanide addition at the Re site to yield the complex [MoReCp{μ-η:κ-PR*CN(4-CHOMe)}(CO){CN(4-CHOMe)}], which displays an azaphosphaallene ligand in a novel bridging coordination mode.
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http://dx.doi.org/10.1021/acs.inorgchem.0c01554DOI Listing
July 2020

P-N and N-Mo Bond Formation Processes in the Reactions of a Pyramidal Phosphinidene-Bridged Dimolybdenum Complex with Diazoalkanes and Organic Azides.

Inorg Chem 2020 Jun 21;59(11):7869-7883. Epub 2020 May 21.

Departamento de Química Orgánica e Inorgánica/IUQOEM, Universidad de Oviedo, E-33071 Oviedo, Spain.

The reactivity of the complex [MoCp(μ-κ:κ,η-PCH)(CO)(η-HMes*)(PMe)] () toward different diazoalkanes and organic azides was investigated. The pyramidal phosphinidene ligand in displayed a strong nucleophilicity, enabling these reactions to proceed rapidly even below room temperature. Thus, reacted rapidly at 253 K with different diazoalkanes NCRR' (R,R' = H,H, Ph,Ph, H,COEt) to give the corresponding P:P-bridged phosphadiazadiene derivatives as major products which, however, could not be isolated. Reaction of the latter with [H(OEt)](BAr') yielded the corresponding cationic derivatives [MoCp{μ-κ:κ,η-P(NHNCRR')CH}(η-HMes*)(CO)(PMe)](BAr'), which were isolated in ca. 70% yield. The related species [MoCp{μ-κ:κ,η-P(NMeNCHCOEt)CH}(η-HMes*)(CO)(PMe)](BAr') was isolated upon reaction of the ethyl diazoacetate derivative with MeI and subsequent anion exchange with Na(BAr'). Reaction of with aryl azides (4-CHMe)N and (4-CHF)N proceeded rapidly at low temperature to give possibly the corresponding P:P-bridged phosphaimine derivatives as major products, which could be neither isolated. Protonation of these products with [H(OEt)](BAr') gave the corresponding aminophosphanyl complexes [MoCp{μ-κ:κ,η-P(NHR)CH}(η-HMes*)(CO)(PMe)](BAr'), isolated in ca. 75% yield. In contrast, the result of reactions of with benzyl azide was strongly dependent on temperature, including the temperature in the subsequent methylation step that gave isolable cationic derivatives. By a careful choice of experimental conditions, different complexes having methylated phosphatriazadiene ligands were isolated, such as [MoCp{μ-κ:κ,η-P(NNNMeCHPh)CH}(η-HMes*)(CO)(PMe)](BAr') and the metallacyclic derivatives - and -[MoCp{μ-κ:κ,η-P(NMeNNCHPh)CH}(η-HMes*)(CO)(PMe)](BAr'). Density functional theory calculations, along with NMR monitoring experiments, revealed that the formation of the latter products stemmed from different and kinetically favored phosphatriazadiene intermediates, thermodynamically disfavored with respect to the denitrogenation process, otherwise yielding phosphaimine derivatives.
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http://dx.doi.org/10.1021/acs.inorgchem.0c00995DOI Listing
June 2020

Expert Consensus on a Set of Outcomes to Assess the Effectiveness of Biologic Treatment in Psoriatic Arthritis: The MERECES Study.

J Rheumatol 2020 11 1;47(11):1637-1643. Epub 2020 Feb 1.

M. Ruiz, PhD, Department of Social Psychology and Methodology, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid.

Objective: To reach a consensus on the instruments to be used in clinical practice to evaluate the effectiveness of biological disease-modifying antirheumatic drug (bDMARD) treatment in patients with psoriatic arthritis (PsA) in the short to medium term (3-6 mos), and to establish the minimum health outcomes for treatment continuation.

Methods: A 2-round Delphi questionnaire was developed based on both the information gathered in the literature review and 4 discussion groups. The suitability and feasibility of the proposed sets of instruments were assessed on a 7-point Likert scale. Consensus was established when at least 75% of healthcare professionals (HCP) reached agreement. To define a minimum health outcome to continue treatment, a combination of 4 disease activity states and 3 health-related quality of life states were defined for 3 hypothetical patient profiles. HCP were given a dichotomous choice (yes/no) to respond to whether they would continue treatment in each case.

Results: The second round was completed by 106 HCP. Consensus was reached on the use of (1) Disease Activity in Psoriatic Arthritis + Psoriatic Arthritis Impact of Disease (PsAID12) or minimal disease activity + PsAID12 + C-reactive protein, in peripheral PsA; and (2) Ankylosing Spondylitis Disease Activity Score + PsAID12, in axial PsA. Health outcomes considered sufficient to continue treatment were stricter for bDMARD-naive patients than for patients who failed several bDMARD.

Conclusion: To the best of our knowledge, this is the first multidisciplinary consensus on a set of outcomes for the evaluation of bDMARD effectiveness in PsA, in routine clinical practice.
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http://dx.doi.org/10.3899/jrheum.191056DOI Listing
November 2020

Coordination and Dehydrogenation of Diphosphine-Borane PhPCHPPh·BH at a Heterometallic MoRe Center to Give an Agostic Boryl-Bridged Derivative.

Inorg Chem 2019 Dec 12;58(23):16134-16143. Epub 2019 Nov 12.

Departamento de Química Orgánica e Inorgánica/IUQOEM , Universidad de Oviedo , E-33071 Oviedo , Spain.

The coordination chemistry of the title diphosphine-borane adduct at heterometallic MoRe centers was examined through its reactions with the hydride complex [MoReCp(μ-H)(μ-PCy)(CO)(NCMe)] (Cp = η-CH). The latter reacted rapidly with stoichiometric amounts of dppm·BH (dppm = PhPCHPPh) in refluxing toluene solution, with displacement of the nitrile ligand, to give [MoReCp(μ-H)(μ-PCy)(CO)(κ-dppm·BH)], with a -bound diphosphine-borane ligand arranged to the PCy group. Decarbonylation of the latter complex was accomplished rapidly upon irradiation with visible-UV light in toluene solution at 263 K, to give the agostic derivative [MoReCp(μ-H)(μ-PCy)(CO)(κ,η-dppm·BH)] as major product (Mo-Re = 3.2075(5) Å), along with small amounts of the diphosphine-bridged complex [MoReCp(μ-H)(μ-PCy)(CO)(μ-dppm)]. Extended photolysis of the agostic complex at 288 K promoted an unprecedented dehydrogenation process involving the borane group and the hydride ligand, to give the diphosphine-boryl complex [MoReCp(μ-η:κ-HB·dppm)(μ-PCy)(CO)] (Mo-Re = 3.075(1) Å). The latter displayed a boryl ligand in a novel bridging coordination mode, it being σ-bound to one of the metal atoms (B-Re = 2.38(2) Å) while interacting with the second metal atom via a strong tricentric B-H-M interaction (B-Mo = 2.31(1); H-Mo = 1.9(1) Å). The overall dehydrogenation process was endergonic by 43 kJ/mol, according to density functional theory calculations.
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http://dx.doi.org/10.1021/acs.inorgchem.9b02693DOI Listing
December 2019

Decline in fertility induced by economic recession in Spain.

Gac Sanit 2020 May - Jun;34(3):238-244. Epub 2019 Oct 19.

Health Information Systems Service, Barcelona Agency of Public Health, Barcelona, Spain; Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain; Biomedical Research Institute Saint Pau, Barcelona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Spain. Electronic address:

Objective: To describe trends in fertility in Spain before (pre-recession; 1998-2008) and during (recession period; 2009-2013) the economic crisis of 2008, taking into account women's age and regional unemployment in 2010.

Method: The study consisted of a panel design including cross-sectional ecological data for the 17 regions of Spain. We describe fertility trends in Spain in two time periods, pre-recession (1998-2008) and recession (2009-2013). We used a cross-sectional, ecological study of Spanish-born women to calculate changes in fertility rates for each period using a linear regression model adjusted for year, period, and interaction between them.

Results: We found that compared to the pre-recession period, the fertility rate in Spain generally decreased during the economic recession. However, in some regions, such as the Canary Islands, this decrease began before the onset of the recession, while in other regions, such as the Basque country, the fertility rate continued to grow until 2011. The effects of the recession on the fertility rate are clearly observed in women aged 30-34 years.

Conclusions: The current economic recession has disrupted the positive trend in fertility that began at the start of this century. Since Spain already had very low fertility rates, the further decline caused by the economic recession could jeopardize the sustainability of welfare-state systems.
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http://dx.doi.org/10.1016/j.gaceta.2019.05.011DOI Listing
June 2021

One-step synthesis and P-H bond cleavage reactions of the phosphanyl complex syn-[MoCp{PH(2,4,6-CHBu)}(CO)] to give heterometallic phosphinidene-bridged derivatives.

Dalton Trans 2019 Oct;48(39):14585-14589

Departamento de Química Orgánica e Inorgánica/IUQOEM, Universidad de Oviedo, E33071 Oviedo, Spain.

Photolysis of [Mo2Cp2(CO)6] and PH2R* (R* = 2,4,6-C6H2tBu3) yielded the title complex, which turned out to be a versatile precursor of novel heterometallic phosphinidene-bridged complexes via three different P-H bond activation processes: photolysis, deprotonation and reduction. In this way the new complexes [MoReCp(μ-PR*)(CO)n] (n = 6,7), [MoFeCp2(μ-PR*)(CO)m], (m = 3, 4) and [MoAuCp(μ-PR*)(CO)2{P(p-tol)3}] were prepared.
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http://dx.doi.org/10.1039/c9dt02382hDOI Listing
October 2019

Development and validation of a sexual relations satisfaction scale in patients with breast cancer - "SEXSAT-Q".

Health Qual Life Outcomes 2019 Aug 17;17(1):143. Epub 2019 Aug 17.

Psychology Department, Universidad Autónoma de Madrid, Madrid, Spain.

Purpose: Because the currently available questionnaires to evaluate sexual changes on breast cancer women only address the sexual sphere with a few questions our purpose was to develop a questionnaire that assesses changes in sexual dysfunction and satisfaction in women treated for breast cancer.

Methods: A sample was selected of women aged between 18 and 65 who had had surgery for breast cancer, completed neoadjuvant/adjuvant chemotherapy treatment and could be receiving adjuvant hormonal treatment, with an active sex life at least 3 months before starting treatment. Metastatic disease was excluded. A questionnaire structured in 4 dimensions was developed. The MOS SF-12 and QLQ-BR23 questionnaires were also provided. The following metric properties were evaluated: item analysis; internal consistency; temporal stability; construct validity; concurrent, convergent and divergent validity; and feasibility.

Results: Three samples were recruited: a pilot sample of 20; a reduction sample of 152; and a validation sample of 148. The presence of 6 dimensions was confirmed: 1) Loss of sex drive; 2) worsening of body image; 3) psychological coping; 4) discomfort during intercourse; 5) satisfaction with sexual relations; and 6) satisfaction with breast reconstruction. Good goodness-of-fit statistics were obtained (χ/df = 1.5, GFI = 0.9, AGFI = 0.84, CFI = 0.959, RMSEA = 0.062). Reliability was good (α = 0.855), as was test-retest stability (r = 0.838). The correlation with the convergent questionnaires proved to be higher than that obtained with generic measurements.

Conclusions: We were able to develop a short questionnaire (17 items) capable of measuring sexual satisfaction in women with breast cancer with good metric properties.
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http://dx.doi.org/10.1186/s12955-019-1197-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698031PMC
August 2019

Deficient Emotional Self-Regulation in Children with Attention Deficit Hyperactivity Disorder: Mindfulness as a Useful Treatment Modality.

J Dev Behav Pediatr 2019 Jul/Aug;40(6):425-431

Children and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Objective: The aim of this study was to investigate the efficacy of a structured mindfulness group intervention program targeting deficient emotional self-regulation (DESR) in a sample of children with attention deficit hyperactivity disorder (ADHD).

Method: Seventy-two children aged 7 to 12 years with ADHD were randomized into 2 groups (mindfulness and control). The dysregulation profile was measured using the Child Behavior Checklist (CBCL) Attention/Anxiety-Depression/Aggression scales.

Results: Children with ADHD who received mindfulness-based group therapy showed lower levels of DESR after treatment, with a reduction in CBCL dysregulation profile (F (1,63) = 4.81; p = 0.032). All ADHD symptoms showed a moderately significant positive correlation with DESR (p < 0.01). Children with combined-type showed higher levels of DESR than children with inattentive-type (p = 0.018); however, no statistically significant changes were observed in the combined-type after mindfulness treatment.

Conclusion: This study suggests that mindfulness in the form of structured group therapy might be clinically relevant in treating children with ADHD and thus make an impact on the overall clinical outcome, regardless of the ADHD subtype.
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http://dx.doi.org/10.1097/DBP.0000000000000682DOI Listing
September 2020

Personal tutoring in nursing studies: A supportive relationship experience aimed at integrating, curricular theory and professional practice.

Nurse Educ Pract 2019 May 20;37:81-87. Epub 2019 May 20.

Campus Docent Sant Joan de Déu, School of Nursing, University of Barcelona, Carrer Miret i Sans 10-16, 08034, Barcelona, Spain.

The goal of personal tutoring is not only to guide future nurse practitioners in all aspects of their professional development in the academic context, but to support their development for nursing practice as well. The aim of this study is to explore how nursing students and personal tutors experience the process of personal tutoring. This was a qualitative study using educational action research methodology and convenience sampling, taking into account the criteria of maximum variation and theoretical saturation. Data were gathered through focus groups conducted separately with nursing students and personal tutors. The analysis revealed three categories that described the participants' experience of personal tutoring: tutoring as a supportive relationship that includes pastoral care; the personal tutor as a professional who links theory and practice; group meetings as an opportunity for peer support and learning. Personal tutoring is perceived by students and tutors as a supportive relationship that contributes to both the personal and the professional development of future nurse practitioners.
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http://dx.doi.org/10.1016/j.nepr.2019.05.005DOI Listing
May 2019

Health-Related Quality of Life and Satisfaction With Health Care: Relation to Clinical Stage in Mexican Patients With Multiple Myeloma.

Cancer Control 2019 Jan-Dec;26(1):1073274819831281

1 Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.

Multiple myeloma (MM) is characterized by bone pain, pathologic fractures, bone destruction, and secondary hypercalcemia, all these conditions impact on health-related quality of life of patients. The objective was to evaluate the global health state and health-related quality of life in a group of patients with MM who attended a tertiary health-care center of the Instituto Mexicano del Seguro Social in Mexico, through the questionnaires designed by European Organization for Research and Treatment of Cancer (EORTC) quality of life group. Exploratory cross-sectional study in patients with MM treated in a Department of Hematology in a High-Specialty Medical Unit was conducted. Patients older than 18 years of age, men and women, were selected, and their informed written consent was obtained. We included all consecutive cases treated from January 2012 to December 2014. Questionnaires EORTC QLQ-C30, EORTC QLQ-MY20, and EORTC IN-PATSAT-32 were used. We studied 37 patients, 19 (51%) men and 18 women. The mean age was 61.9 years. Twenty-two (59.46%) patients presented with clinical stage III. The mean time for diagnosis was 33.11 months. The most used first-line treatment schedule was melphalan/prednisone/thalidomide (15; 40%). The global health median was 66.67, and symptoms showed a median score of 22.22. Treatment side effects score was 16.67; for general satisfaction, the median score was 75. In conclusion, the patients showed an advanced clinical stage and poor prognosis but had scores higher than 50 in functional scales and lower than 50 for symptom scales. The scores for symptom scales were related to age, renal failure, and disease-free survival. Identification of quality of life and satisfaction of care markers allow for early therapeutic intervention and efficiency and enable a change in quality of life and perception of care in Health Services.
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http://dx.doi.org/10.1177/1073274819831281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385332PMC
August 2019

Development and psychometric properties of the assessment questionnaire for the process of the tutorial action plan.

Nurse Educ Today 2019 May 13;76:109-117. Epub 2019 Feb 13.

Campus Docent Sant Joan de Déu-Fundació Privada, School of Nursing, University of Barcelona, Barcelona, Spain; Research Group GIES (Grupo de investigación en Enfermería, Educación y Sociedad), Spain; Research Committee of the Campus Docent SJD, Spain; Neonatal and Pediatric Hospital Pedagogy Research Group, Spain.

Background: Internationally, most countries recognize the right of the student to receive assistance from teachers and tutors. The Tutorial Action Plan is a teaching tool that aims to promote academic, personal, and professional development in students. It is important to monitor this process of tutoring to be able to provide appropriate guidance to nursing students throughout their education.

Objective: The objective of this study was to design and validate an instrument to measure and monitor nursing students' perceptions of the Tutorial Action Plan process.

Methods: This was a cross-sectional study conducted in two phases. The first consisted of the development of the Assessment Questionnaire for the Process of the Tutorial Action Plan through discussion groups and participant consensus. With 35 items related to the tutoring process, the questionnaire was designed to monitor the impact of that process. The items were grouped into four dimensions: Usefulness of the Tutorial Action Plan, Opinion about Tutor and Development of the Tutorial, Development of the Degree Final Project, and Usefulness and Completeness of the Learning Folder. In the second phase the psychometric properties of the questionnaire were evaluated, utilizing a sample of 410 nursing students. Reliability was measured by means of internal consistency, and construct validity was measured by means of confirmatory factor analysis.

Results: The overall Cronbach's alpha was 0.93, ranging from 0.73 to 0.92 for the dimensions. Confirmatory factor analysis showed that the model fitted a four-factor structure.

Conclusions: The results indicate that the Assessment Questionnaire for the Process of the Tutorial Action Plan is a valid and reliable assessment tool. This instrument is essential in monitoring the impact of tutoring of nursing students throughout their time in the program, both from a global perspective of the construct of tutoring and from the perspectives of the four dimensions identified.
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http://dx.doi.org/10.1016/j.nedt.2019.02.002DOI Listing
May 2019

Reliability and validity study of the Spanish adaptation of the "Creighton Simulation Evaluation Instrument (C-SEI)".

Nurse Educ Pract 2019 Feb 7;35:14-20. Epub 2019 Jan 7.

Department of Preventive Medicine, Hospital Germans Trias i Pujol, Carretera del Canyet sn, 08916, Badalona, Barcelona, Spain. Electronic address:

There are multiple advantages to using human patient simulation (HPS) as a teaching method for clinical nursing education. Valid, reliable tools that can be used when applying this teaching method are needed to evaluate nursing student skill acquisition. The aim of this study was to translate the Creighton Simulation Evaluation Instrument (C-SEI) into Spanish and to analyse the reliability and validity of the Spanish C-SEI version with nursing students. The study was conducted in two phases: (1) Adaptation of the instrument into Spanish. (2) Cross-sectional study in a sample of 249 nursing students who were evaluated by two observers. The psychometric properties were analysed in terms of reliability (internal consistency and inter-observer consistency) and construct validity using an exploratory factor analysis. Questionnaire internal consistency was 0.839 for the tool as a whole. Inter-observer concordance for the tool as a whole was 0.936 and greater than 0.80 for the majority of the items. The exploratory factor analysis showed a four-factor structure that explains 49.5% of the total variance. The results of this study show that the C-SEI-sp tool is a valid and reliable tool that is easy to apply in the monitoring of student performance in clinical simulation scenarios.
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http://dx.doi.org/10.1016/j.nepr.2018.12.007DOI Listing
February 2019

N-O Bond Activation and Cleavage Reactions of the Nitrosyl-Bridged Complexes [MCp(μ-PCy)(μ-NO)(NO)] (M = Mo, W).

Inorg Chem 2018 Dec 21;57(24):15314-15329. Epub 2018 Nov 21.

Departamento de Química Orgánica e Inorgánica/IUQOEM , Universidad de Oviedo , E-33071 Oviedo , Spain.

The title complexes (1a,b) were prepared in two steps by first reacting the hydrides [MCp(μ-H)(μ-PCy)(CO)] with [NO](BF) in the presence of NaCO to give dinitrosyls [MCp(μ-PCy)(CO)(NO)](BF), which were then fully decarbonylated upon reaction with NaNO at 323 K. An isomer of the Mo complex having a cisoid arrangement of the terminal ligands ( cis-1a) was prepared upon irradiation of toluene solutions of 1a with visible-UV light at 288 K. The structure of these trinitrosyl complexes was investigated using X-ray diffraction and density functional theory (DFT) calculations, these revealing a genuine pyramidalization of the bridging NO that might be associated in part to an increase of charge at the N atom and anticipated a weakening of the N-O bond upon reaction with bases or reducing reagents. Complexes 1a,b reacted with [FeCp](BF) to give first the radicals [MCp(μ-PCy)(μ-NO)(NO)](BF) according to CV experiments, which then underwent H-abstraction to yield the nitroxyl-bridged complexes [MCp(μ-PCy)(μ-κ:η-HNO)(NO)](BF), alternatively prepared upon protonation with HBF·OEt. The novel coordination mode of the nitroxyl ligand in these products was thermodynamically favored over its tautomeric hydroximido form, according to DFT calculations, and similar nitrosomethane-bridged cations [MCp(μ-PCy)( μ-κ:η-MeNO)(NO)] were prepared by reacting 1a,b with CFSOMe or [MeO]BF. Complexes 1 reacted with M(Hg) (M = Zn, Na) in tetrahydrofuran to give the amido-bridged derivatives [MCp(μ-PCy)(μ-NH)(NO)] with retention of stereochemistry, a transformation also induced by using mild O atom scavengers such as CO and phosphites in the presence of water. In the absence of water, phosphites accomplished a deoxygenation of the bridging NO of the Mo complexes to yield the phosphoraniminato-bridged derivatives [MoCp(μ-PCy){μ-NP(OR)}(NO)] (R = Et, Ph), also with retention of stereochemistry.
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http://dx.doi.org/10.1021/acs.inorgchem.8b02647DOI Listing
December 2018

Mapping of the Gastrointestinal Short Form Questionnaire (GSF-Q) into EQ-5D-3L and SF-6D in patients with gastroesophageal reflux disease.

Health Qual Life Outcomes 2018 Sep 10;16(1):177. Epub 2018 Sep 10.

Faculty of Economics, Universidad Calos III de Madrid, C/ Madrid, 126, 28903 Getafe, Madrid, Spain.

Background: The short, self-administered Gastroesophageal Reflux Disease (GERD) Symptom Frequency Questionnaire (GSFQ) is a specific Quality of Life (QoL) instrument which measures the impact of GERD symptoms on QoL. This study aims to map the specific scores in GSFQ into two generic instruments: SF-6D and EQ-5D-3 L, in order to obtain utility estimates derived from the GERD condition.

Method: A national representative sample of GERD patients was selected, stratified by gender, age (< 45, ≥45 years) and GERD severity (0-I, II-IV Savary-Miller score) for validation purposes. Age, gender, BMI, GERD diagnose, GERD severity, associated comorbidities and risk factors were recorded. GSFQ, SF-6D, EQ-5D-3 L, and the HRQoL Visual Analogue Scale (VAS) were answered by patients. Several mapping methods were estimated, regression using dummy variables, and linear, quadratic and cubic regression using optimal factor scores. The use of a GERD aggregated summary severity derived from the GSFQ was dimed the best predictor. Overall Mean Absolute Error (MAE), overall Mean Absolute Percentage Error (MAPE) were used as goodness-of-fit (GOF) indexes to compare models.

Results: A total of 3405 patients were recruited by 490 clinicians. Mean age was 49 (±14.4) years and 49.8% were women. Reported comorbidities were clustered in 6 antecedents and 15 concomitant pathologies. Aggregation of levels for the frequency of symptoms items was found more suitable for estimation. Regression weights were found to follow a monotonous progressive pattern. Overall MAE ranged from 0.092 to 0.094 for SF-6D utility prediction and from 0.008 to 0.08 for EQ-5D-3 L, while MAPE values ranged from 27.9 to 29% for SF-6D and from 36.8 to 38.4% for EQ-5D-3 L. Cubic regression GOF demonstrated a better fit.

Conclusions: It is possible to translate specific GSFQ scores assessing GERD condition into generic SF-6D and EQ-5D-3 L utility values. Although regression using dummy variables is a suitable mapping procedure, other alternative mapping methods convey better fit, in particular cubic regression.
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http://dx.doi.org/10.1186/s12955-018-1003-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131951PMC
September 2018

Cognitive Assessment Test: Validation of a Short Cognitive Test for the Detection of Mild Cognitive Disorder.

Int J Alzheimers Dis 2018 2;2018:3280621. Epub 2018 Jul 2.

Neurosciences Group, National University of Colombia, Colombia.

Introduction: Cognitive disorders are a clinical and research challenge; in particular, the mild cognitive disorder (MiCD) requires diagnostic suspicion and tools with adequate performance for its detection. The objective of this study was the validation of a short cognitive test (CATest) for the detection of MiCD in population of 50 years or more.

Methods: A diagnostic accuracy study was assembled and performed in a prospective cohort. A consecutive sample of 200 Colombian subjects who represented the whole spectrum of the condition of interest allowed us to reach the objective. Validity was determined by concurrent criteria. The cut points were determined by the ROC curves considering the best overall performance and accuracy of the test.

Results: CATest was validated to detection of MiCD at a cut-off point of 18. As a result, scores lower than 18 classified the participants as MiCD. At this cut-off point, CATest showed sensitivity of 84.3% (CI 76 to 90.16), specificity of 71.4% ( 95% 61.8 to 79.43), positive predictive value of 75% ( 95% CI 66.79 to 82.42), and area under curve AUC 0.8518 (standard error SE 0.0265).

Discussion: CATest has an adequate performance as a short cognitive test for the detection of MiCD. Its performance is superior to MiniMental and similar to Montreal Cognitive test (MoCA) according to the data reported in the literature. The advantages over other tests are the evaluation of all cognitive domains, time of application, and easy interpretation of results. CATest is a free use alternative for MiCD detection.
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http://dx.doi.org/10.1155/2018/3280621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051079PMC
July 2018

Dehydrogenation, Methyl Elimination and Insertion Reactions of the Agostic Methyl-Bridged Complex [Mo Cp (μ-κ :η -CH )(μ-PtBu )(μ-CO)].

Chemistry 2018 Jul 30;24(38):9504-9507. Epub 2018 May 30.

Departamento de Química Orgánica e Inorgánica/IUQOEM, Universidad de Oviedo, E-33071, Oviedo, Spain.

The high unsaturation of the title complex enabled it to react with a wide variety of molecules under mild conditions, whereby the agostic methyl ligand underwent unusual or unprecedented processes. Methane elimination occurred in the reactions with PPh H and SiPh H , this being followed in the latter case by Si-H bond oxidative addition to give the hydride silylene derivative [Mo Cp H(μ-PtBu )(μ-SiPh )(CO)]. Dehydrogenation, however, was the dominant process in the room temperature reaction with [Fe (CO) ], to give the unsaturated methylidyne cluster [Mo FeCp (μ -CH)(μ-PtBu )(CO) ] (Mo-Mo=2.6770(8) Å). In contrast, PMe elimination took place in the reaction with P , to give the unsaturated triphosphorus complex [Mo Cp (μ-η :η -P )(μ-PtBu )] (Mo-Mo=2.6221(3) Å). Yet a most remarkable reaction occurred with BH ⋅THF, involving insertion of two BH units and dehydrogenation to yield [Mo Cp (μ-B H Me)(μ-PtBu )(CO)], with the novel methyldiboranyl ligand acting as a 5-electron donor due to the presence of two 3-centre, 2-electron B-H-Mo interactions, according to spectroscopic data and DFT calculations (Mo-Mo ca. 2.65 Å).
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http://dx.doi.org/10.1002/chem.201801944DOI Listing
July 2018

Reply to the 'Comment on "Hydride, gold(i) and related derivatives of the unsaturated ditungsten anion [WCp(μ-PCy)(μ-CO)]"' by M. Green, Dalton Transactions, 2018, 47, DOI: 10.1039/C8DT00044A.

Dalton Trans 2018 May;47(18):6630-6631

Departamento de Química Orgánica e Inorgánica/IUQOEM, Universidad de Oviedo, E-33071 Oviedo, Spain.

The half-electron and CBC representations of the hydride-bridged complexes [M2Cp2(μ-H)(μ-PR2)(CO)2] are analyzed. It is shown that the former gives a picture in good agreement with the physicochemical properties of these species, while keeping simplicity.
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http://dx.doi.org/10.1039/c8dt00924dDOI Listing
May 2018

Differences in cognitive performance in nondemented Parkinson's disease: A latent profile analysis of cognitive subtypes.

J Clin Exp Neuropsychol 2018 10 12;40(8):777-789. Epub 2018 Feb 12.

b Departamento de Psicología biológica y de la Salud. Facultad de Psicología , Universidad Autónoma de Madrid , Madrid , Spain.

Introduction: Cognitive impairments are common in Parkinson's disease (PD) patients without dementia. These deficits are quite heterogeneous, which makes it difficult to recognize and treat them. For this reason, many authors have attempted to classify patients into more homogeneous groups with diverse results. The present study was designed to analyze the cognitive heterogeneity in PD patients using a novel data-driven approach, latent profile analysis (LPA), to classify patients according to cognitive characteristics. This methodology, which has been used in previous studies focused on motor and psychiatric symptomatology, seems to be better than traditional cluster analysis for the establishment and comparison between different subgroups because it does not require prior decision making about some theoretical or methodological aspects.

Method: LPA was applied to 71 PD patients evaluated with a broad neuropsychological battery including different memory and executive function tests. The clusters obtained from the analysis were described by making comparisons with a control group of 51 healthy subjects matched in age, sex, and educational level.

Results: The LPA resulted in a four-cluster solution, which could be described as: (a) executive dysfunction (32.4%), (b) memory and executive dysfunction (28.2%), (c) memory dysfunction (23.9%), and (d) noncognitive dysfunction (15.5%). These four PD cluster differ in age and Mini-Mental State Examination (MMSE) score. However, there were no differences between clusters in disease duration, clinical impression of severity index, depression, and cognitive reserve.

Conclusions: LPA is a very interesting method for the establishment of more homogeneous groups of PD patients based on their neuropsychological characteristics. Moreover, the distinction between different cognitive profiles will allow us to design interventions better adapted to each patient.
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http://dx.doi.org/10.1080/13803395.2018.1432570DOI Listing
October 2018
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