Miguel F Segura

Miguel F Segura

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Miguel F Segura

Miguel F Segura

Publications by authors named "Miguel F Segura"

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A High-Throughput Screening Identifies MicroRNA Inhibitors That Influence Neuronal Maintenance and/or Response to Oxidative Stress.

Mol Ther Nucleic Acids 2019 Sep 20;17:374-387. Epub 2019 Jun 20.

Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona 08036, Spain; Research Group on Statistics, Econometrics and Health, Universitat de Girona, 17003, Girona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Ministerio de Ciencia Innovación y Universidades, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626867PMC
September 2019

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Jun 15;76(11):2231-2243. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00018-019-03041-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502783PMC
June 2019

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways.

Front Genet 2019 2;10:281. Epub 2019 Apr 2.

Translational Molecular Pathology, Vall d'Hebron Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.3389/fgene.2019.00281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454836PMC
April 2019

Targeting of epigenetic regulators in neuroblastoma.

Exp Mol Med 2018 04 27;50(4):51. Epub 2018 Apr 27.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1038/s12276-018-0077-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938021PMC
April 2018

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer.

Br J Cancer 2018 01 5;118(1):106-116. Epub 2017 Dec 5.

Group of Biomedical Research in Digestive Tract Tumors, CIBBIM-Nanomedicine, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/bjc.2017.420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765235PMC
January 2018

Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis.

J Pathol 2017 05 7;242(1):39-51. Epub 2017 Mar 7.

Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.

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http://dx.doi.org/10.1002/path.4874DOI Listing
May 2017

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

Stem Cells Int 2017 24;2017:7507380. Epub 2017 Jan 24.

Laboratory of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; Pediatric Oncology and Hematology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1155/2017/7507380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294584PMC
January 2017

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells.

Nat Commun 2016 12 20;7:13884. Epub 2016 Dec 20.

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &Shanghai Jiao Tong University School of Medicine, University of Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/ncomms13884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187443PMC
December 2016

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system.

J Neurochem 2016 10 3;139(1):11-21. Epub 2016 Aug 3.

Cell Signaling and Apoptosis Group, Institut de Recerca de l'Hospital Universitari de la Vall d'Hebron (VHIR), Barcelona, Spain.

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http://dx.doi.org/10.1111/jnc.13729DOI Listing
October 2016

[Novel micro RNA-based therapies for the treatment of neuroblastoma].

An Pediatr (Barc) 2016 Aug 29;85(2):109.e1-109.e6. Epub 2015 Aug 29.

Grupo de Investigación Traslacional en el Cáncer de la infancia y adolescencia, Institut de Recerca, Vall d'Hebron, Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.anpedi.2015.07.016DOI Listing
August 2016

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma.

Mol Cell 2015 Jul 4;59(1):75-88. Epub 2015 Jun 4.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490946PMC
July 2015

Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f.

Int J Cancer 2015 Apr 2;136(7):1579-88. Epub 2014 Sep 2.

Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; National Children's Research Centre, Our Ladies Hospital for Sick Children, Dublin 12, Ireland.

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http://dx.doi.org/10.1002/ijc.29144DOI Listing
April 2015

Identification of metastasis-suppressive microRNAs in primary melanoma.

J Natl Cancer Inst 2015 Mar 12;107(3). Epub 2015 Feb 12.

Department of Pathology (DH, MFS, EP, XJS, FD, EH), Interdisciplinary Melanoma Cooperative Group (DH, MFS, JZ, XJS, FD, RSB, RLS, AP, IO, EH), Department of Environmental Medicine (JZ), Department of Dermatology (AP, IO), Department of Medicine (AP, IO), Department of Urology (IO); Department of Surgery (RSB, RLS), NYU Langone Medical Center, New York, NY; Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (BB).

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http://dx.doi.org/10.1093/jnci/dju494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565532PMC
March 2015

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.

Mol Cancer 2015 Mar 19;14:62. Epub 2015 Mar 19.

Cell Signaling and Apoptosis Group, Fundacio Institut de Recerca de l'Hospital Universitari de la Vall d'Hebron, Edifici Collserola, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12943-015-0329-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407790PMC
March 2015

FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.

J Neurosci 2013 Dec;33(49):19262-75

Institut de Recerca de l'Hospital Universitari de la Vall d'Hebron (VHIR), 08035 Barcelona, Spain, Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Spain, Departament de Ciències Experimentals i de la Salut, Cell Signalling Unit, Universitat Pompeu Fabra, 08003 Barcelona, Spain, Laboratoris Clinics, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain, and Institut de Recerca Biomèdica de Lleida, Universitat de Lleida, 25198 Lleida, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.2479-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618789PMC
December 2013

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo.

Pharmaceuticals (Basel) 2013 Nov 11;6(11):1429-50. Epub 2013 Nov 11.

Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.3390/ph6111429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854019PMC
November 2013

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

Cancer Res 2013 Oct 15;73(20):6264-76. Epub 2013 Aug 15.

Authors' Affiliations: Departments of Pathology and Dermatology, New York University School of Medicine; Interdisciplinary Melanoma Cooperative Group, New York University Cancer Institute, New York University Langone Medical Center; Departments of Structural and Chemical Biology and Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Instituto de Salud Carlos III, Majadahonda, Madrid; and Laboratory of Translational Research in Childhood Cancer, Vall d'Hebrón Institut de Recerca (VHIR), Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0122-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254777PMC
October 2013

microRNAs as pharmacological targets in cancer.

Pharmacol Res 2013 Sep 25;75:3-14. Epub 2013 Mar 25.

Laboratory of Translational Research in Childhood Cancer, Vall d'Hebron Institut de Recerca, Universitat Autónoma de Barcelona, Spain.

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http://dx.doi.org/10.1016/j.phrs.2013.03.006DOI Listing
September 2013

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

J Pathol 2012 Oct 18;228(2):204-15. Epub 2012 Apr 18.

Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1002/path.4000DOI Listing
October 2012

MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy.

Carcinogenesis 2012 Oct 12;33(10):1823-32. Epub 2012 Jun 12.

Department of Pathology, NYU Langone Medical Center, New York, NY, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgs205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529555PMC
October 2012

Histology-specific microRNA alterations in melanoma.

J Invest Dermatol 2012 Jul 3;132(7):1860-8. Epub 2012 May 3.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/jid.2011.451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648670PMC
July 2012

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.

Hum Mol Genet 2012 May 10;21(10):2157-65. Epub 2012 Feb 10.

Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), E-28029 Madrid, Spain.

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http://dx.doi.org/10.1093/hmg/dds031DOI Listing
May 2012

6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.

J Neurochem 2008 Mar 6;104(6):1599-612. Epub 2007 Nov 6.

Grupo de Neurofarmacología, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Albacete, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05115.xDOI Listing
March 2008

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment.

J Neurochem 2007 Oct 17;103(1):190-203. Epub 2007 Jul 17.

Unidad Asociada Neurodeath, UCLM-CSIC, Departamento de Ciencias Médicas, Universidad de Castilla-La Mancha, Albacete, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04767.xDOI Listing
October 2007

Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation.

Cereb Cortex 2007 Feb 2;17(2):294-303. Epub 2006 Mar 2.

Developmental Neurobiology and Regeneration Laboratory, Barcelona Science Park-IRB and Department of Cell Biology, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1093/cercor/bhj147DOI Listing
February 2007