Dr. Miguel Angel Martin-Piedra, PhD - University of Granada - Assistant teacher

Dr. Miguel Angel Martin-Piedra

PhD

University of Granada

Assistant teacher

Granada, Andalucia | Spain

Main Specialties: Biotechnology

Additional Specialties: Histology

ORCID logohttps://orcid.org/0000-0002-4639-3175


Top Author

Dr. Miguel Angel Martin-Piedra, PhD - University of Granada - Assistant teacher

Dr. Miguel Angel Martin-Piedra

PhD

Introduction

Degree in Dentistry with University Extraordinary Award in the School of Dentistry, University of Granada (UGR), 2008.
Master's Degree in Tissue Engineering, (School of Medicine, UGR), 2011.
Doctor in Biomedicine, (School of Medicine, UGR), 2014.
Generation of artificial tissues useful for therapeutics, in collaboration with several centers of the Public Health System, (Andalusian Initiative in Advanced Therapies, Junta de Andalucía), 2010-2011.
Interim substitute professor, (Department of Histology, UGR), 2014.
Assistant teacher (Department of Histology, UGR), 2016.

The main lines of research are: Histology and Tissue Engineering using dental pulp and other mesenchymal stem cells.
More than 30 publications in high impact scientific journals, in the field of histology, cell biology and tissue engineering (Cytotherapy, Tissue Engineering ...).
Participation in research and teaching innovation projects funded by public agencies (FIS, Instituto Carlos III; Junta de Andalucía).
Oral presentations and posters in various international conferences in the area of Regenerative Medicine and Tissue Engineering.
Editor of the scientific journal "Actualidad Médica". Reviewer in other journals in the area of Histology and Tissue Engineering.
"Pablo Gálvez Pruñonosa" Prize, awarded by Royal Academy of Medicine and Surgery of Andalucía Oriental (RAMAO), 2010.
Other prizes and distinctions (RAMAO), 2012, 2014, 2017.

Primary Affiliation: University of Granada - Granada, Andalucia , Spain

Specialties:

Additional Specialties:

Research Interests:


View Dr. Miguel Angel Martin-Piedra’s Resume / CV

Education

Sep 2014
Universidad de Granada - School of Medicine
Doctor in Biomedicine
Dept. Histology
Jun 2011
Universidad de Granada - School of Medicine
Master in Tissue Engineering
Dept. Histology
Feb 2010
Universidad de Granada - School of Dentistry
DEA Invest. Odontología (Doct.)
Jun 2008
Universidad de Granada - School of Dentistry
Doctor of Dental Science, DDS // Lienciado en Odontologia

Experience

Aug 2018
Dept. Histology - School of Medicine - UGR
Assistant Teacher
2016-2021
Mar 2016
Dept. Histology - School of medicine - UGR
Teacher (Profesor Sustituto Interino)
2014-2016
Dec 2011 - Sep 2014
Universidad de Granada
In-training Teacher (FPU program)
Histology
Sep 2014
PROGRAMA FPU 2010 - Ministerio Educación - Spain
Fellowship
2010-2014
Dec 2011
FUNDACIÓN PROGRESO Y SALUD – Junta de Andalucía
TÉCNICO DE PRODUCCIÓN SALAS GMP
2010-2011
May 2010
MINISTERIO DE EDUCACIÓN, POLÍTICA SOCIAL Y DEPORTE. Gobierno de España
PREMIOS NACIONALES A LA EXCELENCIA EN EL RENDIMIENTO ACADÉMICO UNIVERSITARIO (MENCIÓN ESPECIAL)
CONVOCATORIA 2007-08
Jul 2008
School of Dentistry (University of Granada)
PREMIO EXTRAORDINARIO FIN DE CARRERA
Curso 2007-08

Publications

26Publications

368Reads

21Profile Views

30PubMed Central Citations

Effective use of mesenchymal stem cells in human skin substitutes generated by tissue engineering.

Eur Cell Mater 2019 03 29;37:233-249. Epub 2019 Mar 29.

Department of Histology, School of Medicine, University of Granada, Avda/Investigación s/n 18071, Granada,

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http://www.ecmjournal.org/papers/vol037/pdf/v037a14.pdf
Publisher Site
http://dx.doi.org/10.22203/eCM.v037a14DOI Listing
March 2019
4 Reads
4.886 Impact Factor

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.

Histochem Cell Biol 2019 Jan 11;151(1):57-73. Epub 2018 Aug 11.

Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Avenida de la Investigación 11, Torre A, Planta 5, 18016, Granada, Spain.

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http://dx.doi.org/10.1007/s00418-018-1701-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328512PMC
January 2019
7 Reads
3.054 Impact Factor

Global Tissue Engineering Trends: A Scientometric and Evolutive Study.

Tissue Eng Part A 2018 10 24;24(19-20):1504-1517. Epub 2018 May 24.

5 Tissue Engineering Group, Department of Histology, University of Granada , Granada, Spain .

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http://dx.doi.org/10.1089/ten.TEA.2018.0007DOI Listing
October 2018
6 Reads

Conceptions of learning factors in postgraduate health sciences master students: a comparative study with non-health science students and between genders.

BMC Med Educ 2018 Jun 7;18(1):128. Epub 2018 Jun 7.

Group of Tissue Engineering, Department of Histology (Tissue Engineering Group), University of Granada and research institute ibs.Granada, Granada, Spain.

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http://dx.doi.org/10.1186/s12909-018-1227-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992711PMC
June 2018
32 Reads
1.410 Impact Factor

Membranes derived from human umbilical cord Wharton's jelly stem cells as novel bioengineered tissue-like constructs.

Histol Histopathol 2018 Feb 26;33(2):147-156. Epub 2017 Apr 26.

Tissue Engineering Group, Department of Histology, University of Granada, Granada, Spain.

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http://dx.doi.org/10.14670/HH-11-897DOI Listing
February 2018
12 Reads
2.100 Impact Factor

Evaluation of freeze-drying and cryopreservation protocols for long-term storage of biomaterials based on decellularized intestine.

J Biomed Mater Res B Appl Biomater 2018 02 10;106(2):488-500. Epub 2017 Feb 10.

Department of Histology (Tissue Engineering Group), University of Granada, Spain.

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http://dx.doi.org/10.1002/jbm.b.33861DOI Listing
February 2018
17 Reads
2.760 Impact Factor

Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics.

J Tissue Eng Regen Med 2018 Jan 30;12(1):204-216. Epub 2017 Jul 30.

Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX, USA.

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http://dx.doi.org/10.1002/term.2397DOI Listing
January 2018
11 Reads
5.200 Impact Factor

Generation and Evaluation of Novel Stromal Cell-Containing Tissue Engineered Artificial Stromas for the Surgical Repair of Abdominal Defects.

Biotechnol J 2017 Dec 13;12(12). Epub 2017 Oct 13.

Tissue Engineering Group, Department of Histology, School of Medicine, University of Granada, Spain, and Instituto de Investigación Biosanitaria ibs.GRANADA, Avda. de la Ilustración, 11, Granada 18016, Spain.

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http://dx.doi.org/10.1002/biot.201700078DOI Listing
December 2017
44 Reads
3.710 Impact Factor

Generation of a bioengineered autologous bone substitute for palate repair: an in vivo study in laboratory animals.

J Tissue Eng Regen Med 2017 06 9;11(6):1907-1914. Epub 2015 Oct 9.

Division of Paediatric Surgery, University Hospital Virgen de las Nieves, Granada, Spain.

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http://dx.doi.org/10.1002/term.2088DOI Listing
June 2017
16 Reads
5.200 Impact Factor

Development of a multilayered palate substitute in rabbits: a histochemical ex vivo and in vivo analysis

Histochem Cell Biol. 2017 Mar;147(3):377-388. doi: 10.1007/s00418-016-1489-5. Epub 2016 Sep 6

Histochem Cell Biol

Current tissue engineering technology focuses on developing simple tissues, whereas multilayered structures comprising several tissue types have rarely been described. We developed a highly biomimetic multilayered palate substitute with bone and oral mucosa tissues using rabbit cells and biomaterials subjected to nanotechnological techniques based on plastic compression. This novel palate substitute was autologously grafted in vivo, and histological and histochemical analyses were used to evaluate biointegration, cell function, and cell differentiation in the multilayered palate substitute. The three-dimensional structure of the multilayered palate substitute was histologically similar to control tissues, but the ex vivo level of cell and tissue differentiation were low as determined by the absence of epithelial differentiation although cytokeratins 4 and 13 were expressed. In vivo grafting was associated with greater cell differentiation, epithelial stratification, and maturation, but the expression of cytokeratins 4, 13, 5, and 19 at did not reach control tissue levels. Histochemical analysis of the oral mucosa stroma and bone detected weak signals for proteoglycans, elastic and collagen fibers, mineralization deposits and osteocalcin in the multilayered palate substitute cultured ex vivo. However, in vivo grafting was able to induce cell and tissue differentiation, although the expression levels of these components were always significantly lower than those found in controls, except for collagen in the bone layer. These results suggest that generation of a full-thickness multilayered palate substitute is achievable and that tissues become partially differentiated upon in vivo grafting.

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March 2017

Impact Factor 3.000

8 Reads

Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study.

PLoS One 2015 12;10(6):e0129419. Epub 2015 Jun 12.

Tissue Engineering Group, Department of Histology, University of Granada, 18012, Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, 18012, Granada, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129419PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466352PMC
April 2016
37 Reads
2 Citations
3.234 Impact Factor

Usefulness of a bioengineered oral mucosa model for preventing palate bone alterations in rabbits with a mucoperiostial defect.

Biomed Mater 2016 Feb 19;11(1):015015. Epub 2016 Feb 19.

Division of Oral and Maxillofacial Surgery, University General Hospital Gregorio Marañón, Madrid, Spain. PhD programme in Biomedicine, University of Granada, Spain.

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http://dx.doi.org/10.1088/1748-6041/11/1/015015DOI Listing
February 2016
8 Reads
1 Citation
3.700 Impact Factor

Identification of histological patterns in clinically affected and unaffected palm regions in dupuytren's disease.

PLoS One 2014 7;9(11):e112457. Epub 2014 Nov 7.

Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain, and Instituto de Investigación Biosanitaria ibs, Granada, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224499PMC
January 2016
13 Reads
3.234 Impact Factor

Human Dental Pulp Stem Cells. A promising epithelial-like cell source.

Med Hypotheses 2015 May 3;84(5):516-7. Epub 2015 Mar 3.

Department of Histology (Tissue Engineering Group), University of Granada, Spain.

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http://dx.doi.org/10.1016/j.mehy.2015.02.020DOI Listing
May 2015
8 Reads
1 Citation
1.152 Impact Factor

Expression of epithelial markers by human umbilical cord stem cells. A topographical analysis.

Placenta 2014 Dec 23;35(12):994-1000. Epub 2014 Sep 23.

Department of Histology (Tissue Engineering Group), University of Granada, Spain; Instituto de Investigación Biosanitaria ibs. Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2014.09.007DOI Listing
December 2014
9 Reads
2 Citations
2.710 Impact Factor

Sequential keratinocytic differentiation and maturation in a three-dimensional model of human artificial oral mucosa.

J Periodont Res 2014. Epub: 3-dec-2014. http://dx.doi.org/10.1111/jre.12247

J Periodont Res

BACKGROUND AND OBJECTIVE: Oral mucosa shortage may limit or condition some clinical approaches in maxillofacial, periodontal and implant treatment. The availability of a human oral mucosa model generated by tissue engineering could help clinicians to address the lack of oral mucosa. In this work, we carried out a sequential maturation and differentiation study of the epithelial cell layer of an artificial human oral mucosa substitute based on fibrin-agarose biomaterials with fibroblasts and keratinocytes. MATERIAL AND METHODS: Histological, immunohistochemical and gene expression analyses were carried out in artificial human oral mucosa models developed and cultured for 1, 2 and 3 wk. RESULTS: Artificial oral mucosa models showed expression of tight junction proteins and cytokeratins from the first week of in vitro development. Mature samples of 3 wk of development subjected to air-liquid conditions showed signs of epithelial differentiation and expressed specific RNAs and proteins corresponding to adherent and gap junctions and basement lamina. Moreover, these mature samples overexpressed some desmosomal and tight junction transcripts, with gap junction components being downregulated. CONCLUSION: These results suggest that bioengineered human oral mucosa substitutes form a well-developed epithelial layer that was very similar to human native tissues. In consequence, the epithelial layer could be fully functional in these oral mucosa substitutes, thus implying that these tissues may have clinical usefulness.

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December 2014
65 Reads

Generation of a biomimetic human artificial cornea model using Wharton's jelly mesenchymal stem cells.

Invest Ophthalmol Vis Sci 2014 Jun 6;55(7):4073-83. Epub 2014 Jun 6.

Department of Histology (Tissue Engineering Group), University of Granada, Instituto de Investigación Biosanitaria ibs.Granada, Spain.

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http://dx.doi.org/10.1167/iovs.14-14304DOI Listing
June 2014
43 Reads
5 Citations
3.404 Impact Factor

Motivational component profiles in university students learning histology: a comparative study between genders and different health science curricula.

BMC Med Educ 2014 Mar 10;14:46. Epub 2014 Mar 10.

Department of Histology, School of Medicine, University of Granada, Avenida de Madrid, 11 E18071 Granada, Spain.

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http://dx.doi.org/10.1186/1472-6920-14-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973968PMC
March 2014
9 Reads
3 Citations
1.410 Impact Factor

Cell viability and proliferation capability of long-term human dental pulp stem cell cultures.

Cytotherapy 2014 Feb;16(2):266-77

Department of Histology (Tissue Engineering Group), Faculty of Medicine, University of Granada, Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.10.016DOI Listing
February 2014
19 Reads
3 Citations
3.293 Impact Factor

An early and late cytotoxicity evaluation of lidocaine on human oral mucosa fibroblasts.

Exp Biol Med (Maywood) 2014 Jan 16;239(1):71-82. Epub 2013 Oct 16.

Tissue Engineering Group, Department of Histology, University of Granada, Granada E18012, Spain.

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http://journals.sagepub.com/doi/10.1177/1535370213503274
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http://dx.doi.org/10.1177/1535370213503274DOI Listing
January 2014
20 Reads
3 Citations

Histological and immunohistochemical changes in the rat oral mucosa used as an autologous urethral graft.

J Pediatr Surg 2013 Jul;48(7):1557-64

Department of Pediatric Surgery, University Hospital Virgen de las Nieves, Granada, Spain.

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http://dx.doi.org/10.1016/j.jpedsurg.2013.01.056DOI Listing
July 2013
10 Reads
1 Citation
1.311 Impact Factor

Average cell viability levels of human dental pulp stem cells: an accurate combinatorial index for quality control in tissue engineering.

Cytotherapy 2013 Apr 23;15(4):507-18. Epub 2013 Jan 23.

Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain.

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http://dx.doi.org/10.1016/j.jcyt.2012.11.017DOI Listing
April 2013
10 Reads
3.293 Impact Factor

Top co-authors

Miguel Alaminos
Miguel Alaminos

University of Granada

16
Ingrid Garzon
Ingrid Garzon

University of Granada

12
Antonio Campos
Antonio Campos

University of Granada

9
Victor Carriel
Victor Carriel

University of Granada

7
Fernando Campos
Fernando Campos

Hospital Italiano de Buenos Aires

4
Victor Carriel
Victor Carriel

University of Granada

4
Ana Celeste Oliveira
Ana Celeste Oliveira

University of Granada

3