Mignon L Loh

Mignon L Loh

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Mignon L Loh

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Molecular assessment of pretransplant chemotherapy in the treatment of juvenile myelomonocytic leukemia.

Pediatr Blood Cancer 2019 Nov 26;66(11):e27948. Epub 2019 Jul 26.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, California.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27948
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http://dx.doi.org/10.1002/pbc.27948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754267PMC
November 2019

Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia.

Pediatr Blood Cancer 2019 Oct 28;66(10):e27905. Epub 2019 Jun 28.

Department of Pediatrics, Section of Hematology Oncology, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.27905DOI Listing
October 2019

Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia.

Cancer Res 2019 May 12;79(9):2339-2351. Epub 2019 Mar 12.

Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497548PMC
May 2019

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.

J Med Chem 2019 Feb 5;62(3):1125-1137. Epub 2018 Dec 5.

Department of Pediatrics, Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467801PMC
February 2019

Using genomics to define pediatric blood cancers and inform practice.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):286-300

Department of Pediatrics, Benioff Children's Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA.

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http://dx.doi.org/10.1182/asheducation-2018.1.286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245969PMC
November 2018

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization.

J Clin Oncol 2018 10 23;36(29):2926-2934. Epub 2018 Aug 23.

Stuart S. Winter, Children's Minnesota Cancer and Blood Disorders Program, Minneapolis, MN; Kimberly P. Dunsmore, Carilion Clinic, Roanoke, VA; Meenakshi Devidas and Zhiguo Chen, University of Florida, Gainesville, FL; Brent L. Wood, Seattle Children's Hospital, Seattle, WA; Natia Esiashvili, Emory University, Atlanta, GA; Nancy Eisenberg, University of New Mexico Health Sciences Center, Albuquerque, NM; Nikki Briegel, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Robert J. Hayashi, St Louis Children's Hospital, St Louis, MO; Julie M. Gastier-Foster, Nationwide Children's Hospital; Julie M. Gastier-Foster and Nyla A. Heerema, Ohio State University, Columbus, OH; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Barbara L. Asselin, University of Rochester Medical Center and Wilmot Cancer Institute, Rochester; Elizabeth A. Raetz and William L. Carroll, Perlmutter Cancer Center at NYU Langone Health, New York, NY; Paul S. Gaynon, Children's Hospital of Los Angeles, Los Angeles; Mignon L. Loh, University of California, San Francisco, San Francisco, CA; Michael J. Borowitz, Johns Hopkins University, Baltimore, MD; Karen R. Rabin, Baylor College of Medicine, Houston; Naomi J. Winick, University of Texas Southwestern, Dallas, TX; Patrick A. Zweidler-Mckay, ImmunoGen, Waltham, MA; and Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2018.77.7250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366301PMC
October 2018

Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies.

Future Oncol 2018 Sep 29;14(21):2115-2129. Epub 2018 Mar 29.

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University & Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.2217/fon-2018-0121DOI Listing
September 2018

Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.

J Clin Oncol 2018 08 29;36(22):2306-2314. Epub 2018 May 29.

William B. Slayton, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, and Sherri L. Mizrahy, University of Florida, Gainesville, FL; Kirk R. Schultz, BC Children's Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Michael A. Pulsipher, Children's Hospital of Los Angeles, Los Angeles; Lance Sieger, University of California Los Angles-Harbor, Torrance; Mignon L. Loh, University of California San Francisco, San Francisco, CA; Bill H. Chang, Oregon Health and Science University, Portland, OR; Charles Mullighan, Ilaria Iacobucci, and Thomas Merchant, St Jude's Research Hospital, Memphis, TN; Lewis B. Silverman, Dana-Farber Cancer Institute, Boston, MA; Michael J. Borowitz, Johns Hopkins University, Baltimore, MD; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema, Ohio State University; Julie M. Gastier-Foster, Nationwide Children's Hospital, Columbus, OH; Brent L. Wood, University of Washington Seattle, Seattle, WA; Valerie I. Brown, Penn State Health Children's Hospital, Hershey; Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; Marilyn J. Siegel, Washington University School of Medicine, St Louis, MO; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; and William L. Carroll, New York University Langone Health Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2017.76.7228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067800PMC
August 2018

Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.

Stem Cell Res 2018 08 5;31:157-160. Epub 2018 Jul 5.

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, United States; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, United States. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.07.001DOI Listing
August 2018

Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group.

Pediatr Blood Cancer 2018 03 1;65(3). Epub 2017 Nov 1.

Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839116PMC
March 2018

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

J Clin Oncol 2018 02 4;36(6):591-599. Epub 2018 Jan 4.

Maoxiang Qian, Xueyuan Cao, Wenjian Yang, Cheng Cheng, Hui Zhang, Takaya Moriyama, Gerard Zambetti, Kim E. Nichols, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Mary V. Relling, and Jun J. Yang, St Jude Children's Research Hospital, Memphis, TN; Meenakshi Devidas and Yunfeng Dai, University of Florida, Gainesville, FL; Andrew Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University and Wexner Medical Center; Julie M. Gastier-Foster and Elaine R. Mardis, Nationwide Children's Hospital, Columbus, OH; Hui Zhang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong; Heng Xu, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX; Paul L. Martin, Duke University, Durham, NC; Robert Fulton, Washington University School of Medicine, St Louis, MO; Michael Borowitz, Johns Hopkins Medical Institute, Baltimore, MD; Brent Wood, University of Washington, Seattle, WA; William L. Carroll, New York University, New York, NY; Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and Mignon L. Loh, Benioff Children's Hospital and University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.5215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815403PMC
February 2018

Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukaemia.

Br J Haematol 2017 12 19;179(5):843-846. Epub 2016 Jul 19.

Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1111/bjh.14258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247399PMC
December 2017

Reply to I.J. Cohen.

J Clin Oncol 2017 12 18;35(35):3989-3991. Epub 2017 Oct 18.

Kristina K. Hardy, Children's National Medical Center, Washington, DC; Leanne M. Embry, University of Texas at San Antonio, San Antonio, TX; John A. Kairalla, University of Florida, Gainesville, FL; Shanjun Helian, Merck, Upper Gwynedd, PA; Meenakshi Devidas, University of Florida, Gainesville, FL; F. Daniel Armstrong, University of Miami, Miami, FL; Stephen Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; William L. Carroll, New York University, New York, NY; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Mignon L. Loh, University of California at San Francisco, San Francisco, CA; Wenjian Yang and Mary V. Relling, St Jude Children's Research Hospital and University of Tennessee, Memphis, TN; Robert B. Noll, University of Pittsburgh, Pittsburgh, PA; and Naomi Winick, University of Texas Southwestern, Dallas, TX.

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http://dx.doi.org/10.1200/JCO.2017.75.7252DOI Listing
December 2017

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1038/s41467-017-02178-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736624PMC
December 2017

Philadelphia chromosome-like acute lymphoblastic leukemia.

Blood 2017 11 2;130(19):2064-2072. Epub 2017 Oct 2.

Department of Pediatrics, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2017-06-743252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680607PMC
November 2017

Precision Medicine in Pediatric Oncology: Translating Genomic Discoveries into Optimized Therapies.

Clin Cancer Res 2017 Sep 9;23(18):5329-5338. Epub 2017 Jun 9.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0115DOI Listing
September 2017

Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group.

J Clin Oncol 2017 Aug 23;35(22):2527-2534. Epub 2017 May 23.

Naomi Winick, University of Texas Southwestern Medical Center, Dallas, TX; Meenakshi Devidas and Si Chen, University of Florida, Gainesville, FL; Kelly Maloney, Children's Hospital Colorado, Aurora, CO; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Leonard Mattano, HARP Pharma Consulting, Mystic, CT; Michael J. Borowitz, Johns Hopkins Medical Institutions, Baltimore, MD; Andrew Carroll, University of Alabama at Birmingham, AL; Julie M. Gastier-Foster, Institute for Genomic Medicine, Nationwide Children's Hospital; Julie M. Gastier-Foster and Nyla A. Heerema, The Ohio State University School of Medicine, Columbus, OH; Cheryl Willman, University of New Mexico, Albuquerque, NM; Brent Wood, University of Washington, Seattle, WA; Mignon L. Loh, University of California, San Francisco, San Francisco, CA; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; and William L. Carroll, New York University Medical Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.4774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536164PMC
August 2017

Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children's Oncology Group.

J Clin Oncol 2017 Aug 3;35(23):2700-2707. Epub 2017 Jul 3.

Kristina K. Hardy, Children's National Medical Center, Washington, DC; Leanne Embry, The University of Texas Health Science Center at San Antonio, San Antonio; Naomi Winick, University of Texas Southwestern Medical Center, Dallas, TX; John A. Kairalla and Meenakshi Devidas, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville; Daniel Armstrong, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Shanjun Helian, Merck, Upper Gwynedd; Stephen Hunger, Children's Hospital of Philadelphia, Philadelphia; Robert B. Noll, University of Pittsburgh School of Medicine, Pittsburgh, PA; William L. Carroll, New York University Medical Center, New York, NY; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Mignon L. Loh, University of California, San Francisco, San Francisco, CA; and Wenjian Yang and Mary V. Relling, St Jude Children's Research Hospital; University of Tennessee Health Science Center, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.71.7587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549456PMC
August 2017

Ph-like acute lymphoblastic leukemia.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):561-566

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; and.

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http://dx.doi.org/10.1182/asheducation-2016.1.561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142516PMC
December 2016

Germline mutations are not associated with Noonan syndrome.

J Med Genet 2016 Nov 7;53(11):728. Epub 2016 Apr 7.

Department of Pediatrics, University of California, San Francisco, Benioff Children's Hospital, San Francisco, California, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-103889DOI Listing
November 2016

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.

Nature 2016 11 26;539(7628):304-308. Epub 2016 Oct 26.

Department of Pediatrics, Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nature20131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317374PMC
November 2016

Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232.

J Clin Oncol 2016 07 25;34(20):2380-8. Epub 2016 Apr 25.

Eric C. Larsen, Maine Children's Cancer Program, Scarborough, ME; Meenakshi Devidas and Si Chen, University of Florida, Gainesville, FL; Wanda L. Salzer, US Army Medical Research and Materiel Command, Frederick; Michael J. Borowitz, Johns Hopkins Medical Institutions, Baltimore, MD; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT, Mignon L. Loh, University of California, San Francisco, San Francisco, CA; Leonard A. Mattano Jr, HARP Pharma Consulting, Mystic, CT; Catherine Cole, Princess Margaret Hospital for Children; University of Western Australia, Perth, Western Australia, Australia; Alisa Eicher, Doernbecher Children's Hospital, Portland, OR; Maureen Haugan, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Mark Sorenson, University of Iowa Hospitals and Clinics, Iowa City, IA; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University School of Medicine, Columbus, OH; Andrew A. Carroll, University of Alabama at Birmingham, Birmingham, AL; Brent L. Wood, University of Washington, Seattle, WA; Cheryl L. Willman, University of New Mexico, Albuquerque, NM; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; Stephen P. Hunger, Children's Hospital of Philadelphia; University of Pennsylvania, Philadelphia, PA; and William L. Carroll, New York University Medical Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.62.4544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981974PMC
July 2016

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

J Clin Oncol 2016 06 25;34(18):2133-40. Epub 2016 Apr 25.

Chengcheng Liu, Wenjian Yang, Cheng Cheng, Deqing Pei, Colton Smith, Sima Jeha, Ching-Hon Pui, William E. Evans, and Mary V. Relling, St Jude Children's Research Hospital; Scott C. Howard, University of Memphis, Memphis, TN; Meenakshi Devidas, University of Florida, Gainesville, FL; William L. Carroll, New York University Langone Medical Center, New York, NY; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; W. Paul Bowman, Cook Children's Hospital, Ft Worth; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; Eric C. Larsen, Maine Children's Cancer Program, Scarborough, ME; Kelly W. Maloney, University of Colorado Denver, Aurora, CO; Paul L. Martin, Duke University, Durham, NC; Leonard A. Mattano Jr, HARP Pharma Consulting, Mystic, CT; Elaine R. Mardis and Robert S. Fulton, The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO; Deepa Bhojwani, Children's Hospital of Los Angeles, Los Angeles; Mignon L. Loh, University of California San Francisco Medical Center-Parnassus, San Francisco, CA; and Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2015.64.5812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962704PMC
June 2016

Pediatric MDS: GATA screen the germline.

Blood 2016 Mar;127(11):1377-8

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO.

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http://dx.doi.org/10.1182/blood-2016-01-690016DOI Listing
March 2016

Childhood acute lymphoblastic leukemia: Integrating genomics into therapy.

Cancer 2015 Oct 20;121(20):3577-90. Epub 2015 Jul 20.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.29573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592406PMC
October 2015

Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: a report from the Children's Oncology Group.

Pediatr Blood Cancer 2015 Apr 8;62(4):629-36. Epub 2014 Dec 8.

Department of Pediatrics, Helen Diller Comprehensive Cancer Center, University of California San Francisco School of Medicine and Benioff Children's Hospital, San Francisco, California.

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http://dx.doi.org/10.1002/pbc.25342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339233PMC
April 2015

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.

Blood 2015 Jan 13;125(3):516-24. Epub 2014 Nov 13.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1182/blood-2014-09-601690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296011PMC
January 2015