Mieke Dewerchin

Mieke Dewerchin

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Mieke Dewerchin

Mieke Dewerchin

Publications by authors named "Mieke Dewerchin"

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Single-Cell Transcriptome Atlas of Murine Endothelial Cells.

Cell 2020 Feb 10. Epub 2020 Feb 10.

Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute (LKI), VIB and KU Leuven, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.015DOI Listing
February 2020

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Cell Metab 2018 12 23;28(6):866-880.e15. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183046
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http://dx.doi.org/10.1016/j.cmet.2018.07.019DOI Listing
December 2018

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Cell Metab 2018 12 23;28(6):881-894.e13. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 51006, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.016DOI Listing
December 2018

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell Metab 2018 10 12;28(4):573-587.e13. Epub 2018 Jul 12.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.009DOI Listing
October 2018

Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish.

Biochem Biophys Res Commun 2018 09 19;503(1):26-31. Epub 2018 Jun 19.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, B-3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven, B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.04.233DOI Listing
September 2018

PP2A Inactivation Mediated by Haploinsufficiency Promotes Cancer Development.

Cancer Res 2017 12 18;77(24):6825-6837. Epub 2017 Oct 18.

Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2911DOI Listing
December 2017

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.

Angiogenesis 2017 Nov 5;20(4):599-613. Epub 2017 Sep 5.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10456-017-9573-6DOI Listing
November 2017

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex.

Cell Stem Cell 2017 03 23;20(3):360-373.e7. Epub 2016 Nov 23.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.020DOI Listing
March 2017

Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.

Physiology (Bethesda) 2017 03;32(2):126-140

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and

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http://dx.doi.org/10.1152/physiol.00031.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337830PMC
March 2017

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

EMBO Mol Med 2016 10 4;8(10):1134-1142. Epub 2016 Oct 4.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, Belgium

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http://dx.doi.org/10.15252/emmm.201606798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048364PMC
October 2016

Metabolic control of the cell cycle.

Cell Cycle 2015 ;14(21):3379-88

a Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven ; Leuven , Belgium.

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http://dx.doi.org/10.1080/15384101.2015.1090068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825590PMC
August 2016

Vascular endothelial growth factor: a neurovascular target in neurological diseases.

Nat Rev Neurol 2016 08 1;12(8):439-54. Epub 2016 Jul 1.

Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Department of Oncology (KU Leuven) and Vesalius Research Center (VIB), Campus Gasthuisberg O&N4, Herestraat 49 - 912, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1038/nrneurol.2016.88DOI Listing
August 2016

Glycolytic regulation of cell rearrangement in angiogenesis.

Nat Commun 2016 07 20;7:12240. Epub 2016 Jul 20.

Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven, Herestraat 49 box 912, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/ncomms12240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961802PMC
July 2016

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.

EMBO J 2016 05 8;35(9):924-41. Epub 2016 Feb 8.

Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven, Belgium Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven Leuven, Belgium

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http://dx.doi.org/10.15252/embj.201592372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207321PMC
May 2016

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.

Cell Rep 2016 Mar 10;14(11):2653-67. Epub 2016 Mar 10.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856PMC
March 2016

The PHD2 oxygen sensor paves the way to metastasis.

Oncotarget 2015 Nov;6(34):35149-50

Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.18632/oncotarget.6216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742092PMC
November 2015

Angiogenesis Revisited: An Overlooked Role of Endothelial Cell Metabolism in Vessel Sprouting.

Microcirculation 2015 Oct;22(7):509-17

Laboratory of Angiogenesis & Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium.

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http://doi.wiley.com/10.1111/micc.12229
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http://dx.doi.org/10.1111/micc.12229DOI Listing
October 2015

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Cell Rep 2015 Aug 30;12(6):992-1005. Epub 2015 Jul 30.

Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.010DOI Listing
August 2015

Placental growth factor in cancer.

Expert Opin Ther Targets 2014 Nov 9;18(11):1339-54. Epub 2014 Oct 9.

Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB and Department of Oncology, KU Leuven , Campus Gasthuisberg O&N4, Herestraat 49 - 912, B-3000, Leuven , Belgium

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http://dx.doi.org/10.1517/14728222.2014.948420DOI Listing
November 2014

Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity.

Chem Biol 2014 Oct 4;21(10):1310-1317. Epub 2014 Sep 4.

Laboratory of Angiogenesis & Neurovascular Link, Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis & Neurovascular Link, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10745521140025
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http://dx.doi.org/10.1016/j.chembiol.2014.07.018DOI Listing
October 2014

Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy?

Cell Cycle 2014 13;13(1):16-22. Epub 2013 Dec 13.

Laboratory of Angiogenesis and Neurovascular Link; Vesalius Research Center; Department of Oncology; University of Leuven; Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link; Vesalius Research Center; Department of Oncology; VIB; Leuven, Belgium.

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http://dx.doi.org/10.4161/cc.27519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925729PMC
September 2014

Tumor vessel normalization by chloroquine independent of autophagy.

Cancer Cell 2014 Aug;26(2):190-206

Department of Oncology, Laboratory of Angiogenesis and Neurovascular Link, KU Leuven, B-3000 Leuven, Belgium; Vesalius Research Center, Laboratory of Angiogenesis and Neurovascular Link, VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ccr.2014.06.025DOI Listing
August 2014

Lymphatics help baby take first breath.

Authors:
Mieke Dewerchin

J Exp Med 2014 May;211(5):745

VIB Vesalius Research Center, KU Leuven.

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http://www.jem.org/lookup/doi/10.1084/jem.2115insight2
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http://dx.doi.org/10.1084/jem.2115insight2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010894PMC
May 2014

Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism.

Stroke 2014 Mar 14;45(3):842-9. Epub 2014 Jan 14.

From the INSERM, U740 and Univ Paris Diderot, Sorbonne Cité, UMR S740, Paris, France (E.C., C.B.-M., V.D.-D., S.C., C.F., M.M.-L., A.J.); and Laboratory of Angiogenesis & Neurovascular Link, Vesalius Research Center, VIB-KU Leuven, Leuven, Belgium (M.D.).

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http://stroke.ahajournals.org/content/45/3/842.full.pdf
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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.113.
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http://dx.doi.org/10.1161/STROKEAHA.113.003339DOI Listing
March 2014

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

Cell Metab 2014 Jan 12;19(1):37-48. Epub 2013 Dec 12.

Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven 3000, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.008DOI Listing
January 2014

Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1α-independent translation-mediated mechanism.

Cell Rep 2014 Jan 2;6(1):155-67. Epub 2014 Jan 2.

Inserm, U1037, 31432 Toulouse, France; Université de Toulouse, UPS, Cancer Research Center of Toulouse, Equipe Labellisee Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, 31432 Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.12.011DOI Listing
January 2014

A transgenic Xenopus laevis reporter model to study lymphangiogenesis.

Biol Open 2013 11;2(9):882-90. Epub 2013 Jul 11.

Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center , VIB, 3000 Leuven , Belgium ; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center , KU Leuven, 3000 Leuven , Belgium.

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http://dx.doi.org/10.1242/bio.20134739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773334PMC
October 2013

PlGF: a multitasking cytokine with disease-restricted activity.

Cold Spring Harb Perspect Med 2012 Aug 1;2(8). Epub 2012 Aug 1.

Laboratory of Angiogenesis and Neurovascular Link, VIB Vesalius Research Center, K.U. Leuven, Leuven, Belgium.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a011056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405829PMC
August 2012

The role of different VEGF isoforms in scar formation after glaucoma filtration surgery.

Exp Eye Res 2011 Nov 1;93(5):689-99. Epub 2011 Sep 1.

Laboratory of Ophthalmology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S00144835110025
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http://dx.doi.org/10.1016/j.exer.2011.08.016DOI Listing
November 2011

Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis.

Biochem Biophys Res Commun 2011 Jun 27;410(1):121-6. Epub 2011 May 27.

Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs & Navorsing 1, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2011.05.117DOI Listing
June 2011

NuSAP is essential for chromatin-induced spindle formation during early embryogenesis.

J Cell Sci 2010 Oct 31;123(Pt 19):3244-55. Epub 2010 Aug 31.

Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1242/jcs.063875DOI Listing
October 2010

Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.

Cardiovasc Res 2008 Jul 13;79(1):179-86. Epub 2008 Mar 13.

Department for Molecular Biomedical Research, Flanders Institute for Biotechnology , Technologiepark 927, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1093/cvr/cvn068DOI Listing
July 2008

A genetic Xenopus laevis tadpole model to study lymphangiogenesis.

Nat Med 2005 Sep 14;11(9):998-1004. Epub 2005 Aug 14.

Flanders Interuniversity Institute for Biotechnology, Center for Transgene Technology and Gene Therapy, Campus Gasthuisberg O&N, Herestraat 49, KULeuven, Leuven, B-3000.

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http://dx.doi.org/10.1038/nm1285DOI Listing
September 2005

Vascular remodeling in mice lacking the cytoplasmic domain of tissue factor.

Circ Res 2005 Aug 14;97(3):293-8. Epub 2005 Jul 14.

Deutsches Herzzentrum und 1, Medizinische Klinik der Technischen, Universität München, Germany.

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http://dx.doi.org/10.1161/01.RES.0000177533.48483.12DOI Listing
August 2005

Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.

Biochem Biophys Res Commun 2005 Jul;333(2):488-95

The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology (VIB), KULeuven Campus Gasthuisberg, Leuven B-3000, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X050113
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http://dx.doi.org/10.1016/j.bbrc.2005.05.144DOI Listing
July 2005

A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia.

J Biol Chem 2005 Feb 29;280(5):3493-9. Epub 2004 Nov 29.

Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology (VIB), KULeuven, Leuven, B-3000, Belgium.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406613200
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http://dx.doi.org/10.1074/jbc.M406613200DOI Listing
February 2005

Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.

Dev Growth Differ 2004 Oct;46(5):459-70

Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology (VIB), Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1111/j.1440-169x.2004.00762.xDOI Listing
October 2004

The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.

Mol Cell Biol 2004 Jul;24(13):5863-74

Division of Biochemistry, Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium.

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http://dx.doi.org/10.1128/MCB.24.13.5863-5874.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC480874PMC
July 2004

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.

Proc Natl Acad Sci U S A 2004 Feb 26;101(5):1327-32. Epub 2004 Jan 26.

Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, B-3000 Leuven, Belgium.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0308114100
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http://dx.doi.org/10.1073/pnas.0308114100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC337052PMC
February 2004

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha.

Cardiovasc Res 2003 Dec;60(3):569-79

Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cardiores.2003.07.003DOI Listing
December 2003

Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.

Circ Res 2003 Nov 30;93(11):1120-6. Epub 2003 Oct 30.

Center for Transgene Technology and Gene Therapy, VIB, KULeuven Campus Gasthuisberg O&N, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1161/01.RES.0000103634.69868.4FDOI Listing
November 2003

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata.

Hum Mol Genet 2003 Sep 15;12(18):2255-67. Epub 2003 Jul 15.

Academic Medical Center, Laboratory of Genetic Metabolic Diseases F0-224, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddg236DOI Listing
September 2003