Publications by authors named "Mickael Le Douget"

2Publications

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

Authors:
Vito Guagnano Audrey Kauffmann Simon Wöhrle Christelle Stamm Moriko Ito Louise Barys Astrid Pornon Yao Yao Fang Li Yun Zhang Zhi Chen Christopher J Wilson Vincent Bordas Mickaël Le Douget L Alex Gaither Jason Borawski John E Monahan Kavitha Venkatesan Thomas Brümmendorf David M Thomas Carlos Garcia-Echeverria Francesco Hofmann William R Sellers Diana Graus-Porta

Cancer Discov 2012 Dec 20;2(12):1118-33. Epub 2012 Sep 20.

Global Discovery Chemistry, 2Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2012

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Authors:
Vito Guagnano Pascal Furet Carsten Spanka Vincent Bordas Mickaël Le Douget Christelle Stamm Josef Brueggen Michael R Jensen Christian Schnell Herbert Schmid Markus Wartmann Joerg Berghausen Peter Drueckes Alfred Zimmerlin Dirksen Bussiere Jeremy Murray Diana Graus Porta

J Med Chem 2011 Oct 21;54(20):7066-83. Epub 2011 Sep 21.

Novartis Institute for BioMedical Research, CH-4002 Basel, Switzerland.

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October 2011