Publications by authors named "Michelle P Bendeck"

50Publications

DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) Axis Senses Matrix Stiffness to Promote Vascular Calcification.

Arterioscler Thromb Vasc Biol 2020 Jul 4;40(7):1763-1776. Epub 2020 Jun 4.

From the Department of Laboratory Medicine and Pathobiology (D.N., M.L., M.P.B.), University of Toronto, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.120.314697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310304PMC
July 2020

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease.

Mol Metab 2020 Sep 28;39:101006. Epub 2020 Apr 28.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, 661 University Avenue, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242876PMC
September 2020

Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalisation of N-cadherin contacts.

Biol Open 2019 Aug 9;8(8). Epub 2019 Aug 9.

Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1M1, Canada

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http://dx.doi.org/10.1242/bio.041913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737968PMC
August 2019

Cell-Matrix Interactions and Matricrine Signaling in the Pathogenesis of Vascular Calcification.

Front Cardiovasc Med 2018 7;5:174. Epub 2018 Dec 7.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fcvm.2018.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292870PMC
December 2018

Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice.

J Biol Chem 2018 02 3;293(8):2841-2849. Epub 2018 Jan 3.

From the Department of Molecular Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, Texas 78229,

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http://dx.doi.org/10.1074/jbc.RA117.000672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827455PMC
February 2018

Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms.

Biomaterials 2017 Nov 15;145:9-22. Epub 2017 Aug 15.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada; Faculty of Dentistry, University of Toronto, Toronto, Ontario, M5G 1G6, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario, M5G 1M1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.08.028DOI Listing
November 2017

Interleukin-1β Is a Key Biomarker and Mediator of Inflammatory Vascular Calcification.

Arterioscler Thromb Vasc Biol 2017 02;37(2):179-180

From the Department of Laboratory Medicine and Pathobiology and Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.116.308724DOI Listing
February 2017

Insulin decreases atherosclerotic plaque burden and increases plaque stability via nitric oxide synthase in apolipoprotein E-null mice.

Am J Physiol Endocrinol Metab 2016 08 24;311(2):E335-45. Epub 2016 May 24.

Department of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpendo.00320.2015DOI Listing
August 2016

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

Arterioscler Thromb Vasc Biol 2016 Mar 21;36(3):525-33. Epub 2016 Jan 21.

From the Department of Medicine, Cardiovascular Division, Center for Excellence in Vascular Biology (J.B.K., E.M.-M., W.S.I., E.A.) and Center for Interdisciplinary Cardiovascular Sciences (J.D.H., E.A.), Harvard Medical School, Boston, MA; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (C.V.C.B.); Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (S.B.); and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (M.P.B.).

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http://dx.doi.org/10.1161/ATVBAHA.115.307009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767541PMC
March 2016

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Atherosclerosis 2015 Jul 25;241(1):111-20. Epub 2015 Apr 25.

Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.04.799DOI Listing
July 2015

Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells.

Cytoskeleton (Hoboken) 2015 Apr 25;72(4):157-70. Epub 2015 May 25.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/cm.21222DOI Listing
April 2015

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen.

Biol Open 2013 13;2(11):1148-59. Epub 2013 Sep 13.

Matrix Dynamics Group, Faculty of Dentistry, University of Toronto , Toronto, ON M5S 3E2 , Canada.

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http://dx.doi.org/10.1242/bio.20135090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828761PMC
November 2013

In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury.

J Vasc Res 2013 9;50(4):279-88. Epub 2013 Jul 9.

Department of Physiology, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000351611DOI Listing
October 2013

Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.

Am J Pathol 2013 Jun 6;182(6):2241-53. Epub 2013 Apr 6.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668035PMC
June 2013

Type VIII collagen signals via β1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration.

Matrix Biol 2013 Aug 21;32(6):332-41. Epub 2013 Mar 21.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.matbio.2013.03.004DOI Listing
August 2013

Cell division fidelity is altered during the vascular response to injury: its novel role in atherosclerosis progression.

Am J Pathol 2013 Mar 20;182(3):628-39. Epub 2012 Dec 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2012.11.007DOI Listing
March 2013

Deletion of discoidin domain receptor 2 does not affect smooth muscle cell adhesion, migration, or proliferation in response to type I collagen.

Cardiovasc Pathol 2012 May-Jun;21(3):214-8. Epub 2011 Aug 23.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.carpath.2011.07.006DOI Listing
October 2012

Cadherins at cell-autonomous membrane contacts control macropinocytosis.

J Cell Sci 2011 Jun 24;124(Pt 12):2013-20. Epub 2011 May 24.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S1A8, Canada.

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http://dx.doi.org/10.1242/jcs.076901DOI Listing
June 2011

Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1.

Circ Res 2010 Jun 6;106(11):1775-83. Epub 2010 May 6.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6213, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.213637DOI Listing
June 2010

Insulin inhibits and oral sucrose increases neointimal growth after arterial injury in rats.

J Vasc Res 2010 6;47(5):412-22. Epub 2010 Feb 6.

Department of Physiology, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000281581DOI Listing
September 2010

Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.

Cardiovasc Pathol 2011 Mar-Apr;20(2):71-6. Epub 2010 Jan 25.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.carpath.2009.12.006DOI Listing
May 2011

Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis.

Circ Res 2009 Nov 15;105(11):1141-8. Epub 2009 Oct 15.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.109.20735
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http://dx.doi.org/10.1161/CIRCRESAHA.109.207357DOI Listing
November 2009

Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells.

Cell Adh Migr 2009 Apr-Jun;3(2):174-6. Epub 2009 Apr 10.

Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679879PMC
http://dx.doi.org/10.4161/cam.3.2.7374DOI Listing
September 2009

Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.

Circ Res 2009 Mar 22;104(5):609-18. Epub 2009 Jan 22.

Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.186064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758767PMC
March 2009

Collagens in the progression and complications of atherosclerosis.

Vasc Med 2009 Feb;14(1):73-89

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1358863X08094801DOI Listing
February 2009

Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury.

Exp Cell Res 2008 Oct 22;314(16):2919-29. Epub 2008 Jul 22.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Rm. 6213, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1016/j.yexcr.2008.07.010DOI Listing
October 2008

Homotypic and endothelial cell adhesions via N-cadherin determine polarity and regulate migration of vascular smooth muscle cells.

Circ Res 2008 Aug 10;103(4):405-12. Epub 2008 Jul 10.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.175307DOI Listing
August 2008

Integrin-linked kinase in the vascular smooth muscle cell response to injury.

Am J Pathol 2008 Jul 5;173(1):278-88. Epub 2008 Jun 5.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2353/ajpath.2008.071046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438304PMC
July 2008

Bouncing back from elastin deficiency.

Circ Res 2007 Aug;101(5):439-40

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http://dx.doi.org/10.1161/CIRCRESAHA.107.160358DOI Listing
August 2007

Cardiac valve interstitial cells secrete fibronectin and form fibrillar adhesions in response to injury.

Cardiovasc Pathol 2007 Jul-Aug;16(4):203-11. Epub 2007 May 11.

Toronto General Research Institute and Department of Pathology, University Health Network, Toronto, Ontario, Canada M5G 2C4.

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http://dx.doi.org/10.1016/j.carpath.2007.02.008DOI Listing
September 2007

Anti-atherogenic effect of insulin in vivo.

J Vasc Res 2005 Nov-Dec;42(6):455-62. Epub 2005 Sep 6.

Department of Physiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1159/000088099DOI Listing
December 2005

Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline.

J Vasc Res 2004 Mar-Apr;41(2):157-65. Epub 2004 Mar 3.

Terrence Donnelly Cardiovascular Research Laboratories, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1159/000077145DOI Listing
May 2004

A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening.

Am J Pathol 2003 Oct;163(4):1557-66

Departments of Laboratory Medicine and Pathobiology and Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868303PMC
http://dx.doi.org/10.1016/S0002-9440(10)63512-2DOI Listing
October 2003

N-cadherin upregulation and function in response of smooth muscle cells to arterial injury.

Arterioscler Thromb Vasc Biol 2002 Dec;22(12):1972-7

Toronto General Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1161/01.atv.0000036416.14084.5aDOI Listing
December 2002

Targeting pericellular proteolysis in vascular disease.

Circ Res 2002 Nov;91(10):861-2

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http://dx.doi.org/10.1161/01.res.0000043396.97121.9cDOI Listing
November 2002

Biochemical analysis of collagen and elastin synthesis in the balloon injured rat carotid artery.

Cardiovasc Pathol 2002 Sep-Oct;11(5):272-6

Department of Laboratory Medicine, University of Toronto, 1 King's College Circle, Room 6217, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1016/s1054-8807(02)00119-9DOI Listing
February 2003

Collagens, integrins, and the discoidin domain receptors in arterial occlusive disease.

Trends Cardiovasc Med 2002 May;12(4):143-8

Department of Laboratory Medicine, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s1050-1738(01)00165-7DOI Listing
May 2002

Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.

Circ Res 2002 Jun;90(11):1147-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/01.res.0000022166.74073.f8DOI Listing
June 2002

Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury.

Am J Pathol 2002 Mar;160(3):1089-95

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867154PMC
http://dx.doi.org/10.1016/S0002-9440(10)64929-2DOI Listing
March 2002