Michelle M Le Beau

Michelle M Le Beau

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Michelle M Le Beau

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The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.

Cell Stem Cell 2018 11;23(5):634-635

Department of Medicine, The University of Chicago, Chicago, IL 60637, USA; University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL 60637, US. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183048
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http://dx.doi.org/10.1016/j.stem.2018.10.003DOI Listing
November 2018

Therapy-related myeloid neoplasms: when genetics and environment collide.

Nat Rev Cancer 2017 08;17(9):513-527

Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nrc.2017.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946699PMC
August 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell 2017 02 16;168(5):817-829.e15. Epub 2017 Feb 16.

Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173010
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http://dx.doi.org/10.1016/j.cell.2017.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541948PMC
February 2017

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

Cancer Discov 2016 05 25;6(5):501-15. Epub 2016 Mar 25.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861898PMC
May 2016

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.

Blood 2016 Jan 7;127(3):310-3. Epub 2015 Dec 7.

Section of Hematology/Oncology, Department of Medicine, The University of Chicago Medicine Comprehensive Cancer Center, and Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1182/blood-2015-03-635599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722284PMC
January 2016

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.

Blood 2015 Dec 13;126(26):2899-901. Epub 2015 Nov 13.

Department of Medicine, Comprehensive Cancer Center, University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1182/blood-2015-10-673228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692148PMC
December 2015

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Nat Genet 2015 May 30;47(5):539-43. Epub 2015 Mar 30.

1] Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414804PMC
May 2015

Dissecting the role of aberrant DNA methylation in human leukaemia.

Nat Commun 2015 May 22;6:7091. Epub 2015 May 22.

1] Harvard Medical School, Boston, Massachusetts 02115, USA [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA [3] Cancer Science Institute, National University of Singapore, Singapore 66123, Singapore.

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http://dx.doi.org/10.1038/ncomms8091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443494PMC
May 2015

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.

Nat Commun 2014 Nov 17;5:5467. Epub 2014 Nov 17.

Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://www.nature.com/articles/ncomms6467
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http://dx.doi.org/10.1038/ncomms6467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235626PMC
November 2014

The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).

Br J Haematol 2014 Aug 13;166(4):550-6. Epub 2014 Jun 13.

Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/bjh.12964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479678PMC
August 2014

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Nature 2014 Aug 30;512(7513):198-202. Epub 2014 Jul 30.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Hem/Onc Division, University of California San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456040PMC
August 2014

Janet Davidson Rowley (1925-2013).

Cancer Cell 2014 Jan;25(1):1-2

University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL 60637, USA.

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January 2014

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Cancer Discov 2013 Sep 3;3(9):993-1001. Epub 2013 Jun 3.

1Department of Pediatrics and 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California; 3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, 4Department of Biology, David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; 5Department of Pathology, Institute for Genomics and Systems Biology, 6Ben May Department for Cancer Research, 7Section of Hematology/Oncology and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois; 8Department of Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan; and 9Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770749PMC
September 2013

The role of comprehensive cancer centers in survivorship care.

Cancer 2013 Jun;119 Suppl 11:2200-1

Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/cncr.28054DOI Listing
June 2013

PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.

Haematologica 2013 Mar 9;98(3):424-7. Epub 2012 Nov 9.

Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California San Francisco, USA.

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http://dx.doi.org/10.3324/haematol.2011.057067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659942PMC
March 2013

BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.

Cancer Cell 2012 Nov;22(5):567-8

Division of Hematology/Oncology, Northwestern University, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501979PMC
November 2012

The histone code and treatments for acute myeloid leukemia.

N Engl J Med 2012 Mar;366(10):960-1

Section of Hematology and Oncology and the Comprehensive Cancer Center, University of Chicago, Chicago, USA.

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http://dx.doi.org/10.1056/NEJMcibr1113401DOI Listing
March 2012

Myelodysplastic syndromes.

Clin Lab Med 2011 Dec 10;31(4):763-84. Epub 2011 Oct 10.

Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 South Maryland, MC2115, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cll.2011.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340482PMC
December 2011

Prognosis and therapy when acute promyelocytic leukemia and other "good risk" acute myeloid leukemias occur as a therapy-related myeloid neoplasm.

Mediterr J Hematol Infect Dis 2011 8;3(1):e2011032. Epub 2011 Jul 8.

Department of Medicine and Comprehensive Cancer Center, University of Chicago, Chicago IL, USA.

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http://dx.doi.org/10.4084/MJHID.2011.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152454PMC
November 2011

The dawn of the molecular era of the myelodysplastic syndromes.

N Engl J Med 2011 Jun;364(26):2545-6

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http://dx.doi.org/10.1056/NEJMe1102921DOI Listing
June 2011

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.

J Exp Med 2010 Nov 8;207(12):2581-94. Epub 2010 Nov 8.

Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1084/jem.20091071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989761PMC
November 2010

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.

Cell Stem Cell 2010 Aug 8;7(2):174-85. Epub 2010 Jul 8.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.stem.2010.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924905PMC
August 2010

Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.

Chem Biol Interact 2010 Mar 1;184(1-2):50-7. Epub 2009 Dec 1.

Section of Hematology/Oncology, Department of Medicine and the Cancer Research Center, University of Chicago, 5841 S Maryland Ave, MC2115, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cbi.2009.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642715PMC
March 2010

Impaired replication dynamics at the FRA3B common fragile site.

Hum Mol Genet 2010 Jan;19(1):99-110

Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddp470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800779PMC
January 2010

Common fragile sites are characterized by histone hypoacetylation.

Hum Mol Genet 2009 Dec 28;18(23):4501-12. Epub 2009 Aug 28.

Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddp410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773265PMC
December 2009

Tumor suppressor gene inactivation in myeloid malignancies.

Best Pract Res Clin Haematol 2008 Dec;21(4):601-14

Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143 USA.

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http://dx.doi.org/10.1016/j.beha.2008.09.001DOI Listing
December 2008

A critical role for Apc in hematopoietic stem and progenitor cell survival.

J Exp Med 2008 Sep 25;205(9):2163-75. Epub 2008 Aug 25.

Section of Hematology/Oncology and the Cancer Research Center, University of Chicago, Chicago, IL 60637, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20080578
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http://dx.doi.org/10.1084/jem.20080578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526209PMC
September 2008

MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility.

Blood 2008 Aug 21;112(3):741-9. Epub 2008 Apr 21.

Department of Medicine, University of Chicago Cancer Research Center, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1182/blood-2007-11-126508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481552PMC
August 2008

BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Nature 2008 May 13;453(7191):110-4. Epub 2008 Apr 13.

Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature06866DOI Listing
May 2008

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.

Blood 2008 Jan 27;111(2):767-75. Epub 2007 Sep 27.

Ben May Department for Cancer Research, University of Chicago, IL 60611, USA.

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http://dx.doi.org/10.1182/blood-2007-04-085670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200841PMC
January 2008

Cancer: hay in a haystack.

Nature 2008 Jan;451(7176):252-3

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http://dx.doi.org/10.1038/451252aDOI Listing
January 2008

High-throughput mapping of origins of replication in human cells.

EMBO Rep 2007 Aug 13;8(8):770-7. Epub 2007 Jul 13.

Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/sj.embor.7401026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978075PMC
August 2007

A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy.

Blood 2007 May 29;109(9):3963-71. Epub 2006 Dec 29.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2006-09-045583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874577PMC
May 2007

Evaluation of recurring cytogenetic abnormalities in the treatment of myelodysplastic syndromes.

Leuk Res 2007 Apr 11;31(4):427-34. Epub 2006 Dec 11.

Université de Montréal, CHUM Hospital Notre-Dame, 1560 Sherbrooke St E, Montréal, Québec, H2L 4M1, Canada.

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http://dx.doi.org/10.1016/j.leukres.2006.10.023DOI Listing
April 2007

Therapy-related myelodysplastic syndrome: morphologic subclassification may not be clinically relevant.

Am J Clin Pathol 2007 Feb;127(2):197-205

Section of Hematopathology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1309/NQ3PMV4U8YV39JWJDOI Listing
February 2007

Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).

Cancer Res 2007 Feb;67(3):992-1000

Laboratory of Cellular Oncology, National Cancer Institute and National Human Genome Research Institute/NIH, 37 Convent Drive, Bethesda, MD 20892, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-06-2964DOI Listing
February 2007

Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

Blood 2006 Sep 4;108(5):1708-15. Epub 2006 May 4.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2006-04-015040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895511PMC
September 2006

Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities.

Genes Chromosomes Cancer 2006 Mar;45(3):313-8

Department of Pathology, University of Chicago Medical Center, 5841 S. Maryland , MC 0008, Illinois 60637, USA.

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http://dx.doi.org/10.1002/gcc.20287DOI Listing
March 2006

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.

Cancer Cell 2006 Feb;9(2):81-94

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.12.030DOI Listing
February 2006

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.

Cancer Cell 2006 Jan;9(1):57-68

Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.12.014DOI Listing
January 2006

c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.

Blood 2005 Oct 21;106(7):2452-61. Epub 2005 Jun 21.

Department of Medicine and Genetics, Division of Oncology, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1182/blood-2005-02-0734DOI Listing
October 2005

Therapy-related myeloid leukaemia: a model for leukemogenesis in humans.

Chem Biol Interact 2005 May 13;153-154:187-95. Epub 2005 Apr 13.

Section of Hematology/Oncology, Department of Medicine and Cancer Research Center, University of Chicago, MC-2115, 5341 S. Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cbi.2005.03.023DOI Listing
May 2005

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.

Blood 2004 Jun 24;103(11):4243-50. Epub 2004 Feb 24.

Department of Pediatrics, University of California, San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-08-26
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http://dx.doi.org/10.1182/blood-2003-08-2650DOI Listing
June 2004

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Nat Genet 2004 Jun 16;36(6):624-30. Epub 2004 May 16.

Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng1361DOI Listing
June 2004

Multiple unrelated clonal abnormalities in host bone marrow cells after allogeneic stem cell transplantation.

Leuk Res 2004 May;28(5):537-40

Department of Medicine and Cancer Research Center, University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.leukres.2003.09.010DOI Listing
May 2004