Publications by authors named "Michelle A Kelliher"

54Publications

NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies.

Front Immunol 2018 20;9:1718. Epub 2018 Aug 20.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2018.01718
Publisher Site
http://dx.doi.org/10.3389/fimmu.2018.01718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109642PMC
September 2019

BID-ding on necroptosis in MDS.

Blood 2019 01;133(2):103-104

University of Massachusetts Medical School.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-11-886242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328628PMC
January 2019

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Science 2018 11 25;362(6418):1064-1069. Epub 2018 Oct 25.

Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aau2818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522129PMC
November 2018

Analyzing Necroptosis Using an RIPK1 Kinase Inactive Mouse Model of TNF Shock.

Methods Mol Biol 2018 ;1857:125-134

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8754-2_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250063PMC
May 2019

ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data.

BMC Genomics 2018 03 1;19(1):169. Epub 2018 Mar 1.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA, 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-018-4559-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831847PMC
March 2018

RUNX1 is required for oncogenic and enhancer activity in T-cell acute lymphoblastic leukemia.

Blood 2017 10 8;130(15):1722-1733. Epub 2017 Aug 8.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-03-775536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639483PMC
October 2017

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.

Proc Natl Acad Sci U S A 2016 12 12;113(52):15024-15029. Epub 2016 Dec 12.

Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1611798114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206519PMC
December 2016

High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML.

Methods Mol Biol 2016 ;1465:159-73

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA, 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-4011-0_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508520PMC
January 2018

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.

Cell Rep 2016 09 25;16(10):2618-2629. Epub 2016 Aug 25.

Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031082PMC
September 2016

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Science 2016 Aug;353(6299):603-8

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 QiuYue Road, PuDong District, Shanghai, 201210, China.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aaf6803
Publisher Site
http://dx.doi.org/10.1126/science.aaf6803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444917PMC
August 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN.

Cell Rep 2016 06 2;15(11):2449-61. Epub 2016 Jun 2.

Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909532PMC
June 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):14436-41. Epub 2014 Sep 22.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1409389111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209989PMC
October 2014

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Proc Natl Acad Sci U S A 2014 May 5;111(20):7391-6. Epub 2014 May 5.

Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine,Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1403477111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034196PMC
May 2014

Leukemia propagating cells Akt up.

Cancer Cell 2014 Mar;25(3):263-5

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.02.022DOI Listing
March 2014

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ng.2913
Publisher Site
http://dx.doi.org/10.1038/ng.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response.

Innate Immun 2014 May 24;20(4):377-89. Epub 2013 Jul 24.

1Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753425913493453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880408PMC
May 2014

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Nature 2013 Jun 26;498(7453):224-7. Epub 2013 May 26.

Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683390PMC
June 2013

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

Blood 2011 Aug 13;118(6):1579-90. Epub 2011 Jun 13.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-08-300343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156046PMC
August 2011

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.

Mol Cell Biol 2011 Jul 23;31(14):2774-86. Epub 2011 May 23.

Departments of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01139-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133388PMC
July 2011

NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.

PLoS Pathog 2009 Jul 3;5(7):e1000500. Epub 2009 Jul 3.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1000500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698121PMC
July 2009

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

J Biol Chem 2007 Dec 18;282(50):36223-9. Epub 2007 Oct 18.

Department of Pathology, Case Western University School of Medicine, Cleveland, Ohio 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M703079200DOI Listing
December 2007

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Mol Cell Biol 2007 Sep 11;27(17):6012-25. Epub 2007 Jun 11.

Department of Pathology, Case Western Reserve University School of Medicine, Room 5123 Wolstein Research Building, Cleveland, OH 44106, and Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00270-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952158PMC
September 2007

The Notch1/c-Myc pathway in T cell leukemia.

Cell Cycle 2007 Apr 11;6(8):927-30. Epub 2007 Apr 11.

Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/cc.6.8.4134
Publisher Site
http://dx.doi.org/10.4161/cc.6.8.4134DOI Listing
April 2007

NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells.

Cancer Res 2006 Jun;66(12):6008-13

Program in Molecular and Cellular Pharmacology, Department of Pharmacology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-06-0194DOI Listing
June 2006

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.

J Biol Chem 2005 Nov 22;280(44):36560-6. Epub 2005 Aug 22.

Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M506831200
Publisher Site
http://dx.doi.org/10.1074/jbc.M506831200DOI Listing
November 2005

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

J Biol Chem 2005 Jun 15;280(25):23748-57. Epub 2005 Apr 15.

Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/280/25/23748.full.pdf
Web Search
http://www.jbc.org/lookup/doi/10.1074/jbc.M412837200
Publisher Site
http://dx.doi.org/10.1074/jbc.M412837200DOI Listing
June 2005

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

J Biol Chem 2004 Aug 1;279(32):33185-91. Epub 2004 Jun 1.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M404206200DOI Listing
August 2004

The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.

Mol Cell Biol 2003 Nov;23(22):8377-85

Department of Cancer Biology and Interdisciplinary Graduate Program, University of Massachusetts Medical School, Lazare Research Building, Worcester, MA 01605

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC262426PMC
http://dx.doi.org/10.1128/mcb.23.22.8377-8385.2003DOI Listing
November 2003