Michele Vendruscolo

Michele Vendruscolo

UNVERIFIED PROFILE

Are you Michele Vendruscolo?   Register this Author

Register author
Michele Vendruscolo

Michele Vendruscolo

Publications by authors named "Michele Vendruscolo"

Are you Michele Vendruscolo?   Register this Author

100Publications

1671Reads

45Profile Views

Probing the dynamic stalk region of the ribosome using solution NMR.

Sci Rep 2019 Sep 19;9(1):13528. Epub 2019 Sep 19.

Institute of Structural and Molecular Biology, UCL and Birkbeck College London, Gower Street, London, WC1E 6BT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-49190-1DOI Listing
September 2019

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers.

ACS Chem Neurosci 2019 Aug 2;10(8):3464-3478. Epub 2019 Aug 2.

Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) - Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (CSIC) , Universidad Pablo de Olavide , 41092 Seville , Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.9b00088DOI Listing
August 2019

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging .

ACS Chem Biol 2019 Jul 27;14(7):1628-1636. Epub 2019 Jun 27.

Laser Analytics Group, Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge CB3 0AS , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.9b00354DOI Listing
July 2019

The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli.

Cell Rep 2019 Jul;28(5):1335-1345.e6

Department of Cellular Biochemistry, Group Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.06.081DOI Listing
July 2019

Determination of protein structural ensembles using cryo-electron microscopy.

Curr Opin Struct Biol 2019 Jun 28;56:37-45. Epub 2018 Nov 28.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2018.10.006DOI Listing
June 2019

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

Neurosci Lett 2019 Jun 3;704:89-94. Epub 2019 Apr 3.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2019.04.001DOI Listing
June 2019

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.

ACS Chem Biol 2019 Jun 14;14(6):1352-1362. Epub 2019 May 14.

Department of Life Sciences , Imperial College London , London SW7 2AZ , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.9b00312DOI Listing
June 2019

Effects of α-tubulin acetylation on microtubule structure and stability.

Proc Natl Acad Sci U S A 2019 May 9;116(21):10366-10371. Epub 2019 May 9.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1900441116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535015PMC
May 2019

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.

Cell Rep 2019 May;27(9):2759-2771.e5

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre, London SE5 9NU, UK; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193061
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547019PMC
May 2019

The Amyloid Phenomenon and Its Significance in Biology and Medicine.

Cold Spring Harb Perspect Biol 2019 Apr 1. Epub 2019 Apr 1.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
Publisher Site
http://dx.doi.org/10.1101/cshperspect.a033878DOI Listing
April 2019

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming.

Sci Rep 2019 Apr 18;9(1):6256. Epub 2019 Apr 18.

Bioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42348-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472398PMC
April 2019

Atomic force microscopy for single molecule characterisation of protein aggregation.

Arch Biochem Biophys 2019 Mar 8;664:134-148. Epub 2019 Feb 8.

Centre for Misfolding Disease, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom; Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420408PMC
March 2019

Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis.

Cold Spring Harb Perspect Biol 2019 Mar 4. Epub 2019 Mar 4.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a033845DOI Listing
March 2019

Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling.

Structure 2019 Jan 1;27(1):175-188.e6. Epub 2018 Nov 1.

Institut Pasteur, Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, CNRS UMR 3528, C3BI USR 3756 CNRS & IP, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09692126183033
Publisher Site
http://dx.doi.org/10.1016/j.str.2018.09.011DOI Listing
January 2019

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.

Chem Commun (Camb) 2019 Jan 11;55(8):1152-1155. Epub 2019 Jan 11.

KAIST Institute for the BioCentury, Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc09288eDOI Listing
January 2019

A Practical Guide to the Simultaneous Determination of Protein Structure and Dynamics Using Metainference.

Methods Mol Biol 2019 ;2022:313-340

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9608-7_13DOI Listing
January 2019

Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

ACS Chem Neurosci 2018 12 10;9(12):2959-2971. Epub 2018 Aug 10.

Centre for Misfolding Diseases, Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.8b00141DOI Listing
December 2018

Third generation antibody discovery methods: in silico rational design.

Chem Soc Rev 2018 Dec;47(24):9137-9157

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cs00523kDOI Listing
December 2018

Determination of Structural Ensembles of Proteins: Restraining vs Reweighting.

J Chem Theory Comput 2018 Dec 28;14(12):6632-6641. Epub 2018 Nov 28.

Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jctc.8b00738DOI Listing
December 2018

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.

J Vis Exp 2018 11 28(141). Epub 2018 Nov 28.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/58643DOI Listing
November 2018

SAR by kinetics for drug discovery in protein misfolding diseases.

Proc Natl Acad Sci U S A 2018 10 26;115(41):10245-10250. Epub 2018 Sep 26.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1807884115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187117PMC
October 2018

Parapred: antibody paratope prediction using convolutional and recurrent neural networks.

Bioinformatics 2018 09;34(17):2944-2950

Department of Computer Science and Technology, University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bty305DOI Listing
September 2018

A method for partitioning the information contained in a protein sequence between its structure and function.

Proteins 2018 09;86(9):956-964

Center for Complexity and Biosystems and Department of Physics, Università degli Studi di Milano and INFN, via Celoria 16, 20133, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.25527DOI Listing
September 2018

Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach.

Methods 2018 09 21;148:4-8. Epub 2018 Jul 21.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2018.07.005DOI Listing
September 2018

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.

J Mol Biol 2018 08 26;430(16):2288-2292. Epub 2018 Mar 26.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2018.03.015DOI Listing
August 2018

Molecular determinants of the interaction of EGCG with ordered and disordered proteins.

Biopolymers 2018 Aug 30;109(10):e23117. Epub 2018 Mar 30.

Department of Life Sciences, Imperial College London, London, SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23117DOI Listing
August 2018

Structural differences between toxic and nontoxic HypF-N oligomers.

Chem Commun (Camb) 2018 Aug 18;54(62):8637-8640. Epub 2018 Jul 18.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Firenze, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc03446jDOI Listing
August 2018

Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

Sci Rep 2018 Aug 2;8(1):11848. Epub 2018 Aug 2.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-29893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070565PMC
August 2018

Cooperative Assembly of Hsp70 Subdomain Clusters.

Biochemistry 2018 07 29;57(26):3641-3649. Epub 2018 May 29.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.8b00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202011PMC
July 2018

Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs.

PeerJ 2018 4;6:e5125. Epub 2018 Jul 4.

Structural Biology and NMR Laboratory, Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.5125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035720PMC
July 2018

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

Int J Mol Sci 2018 May 12;19(5). Epub 2018 May 12.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19051443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983706PMC
May 2018

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Annu Rev Phys Chem 2018 04 28;69:273-298. Epub 2018 Feb 28.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-physchem-050317-021322DOI Listing
April 2018

Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy.

Biophys J 2018 04;114(7):1604-1613

Department of Chemistry, University of Cambridge, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2018.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954442PMC
April 2018

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Cell 2018 04;173(3):720-734.e15

Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK; Tanz Centre for Research in Neurodegenerative Diseases and Departments of Medicine, Medical Biophysics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3H2, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.03.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927716PMC
April 2018

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

Sci Rep 2017 11 8;7(1):15045. Epub 2017 Nov 8.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-13755-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678089PMC
November 2017

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Chem Sci 2017 Oct 31;8(10):7087-7097. Epub 2017 Aug 31.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: ; Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7sc01965cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637470PMC
October 2017

Methods of probing the interactions between small molecules and disordered proteins.

Cell Mol Life Sci 2017 09 19;74(17):3225-3243. Epub 2017 Jun 19.

Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2563-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533867PMC
September 2017

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.

J Mol Biol 2017 09 22;429(18):2772-2779. Epub 2017 Jul 22.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2017.07.016DOI Listing
September 2017

Rapid and accurate in silico solubility screening of a monoclonal antibody library.

Sci Rep 2017 08 15;7(1):8200. Epub 2017 Aug 15.

Antibody Discovery and Protein Engineering, Medimmune Ltd, Granta Park, Cambridge, CB21 6GH, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-017-07800-w
Publisher Site
http://dx.doi.org/10.1038/s41598-017-07800-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558012PMC
August 2017

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.

Sci Rep 2017 08 22;7(1):9039. Epub 2017 Aug 22.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-08324-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567236PMC
August 2017

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

Proc Natl Acad Sci U S A 2017 07 26;114(28):E5703-E5711. Epub 2017 Jun 26.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1618417114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514703PMC
July 2017

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Proc Natl Acad Sci U S A 2017 07 11;114(30):8005-8010. Epub 2017 Jul 11.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1700239114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544282PMC
July 2017

Amyloid-like Fibrils from an α-Helical Transmembrane Protein.

Biochemistry 2017 06 12;56(25):3225-3233. Epub 2017 Jun 12.

Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.7b00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489960PMC
June 2017

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Proc Natl Acad Sci U S A 2017 06 5;114(25):6444-6449. Epub 2017 Jun 5.

Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE221 00 Lund, Sweden;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1700407114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488933PMC
June 2017

MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.

J Biol Chem 2017 05 23;292(20):8269-8278. Epub 2017 Mar 23.

From the Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.764886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437234PMC
May 2017

Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process.

J Am Chem Soc 2017 05 10;139(20):6899-6910. Epub 2017 May 10.

Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.7b01540DOI Listing
May 2017

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Biochemistry 2017 03 23;56(9):1177-1180. Epub 2017 Feb 23.

Biocomputation and Complex Systems Physics Institute (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza , 50018 Zaragoza, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.6b01178DOI Listing
March 2017

Principles of protein structural ensemble determination.

Curr Opin Struct Biol 2017 02 5;42:106-116. Epub 2017 Jan 5.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2016.12.004DOI Listing
February 2017

Networks of Dynamic Allostery Regulate Enzyme Function.

Structure 2017 02 12;25(2):276-286. Epub 2017 Jan 12.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, 12801 East 17th Avenue, MS 8101, Aurora, CO 80045, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336394PMC
February 2017

Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics.

Sci Rep 2016 08 26;6:31232. Epub 2016 Aug 26.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep31232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999896PMC
August 2016

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.

Biochemistry 2016 06 26;55(22):3116-22. Epub 2016 May 26.

Department of Chemistry, University of Cambridge , Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.6b00149DOI Listing
June 2016

Structure of a low-population binding intermediate in protein-RNA recognition.

Proc Natl Acad Sci U S A 2016 06 10;113(26):7171-6. Epub 2016 Jun 10.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1521349113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932932PMC
June 2016

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain.

J Biol Chem 2016 May 21;291(20):10886-92. Epub 2016 Mar 21.

From the Istituto Pasteur-Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli," Sapienza Università di Roma, 00185 Rome, Italy, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.721126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865933PMC
May 2016

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.

Proc Natl Acad Sci U S A 2016 May 18;113(18):5012-7. Epub 2016 Apr 18.

Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom; Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1519124113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983817PMC
May 2016

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

Proc Natl Acad Sci U S A 2016 Apr 11;113(17):4753-8. Epub 2016 Apr 11.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1516604113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855616PMC
April 2016