Michele P Lambert

Michele P Lambert

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Michele P Lambert

Michele P Lambert

Publications by authors named "Michele P Lambert"

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Immunomodulatory Second-Line Therapies for Immune Thrombocytopenia.

Hamostaseologie 2019 Aug 5;39(3):266-271. Epub 2019 Jun 5.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1055/s-0039-1684032DOI Listing
August 2019

Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.

J Allergy Clin Immunol 2019 Aug 22. Epub 2019 Aug 22.

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.08.007DOI Listing
August 2019

Inherited Platelet Disorders: A Modern Approach to Evaluation and Treatment.

Hematol Oncol Clin North Am 2019 Jun 2;33(3):471-487. Epub 2019 Apr 2.

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Special Coagulation Laboratory, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Frontier Program in Immune Dysregulation, Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588193002
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http://dx.doi.org/10.1016/j.hoc.2019.01.008DOI Listing
June 2019

Association of a positive direct antiglobulin test with chronic immune thrombocytopenia and use of second line therapies in children: A multi-institutional review.

Am J Hematol 2019 Apr 4;94(4):461-466. Epub 2019 Feb 4.

Baylor College of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Houston, Texas.

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http://dx.doi.org/10.1002/ajh.25409DOI Listing
April 2019

More than one pathway: novel treatment for ITP.

Blood 2019 02;133(7):629-630

The Children's Hospital of Philadelphia.

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http://dx.doi.org/10.1182/blood-2018-12-892778DOI Listing
February 2019

Intravenous immunoglobulin use in children with ITP does not affect development of chronic disease.

J Pediatr 2019 Jan;204:320-323

The Children's Hospital of Philadelphia Philadelphia, Pennsylvania.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183158
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http://dx.doi.org/10.1016/j.jpeds.2018.10.076DOI Listing
January 2019

Standardization of prophylactic platelet transfusion dosing in a pediatric oncology population: a quality improvement project.

Transfusion 2018 12 27;58(12):2836-2840. Epub 2018 Sep 27.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.14924DOI Listing
December 2018

The 22q11.2 deletion syndrome: Cancer predisposition, platelet abnormalities and cytopenias.

Am J Med Genet A 2018 10 22;176(10):2121-2127. Epub 2017 Sep 22.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ajmg.a.38474DOI Listing
October 2018

22q and two: 22q11.2 deletion syndrome and coexisting conditions.

Am J Med Genet A 2018 10 23;176(10):2203-2214. Epub 2018 Sep 23.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ajmg.a.40494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467269PMC
October 2018

MYH9-macrothrombocytopenia caused by a novel variant (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia.

Pediatr Blood Cancer 2018 04 29;65(4). Epub 2017 Dec 29.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26949DOI Listing
April 2018

Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk.

Pediatr Blood Cancer 2018 Feb 17;65(2). Epub 2017 Sep 17.

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26812DOI Listing
February 2018

Eltrombopag for use in children with immune thrombocytopenia.

Blood Adv 2018 02;2(4):454-461

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/bloodadvances.2017010660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858473PMC
February 2018

Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets.

Curr Opin Hematol 2017 Nov;24(6):565-571

Division of Hematology, Children's Hospital of Philadelphia and the Department of Pediatrics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764191PMC
November 2017

Therapy induced iron deficiency in children treated with eltrombopag for immune thrombocytopenia.

Am J Hematol 2017 Jun 20;92(6):E88-E91. Epub 2017 Mar 20.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/ajh.24705DOI Listing
June 2017

Clinical updates in adult immune thrombocytopenia.

Blood 2017 05 17;129(21):2829-2835. Epub 2017 Apr 17.

Division of Hematology, University of Washington School of Medicine, Seattle, WA.

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http://dx.doi.org/10.1182/blood-2017-03-754119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813736PMC
May 2017

Platelets in liver and renal disease.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):251-255

Divisions of Hematology, Departments of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/asheducation-2016.1.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142504PMC
December 2016

Multicenter Cohort Study Comparing U.S. Management of Inpatient Pediatric Immune Thrombocytopenia to Current Treatment Guidelines.

Pediatr Blood Cancer 2016 Jul 29;63(7):1227-31. Epub 2016 Feb 29.

Division of Pediatric Hematology, Oncology/Bone Marrow Transplant, Columbia University, New York, New York.

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http://dx.doi.org/10.1002/pbc.25961DOI Listing
July 2016

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood 2016 06 15;127(23):2791-803. Epub 2016 Apr 15.

Department of Haematology, University of Cambridge, National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-12-688267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016734PMC
June 2016

Spotlight on eltrombopag in the treatment of children with chronic immune thrombocytopenia.

Pediatric Health Med Ther 2016 8;7:39-43. Epub 2016 Jun 8.

Division of Hematology, The Children's Hospital of Philadelphia.

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http://dx.doi.org/10.2147/PHMT.S90688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683296PMC
June 2016

Chemotherapy induced thrombocytopenia in pediatric oncology.

Crit Rev Oncol Hematol 2016 Mar 15;99:299-307. Epub 2016 Jan 15.

Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, PA, USA; University of Pennsylvania, Perelman School of Medicine, Department of Pediatrics, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.critrevonc.2016.01.005DOI Listing
March 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/scitranslmed.aad7666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903547PMC
March 2016

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial.

Blood 2016 Jan 26;127(1):17-28. Epub 2015 Oct 26.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2015-07-657981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705607PMC
January 2016

Sports Participation in Children and Adolescents with Immune Thrombocytopenia (ITP).

Pediatr Blood Cancer 2015 Dec 14;62(12):2223-5. Epub 2015 Jul 14.

Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.

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http://dx.doi.org/10.1002/pbc.25644DOI Listing
December 2015

Update on the inherited platelet disorders.

Curr Opin Hematol 2015 Sep;22(5):460-6

The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000171DOI Listing
September 2015

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia.

Blood 2015 Jan 13;125(3):525-33. Epub 2014 Nov 13.

Molecular & Cell Biophysics Laboratory and Graduate Group in Pharmacological Science, University of Pennsylvania, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2014-05-576462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296012PMC
January 2015

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.

Nat Med 2014 Nov 19;20(11):1315-20. Epub 2014 Oct 19.

1] Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. [2] Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA. [3] Mount Sinai School of Medicine, New York, New York, USA. [4] Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1038/nm.3707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258871PMC
November 2014

Influence of the American Society of Hematology guidelines on the management of newly diagnosed childhood immune thrombocytopenia.

JAMA Pediatr 2014 Oct 6;168(10):e142214. Epub 2014 Oct 6.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania5Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamapediatrics.2014.2214DOI Listing
October 2014

Diagnosis and management of autoimmune cytopenias in childhood.

Pediatr Clin North Am 2013 Dec 5;60(6):1489-511. Epub 2013 Oct 5.

Pediatric Hematology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pcl.2013.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384653PMC
December 2013

Challenges and promises for the development of donor-independent platelet transfusions.

Blood 2013 Apr 15;121(17):3319-24. Epub 2013 Jan 15.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.

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http://dx.doi.org/10.1182/blood-2012-09-455428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976218PMC
April 2013

RhIG for the treatment of immune thrombocytopenia: consensus and controversy (CME).

Transfusion 2012 May 7;52(5):1126-36; quiz 1125. Epub 2011 Oct 7.

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA.

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http://doi.wiley.com/10.1111/j.1537-2995.2011.03384.x
Publisher Site
http://dx.doi.org/10.1111/j.1537-2995.2011.03384.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427798PMC
May 2012

A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia.

Am J Hematol 2012 May 3;87(5):532-4. Epub 2012 Mar 3.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/ajh.23138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388505PMC
May 2012

What to do when you suspect an inherited platelet disorder.

Hematology Am Soc Hematol Educ Program 2011 ;2011:377-83

The Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/asheducation-2011.1.377DOI Listing
April 2012

Platelets and eltrombopag: a not-so-sticky situation.

Blood 2012 Apr;119(17):3876-7

University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2012-03-410415DOI Listing
April 2012

Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same?

J Genet Syndr Gene Ther 2011 Nov;Suppl 1(1)

Department of Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4172/2157-7412.S1-001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852407PMC
November 2011

The role of platelet factor 4 in radiation-induced thrombocytopenia.

Int J Radiat Oncol Biol Phys 2011 Aug;80(5):1533-40

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2011.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134787PMC
August 2011

The incidence of thrombocytopenia in children with Cornelia de Lange syndrome.

Am J Med Genet A 2011 Jan 10;155A(1):33-7. Epub 2010 Dec 10.

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://dx.doi.org/10.1002/ajmg.a.33631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058755PMC
January 2011

Childhood ITP: knowing when to worry?

Blood 2009 Nov;114(23):4758-9

University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2009-09-244897DOI Listing
November 2009

TPO-mimetics and myelofibrosis? A reticulin question!

Blood 2009 Oct;114(18):3722-3

University of Pennsylvania, USA.

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http://dx.doi.org/10.1182/blood-2009-09-239863DOI Listing
October 2009

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.

Pediatr Blood Cancer 2008 Feb;50(2):223-6

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pbc.21155DOI Listing
February 2008

Chemokines and thrombogenicity.

Thromb Haemost 2007 May;97(5):722-9

Division of Hematology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd ARC Rm. 316I, Philadelphia, PA 19104, USA.

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May 2007