Publications by authors named "Michele P Lambert"

79Publications

Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and platelet disorders.

Hematology Am Soc Hematol Educ Program 2020 12;2020(1):76-81

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA; and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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December 2020

Population based frequency of naturally occurring loss-of-function variants in genes associated with platelet disorders.

J Thromb Haemost 2021 Jan 23;19(1):248-254. Epub 2020 Oct 23.

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

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January 2021

Updates in diagnosis of the inherited platelet disorders.

Curr Opin Hematol 2020 09;27(5):333-340

Division of Hematology, The Children's Hospital of Philadelphia.

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September 2020

Thrombocytosis in an infant with a mutation: a case report.

Platelets 2020 Apr 22:1-3. Epub 2020 Apr 22.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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April 2020

Glanzmann thrombasthenia: genetic basis and clinical correlates.

Haematologica 2020 04 5;105(4):888-894. Epub 2020 Mar 5.

Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, MO, USA

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April 2020

Neonatal platelet count trends during inhaled nitric oxide therapy.

Br J Haematol 2020 02 15;188(3):e28-e30. Epub 2019 Dec 15.

Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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February 2020

Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.

J Allergy Clin Immunol 2019 12 22;144(6):1660-1673. Epub 2019 Aug 22.

Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. Electronic address:

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December 2019

Immunomodulatory Second-Line Therapies for Immune Thrombocytopenia.

Hamostaseologie 2019 Aug 5;39(3):266-271. Epub 2019 Jun 5.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

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August 2019

Inherited Platelet Disorders: A Modern Approach to Evaluation and Treatment.

Hematol Oncol Clin North Am 2019 06 2;33(3):471-487. Epub 2019 Apr 2.

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Special Coagulation Laboratory, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Frontier Program in Immune Dysregulation, Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

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June 2019

More than one pathway: novel treatment for ITP.

Blood 2019 02;133(7):629-630

The Children's Hospital of Philadelphia.

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February 2019

Intravenous immunoglobulin use in children with ITP does not affect development of chronic disease.

J Pediatr 2019 01;204:320-323

The Children's Hospital of Philadelphia Philadelphia, Pennsylvania.

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January 2019

Standardization of prophylactic platelet transfusion dosing in a pediatric oncology population: a quality improvement project.

Transfusion 2018 12 27;58(12):2836-2840. Epub 2018 Sep 27.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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December 2018

22q and two: 22q11.2 deletion syndrome and coexisting conditions.

Am J Med Genet A 2018 10 23;176(10):2203-2214. Epub 2018 Sep 23.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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October 2018

Eltrombopag for use in children with immune thrombocytopenia.

Blood Adv 2018 02;2(4):454-461

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.

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February 2018

MYH9-macrothrombocytopenia caused by a novel variant (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia.

Pediatr Blood Cancer 2018 04 29;65(4). Epub 2017 Dec 29.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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April 2018

Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets.

Curr Opin Hematol 2017 Nov;24(6):565-571

Division of Hematology, Children's Hospital of Philadelphia and the Department of Pediatrics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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November 2017

The 22q11.2 deletion syndrome: Cancer predisposition, platelet abnormalities and cytopenias.

Am J Med Genet A 2018 10 22;176(10):2121-2127. Epub 2017 Sep 22.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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October 2018

Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk.

Pediatr Blood Cancer 2018 Feb 17;65(2). Epub 2017 Sep 17.

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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February 2018

Clinical updates in adult immune thrombocytopenia.

Blood 2017 05 17;129(21):2829-2835. Epub 2017 Apr 17.

Division of Hematology, University of Washington School of Medicine, Seattle, WA.

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May 2017

Therapy induced iron deficiency in children treated with eltrombopag for immune thrombocytopenia.

Am J Hematol 2017 Jun 20;92(6):E88-E91. Epub 2017 Mar 20.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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June 2017

Platelets in liver and renal disease.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):251-255

Divisions of Hematology, Departments of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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December 2016

Spotlight on eltrombopag in the treatment of children with chronic immune thrombocytopenia.

Pediatric Health Med Ther 2016 8;7:39-43. Epub 2016 Jun 8.

Division of Hematology, The Children's Hospital of Philadelphia.

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June 2016

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood 2016 06 15;127(23):2791-803. Epub 2016 Apr 15.

Department of Haematology, University of Cambridge, National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;

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June 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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March 2016

Multicenter Cohort Study Comparing U.S. Management of Inpatient Pediatric Immune Thrombocytopenia to Current Treatment Guidelines.

Pediatr Blood Cancer 2016 Jul 29;63(7):1227-31. Epub 2016 Feb 29.

Division of Pediatric Hematology, Oncology/Bone Marrow Transplant, Columbia University, New York, New York.

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July 2016

Chemotherapy induced thrombocytopenia in pediatric oncology.

Crit Rev Oncol Hematol 2016 Mar 15;99:299-307. Epub 2016 Jan 15.

Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, PA, USA; University of Pennsylvania, Perelman School of Medicine, Department of Pediatrics, Philadelphia, PA, USA.

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March 2016

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial.

Blood 2016 Jan 26;127(1):17-28. Epub 2015 Oct 26.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

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January 2016

Sports Participation in Children and Adolescents with Immune Thrombocytopenia (ITP).

Pediatr Blood Cancer 2015 Dec 14;62(12):2223-5. Epub 2015 Jul 14.

Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.

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December 2015

Update on the inherited platelet disorders.

Curr Opin Hematol 2015 Sep;22(5):460-6

The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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September 2015

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia.

Blood 2015 Jan 13;125(3):525-33. Epub 2014 Nov 13.

Molecular & Cell Biophysics Laboratory and Graduate Group in Pharmacological Science, University of Pennsylvania, Philadelphia, PA;

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January 2015

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.

Nat Med 2014 Nov 19;20(11):1315-20. Epub 2014 Oct 19.

1] Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. [2] Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA. [3] Mount Sinai School of Medicine, New York, New York, USA. [4] Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

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November 2014

Influence of the American Society of Hematology guidelines on the management of newly diagnosed childhood immune thrombocytopenia.

JAMA Pediatr 2014 Oct 6;168(10):e142214. Epub 2014 Oct 6.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania5Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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October 2014

Diagnosis and management of autoimmune cytopenias in childhood.

Pediatr Clin North Am 2013 Dec 5;60(6):1489-511. Epub 2013 Oct 5.

Pediatric Hematology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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December 2013

Challenges and promises for the development of donor-independent platelet transfusions.

Blood 2013 Apr 15;121(17):3319-24. Epub 2013 Jan 15.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA19104, USA.

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April 2013

Platelets and eltrombopag: a not-so-sticky situation.

Blood 2012 Apr;119(17):3876-7

University of Pennsylvania.

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April 2012

A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia.

Am J Hematol 2012 May 3;87(5):532-4. Epub 2012 Mar 3.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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May 2012

What to do when you suspect an inherited platelet disorder.

Hematology Am Soc Hematol Educ Program 2011 ;2011:377-83

The Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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April 2012

Ectopic platelet-delivered factor (F) VIII for the treatment of Hemophilia A: Plasma and platelet FVIII, is it all the same?

J Genet Syndr Gene Ther 2011 Nov;Suppl 1(1)

Department of Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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November 2011

RhIG for the treatment of immune thrombocytopenia: consensus and controversy (CME).

Transfusion 2012 May 7;52(5):1126-36; quiz 1125. Epub 2011 Oct 7.

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA.

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May 2012

The role of platelet factor 4 in radiation-induced thrombocytopenia.

Int J Radiat Oncol Biol Phys 2011 Aug;80(5):1533-40

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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August 2011

The incidence of thrombocytopenia in children with Cornelia de Lange syndrome.

Am J Med Genet A 2011 Jan 10;155A(1):33-7. Epub 2010 Dec 10.

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, USA.

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January 2011

Childhood ITP: knowing when to worry?

Blood 2009 Nov;114(23):4758-9

University of Pennsylvania.

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November 2009

TPO-mimetics and myelofibrosis? A reticulin question!

Blood 2009 Oct;114(18):3722-3

University of Pennsylvania, USA.

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October 2009

Chemokines and thrombogenicity.

Thromb Haemost 2007 May;97(5):722-9

Division of Hematology, Children's Hospital of Philadelphia, 3615 Civic Center Blvd ARC Rm. 316I, Philadelphia, PA 19104, USA.

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May 2007

A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.

Pediatr Blood Cancer 2008 Feb;50(2):223-6

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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February 2008