Publications Authored by Michele Orini

Non-Invasive Detection of Mechanical Alternans Utilizing Photoplethysmography.

Authors:

Tudor Besleaga Sveeta Badiani Guy Lloyd Nicola Toschi Antonio Canichella Andreas Demosthenous Pier David Lambiase Michele Orini

IEEE J Biomed Health Inform 2019 11 21;23(6):2409-2416. Epub 2018 Nov 21.

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https://ieeexplore.ieee.org/document/8542777/	Publisher Site
http://dx.doi.org/10.1109/JBHI.2018.2882550	DOI Listing

November 2019

Human Emotion Characterization by Heart Rate Variability Analysis Guided by Respiration.

Authors:

Maria Teresa Valderas Yamuza Juan Bolea Michele Orini Pablo Laguna Carlos Orrite Montserrat Vallverdu Raquel Bailon

IEEE J Biomed Health Inform 2019 11 28;23(6):2446-2454. Epub 2019 Jan 28.

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http://dx.doi.org/10.1109/JBHI.2019.2895589	DOI Listing

November 2019

Further Evidence on How to Measure Local Repolarization Time Using Intracardiac Unipolar Electrograms in the Intact Human Heart.

Authors:

Michele Orini Neil Srinivasan Adam J Graham Peter Taggart Pier D Lambiase

Circ Arrhythm Electrophysiol 2019 Nov 8;12(11):e007733. Epub 2019 Nov 8.

Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom (M.O., N.S., A.J.G., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.119.007733	DOI Listing

November 2019

Evaluation of the Re-entry Vulnerability Index to Predict Ventricular Tachycardia Circuits Using High Density Contact Mapping.

Heart Rhythm 2019 Nov 18. Epub 2019 Nov 18.

Institute of Cardiovascular Science, University College London, London, United Kingdom; Electrophysiology Department, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.11.013	DOI Listing

November 2019

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics.

Authors:

Julia Ramírez Stefan van Duijvenboden Nay Aung Pablo Laguna Esther Pueyo Andrew Tinker Pier D Lambiase Michele Orini Patricia B Munroe

Circ Arrhythm Electrophysiol 2019 Oct 14;12(10):e007549. Epub 2019 Oct 14.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry (J.R., S.v.D., A.T., M.O., P.B.M.), Queen Mary University of London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCEP.119.007549	DOI Listing

October 2019

Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children.

Authors:

Javier Milagro Javier Gracia Ville-Pekka Seppa Jussi Karjalainen Marita Paassilta Michele Orini Raquel Bailon Eduardo Gil Jari Viik

IEEE Trans Biomed Eng 2019 Oct 28. Epub 2019 Oct 28.

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http://dx.doi.org/10.1109/TBME.2019.2949873	DOI Listing

October 2019

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Authors:

Malcolm Finlay Justine Bhar-Amato Keat-Eng Ng Diogo Santos Michele Orini Vishal Vyas Peter Taggart Andrew A Grace Christopher L-H Huang Pier D Lambiase Andrew Tinker

Am J Physiol Cell Physiol 2019 Sep 10;317(3):C576-C583. Epub 2019 Jul 10.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1152/ajpcell.00028.2019	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766618	PMC

September 2019

Noninvasive Mapping of the Electrophysiological Substrate in Cardiac Amyloidosis and Its Relationship to Structural Abnormalities.

Authors:

Michele Orini Adam J Graham Ana Martinez-Naharro Christopher M Andrews Antonio de Marvao Ben Statton Stuart A Cook Declan P O'Regan Philip N Hawkins Yoram Rudy Marianna Fontana Pier D Lambiase

J Am Heart Assoc 2019 Sep 8;8(18):e012097. Epub 2019 Sep 8.

Barts Heart Centre Barts Health NHS Trust London United Kingdom.

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http://dx.doi.org/10.1161/JAHA.119.012097	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818012	PMC

September 2019

Differences in the upslope of the precordial body surface ECG T wave reflect right to left dispersion of repolarization in the intact human heart.

Authors:

Neil T Srinivasan Michele Orini Rui Providencia Ron Simon Martin Lowe Oliver R Segal Anthony W Chow Richard J Schilling Ross J Hunter Peter Taggart Pier D Lambiase

Heart Rhythm 2019 Jun 12;16(6):943-951. Epub 2018 Dec 12.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.12.006	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546969	PMC

June 2019

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

Authors:

Michele Orini Joseph Yanni Peter Taggart Ben Hanson Martin Hayward Andrew Smith Henggui Zhang Michael Colman Gareth Jones Xiao Jie Halina Dobrzynski Mark R Boyett Pier D Lambiase

Europace 2019 Jun;21(6):981-989

Institute of Cardiovascular Science, University College London, London, UK.

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http://dx.doi.org/10.1093/europace/euz007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545501	PMC

June 2019

Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans.

Authors:

Stefan van Duijvenboden Ben Hanson Nick Child Pier D Lambiase Christopher A Rinaldi Gill Jaswinder Peter Taggart Michele Orini

Ann Biomed Eng 2019 May 12;47(5):1291-1299. Epub 2019 Feb 12.

Department of Mechanical Engineering, University College London, London, UK.

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http://dx.doi.org/10.1007/s10439-019-02221-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453876	PMC

May 2019

Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models.

Authors:

Fernando O Campos Michele Orini Peter Taggart Ben Hanson Pier D Lambiase Bradley Porter Christopher Aldo Rinaldi Jaswinder Gill Martin J Bishop

Comput Biol Med 2019 May 23;108:263-275. Epub 2019 Mar 23.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: https://kclpure.kcl.ac.uk/portal/martin.bishop.html.

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193009	Publisher Site
http://dx.doi.org/10.1016/j.compbiomed.2019.03.018	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538827	PMC

May 2019

Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation.

Authors:

Neil T Srinivasan Michele Orini Rui Providencia Mehul B Dhinoja Martin D Lowe Syed Y Ahsan Anthony W Chow Ross J Hunter Richard J Schilling Peter Taggart Pier D Lambiase

Europace 2019 Apr;21(4):616-625

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, West Smithfield, London, UK.

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http://dx.doi.org/10.1093/europace/euy260	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452309	PMC

April 2019

Simultaneous Comparison of Electrocardiographic Imaging and Epicardial Contact Mapping in Structural Heart Disease.

Circ Arrhythm Electrophysiol 2019 Apr;12(4):e007120

Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.118.007120	DOI Listing

April 2019

Baroreflex Sensitivity Measured by Pulse Photoplethysmography.

Authors:

Jesús Lázaro Eduardo Gil Michele Orini Pablo Laguna Raquel Bailón

Front Neurosci 2019 18;13:339. Epub 2019 Apr 18.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.3389/fnins.2019.00339	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482265	PMC

April 2019

Structural remodeling and conduction velocity dynamics in the human left atrium: Relationship with reentrant mechanisms sustaining atrial fibrillation.

Authors:

Shohreh Honarbakhsh Richard J Schilling Michele Orini Rui Providencia Emily Keating Malcolm Finlay Simon Sporton Anthony Chow Mark J Earley Pier D Lambiase Ross J Hunter

Heart Rhythm 2019 Jan 17;16(1):18-25. Epub 2018 Jul 17.

Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.07.019	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317307	PMC

January 2019

Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).

Authors:

Richard Ang Svetlana Mastitskaya Patrick S Hosford Marina Basalay Mark Specterman Qadeer Aziz Yiwen Li Michele Orini Peter Taggart Pier D Lambiase Andrey Gourine Andrew Tinker Alexander V Gourine

Circ Arrhythm Electrophysiol 2018 10;11(10):e006740

Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, United Kingdom (R.A., S.M., P.S.H., M.B., A.V.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCEP.118.006740	Publisher Site
http://dx.doi.org/10.1161/CIRCEP.118.006740	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553567	PMC

October 2018

Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.

Authors:

Justine Bhar-Amato Malcolm Finlay Diogo Santos Michele Orini Sanjay Chaubey Vishal Vyas Peter Taggart Andrew A Grace Christopher L-H Huang Ron Ben Simon Andrew Tinker Pier D Lambiase

Circ Arrhythm Electrophysiol 2018 09;11(9):e006330

University College London, United Kingdom (J.B.-A., D.S., M.O., P.T., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.118.006330	DOI Listing

September 2018

Corrigendum to "Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans" [J. Mol. Cell. Cardiol. 97 (2016) 93-105].

Authors:

Esther Pueyo Michele Orini José F Rodríguez Peter Taggart

J Mol Cell Cardiol 2018 08 21;121:305. Epub 2018 May 21.

Institute of Cardiovascular Science, University College London, Gower Street, WC1E 6BT London, United Kingdom.

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http://dx.doi.org/10.1016/j.yjmcc.2018.05.006	DOI Listing

August 2018

A Time-Varying Nonparametric Methodology for Assessing Changes in QT Variability Unrelated to Heart Rate Variability.

Authors:

Michele Orini Esther Pueyo Pablo Laguna Raquel Bailon

IEEE Trans Biomed Eng 2018 07 6;65(7):1443-1451. Epub 2017 Oct 6.

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https://ieeexplore.ieee.org/document/8060992/	Publisher Site
http://dx.doi.org/10.1109/TBME.2017.2758925	DOI Listing

July 2018

In vivo human sock-mapping validation of a simple model that explains unipolar electrogram morphology in relation to conduction-repolarization dynamics.

Authors:

Michele Orini Peter Taggart Pier D Lambiase

J Cardiovasc Electrophysiol 2018 07 3;29(7):990-997. Epub 2018 May 3.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1111/jce.13606	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055721	PMC

July 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:

Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

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http://dx.doi.org/10.1186/s13059-018-1457-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048820	PMC

July 2018

Instantaneous Transfer Entropy for the Study of Cardiovascular and Cardiorespiratory Nonstationary Dynamics.

Authors:

Gaetano Valenza Luca Faes Luca Citi Michele Orini Riccardo Barbieri

IEEE Trans Biomed Eng 2018 05 15;65(5):1077-1085. Epub 2017 Aug 15.

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http://dx.doi.org/10.1109/TBME.2017.2740259	DOI Listing

May 2018

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

Authors:

Julia Ramírez Stefan van Duijvenboden Ioanna Ntalla Borbala Mifsud Helen R Warren Evan Tzanis Michele Orini Andrew Tinker Pier D Lambiase Patricia B Munroe

Nat Commun 2018 05 16;9(1):1947. Epub 2018 May 16.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://www.nature.com/articles/s41467-018-04148-1	Publisher Site
http://dx.doi.org/10.1038/s41467-018-04148-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955978	PMC

May 2018

Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing.

Authors:

Juan Bolea Esther Pueyo Michele Orini Raquel Bailón

Front Physiol 2018 28;9:620. Epub 2018 May 28.

Centro de Investigación Biomédica en Red Bioingeniería Biomateriales y Nanomedicina, Zaragoza, Spain.

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http://dx.doi.org/10.3389/fphys.2018.00620	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985556	PMC

May 2018

Beat-to-Beat Variability of Ventricular Action Potential Duration Oscillates at Low Frequency During Sympathetic Provocation in Humans.

Authors:

Bradley Porter Stefan van Duijvenboden Martin J Bishop Michele Orini Simon Claridge Justin Gould Benjamin J Sieniewicz Baldeep Sidhu Reza Razavi Christopher A Rinaldi Jaswinder S Gill Peter Taggart

Front Physiol 2018 4;9:147. Epub 2018 Apr 4.

Guy's and St Thomas' Hospital, London, United Kingdom.

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http://dx.doi.org/10.3389/fphys.2018.00147	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893843	PMC

April 2018

Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.

Authors:

Michele Orini Andrew Tinker Patricia B Munroe Pier D Lambiase

PLoS One 2018 12;13(2):e0193039. Epub 2018 Feb 12.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193039	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809086	PMC

February 2018

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.

Authors:

Michele Orini Andrew Tinker Patricia B Munroe Pier D Lambiase

PLoS One 2017 5;12(9):e0183732. Epub 2017 Sep 5.

Institute of Cardiovascular Science, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183732	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584807	PMC

October 2017

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model.

Authors:

Julia Ramírez Michele Orini Ana Mincholé Violeta Monasterio Iwona Cygankiewicz Antonio Bayés de Luna Juan Pablo Martínez Pablo Laguna Esther Pueyo

PLoS One 2017 11;12(10):e0186152. Epub 2017 Oct 11.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) group, Aragón Institute of Engineering Research, IIS Aragón, University of Zaragoza, Zaragoza, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186152	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636125	PMC

October 2017

Response by Andrews et al to Letter Regarding Article, "Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging".

Authors:

Christopher M Andrews Neil T Srinivasan Stefania Rosmini Heerajnarain Bulluck Michele Orini Sharon Jenkins Antonis Pantazis William J McKenna James C Moon Pier D Lambiase Yoram Rudy

Circ Arrhythm Electrophysiol 2017 10;10(10)

From the Cardiac Bioelectricity and Arrhythmia Center and Department of Biomedical Engineering (C.M.A., Y.R.) and Cardiovascular Division, Department of Medicine, MO (Y.R.), Washington University in St. Louis, MO; Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom (N.T.S., M.O., S.J., A.P., W.J.M., P.D.L.); and Institute of Cardiovascular Science, University College London, United Kingdom (N.T.S., S.R., H.B., M.O., S.J., A.P., W.J.M., J.C.M., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.117.005768	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687271	PMC

October 2017

Interactions between Activation and Repolarization Restitution Properties in the Intact Human Heart: In-Vivo Whole-Heart Data and Mathematical Description.

Authors:

Michele Orini Peter Taggart Neil Srinivasan Martin Hayward Pier D Lambiase

PLoS One 2016 2;11(9):e0161765. Epub 2016 Sep 2.

Institute of Cardiovascular Science, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161765	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010207	PMC

August 2017

Limitations and Challenges in Mapping Ventricular Tachycardia: New Technologies and Future Directions.

Authors:

Adam J Graham Michele Orini Pier D Lambiase

Arrhythm Electrophysiol Rev 2017 Aug;6(3):118-124

Barts Heart Centre, London.

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http://dx.doi.org/10.15420/aer.2017.20.1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610733	PMC

August 2017

Variability of Ventricular Repolarization Dispersion Quantified by Time-Warping the Morphology of the T-Waves.

Authors:

Julia Ramirez Michele Orini J Derek Tucker Esther Pueyo Pablo Laguna

IEEE Trans Biomed Eng 2017 07 4;64(7):1619-1630. Epub 2016 Oct 4.

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http://ieeexplore.ieee.org/document/7582410/	Publisher Site
http://dx.doi.org/10.1109/TBME.2016.2614899	DOI Listing

July 2017

Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging.

Authors:

Christopher M Andrews Neil T Srinivasan Stefania Rosmini Heerajnarain Bulluck Michele Orini Sharon Jenkins Antonis Pantazis William J McKenna James C Moon Pier D Lambiase Yoram Rudy

Circ Arrhythm Electrophysiol 2017 Jul;10(7)

From the Department of Biomedical Engineering (C.M.A., Y.R.) and Cardiac Bioelectricity and Arrhythmia Center (C.M.A., Y.R.), Washington University, St. Louis, MO; Department of Medicine, Cardiovascular Division, Washington University in St. Louis, MO (Y.R.); Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom (N.T.S., M.O., S.J., A.P., W.J.M., P.D.L.); and Institute of Cardiovascular Science, University College London, United Kingdom (N.T.S., S.R., H.B., M.O., S.J., A.P., W.J.M., J.C.M., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.116.005105	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533087	PMC

July 2017

T-Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure.

Authors:

Julia Ramírez Michele Orini Ana Mincholé Violeta Monasterio Iwona Cygankiewicz Antonio Bayés de Luna Juan Pablo Martínez Esther Pueyo Pablo Laguna

J Am Heart Assoc 2017 May 19;6(5). Epub 2017 May 19.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research, IIS Aragón University of Zaragoza, Spain.

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http://dx.doi.org/10.1161/JAHA.116.005310	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524085	PMC

May 2017

Spatiotemporal characterization of the transition from sinus rhythm to ventricular fibrillation during an acute ischemic event in the intact human heart by whole-heart sock-mapping.

Authors:

Michele Orini Peter Taggart Martin Hayward Pier D Lambiase

HeartRhythm Case Rep 2017 May 20;3(5):259-263. Epub 2017 Feb 20.

Institute of Cardiovascular Science, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.hrcr.2017.01.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509912	PMC

May 2017

Accuracy of measurements derived from intracardiac unipolar electrograms: A simulation study.

Authors:

Stefan van Duijvenboden Michele Orini Peter Taggart Ben Hanson

Conf Proc IEEE Eng Med Biol Soc 2015 ;2015:76-9

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http://dx.doi.org/10.1109/EMBC.2015.7318304	DOI Listing

November 2016

Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing.

Authors:

Juan Bolea Esther Pueyo Michele Orini Raquel Bailón

Front Physiol 2016 15;7:501. Epub 2016 Nov 15.

Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y NanomedicinaZaragoza, Spain; BSICoS Group, Aragón Institute of Engineering Research (I3A), ISS Aragón, Universidad de ZaragozaZaragoza, Spain.

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http://dx.doi.org/10.3389/fphys.2016.00501	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108795	PMC

November 2016

Ventricular stimulus site influences dynamic dispersion of repolarization in the intact human heart.

Authors:

Neil T Srinivasan Michele Orini Ron B Simon Rui Providência Fakhar Z Khan Oliver R Segal Girish G Babu Richard Bradley Edward Rowland Syed Ahsan Anthony W Chow Martin D Lowe Peter Taggart Pier D Lambiase

Am J Physiol Heart Circ Physiol 2016 09 1;311(3):H545-54. Epub 2016 Jul 1.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom; and Institute of Cardiovascular Science, University College London, London, United Kingdom

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http://dx.doi.org/10.1152/ajpheart.00159.2016	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142177	PMC

September 2016

Instantaneous transfer entropy for the study of cardio-respiratory dynamics.

Authors:

Gaetano Valenza Luca Faes Luca Citi Michele Orini Riccardo Barbieri

Conf Proc IEEE Eng Med Biol Soc 2015 ;2015:7885-8

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http://dx.doi.org/10.1109/EMBC.2015.7320220	DOI Listing

August 2016

Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans.

Authors:

Esther Pueyo Michele Orini José F Rodríguez Peter Taggart

J Mol Cell Cardiol 2016 08 11;97:93-105. Epub 2016 May 11.

Institute of Cardiovascular Science, University College London, Gower Street, WC1E 6BT London, United Kingdom.

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http://dx.doi.org/10.1016/j.yjmcc.2016.05.003	DOI Listing

August 2016

Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart.

Authors:

Diogo Santos Michele Orini Xin Zhou Alfonso Bueno-Orovio Ben Hanson Peter Taggart Martin Hayward Blanca Rodriguez Pier Lambiase

Conf Proc IEEE Eng Med Biol Soc 2016 08;2016:157-160

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http://ieeexplore.ieee.org/document/7590664/	Publisher Site
http://dx.doi.org/10.1109/EMBC.2016.7590664	DOI Listing

August 2016

A multivariate time-frequency approach for tracking QT variability changes unrelated to heart rate variability.

Authors:

Michele Orini Peter Taggart Pier D Lambiase

Conf Proc IEEE Eng Med Biol Soc 2016 08;2016:924-927

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http://dx.doi.org/10.1109/EMBC.2016.7590852	DOI Listing

August 2016

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes.

Authors:

Xin Zhou Alfonso Bueno-Orovio Michele Orini Ben Hanson Martin Hayward Peter Taggart Pier D Lambiase Kevin Burrage Blanca Rodriguez

Circ Res 2016 Jan 24;118(2):266-78. Epub 2015 Nov 24.

From the Department of Computer Science, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom (X.Z., A.B.-O., K.B., B.R.); Institute of Cardiovascular Science, University College London, London, United Kingdom (M.O., P.T., P.D.L.); Mechanical Engineering Department, University College London, London, United Kingdom (B.H.); The Heart Hospital, University College London Hospital, London, United Kingdom (M.O., M.H., P.T., P.D.L.); and ACEMS ARC Centre of Excellence and School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia (K.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307836	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719495	PMC

January 2016

Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.

Authors:

Stefan van Duijvenboden Ben Hanson Nick Child Michele Orini Christopher A Rinaldi Jaswinder S Gill Peter Taggart

Am J Physiol Heart Circ Physiol 2015 Dec 16;309(12):H2108-17. Epub 2015 Oct 16.

Institute of Cardiovascular Science, University College London, London, UK

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http://dx.doi.org/10.1152/ajpheart.00560.2015	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698427	PMC

December 2015

Analytical description of the slope of the APD-restitution curve to assess the interacting contribution of conduction and repolarization dynamics.

Authors:

Michele Orini Peter Taggart Martin Hayward Pier D Lambiase

Conf Proc IEEE Eng Med Biol Soc 2015 08;2015:5672-5

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http://dx.doi.org/10.1109/EMBC.2015.7319679	DOI Listing

August 2015

On how 2∶1 conduction block can induce T-wave alternans in the unipolar intracavitary electrogram: Modelling in-vivo human recordings from an ischemic heart.

Authors:

Michele Orini Peter Taggart Martin Hayward Pier Lambiase

Conf Proc IEEE Eng Med Biol Soc 2015 08;2015:5676-9

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http://dx.doi.org/10.1109/EMBC.2015.7319680	DOI Listing

August 2015

Detection of transient, regional cardiac repolarization alternans by time-frequency analysis of synthetic electrograms.

Authors:

Michele Orini Ben Hanson Peter Taggart Pier Lambiase

Conf Proc IEEE Eng Med Biol Soc 2013 ;2013:3773-6

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http://dx.doi.org/10.1109/EMBC.2013.6610365	DOI Listing

June 2015

Oscillatory behavior of ventricular action potential duration in heart failure patients at respiratory rate and low frequency.

Authors:

Ben Hanson Nick Child Stefan Van Duijvenboden Michele Orini Zhong Chen Ruben Coronel Christopher A Rinaldi Jaspal S Gill Jaswinder S Gill Peter Taggart

Front Physiol 2014 28;5:414. Epub 2014 Oct 28.

Institute of Cardiovascular Science, University College London London, UK.

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http://dx.doi.org/10.3389/fphys.2014.00414	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211392	PMC

November 2014

Cardiorespiratory dynamic response to mental stress: a multivariate time-frequency analysis.

Authors:

Devy Widjaja Michele Orini Elke Vlemincx Sabine Van Huffel

Comput Math Methods Med 2013 10;2013:451857. Epub 2013 Dec 10.

KU Leuven, Department of Electrical Engineering (ESAT), STADIUS, Kasteelpark Arenberg 10, P.O. Box 2446, 3001 Leuven, Belgium ; iMinds, Future Health Department, Kasteelpark Arenberg 10, P.O. Box 2446, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1155/2013/451857	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872389	PMC

August 2014

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects.

Authors:

Peter Taggart Michele Orini Ben Hanson Martin Hayward Richard Clayton Halina Dobrzynski Joseph Yanni Mark Boyett Pier D Lambiase

Prog Biophys Mol Biol 2014 Aug 24;115(2-3):252-60. Epub 2014 Jun 24.

The Heart Hospital, University College London, Westmoreland Street, London WIG8PH, UK; Institute of Cardiovascular Science, University College London, UK.

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