Michele Orini

Michele Orini

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Michele Orini

Publications by authors named "Michele Orini"

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Further Evidence on How to Measure Local Repolarization Time Using Intracardiac Unipolar Electrograms in the Intact Human Heart.

Circ Arrhythm Electrophysiol 2019 Nov 8;12(11):e007733. Epub 2019 Nov 8.

Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom (M.O., N.S., A.J.G., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.119.007733DOI Listing
November 2019

Evaluation of the Re-entry Vulnerability Index to Predict Ventricular Tachycardia Circuits Using High Density Contact Mapping.

Heart Rhythm 2019 Nov 18. Epub 2019 Nov 18.

Institute of Cardiovascular Science, University College London, London, United Kingdom; Electrophysiology Department, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.11.013DOI Listing
November 2019

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics.

Circ Arrhythm Electrophysiol 2019 Oct 14;12(10):e007549. Epub 2019 Oct 14.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry (J.R., S.v.D., A.T., M.O., P.B.M.), Queen Mary University of London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCEP.119.007549DOI Listing
October 2019

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome.

Am J Physiol Cell Physiol 2019 Sep 10;317(3):C576-C583. Epub 2019 Jul 10.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1152/ajpcell.00028.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766618PMC
September 2019

Differences in the upslope of the precordial body surface ECG T wave reflect right to left dispersion of repolarization in the intact human heart.

Heart Rhythm 2019 Jun 12;16(6):943-951. Epub 2018 Dec 12.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom; Institute of Cardiovascular Science, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546969PMC
June 2019

Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans.

Ann Biomed Eng 2019 May 12;47(5):1291-1299. Epub 2019 Feb 12.

Department of Mechanical Engineering, University College London, London, UK.

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http://dx.doi.org/10.1007/s10439-019-02221-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453876PMC
May 2019

Simultaneous Comparison of Electrocardiographic Imaging and Epicardial Contact Mapping in Structural Heart Disease.

Circ Arrhythm Electrophysiol 2019 Apr;12(4):e007120

Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom (A.J.G., M.O., G.D., H.D., N.T.S., J.D.L., A. Cambridge, J.G., N.J.O., S.W.-A., M.L., M.F., M.J.E., A. Chow, S.S., M.D., R.J.S., R.J.H., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.118.007120DOI Listing
April 2019

Baroreflex Sensitivity Measured by Pulse Photoplethysmography.

Front Neurosci 2019 18;13:339. Epub 2019 Apr 18.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.3389/fnins.2019.00339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482265PMC
April 2019

Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).

Circ Arrhythm Electrophysiol 2018 10;11(10):e006740

Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology & Pharmacology, University College London, United Kingdom (R.A., S.M., P.S.H., M.B., A.V.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCEP.118.006740
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http://dx.doi.org/10.1161/CIRCEP.118.006740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553567PMC
October 2018

Corrigendum to "Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans" [J. Mol. Cell. Cardiol. 97 (2016) 93-105].

J Mol Cell Cardiol 2018 08 21;121:305. Epub 2018 May 21.

Institute of Cardiovascular Science, University College London, Gower Street, WC1E 6BT London, United Kingdom.

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http://dx.doi.org/10.1016/j.yjmcc.2018.05.006DOI Listing
August 2018

In vivo human sock-mapping validation of a simple model that explains unipolar electrogram morphology in relation to conduction-repolarization dynamics.

J Cardiovasc Electrophysiol 2018 07 3;29(7):990-997. Epub 2018 May 3.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1111/jce.13606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055721PMC
July 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:
Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

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http://dx.doi.org/10.1186/s13059-018-1457-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048820PMC
July 2018

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

Nat Commun 2018 05 16;9(1):1947. Epub 2018 May 16.

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://www.nature.com/articles/s41467-018-04148-1
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http://dx.doi.org/10.1038/s41467-018-04148-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955978PMC
May 2018

Corrigendum: Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing.

Front Physiol 2018 28;9:620. Epub 2018 May 28.

Centro de Investigación Biomédica en Red Bioingeniería Biomateriales y Nanomedicina, Zaragoza, Spain.

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http://dx.doi.org/10.3389/fphys.2018.00620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985556PMC
May 2018

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model.

PLoS One 2017 11;12(10):e0186152. Epub 2017 Oct 11.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) group, Aragón Institute of Engineering Research, IIS Aragón, University of Zaragoza, Zaragoza, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186152PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636125PMC
October 2017

Response by Andrews et al to Letter Regarding Article, "Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging".

Circ Arrhythm Electrophysiol 2017 10;10(10)

From the Cardiac Bioelectricity and Arrhythmia Center and Department of Biomedical Engineering (C.M.A., Y.R.) and Cardiovascular Division, Department of Medicine, MO (Y.R.), Washington University in St. Louis, MO; Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom (N.T.S., M.O., S.J., A.P., W.J.M., P.D.L.); and Institute of Cardiovascular Science, University College London, United Kingdom (N.T.S., S.R., H.B., M.O., S.J., A.P., W.J.M., J.C.M., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.117.005768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687271PMC
October 2017

Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging.

Circ Arrhythm Electrophysiol 2017 Jul;10(7)

From the Department of Biomedical Engineering (C.M.A., Y.R.) and Cardiac Bioelectricity and Arrhythmia Center (C.M.A., Y.R.), Washington University, St. Louis, MO; Department of Medicine, Cardiovascular Division, Washington University in St. Louis, MO (Y.R.); Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom (N.T.S., M.O., S.J., A.P., W.J.M., P.D.L.); and Institute of Cardiovascular Science, University College London, United Kingdom (N.T.S., S.R., H.B., M.O., S.J., A.P., W.J.M., J.C.M., P.D.L.).

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http://dx.doi.org/10.1161/CIRCEP.116.005105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533087PMC
July 2017

T-Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure.

J Am Heart Assoc 2017 May 19;6(5). Epub 2017 May 19.

Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research, IIS Aragón University of Zaragoza, Spain.

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http://dx.doi.org/10.1161/JAHA.116.005310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524085PMC
May 2017

Influence of Heart Rate in Non-linear HRV Indices as a Sampling Rate Effect Evaluated on Supine and Standing.

Front Physiol 2016 15;7:501. Epub 2016 Nov 15.

Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y NanomedicinaZaragoza, Spain; BSICoS Group, Aragón Institute of Engineering Research (I3A), ISS Aragón, Universidad de ZaragozaZaragoza, Spain.

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http://dx.doi.org/10.3389/fphys.2016.00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108795PMC
November 2016

Ventricular stimulus site influences dynamic dispersion of repolarization in the intact human heart.

Am J Physiol Heart Circ Physiol 2016 09 1;311(3):H545-54. Epub 2016 Jul 1.

Department of Cardiac Electrophysiology, The Barts Heart Center, St Bartholomew's Hospital, London, United Kingdom; and Institute of Cardiovascular Science, University College London, London, United Kingdom

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http://dx.doi.org/10.1152/ajpheart.00159.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142177PMC
September 2016

Interactive effect of beta-adrenergic stimulation and mechanical stretch on low-frequency oscillations of ventricular action potential duration in humans.

J Mol Cell Cardiol 2016 08 11;97:93-105. Epub 2016 May 11.

Institute of Cardiovascular Science, University College London, Gower Street, WC1E 6BT London, United Kingdom.

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http://dx.doi.org/10.1016/j.yjmcc.2016.05.003DOI Listing
August 2016

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes.

Circ Res 2016 Jan 24;118(2):266-78. Epub 2015 Nov 24.

From the Department of Computer Science, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom (X.Z., A.B.-O., K.B., B.R.); Institute of Cardiovascular Science, University College London, London, United Kingdom (M.O., P.T., P.D.L.); Mechanical Engineering Department, University College London, London, United Kingdom (B.H.); The Heart Hospital, University College London Hospital, London, United Kingdom (M.O., M.H., P.T., P.D.L.); and ACEMS ARC Centre of Excellence and School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia (K.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719495PMC
January 2016

Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.

Am J Physiol Heart Circ Physiol 2015 Dec 16;309(12):H2108-17. Epub 2015 Oct 16.

Institute of Cardiovascular Science, University College London, London, UK

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http://dx.doi.org/10.1152/ajpheart.00560.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698427PMC
December 2015

Cardiorespiratory dynamic response to mental stress: a multivariate time-frequency analysis.

Comput Math Methods Med 2013 10;2013:451857. Epub 2013 Dec 10.

KU Leuven, Department of Electrical Engineering (ESAT), STADIUS, Kasteelpark Arenberg 10, P.O. Box 2446, 3001 Leuven, Belgium ; iMinds, Future Health Department, Kasteelpark Arenberg 10, P.O. Box 2446, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1155/2013/451857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872389PMC
August 2014

Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: historical perspectives, current progress and future prospects.

Prog Biophys Mol Biol 2014 Aug 24;115(2-3):252-60. Epub 2014 Jun 24.

The Heart Hospital, University College London, Westmoreland Street, London WIG8PH, UK; Institute of Cardiovascular Science, University College London, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2014.06.004DOI Listing
August 2014

Bivariate point process modeling and joint non-stationary analysis of pulse transit time and heart period.

Conf Proc IEEE Eng Med Biol Soc 2012 ;2012:2831-4

GTC, I3A, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.1109/EMBC.2012.6346553DOI Listing
August 2013

Time-frequency phase differences and phase locking to characterize dynamic interactions between cardiovascular signals.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:4689-92

GTC, I3A, IIS Aragón, Universidad de Zaragoza and with CIBER–BBN, Zaragoza, Spain.

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http://dx.doi.org/10.1109/IEMBS.2011.6091161DOI Listing
July 2012

Characterization of dynamic interactions between cardiovascular signals by time-frequency coherence.

IEEE Trans Biomed Eng 2012 Mar 1;59(3):663-73. Epub 2011 Dec 1.

Aragón Institute of Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.1109/TBME.2011.2171959DOI Listing
March 2012

Dynamic assessment of spontaneous baroreflex sensitivity by means of time-frequency analysis using either RR or pulse interval variability.

Conf Proc IEEE Eng Med Biol Soc 2010 ;2010:1630-3

Technology Communication Group, i3A, University of Zaragoza, 50018, Spain.

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http://dx.doi.org/10.1109/IEMBS.2010.5626877DOI Listing
April 2011

Time-varying spectral analysis for comparison of HRV and PPG variability during tilt table test.

Conf Proc IEEE Eng Med Biol Soc 2010 ;2010:3579-82

Communications Technology Group, Aragóln Institute of Engineering Research, University of Zaragoza, Spain.

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http://dx.doi.org/10.1109/IEMBS.2010.5627476DOI Listing
April 2011

The integral pulse frequency modulation model with time-varying threshold: application to heart rate variability analysis during exercise stress testing.

IEEE Trans Biomed Eng 2011 Mar 6;58(3):642-52. Epub 2010 Dec 6.

Communications Technology Group (GTC), Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain.

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http://dx.doi.org/10.1109/TBME.2010.2095011DOI Listing
March 2011

A method for continuously assessing the autonomic response to music-induced emotions through HRV analysis.

Med Biol Eng Comput 2010 May 19;48(5):423-33. Epub 2010 Mar 19.

Communication Technology Group, Aragón Institute of Engineering Research, University of Zaragoza, M. de Luna 1, 50018, Zaragoza, Spain.

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http://dx.doi.org/10.1007/s11517-010-0592-3DOI Listing
May 2010

Time-frequency analysis of cardiac and respiratory parameters for the prediction of ventilator weaning.

Conf Proc IEEE Eng Med Biol Soc 2008 ;2008:2793-6

CIBER de Bioingenierá, Biomateriales y Nanomedicina from ISCIII, Spain.

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http://dx.doi.org/10.1109/IEMBS.2008.4649782DOI Listing
April 2009