Michel Sadelain

Michel Sadelain

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Michel Sadelain

Michel Sadelain

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Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells.

Clin Cancer Res 2019 Jul 12;25(13):4014-4025. Epub 2019 Apr 12.

Department of Haematology, Amsterdam University Medical Centers, Cancer Center Amsterdam, Location VUmc, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2559DOI Listing
July 2019

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.

Sci Transl Med 2019 Jul;11(499)

Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aau5907DOI Listing
July 2019

Publisher Correction: Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.

Nat Med 2019 Mar;25(3):530

Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41591-019-0360-3
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http://dx.doi.org/10.1038/s41591-019-0360-3DOI Listing
March 2019

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.

Nat Med 2019 01 17;25(1):82-88. Epub 2018 Dec 17.

Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-018-0290-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532069PMC
January 2019

Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes.

J Nucl Med 2018 Dec 14;59(12):1894-1900. Epub 2018 Jun 14.

Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.2967/jnumed.118.208041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278895PMC
December 2018

Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape.

Mol Ther 2018 11 13;26(11):2542-2552. Epub 2018 Sep 13.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology Program, Sloan Kettering Institute, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183044
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http://dx.doi.org/10.1016/j.ymthe.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225039PMC
November 2018

Insights into Chimeric Antigen Receptor Therapy for Chronic Lymphoblastic Leukemia.

Trends Mol Med 2018 09 4;24(9):729-731. Epub 2018 Jul 4.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.06.007DOI Listing
September 2018

Autologous CD19-Targeted CAR T Cells in Patients with Residual CLL following Initial Purine Analog-Based Therapy.

Mol Ther 2018 08 15;26(8):1896-1905. Epub 2018 Jun 15.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.ymthe.2018.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094824PMC
August 2018

Chimeric Antigen Receptor Therapy.

N Engl J Med 2018 07;379(1):64-73

From the Center for Cellular Immunotherapies, Perelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia (C.H.J.); and the Center for Cell Engineering, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York (M.S.).

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http://dx.doi.org/10.1056/NEJMra1706169DOI Listing
July 2018

CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.

Nat Med 2018 06 28;24(6):731-738. Epub 2018 May 28.

Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-018-0041-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410714PMC
June 2018

Gene Therapy and Genome Editing.

Hematol Oncol Clin North Am 2018 04 9;32(2):329-342. Epub 2018 Jan 9.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.hoc.2017.11.007DOI Listing
April 2018

Posttransplant chimeric antigen receptor therapy.

Blood 2018 03 22;131(10):1045-1052. Epub 2018 Jan 22.

Center for Cell Engineering and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-08
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http://dx.doi.org/10.1182/blood-2017-08-752121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865610PMC
March 2018

Reprint of: Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR.

Biol Blood Marrow Transplant 2018 Mar;24(3S):S15-S19

Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1016/j.bbmt.2017.12.789DOI Listing
March 2018

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.

N Engl J Med 2018 02;378(5):449-459

From the Leukemia Service, Department of Medicine (J.H.P., C.S., P.M., R.J.B.), the Michael G. Harris Cell Therapy and Cell Engineering Facility (I.R., X.W., B. Sénéchal, Y.W.), the Center for Cell Engineering (J.H.P., I.R., X.W., R.J.B., M.S.), and the Departments of Epidemiology and Biostatistics (M.G.), Pediatrics (K.J.C.), Neurology (B. Santomasso), Anesthesiology and Critical Care Medicine (E.M.), and Pathology (M.R.), Memorial Sloan Kettering Cancer Center, and the Department of Medicine, Joan and Sanford Weill Medical College of Cornell University (J.H.P., C.S., R.J.B.) - all in New York; and the Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center, Tampa, FL (M.D.).

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http://dx.doi.org/10.1056/NEJMoa1709919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637939PMC
February 2018

Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR.

Biol Blood Marrow Transplant 2018 01 13;24(1):27-31. Epub 2017 Oct 13.

Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1016/j.bbmt.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901894PMC
January 2018

Gene therapy comes of age.

Science 2018 01;359(6372)

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1126/science.aan4672DOI Listing
January 2018

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy.

Proc Natl Acad Sci U S A 2018 01 17;115(5):992-997. Epub 2018 Jan 17.

Department of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.1073/pnas.1714900115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798350PMC
January 2018

CD19 CAR T Cells.

Authors:
Michel Sadelain

Cell 2017 Dec;171(7):1471

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.002DOI Listing
December 2017

Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.

Cancer Cell 2017 10;32(4):506-519.e5

Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173040
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http://dx.doi.org/10.1016/j.ccell.2017.09.004DOI Listing
October 2017

Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective.

Mol Ther 2017 05 26;25(5):1117-1124. Epub 2017 Apr 26.

Center for Cell Engineering, Molecular Pharmacology and Immunology Programs, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417838PMC
May 2017

Therapeutic T cell engineering.

Nature 2017 05;545(7655):423-431

Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/nature22395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632949PMC
May 2017

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

Nature 2017 03 22;543(7643):113-117. Epub 2017 Feb 22.

Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, New York, New York 10065, USA.

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http://www.nature.com/articles/nature21405
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http://dx.doi.org/10.1038/nature21405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558614PMC
March 2017

LiPS-A3S, a human genomic site for robust expression of inserted transgenes.

Mol Ther Nucleic Acids 2016 11 29;5(11):e394. Epub 2016 Nov 29.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/mtna.2016.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155331PMC
November 2016

Chimeric antigen receptors: driving immunology towards synthetic biology.

Authors:
Michel Sadelain

Curr Opin Immunol 2016 08 30;41:68-76. Epub 2016 Jun 30.

Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520666PMC
August 2016

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy.

Transl Cancer Res 2016 Aug;5(Suppl 2):S221-S225

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.21037/tcr.2016.08.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558892PMC
August 2016

Biology and clinical application of CAR T cells for B cell malignancies.

Int J Hematol 2016 Jul 4;104(1):6-17. Epub 2016 Jun 4.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/s12185-016-2039-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512169PMC
July 2016

Tales of Antigen Evasion from CAR Therapy.

Authors:
Michel Sadelain

Cancer Immunol Res 2016 06;4(6):473

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0089DOI Listing
June 2016

Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response.

Trends Mol Med 2016 Apr 10;22(4):271-273. Epub 2016 Mar 10.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Memorial Sloan Kettering Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994806PMC
April 2016

Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects.

Hum Gene Ther 2016 Apr;27(4):295-304

1 Center for Cell Engineering, Memorial Sloan Kettering Cancer Center , New York, New York.

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http://dx.doi.org/10.1089/hum.2016.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994056PMC
April 2016

Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.

PLoS One 2015 25;10(6):e0130518. Epub 2015 Jun 25.

Center for Cell Engineering and Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130518PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482147PMC
March 2016

CD19 CAR Therapy for Acute Lymphoblastic Leukemia.

Am Soc Clin Oncol Educ Book 2015 :e360-3

From the Center for Cell Engineering and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.e360DOI Listing
February 2016

Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors.

Cancer Discov 2016 Feb 26;6(2):133-46. Epub 2015 Oct 26.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, New York. Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744527PMC
February 2016

The quest for spatio-temporal control of CAR T cells.

Cell Res 2015 Dec 17;25(12):1281-2. Epub 2015 Nov 17.

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/cr.2015.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670991PMC
December 2015

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.

Cancer Cell 2015 Oct;28(4):415-428

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003056PMC
October 2015

CAR therapy: the CD19 paradigm.

Authors:
Michel Sadelain

J Clin Invest 2015 Sep 1;125(9):3392-400. Epub 2015 Sep 1.

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http://dx.doi.org/10.1172/JCI80010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588281PMC
September 2015

ASGCT and JSGT Joint Position Statement on Human Genomic Editing.

Mol Ther 2015 Aug;23(8):1282

Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; President, ASGCT. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817859PMC
August 2015

The pharmacology of second-generation chimeric antigen receptors.

Nat Rev Drug Discov 2015 Jul;14(7):499-509

1] The Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. [2] Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrd4597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410718PMC
July 2015

Large-scale clinical-grade retroviral vector production in a fixed-bed bioreactor.

J Immunother 2015 Apr;38(3):127-35

*Cell Therapy and Cell Engineering Facility †Molecular Pharmacology and Chemistry Program §Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York ‡Pall Life Sciences, Port Washington, NY.

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http://dx.doi.org/10.1097/CJI.0000000000000072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353472PMC
April 2015

New cell sources for T cell engineering and adoptive immunotherapy.

Cell Stem Cell 2015 Apr;16(4):357-66

The Center for Cell Engineering, Immunology and Molecular Pharmacology and Chemistry Programs, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611846PMC
April 2015

The journey from discoveries in fundamental immunology to cancer immunotherapy.

Cancer Cell 2015 Apr 6;27(4):439-49. Epub 2015 Apr 6.

The Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.007DOI Listing
April 2015

From the guest editor: The rise of CAR therapy: the CD19 paradigm, and beyond. Introduction.

Authors:
Michel Sadelain

Cancer J 2014 Mar-Apr;20(2):105-6

From the Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/PPO.0000000000000042DOI Listing
November 2014

Novel approaches to enhance the specificity and safety of engineered T cells.

Cancer J 2014 Mar-Apr;20(2):160-5

From the *Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, NY; †Tri-Institutional MSTP Program (MSKCC, Rockefeller University, Weill-Cornell Medical College), New York, NY; ‡Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY; and §Department of Genetic Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY.

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http://dx.doi.org/10.1097/PPO.0000000000000040DOI Listing
November 2014

Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity.

Sci Transl Med 2014 Nov;6(261):261ra151

Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373413PMC
November 2014

A cell engineering strategy to enhance the safety of stem cell therapies.

Cell Rep 2014 Sep 18;8(6):1677-1685. Epub 2014 Sep 18.

Cancer Biology & Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177332PMC
September 2014

Highly divergent integration profile of adeno-associated virus serotype 5 revealed by high-throughput sequencing.

J Virol 2014 Mar 11;88(5):2481-8. Epub 2013 Dec 11.

Tri-Institutional MD-PhD Program, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1128/JVI.03419-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958079PMC
March 2014

Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma.

Clin Cancer Res 2014 Feb 13;20(4):1020-8. Epub 2013 Dec 13.

Authors' Affiliations: Division of Thoracic Surgery; Center for Cell Engineering; Departments of Pathology, Epidemiology and Biostatistics, and Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944669PMC
February 2014

Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints.

Virol J 2014 Jan 27;11:15. Epub 2014 Jan 27.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1186/1743-422X-11-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918229PMC
January 2014

PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.

Sci Transl Med 2013 Dec;5(215):215ra172

Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30065
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http://dx.doi.org/10.1126/scitranslmed.3006597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238416PMC
December 2013

CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.

PLoS One 2013 9;8(4):e61338. Epub 2013 Apr 9.

Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621858PMC
October 2013

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy.

Nat Biotechnol 2013 Oct 11;31(10):928-33. Epub 2013 Aug 11.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.2678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722218PMC
October 2013

High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration.

J Virol 2013 Aug 29;87(15):8559-68. Epub 2013 May 29.

Tri-Institutional MD-PhD Program, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1128/JVI.01135-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719808PMC
August 2013

The basic principles of chimeric antigen receptor design.

Cancer Discov 2013 Apr 2;3(4):388-98. Epub 2013 Apr 2.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667586PMC
April 2013

Gene therapy through autologous transplantation of gene-modified hematopoietic stem cells.

Biol Blood Marrow Transplant 2013 Jan 29;19(1 Suppl):S64-9. Epub 2012 Sep 29.

Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.09.021DOI Listing
January 2013

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.

Nat Biotechnol 2013 Jan 16;31(1):71-5. Epub 2012 Dec 16.

Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.2459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505184PMC
January 2013

How do CARs work?: Early insights from recent clinical studies targeting CD19.

Oncoimmunology 2012 Dec;1(9):1577-1583

Center for Cell Engineering; Department of Medicine; Molecular Pharmacology and Chemistry Program; Memorial Sloan-Kettering Cancer Center; New York, NY.

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http://www.tandfonline.com/doi/abs/10.4161/onci.22524
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http://dx.doi.org/10.4161/onci.22524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525612PMC
December 2012

T-cell therapy at the threshold.

Nat Biotechnol 2012 Jul 10;30(7):611-4. Epub 2012 Jul 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nbt.2305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332500PMC
July 2012

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.

Blood 2012 May 21;119(18):4133-41. Epub 2012 Feb 21.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.

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http://dx.doi.org/10.1182/blood-2011-12-400044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359735PMC
May 2012

An in vivo platform for tumor biomarker assessment.

PLoS One 2011 26;6(10):e26722. Epub 2011 Oct 26.

Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026722PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202552PMC
March 2012

Hematopoietic stem cell engineering at a crossroads.

Blood 2012 Feb 17;119(5):1107-16. Epub 2011 Nov 17.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2011-09-349993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277348PMC
February 2012

The potential of stem cells as an in vitro source of red blood cells for transfusion.

Cell Stem Cell 2012 Feb;10(2):115-9

Tisch Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.stem.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676433PMC
February 2012

Safe harbours for the integration of new DNA in the human genome.

Nat Rev Cancer 2011 12 1;12(1):51-8. Epub 2011 Dec 1.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrc3179DOI Listing
December 2011

Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγ mice.

Stem Cells Int 2011 16;2011:673752. Epub 2011 Aug 16.

The Tisch Cancer Institute and Myeloproliferative Disease Research Consortium (MPD-RC), Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1079, New York, NY 10029, USA.

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http://dx.doi.org/10.4061/2011/673752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161306PMC
November 2011

Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma.

Cancer Immunol Immunother 2011 Nov 13;60(11):1509-27. Epub 2011 Sep 13.

Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, NY 10065, USA.

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http://dx.doi.org/10.1007/s00262-011-1103-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268654PMC
November 2011

Eliminating cells gone astray.

Authors:
Michel Sadelain

N Engl J Med 2011 Nov;365(18):1735-7

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http://dx.doi.org/10.1056/NEJMe1109971DOI Listing
November 2011

Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector.

Nat Protoc 2011 Aug 4;6(9):1251-73. Epub 2011 Aug 4.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nprot.2011.374DOI Listing
August 2011

Derivation of genetically modified human pluripotent stem cells with integrated transgenes at unique mapped genomic sites.

Nat Protoc 2011 Aug 4;6(9):1274-89. Epub 2011 Aug 4.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nprot.2011.362DOI Listing
August 2011