Michel Goedert

Michel Goedert

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Michel Goedert

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Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.

Authors:
Isabelle Lavenir Daniela Passarella Masami Masuda-Suzukake Annabelle Curry Janice L Holton Bernardino Ghetti Michel Goedert

Acta Neuropathol Commun 2019 Sep 16;7(1):148. Epub 2019 Sep 16.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1186/s40478-019-0804-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745790PMC
September 2019

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy.

Authors:
Janice C Malcolm Lionel Breuillaud Sonia Do Carmo Hélène Hall Lindsay A Welikovitch Jennifer A Macdonald Michel Goedert A Claudio Cuello

Neurobiol Dis 2019 07 21;127:323-338. Epub 2019 Mar 21.

Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC H3A 2B4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961193007
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http://dx.doi.org/10.1016/j.nbd.2019.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597947PMC
July 2019

Aaron Klug and the study of Alzheimer's disease.

Authors:
Michel Goedert

Alzheimers Dement 2019 Jun 19;15(6):859-861. Epub 2019 Apr 19.

MRC Laboratory of Molecular Biology, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2019.03.001DOI Listing
June 2019

Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice.

Authors:
Zhiva Skachokova Alfonso Martinisi Martin Flach Frederik Sprenger Yvonne Naegelin Viviane Steiner-Monard Marc Sollberger Andreas U Monsch Michel Goedert Markus Tolnay David T Winkler

Acta Neuropathol Commun 2019 May 7;7(1):72. Epub 2019 May 7.

Institute of Medical Genetics and Pathology, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland.

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http://dx.doi.org/10.1186/s40478-019-0725-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503541PMC
May 2019

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.

Authors:
Benjamin Falcon Jasenko Zivanov Wenjuan Zhang Alexey G Murzin Holly J Garringer Ruben Vidal R Anthony Crowther Kathy L Newell Bernardino Ghetti Michel Goedert Sjors H W Scheres

Nature 2019 Apr 20;568(7752):420-423. Epub 2019 Mar 20.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/s41586-019-1026-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472968PMC
April 2019

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord.

Authors:
Jennifer A Macdonald Iraad F Bronner Lesley Drynan Juan Fan Annabelle Curry Graham Fraser Isabelle Lavenir Michel Goedert

Acta Neuropathol Commun 2019 Mar 18;7(1):44. Epub 2019 Mar 18.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1186/s40478-019-0695-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421678PMC
March 2019

Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.

Authors:
Michel Goedert Benjamin Falcon Wenjuan Zhang Bernardino Ghetti Sjors H W Scheres

Cold Spring Harb Symp Quant Biol 2018 18;83:163-171. Epub 2019 Mar 18.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/sqb.2018.83.037580DOI Listing
March 2019

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.

Authors:
Wenjuan Zhang Benjamin Falcon Alexey G Murzin Juan Fan R Anthony Crowther Michel Goedert Sjors Hw Scheres

Elife 2019 Feb 5;8. Epub 2019 Feb 5.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.43584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375701PMC
February 2019

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases.

Authors:
Thomas Mund Masami Masuda-Suzukake Michel Goedert Hugh R Pelham

PLoS One 2018 18;13(7):e0200763. Epub 2018 Jul 18.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200763PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051637PMC
January 2019

Beta-sheet assembly of Tau and neurodegeneration in Drosophila melanogaster.

Authors:
Daniela Passarella Michel Goedert

Neurobiol Aging 2018 12 3;72:98-105. Epub 2018 Aug 3.

MRC Laboratory of Molecular Biology, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327151PMC
December 2018

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.

Authors:
Benjamin Falcon Wenjuan Zhang Manuel Schweighauser Alexey G Murzin Ruben Vidal Holly J Garringer Bernardino Ghetti Sjors H W Scheres Michel Goedert

Acta Neuropathol 2018 11 1;136(5):699-708. Epub 2018 Oct 1.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1007/s00401-018-1914-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208733PMC
November 2018

Rodent models for Alzheimer disease.

Authors:
Jürgen Götz Liviu-Gabriel Bodea Michel Goedert

Nat Rev Neurosci 2018 10;19(10):583-598

Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/s41583-018-0054-8DOI Listing
October 2018

Structures of filaments from Pick's disease reveal a novel tau protein fold.

Authors:
Benjamin Falcon Wenjuan Zhang Alexey G Murzin Garib Murshudov Holly J Garringer Ruben Vidal R Anthony Crowther Bernardino Ghetti Sjors H W Scheres Michel Goedert

Nature 2018 09 29;561(7721):137-140. Epub 2018 Aug 29.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/s41586-018-0454-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204212PMC
September 2018

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia.

Authors:
Jack Brelstaff Aviva M Tolkovsky Bernardino Ghetti Michel Goedert Maria Grazia Spillantini

Cell Rep 2018 08;24(8):1939-1948.e4

Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge, CB2 0AH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161320PMC
August 2018

Neurodegeneration and the ordered assembly of α-synuclein.

Authors:
Maria Grazia Spillantini Michel Goedert

Cell Tissue Res 2018 07 8;373(1):137-148. Epub 2017 Nov 8.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://link.springer.com/10.1007/s00441-017-2706-9
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http://dx.doi.org/10.1007/s00441-017-2706-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015613PMC
July 2018

Tau filaments in neurodegenerative diseases.

Authors:
Michel Goedert

FEBS Lett 2018 07 6;592(14):2383-2391. Epub 2018 Jul 6.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://doi.wiley.com/10.1002/1873-3468.13108
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http://dx.doi.org/10.1002/1873-3468.13108DOI Listing
July 2018

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Authors:
Franziska Kundel Liu Hong Benjamin Falcon William A McEwan Thomas C T Michaels Georg Meisl Noemi Esteras Andrey Y Abramov Tuomas J P Knowles Michel Goedert David Klenerman

ACS Chem Neurosci 2018 06 8;9(6):1276-1282. Epub 2018 Apr 8.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acschemneuro.8b00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014609PMC
June 2018

Galectin-8-mediated selective autophagy protects against seeded tau aggregation.

Authors:
Benjamin Falcon Jessica Noad Harvey McMahon Felix Randow Michel Goedert

J Biol Chem 2018 02 27;293(7):2438-2451. Epub 2017 Dec 27.

From the MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M117.809293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818177PMC
February 2018

Tau Filaments and the Development of Positron Emission Tomography Tracers.

Authors:
Michel Goedert Yoshiki Yamaguchi Sushil K Mishra Makoto Higuchi Naruhiko Sahara

Front Neurol 2018 15;9:70. Epub 2018 Feb 15.

National Institute of Radiological Sciences, Chiba, Japan.

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http://dx.doi.org/10.3389/fneur.2018.00070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818396PMC
February 2018

Parkinson's disease - the story of an eponym.

Authors:
Michel Goedert Alastair Compston

Nat Rev Neurol 2018 01 8;14(1):57-62. Epub 2017 Dec 8.

Department of Clinical Neurosciences, University of Cambridge, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/nrneurol.2017.165DOI Listing
January 2018

What is the evidence that tau pathology spreads through prion-like propagation?

Authors:
Amrit Mudher Morvane Colin Simon Dujardin Miguel Medina Ilse Dewachter Seyedeh Maryam Alavi Naini Eva-Maria Mandelkow Eckhard Mandelkow Luc Buée Michel Goedert Jean-Pierre Brion

Acta Neuropathol Commun 2017 Dec 19;5(1):99. Epub 2017 Dec 19.

Laboratory of Histology, Neuroanatomy and Neuropathology Université Libre de Bruxelles, Faculty of Medicine, ULB Neuroscience Institute (UNI) 808, route de Lennik 1070, Brussels, Belgium.

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http://dx.doi.org/10.1186/s40478-017-0488-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735872PMC
December 2017

The Prion-Like Behavior of Assembled Tau in Transgenic Mice.

Authors:
Florence Clavaguera Markus Tolnay Michel Goedert

Cold Spring Harb Perspect Med 2017 Oct 3;7(10). Epub 2017 Oct 3.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a024372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629990PMC
October 2017

The Synucleinopathies: Twenty Years On.

Authors:
Michel Goedert Ross Jakes Maria Grazia Spillantini

J Parkinsons Dis 2017 ;7(s1):S51-S69

Department of Clinical Neurosciences, Clifford Allbutt Building, Cambridge, AH, UK.

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http://dx.doi.org/10.3233/JPD-179005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345650PMC
October 2017

The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.

Authors:
George K Tofaris Michel Goedert Maria Grazia Spillantini

Cold Spring Harb Perspect Med 2017 Sep 1;7(9). Epub 2017 Sep 1.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1101/cshperspect.a024380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580513PMC
September 2017

Cryo-EM structures of tau filaments from Alzheimer's disease.

Authors:
Anthony W P Fitzpatrick Benjamin Falcon Shaoda He Alexey G Murzin Garib Murshudov Holly J Garringer R Anthony Crowther Bernardino Ghetti Michel Goedert Sjors H W Scheres

Nature 2017 07 5;547(7662):185-190. Epub 2017 Jul 5.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1038/nature23002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552202PMC
July 2017

Propagation of Tau Aggregates and Neurodegeneration.

Authors:
Michel Goedert David S Eisenberg R Anthony Crowther

Annu Rev Neurosci 2017 07;40:189-210

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-neuro-072116-031153DOI Listing
July 2017

Propagation of Tau aggregates.

Authors:
Michel Goedert Maria Grazia Spillantini

Mol Brain 2017 05 30;10(1):18. Epub 2017 May 30.

Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Hills Road, Cambridge, CB2 0AH, UK.

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http://dx.doi.org/10.1186/s13041-017-0298-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450399PMC
May 2017

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.

Authors:
Michel Goedert Masami Masuda-Suzukake Benjamin Falcon

Brain 2017 02 21;140(2):266-278. Epub 2016 Sep 21.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/brain/aww230DOI Listing
February 2017

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

Authors:
William A McEwan Benjamin Falcon Marina Vaysburd Dean Clift Adrian L Oblak Bernardino Ghetti Michel Goedert Leo C James

Proc Natl Acad Sci U S A 2017 01 3;114(3):574-579. Epub 2017 Jan 3.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1607215114
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http://dx.doi.org/10.1073/pnas.1607215114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255578PMC
January 2017

Tau: From research to clinical development.

Authors:
David M Holtzman Maria C Carrillo James A Hendrix Lisa J Bain Ana M Catafau Laura M Gault Michel Goedert Eckhard Mandelkow Eva-Maria Mandelkow David S Miller Susanne Ostrowitzki Manuela Polydoro Sean Smith Marion Wittmann Michael Hutton

Alzheimers Dement 2016 10 4;12(10):1033-1039. Epub 2016 May 4.

Eli Lilly, Inc, Windlesham, Surrey, UK.

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http://dx.doi.org/10.1016/j.jalz.2016.03.018DOI Listing
October 2016

The ordered assembly of tau is the gain-of-toxic function that causes human tauopathies.

Authors:
Michel Goedert

Alzheimers Dement 2016 10 26;12(10):1040-1050. Epub 2016 Sep 26.

MRC Laboratory of Molecular Biology, Cambridge United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.09.001DOI Listing
October 2016

Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.

Authors:
Nadia Mazzaro Erica Barini Maria Grazia Spillantini Michel Goedert Paolo Medini Laura Gasparini

J Neurosci 2016 Feb;36(7):2086-100

Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163 Genova, Italy,

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http://dx.doi.org/10.1523/JNEUROSCI.0774-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756149PMC
February 2016

Why has therapy development for dementia failed in the last two decades?

Authors:
Serge Gauthier Marilyn Albert Nick Fox Michel Goedert Miia Kivipelto Jorge Mestre-Ferrandiz Lefkos T Middleton

Alzheimers Dement 2016 Jan 19;12(1):60-4. Epub 2015 Dec 19.

Neuroepidemiology and Ageing Research, School of Public Health, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.12.003DOI Listing
January 2016

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.

Authors:
Samuel J Jackson Caroline Kerridge Jane Cooper Annalisa Cavallini Benjamin Falcon Claire V Cella Alessia Landi Philip G Szekeres Tracey K Murray Zeshan Ahmed Michel Goedert Michael Hutton Michael J O'Neill Suchira Bose

J Neurosci 2016 Jan;36(3):762-72

Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom, and

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http://dx.doi.org/10.1523/JNEUROSCI.3542-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719013PMC
January 2016

A Brief History of Tau.

Authors:
Michel Goedert Maria Grazia Spillantini R Anthony Crowther

Clin Chem 2015 Nov 1;61(11):1417-8. Epub 2015 Sep 1.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK;

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http://dx.doi.org/10.1373/clinchem.2015.245142DOI Listing
November 2015

Tau silencing by siRNA in the P301S mouse model of tauopathy.

Authors:
Hong Xu Thomas W Rösler Thomas Carlsson Anderson de Andrade Ondrej Fiala Matthias Hollerhage Wolfgang H Oertel Michel Goedert Achim Aigner Gunter U Höglinger

Curr Gene Ther 2014 ;14(5):343-51

Department of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Max-Lebsche-Platz 30, 81377 Munich, Germany.

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October 2015

Piericidin A aggravates Tau pathology in P301S transgenic mice.

Authors:
Matthias Höllerhage Roman Deck Anderson De Andrade Gesine Respondek Hong Xu Thomas W Rösler Mohamed Salama Thomas Carlsson Elizabeth S Yamada Seham A Gad El Hak Michel Goedert Wolfgang H Oertel Günter U Höglinger

PLoS One 2014 1;9(12):e113557. Epub 2014 Dec 1.

Dept. of Neurology, Philipps-Universität, Marburg, Germany; German Center for Neurodegenerative Diseases, Dept. for Translational Neurodegeneration, Munich, Germany; Department of Neurology, Technische Universität München, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113557PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249965PMC
September 2015

Parkinson's disease: Crystals of a toxic core.

Authors:
Michel Goedert Yifan Cheng

Nature 2015 Sep 9;525(7570):458-9. Epub 2015 Sep 9.

Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature15630DOI Listing
September 2015

NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.

Authors:
Michel Goedert

Science 2015 Aug;349(6248):1255555

Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.1255555DOI Listing
August 2015

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates.

Authors:
Therése Klingstedt Hamid Shirani Jasmin Mahler Bettina M Wegenast-Braun Sofie Nyström Michel Goedert Mathias Jucker K Peter R Nilsson

Chemistry 2015 Jun 26;21(25):9072-82. Epub 2015 May 26.

Department of Chemistry, Linköping University, SE-581 83 Linköping (Sweden).

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http://dx.doi.org/10.1002/chem.201500556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517144PMC
June 2015

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.

Authors:
Jack Brelstaff Bernardino Ossola Jonas J Neher Therése Klingstedt K Peter R Nilsson Michel Goedert Maria Grazia Spillantini Aviva M Tolkovsky

Front Neurosci 2015 29;9:184. Epub 2015 May 29.

Department of Clinical Neurosciences, University of Cambridge Cambridge, UK.

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http://dx.doi.org/10.3389/fnins.2015.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448042PMC
June 2015

PART is part of Alzheimer disease.

Authors:
Charles Duyckaerts Heiko Braak Jean-Pierre Brion Luc Buée Kelly Del Tredici Michel Goedert Glenda Halliday Manuela Neumann Maria Grazia Spillantini Markus Tolnay Toshiki Uchihara

Acta Neuropathol 2015 May 28;129(5):749-56. Epub 2015 Jan 28.

Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75651, Paris Cedex 13, France,

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http://dx.doi.org/10.1007/s00401-015-1390-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405349PMC
May 2015

Conformation determines the seeding potencies of native and recombinant Tau aggregates.

Authors:
Benjamin Falcon Annalisa Cavallini Rachel Angers Sarah Glover Tracey K Murray Luanda Barnham Samuel Jackson Michael J O'Neill Adrian M Isaacs Michael L Hutton Philip G Szekeres Michel Goedert Suchira Bose

J Biol Chem 2015 Jan 18;290(2):1049-65. Epub 2014 Nov 18.

Eli Lilly and Co., Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom, and

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http://www.jbc.org/content/290/2/1049.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.589309
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.589309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294473PMC
January 2015

Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.

Authors:
Michel Goedert Ben Falcon Florence Clavaguera Markus Tolnay

Curr Neurol Neurosci Rep 2014 Nov;14(11):495

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK,

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http://dx.doi.org/10.1007/s11910-014-0495-zDOI Listing
November 2014

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

Authors:
Katharina Flach Ellen Ramminger Isabel Hilbrich Annika Arsalan-Werner Franziska Albrecht Lydia Herrmann Michel Goedert Thomas Arendt Max Holzer

Biochim Biophys Acta 2014 Sep 4;1842(9):1527-38. Epub 2014 Jun 4.

Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, 04109 Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311138PMC
September 2014

Parkinson's disease--the debate on the clinical phenomenology, aetiology, pathology and pathogenesis.

Authors:
Peter Jenner Huw R Morris Trevor W Robbins Michel Goedert John Hardy Yoav Ben-Shlomo Paul Bolam David Burn John V Hindle David Brooks

J Parkinsons Dis 2013 ;3(1):1-11

Neurodegenerative Diseases Research Group, Institute of Pharmaceutical Sciences, School of Biomedical Sciences, King's College, London, UK.

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http://dx.doi.org/10.3233/JPD-130175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078250PMC
June 2014

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Authors:
Zeshan Ahmed Jane Cooper Tracey K Murray Katya Garn Emily McNaughton Hannah Clarke Samira Parhizkar Mark A Ward Annalisa Cavallini Samuel Jackson Suchira Bose Florence Clavaguera Markus Tolnay Isabelle Lavenir Michel Goedert Michael L Hutton Michael J O'Neill

Acta Neuropathol 2014 May 16;127(5):667-83. Epub 2014 Feb 16.

Eli Lilly and Company, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK,

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http://dx.doi.org/10.1007/s00401-014-1254-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252866PMC
May 2014

Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).

Authors:
Maria Eugenia Herva Shahin Zibaee Graham Fraser Roger A Barker Michel Goedert Maria Grazia Spillantini

J Biol Chem 2014 Apr 28;289(17):11897-905. Epub 2014 Feb 28.

From the John Van Geest Centre for Brain Repair, E. D. Adrian Building, Robinson Way, Cambridge CB2 0PY, United Kingdom and.

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http://dx.doi.org/10.1074/jbc.M113.542340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002097PMC
April 2014

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons.

Authors:
Mariangela Iovino Ulrich Pfisterer Janice L Holton Tammaryn Lashley Robert J Swingler Laura Calo Rebecca Treacy Tamas Revesz Malin Parmar Michel Goedert Miratul M K Muqit Maria Grazia Spillantini

Acta Neuropathol 2014 Feb 30;127(2):283-95. Epub 2013 Nov 30.

Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00401-013-1219-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895181PMC
February 2014

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice.

Authors:
Florence Clavaguera Jürgen Hench Isabelle Lavenir Gabriel Schweighauser Stephan Frank Michel Goedert Markus Tolnay

Acta Neuropathol 2014 Feb 21;127(2):299-301. Epub 2013 Dec 21.

Department of Neuropathology, Institute of Pathology, University Hospital, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00401-013-1231-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253855PMC
February 2014

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Authors:
Sefika Ozcelik Graham Fraser Perrine Castets Véronique Schaeffer Zhiva Skachokova Karin Breu Florence Clavaguera Michael Sinnreich Ludwig Kappos Michel Goedert Markus Tolnay David Theo Winkler

PLoS One 2013 7;8(5):e62459. Epub 2013 May 7.

Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646815PMC
December 2013

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.

Authors:
Nadine A Hoffmann Mario M Dorostkar Sonja Blumenstock Michel Goedert Jochen Herms

Acta Neuropathol Commun 2013 Dec 17;1:82. Epub 2013 Dec 17.

Department of Translational Brain Research, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1186/2051-5960-1-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880070PMC
December 2013

Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.

Authors:
Manuela Mellone Dimitra Kestoras Melissa R Andrews Elisa Dassie R Anthony Crowther Gorazd B Stokin Jon Tinsley Graeme Horne Michel Goedert Aviva M Tolkovsky Maria Grazia Spillantini

J Neurosci 2013 Nov;33(46):18175-89

John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, United Kingdom, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom, Division of Neurology, University Psychiatric Hospital, SI-1000 Ljubljana, Slovenia, and Summit plc, Abingdon, OX14 4RY, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.4933-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828468PMC
November 2013

Circadian clocks and neurodegenerative diseases: time to aggregate?

Authors:
Michael H Hastings Michel Goedert

Curr Opin Neurobiol 2013 Oct 21;23(5):880-7. Epub 2013 Jun 21.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782660PMC
October 2013

The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.

Authors:
Therése Klingstedt Hamid Shirani K O Andreas Åslund Nigel J Cairns Christina J Sigurdson Michel Goedert K Peter R Nilsson

Chemistry 2013 Jul 18;19(31):10179-92. Epub 2013 Jun 18.

Department of Chemistry, Linköping University, 581 83 Linköping, Sweden.

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http://doi.wiley.com/10.1002/chem.201301463
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http://dx.doi.org/10.1002/chem.201301463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884759PMC
July 2013

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.

Authors:
Christian Schön Nadine A Hoffmann Simon M Ochs Steffen Burgold Severin Filser Sonja Steinbach Mathias W Seeliger Thomas Arzberger Michel Goedert Hans A Kretzschmar Boris Schmidt Jochen Herms

PLoS One 2012 31;7(12):e53547. Epub 2012 Dec 31.

Department of Translational Brain Research, DZNE - German Centre for Neurodegenerative Diseases, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534024PMC
June 2013

Tau pathology and neurodegeneration.

Authors:
Maria Grazia Spillantini Michel Goedert

Lancet Neurol 2013 Jun;12(6):609-22

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S1474-4422(13)70090-5DOI Listing
June 2013

Brain homogenates from human tauopathies induce tau inclusions in mouse brain.

Authors:
Florence Clavaguera Hiroyasu Akatsu Graham Fraser R Anthony Crowther Stephan Frank Jürgen Hench Alphonse Probst David T Winkler Julia Reichwald Matthias Staufenbiel Bernardino Ghetti Michel Goedert Markus Tolnay

Proc Natl Acad Sci U S A 2013 Jun 20;110(23):9535-40. Epub 2013 May 20.

Department of Neuropathology, Institute of Pathology, University Hospital, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.1301175110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677441PMC
June 2013

"Prion-like" templated misfolding in tauopathies.

Authors:
Florence Clavaguera Isabelle Lavenir Ben Falcon Stephan Frank Michel Goedert Markus Tolnay

Brain Pathol 2013 May;23(3):342-9

Department of Neuropathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/bpa.12044DOI Listing
May 2013

The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1.

Authors:
Kyle L Morris Shahin Zibaee Lin Chen Michel Goedert Pawel Sikorski Louise C Serpell

Angew Chem Int Ed Engl 2013 Feb 10;52(8):2279-83. Epub 2013 Jan 10.

School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QG, UK.

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http://dx.doi.org/10.1002/anie.201207699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279883PMC
February 2013

100 years of Lewy pathology.

Authors:
Michel Goedert Maria Grazia Spillantini Kelly Del Tredici Heiko Braak

Nat Rev Neurol 2013 01 27;9(1):13-24. Epub 2012 Nov 27.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/nrneurol.2012.242DOI Listing
January 2013

Polystyrene microsphere and 5-fluorouracil release from custom-designed wound dressing films.

Authors:
Maryam Mobed-Miremadi Raki Komarla Nagendra Sujana Lakshmi Ramachandruni Jason James Rook Mallika Keralapura Michel Goedert

Prog Biomater 2013 Jan 24;2(1). Epub 2013 Jan 24.

Department of Biomedical, Chemical and Materials Engineering, San Jose State University, San Jose, CA, 95192-0082, USA.

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http://dx.doi.org/10.1186/2194-0517-2-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151105PMC
January 2013

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy.

Authors:
Véronique Schaeffer Michel Goedert

Autophagy 2012 Nov 9;8(11):1686-7. Epub 2012 Aug 9.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.4161/auto.21488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494601PMC
November 2012

Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.

Authors:
Natalie D Bull Alessandra Guidi Michel Goedert Keith R Martin Maria Grazia Spillantini

PLoS One 2012 4;7(4):e34724. Epub 2012 Apr 4.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034724PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319610PMC
August 2012

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.

Authors:
Véronique Schaeffer Isabelle Lavenir Sefika Ozcelik Markus Tolnay David T Winkler Michel Goedert

Brain 2012 Jul 10;135(Pt 7):2169-77. Epub 2012 Jun 10.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/brain/aws143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381726PMC
July 2012

Frontotemporal dementia: implications for understanding Alzheimer disease.

Authors:
Michel Goedert Bernardino Ghetti Maria Grazia Spillantini

Cold Spring Harb Perspect Med 2012 Feb;2(2):a006254

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a006254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281593PMC
February 2012

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

Authors:
Hirotaka Yoshida Michel Goedert

J Neurochem 2012 Jan 11;120(1):165-76. Epub 2011 Nov 11.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07523.xDOI Listing
January 2012

Pathogenesis of the tauopathies.

Authors:
Michel Goedert Maria Grazia Spillantini

J Mol Neurosci 2011 Nov 23;45(3):425-31. Epub 2011 Jul 23.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1007/s12031-011-9593-4DOI Listing
November 2011

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.

Authors:
Laura Gasparini R Anthony Crowther Keith R Martin Nicola Berg Michael Coleman Michel Goedert Maria Grazia Spillantini

Neurobiol Aging 2011 Mar 7;32(3):419-33. Epub 2009 Apr 7.

Cambridge Centre for Brain Repair, The University of Cambridge, Robinson Way, Forvie site, Cambridge CB2 0PY, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.03.002DOI Listing
March 2011

Human beta-synuclein rendered fibrillogenic by designed mutations.

Authors:
Shahin Zibaee Graham Fraser Ross Jakes David Owen Louise C Serpell R Anthony Crowther Michel Goedert

J Biol Chem 2010 Dec 10;285(49):38555-67. Epub 2010 Sep 10.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.160721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992288PMC
December 2010

The propagation of prion-like protein inclusions in neurodegenerative diseases.

Authors:
Michel Goedert Florence Clavaguera Markus Tolnay

Trends Neurosci 2010 Jul 20;33(7):317-25. Epub 2010 May 20.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tins.2010.04.003DOI Listing
July 2010

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.

Authors:
Pablo Garcia-Reitböck Oleg Anichtchik Arianna Bellucci Mariangela Iovino Chiara Ballini Elena Fineberg Bernardino Ghetti Laura Della Corte PierFranco Spano George K Tofaris Michel Goedert Maria Grazia Spillantini

Brain 2010 Jul 9;133(Pt 7):2032-44. Epub 2010 Jun 9.

Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.

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http://dx.doi.org/10.1093/brain/awq132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892942PMC
July 2010

Cell-mediated neuroprotection in a mouse model of human tauopathy.

Authors:
David W Hampton Daniel J Webber Bilada Bilican Michel Goedert Maria Grazia Spillantini Siddharthan Chandran

J Neurosci 2010 Jul;30(30):9973-83

Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0834-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633376PMC
July 2010

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Authors:
Janaky Coomaraswamy Ellen Kilger Heidrun Wölfing Claudia Schäfer Stephan A Kaeser Bettina M Wegenast-Braun Jasmin K Hefendehl Hartwig Wolburg Matthew Mazzella Jorge Ghiso Michel Goedert Haruhiko Akiyama Francisco Garcia-Sierra David P Wolfer Paul M Mathews Mathias Jucker

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7969-74. Epub 2010 Apr 12.

Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1073/pnas.1001056107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867864PMC
April 2010

Early behavioural markers of disease in P301S tau transgenic mice.

Authors:
Maria Luisa Scattoni Laura Gasparini Enrico Alleva Michel Goedert Gemma Calamandrei Maria Grazia Spillantini

Behav Brain Res 2010 Mar 11;208(1):250-7. Epub 2009 Dec 11.

Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bbr.2009.12.002DOI Listing
March 2010

A role for FKBP52 in Tau protein function.

Authors:
Béatrice Chambraud Elodie Sardin Julien Giustiniani Omar Dounane Michael Schumacher Michel Goedert Etienne-Emile Baulieu

Proc Natl Acad Sci U S A 2010 Feb 25;107(6):2658-63. Epub 2010 Jan 25.

Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 788, Université Paris XI, Kremlin Bicêtre 94276, France.

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http://dx.doi.org/10.1073/pnas.0914957107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823896PMC
February 2010

[Induction and spreading of tau pathology in a mouse model of Alzheimer's disease].

Authors:
Florence Clavaguera Michel Goedert Markus Tolnay

Med Sci (Paris) 2010 Feb;26(2):121-4

Department of Neuropathology, Schönbeinstrasse 40, CH-4031 Basel, Suisse.

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http://dx.doi.org/10.1051/medsci/2010262121DOI Listing
February 2010

Transmission and spreading of tauopathy in transgenic mouse brain.

Authors:
Florence Clavaguera Tristan Bolmont R Anthony Crowther Dorothee Abramowski Stephan Frank Alphonse Probst Graham Fraser Anna K Stalder Martin Beibel Matthias Staufenbiel Mathias Jucker Michel Goedert Markus Tolnay

Nat Cell Biol 2009 Jul 7;11(7):909-13. Epub 2009 Jun 7.

Department of Neuropathology, Institute of Pathology, University of Basel, Switzerland.

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http://dx.doi.org/10.1038/ncb1901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726961PMC
July 2009

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.

Authors:
Makiko Yamashita Takashi Nonaka Tetsuaki Arai Fuyuki Kametani Vladimir L Buchman Natalia Ninkina Sergey O Bachurin Haruhiko Akiyama Michel Goedert Masato Hasegawa

FEBS Lett 2009 Jul 26;583(14):2419-24. Epub 2009 Jun 26.

Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.

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http://doi.wiley.com/10.1016/j.febslet.2009.06.042
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July 2009

Oskar Fischer and the study of dementia.

Authors:
Michel Goedert

Brain 2009 Apr 24;132(Pt 4):1102-11. Epub 2008 Oct 24.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/brain/awn256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668940PMC
April 2009

Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

Authors:
Masami Masuda Masato Hasegawa Takashi Nonaka Takayuki Oikawa Motokuni Yonetani Yoshiki Yamaguchi Koichi Kato Shin-Ichi Hisanaga Michel Goedert

FEBS Lett 2009 Feb 4;583(4):787-91. Epub 2009 Feb 4.

Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.

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http://dx.doi.org/10.1016/j.febslet.2009.01.037DOI Listing
February 2009

White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.

Authors:
Gabor G Kovacs Katalin Majtenyi Salvatore Spina Jill R Murrell Ellen Gelpi Romana Hoftberger Graham Fraser R Anthony Crowther Michel Goedert Herbert Budka Bernardino Ghetti

J Neuropathol Exp Neurol 2008 Oct;67(10):963-75

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1097/NEN.0b013e318187a80fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785030PMC
October 2008

In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.

Authors:
Liang Ye Ana Velasco Graham Fraser Thomas G Beach Lucia Sue Tracy Osredkar Vincenzo Libri Maria Grazia Spillantini Michel Goedert Andrew Lockhart

J Neurochem 2008 May 21;105(4):1428-37. Epub 2008 Jan 21.

GlaxoSmithKline, Clinical Science and Technology, Neurology DM, New Frontiers Science Park, Harlow, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05245.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408655PMC
May 2008

The value of incomplete mouse models of Alzheimer's disease.

Authors:
Rebecca Radde Cecilia Duma Michel Goedert Mathias Jucker

Eur J Nucl Med Mol Imaging 2008 Mar;35 Suppl 1:S70-4

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00259-007-0704-yDOI Listing
March 2008

Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene].

Authors:
Ana Velasco Graham Fraser Patrice Delobel Bernardino Ghetti Isabelle Lavenir Michel Goedert

FEBS Lett 2008 Mar 20;582(6):901-6. Epub 2008 Feb 20.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.febslet.2008.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726283PMC
March 2008

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.

Authors:
Salvatore Spina Martin R Farlow Frederick W Unverzagt David A Kareken Jill R Murrell Graham Fraser Francine Epperson R Anthony Crowther Maria G Spillantini Michel Goedert Bernardino Ghetti

Brain 2008 Jan 7;131(Pt 1):72-89. Epub 2007 Dec 7.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/brain/awm280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702832PMC
January 2008

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.

Authors:
Patrice Delobel Isabelle Lavenir Graham Fraser Esther Ingram Max Holzer Bernardino Ghetti Maria Grazia Spillantini R Anthony Crowther Michel Goedert

Am J Pathol 2008 Jan 13;172(1):123-31. Epub 2007 Dec 13.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, UK.

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http://dx.doi.org/10.2353/ajpath.2008.070627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189621PMC
January 2008

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.

Authors:
Shahin Zibaee Ross Jakes Graham Fraser Louise C Serpell R Anthony Crowther Michel Goedert

J Mol Biol 2007 Nov 20;374(2):454-64. Epub 2007 Sep 20.

MRC Laboratory of Molecular Biology, Cambridge,CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2007.09.039DOI Listing
November 2007

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.

Authors:
Aasami Ishii Takashi Nonaka Sayuri Taniguchi Taro Saito Tetsuaki Arai David Mann Takeshi Iwatsubo Shin-Ichi Hisanaga Michel Goedert Masato Hasegawa

FEBS Lett 2007 Oct 6;581(24):4711-7. Epub 2007 Sep 6.

Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan.

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http://dx.doi.org/10.1016/j.febslet.2007.08.067DOI Listing
October 2007

Interaction of tau protein with the dynactin complex.

Authors:
Enrico Magnani Juan Fan Laura Gasparini Matthew Golding Meredith Williams Giampietro Schiavo Michel Goedert Linda A Amos Maria Grazia Spillantini

EMBO J 2007 Oct 11;26(21):4546-54. Epub 2007 Oct 11.

Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063488PMC
October 2007

Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.

Authors:
Kanwar Virdee Hirotaka Yoshida Sew Peak-Chew Michel Goedert

FEBS Lett 2007 Jun 11;581(14):2657-62. Epub 2007 May 11.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.febslet.2007.05.009DOI Listing
June 2007

A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone.

Authors:
Shahin Zibaee O Sumner Makin Michel Goedert Louise C Serpell

Protein Sci 2007 May;16(5):906-18

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1110/ps.062624507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206631PMC
May 2007

The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.

Authors:
Salvatore Spina Jill R Murrell Hirotaka Yoshida Bernardino Ghetti Niamh Bermingham Brian Sweeney Stephen R Dlouhy R Anthony Crowther Michel Goedert Catherine Keohane

Acta Neuropathol 2007 Apr 22;113(4):461-70. Epub 2006 Dec 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive MS A138, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1007/s00401-006-0182-5DOI Listing
April 2007

Alois Alzheimer: his life and times.

Authors:
Michel Goedert Bernardino Ghetti

Brain Pathol 2007 Jan;17(1):57-62

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00056.xDOI Listing
January 2007

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.

Authors:
Kerensa Broersen Daan van den Brink Graham Fraser Michel Goedert Bazbek Davletov

Biochemistry 2006 Dec 7;45(51):15610-6. Epub 2006 Dec 7.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://pubs.acs.org/doi/abs/10.1021/bi061743l
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http://dx.doi.org/10.1021/bi061743lDOI Listing
December 2006

Frontotemporal lobar degeneration through loss of progranulin function.

Authors:
Michel Goedert Maria Grazia Spillantini

Brain 2006 Nov;129(Pt 11):2808-10

MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK.

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http://dx.doi.org/10.1093/brain/awl291DOI Listing
November 2006

A century of Alzheimer's disease.

Authors:
Michel Goedert Maria Grazia Spillantini

Science 2006 Nov;314(5800):777-81

Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1126/science.1132814DOI Listing
November 2006

Tau protein, the paired helical filament and Alzheimer's disease.

Authors:
Michel Goedert Aaron Klug R Anthony Crowther

J Alzheimers Dis 2006 ;9(3 Suppl):195-207

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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October 2006

Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD).

Authors:
Maria Grazia Spillantini Jill R Murrell Michel Goedert Martin Farlow Aaron Klug Bernardino Ghetti

J Alzheimers Dis 2006 ;9(3 Suppl):373-80

Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK.

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October 2006

Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.

Authors:
Hirotaka Yoshida Michel Goedert

J Neurochem 2006 Oct;99(1):154-64

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04052.xDOI Listing
October 2006