Michel C Nussenzweig

Michel C Nussenzweig

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Michel C Nussenzweig

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J Exp Med 2020 05;217(5)

Executive Editor, Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20200567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105390PMC
May 2020

JEM goes viral.

J Exp Med 2020 Feb;217(2)

Executive Editor, Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20200046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041700PMC
February 2020

Editorial Board: Expanding on the basis of cancer.

J Exp Med 2019 Aug 1;216(8):1725. Epub 2019 Jul 1.

Executive Editor, Journal of Experimental Medicine

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http://dx.doi.org/10.1084/jem.20191171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683983PMC
August 2019

Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity.

Immunity 2019 08 23;51(2):324-336.e5. Epub 2019 Jul 23.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute (HHMI), The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703930PMC
August 2019

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic.

Nat Med 2019 04 1;25(4):547-553. Epub 2019 Apr 1.

Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-019-0412-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322694PMC
April 2019

Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion.

Cell Host Microbe 2018 10;24(4):579-592.e4

Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185872PMC
October 2018

Redemption for self-reactive antibodies.

Science 2018 04;360(6385):152-153

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aat5758DOI Listing
April 2018

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.

Cell 2017 Aug 27;170(4):637-648.e10. Epub 2017 Jul 27.

Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173076
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http://dx.doi.org/10.1016/j.cell.2017.06.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554461PMC
August 2017

JEM Advisory Editorial Board: Increasing diversity.

J Exp Med 2017 Aug;214(8):2169

Executive Editor, The Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20171220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551585PMC
August 2017

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.

Elife 2017 05 26;6. Epub 2017 May 26.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.

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http://dx.doi.org/10.7554/eLife.27389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472438PMC
May 2017

HIV: Persistence through division.

J Exp Med 2017 04 27;214(4):875-876. Epub 2017 Mar 27.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065 and Howard Hughes Medical Institute, Chevy Chase, MD 20815.

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http://dx.doi.org/10.1084/jem.20170463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379988PMC
April 2017

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.

J Exp Med 2017 03 8;214(3):815-831. Epub 2017 Feb 8.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20161638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339680PMC
March 2017

Progress toward active or passive HIV-1 vaccination.

J Exp Med 2017 01 21;214(1):3-16. Epub 2016 Dec 21.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065

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http://www.jem.org/lookup/doi/10.1084/jem.20161765
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http://dx.doi.org/10.1084/jem.20161765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206506PMC
January 2017

A time of change.

J Exp Med 2017 Jan;214(1):1-2

Executive Editor, The Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20162116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206507PMC
January 2017

Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs.

J Exp Med 2016 12 18;213(13):2861-2870. Epub 2016 Nov 18.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065.

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http://dx.doi.org/10.1084/jem.20161135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154947PMC
December 2016

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy.

N Engl J Med 2016 Nov 9;375(21):2019-2021. Epub 2016 Nov 9.

From the Laboratory of Molecular Immunology (M.C., M.C.N.) and the Howard Hughes Medical Institute (M.C.N.), Rockefeller University, New York; and the Laboratory of Experimental Immunology, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, and the German Center for Infection Research, partner site Bonn-Cologne - all in Cologne, Germany (F.K.).

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http://www.nejm.org/doi/10.1056/NEJMp1613362
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http://dx.doi.org/10.1056/NEJMp1613362DOI Listing
November 2016

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.

Nat Protoc 2016 Oct 15;11(10):1908-1923. Epub 2016 Sep 15.

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nprot.2016.102DOI Listing
October 2016

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Immunity 2016 09 8;45(3):483-496. Epub 2016 Sep 8.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040827PMC
http://dx.doi.org/10.1016/j.immuni.2016.08.016DOI Listing
September 2016

Inducible targeting of cDCs and their subsets in vivo.

J Immunol Methods 2016 07 9;434:32-8. Epub 2016 Apr 9.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, USA.

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http://dx.doi.org/10.1016/j.jim.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902770PMC
July 2016

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency.

Cell 2016 Jun;165(7):1609-1620

Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970321PMC
June 2016

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.

Immunity 2016 Apr 2;44(4):769-81. Epub 2016 Mar 2.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065 USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838502PMC
April 2016

Human studies at JEM: Immunology and beyond.

J Exp Med 2016 Apr 14;213(4):467-8. Epub 2016 Mar 14.

Editors, The Journal of Experimental Medicine

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http://dx.doi.org/10.1084/jem.20160211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821652PMC
April 2016

Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation.

J Exp Med 2016 Apr 21;213(4):517-34. Epub 2016 Mar 21.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065 Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10065

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http://dx.doi.org/10.1084/jem.20160062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821651PMC
April 2016

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1.

J Acquir Immune Defic Syndr 2016 Mar;71(3):237-45

*Université François Rabelais, Inserm U966, Tours, France; †Université de Rouen and CHU Charles Nicolle, Rouen, France; ‡Laboratoire de Virologie, Hôpital St Louis, Paris, France; §Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY; ‖Vaccine Research Center, National Institutes of Health, Bethesda, MD; ¶Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA; #California Institute of Technology, CA; **Laboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France; ††Howard Hughes Medical Institute, The Rockefeller University, New York, NY; ‡‡CRCM, Inserm U1068; Institut Paoli-Calmettes; CNRS UMR7258; AMU UM105; Marseille, France; and §§Laboratoire de Bactériologie-Virologie, Centre National de Référence du VIH, CHU Bretonneau, Tours, France.

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http://dx.doi.org/10.1097/QAI.0000000000000854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770367PMC
March 2016

A New Way to Diversify Antibodies by DNA Transposition.

Cell 2016 Feb;164(4):601-2

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30045-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741630045
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http://dx.doi.org/10.1016/j.cell.2016.01.031DOI Listing
February 2016

Clonal analysis of human dendritic cell progenitor using a stromal cell culture.

J Immunol Methods 2015 Oct 6;425:21-26. Epub 2015 Jun 6.

Columbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604063PMC
October 2015

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

PLoS Pathog 2015 Oct 30;11(10):e1005238. Epub 2015 Oct 30.

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627763PMC
October 2015

Defining human dendritic cell progenitors by multiparametric flow cytometry.

Nat Protoc 2015 Sep 20;10(9):1407-22. Epub 2015 Aug 20.

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nprot.2015.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607256PMC
September 2015

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Nature 2015 Sep 26;525(7567):134-139. Epub 2015 Aug 26.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nature14970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165PMC
September 2015

HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.

Science 2015 Aug 16;349(6248):643-6. Epub 2015 Jul 16.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. Howard Hughes Medical Institute (HHMI), The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aac4919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809261PMC
August 2015

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient.

J Immunol Methods 2015 Mar 7;418:61-5. Epub 2015 Feb 7.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2015.01.011DOI Listing
March 2015

Circulating precursors of human CD1c+ and CD141+ dendritic cells.

J Exp Med 2015 Mar 16;212(3):401-13. Epub 2015 Feb 16.

Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1084/jem.20141441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354370PMC
March 2015

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.

J Exp Med 2015 Mar 16;212(3):385-99. Epub 2015 Feb 16.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20141442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354373PMC
March 2015

Immunology: Fifty years of B lymphocytes.

Nature 2015 Jan;517(7533):139-41

Rockefeller University in New York, New York, USA.

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http://dx.doi.org/10.1038/517139aDOI Listing
January 2015

Intra-spike crosslinking overcomes antibody evasion by HIV-1.

Cell 2015 Jan;160(3):433-46

Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA; Howard Hughes Medical Institute. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401576PMC
January 2015

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.

Cell 2014 Dec 4;159(7):1538-48. Epub 2014 Dec 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322776PMC
December 2014