Michel Bottlaender

Michel Bottlaender

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Michel Bottlaender

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[F]-AV-1451 tau PET imaging in Alzheimer's disease and suspected non-AD tauopathies using a late acquisition time window.

J Neurol 2019 Sep 18. Epub 2019 Sep 18.

Unit of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre Hospitalier Sainte Anne, 1 rue Cabanis, 75014, Paris, France.

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http://dx.doi.org/10.1007/s00415-019-09530-7DOI Listing
September 2019

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer's disease.

Ann Clin Transl Neurol 2019 Jul 23;6(7):1345-1351. Epub 2019 Jun 23.

Unit of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France.

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http://dx.doi.org/10.1002/acn3.50818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649639PMC
July 2019

Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition.

Neurobiol Aging 2019 Jul 29;84:41-49. Epub 2019 Jul 29.

Unit of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre Hospitalier Sainte Anne, Paris, France; UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.07.015DOI Listing
July 2019

C-glyburide PET imaging unveils the negligible brain penetration of glyburide in humans.

Neurology 2019 Apr;92(17):813-814

From Imagerie Moléculaire In Vivo (S.M., C.C., F.C., M.B., N.T.), IMIV, Institut des Sciences du Vivant Frédéric Joliot, Direction de la Recherche Fondamentale, CEA, Inserm, CNRS, Paris-Sud University, Université Paris-Saclay, CEA-SHFJ, Orsay; Hôpital Bicêtre (S.M., L.B.), APHP, Le Kremlin Bicêtre; Faculté de Pharmacie (S.M.), Paris-Sud University, Châtenay-Malabry; Department of Pharmacology (L.B.), Paris-Sud University, Faculty of Medicine Paris Sud, INSERM UMR-1178, CESP, Le Kremlin Bicêtre, France.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000007378DOI Listing
April 2019

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Ann Neurol 2018 11;84(5):729-740

Alzheimer center Amsterdam, Amsterdam UMC, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/ana.25333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354051PMC
November 2018

Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease.

Brain 2018 06;141(6):1855-1870

Unit of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre Hospitalier Sainte Anne, Paris, France.

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http://dx.doi.org/10.1093/brain/awy079DOI Listing
June 2018

In vivo PET imaging of neuroinflammation in Alzheimer's disease.

J Neural Transm (Vienna) 2018 05 17;125(5):847-867. Epub 2017 May 17.

UNIACT, NeuroSpin, Institut d'Imagerie Biomédicale, Direction de la Recherche Fondamentale, Commissariat à l'Energie Atomique, 91191, Gif-sur-Yvette, France.

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http://dx.doi.org/10.1007/s00702-017-1731-xDOI Listing
May 2018

Validation of an automatic reference region extraction for the quantification of [F]DPA-714 in dynamic brain PET studies.

J Cereb Blood Flow Metab 2018 02 9;38(2):333-346. Epub 2017 Feb 9.

4 Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Département de Recherche Fondamentale (DRF), Institut d'Imagerie Biomédicale (I2BM), Service Hospitalier Frédéric Joliot, Orsay, France.

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http://dx.doi.org/10.1177/0271678X17692599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951011PMC
February 2018

Impact of Endothelial 18-kDa Translocator Protein on the Quantification of F-DPA-714.

J Nucl Med 2018 02 3;59(2):307-314. Epub 2017 Aug 3.

IMIV, Inserm, CEA, Université Paris-Sud, Université Paris Saclay, Orsay, France.

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http://dx.doi.org/10.2967/jnumed.117.195396DOI Listing
February 2018

Neutrophil hyperactivation correlates with Alzheimer's disease progression.

Ann Neurol 2018 02;83(2):387-405

Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre de Recherche Saint-Antoine, team "Immune System, Neuroinflammation and Neurodegenerative Diseases", Hôpital Saint-Antoine, Paris, France.

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http://dx.doi.org/10.1002/ana.25159DOI Listing
February 2018

Cholinergic Changes in Aging and Alzheimer Disease: An [18F]-F-A-85380 Exploratory PET Study.

Alzheimer Dis Assoc Disord 2017 Jan-Mar;31(1):8-12

*Neurology of Memory and Language Unit, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Sainte-Anne hospital ‡Department of Neurology, Saint-Antoine hospital, APHP §Sorbonne universités, UPMC Univ Paris 06, Inserm U 1127, and CNRS UMR 7225 ∥Department of Nuclear Medicine, APHP, Pitié-Salpêtrière Hospital ¶Department of Neurology, Pitié-Salpêtrière hospital APHP, Paris #IMIV, CEA, INSERM, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay †Department of Neurology, CHU d'Angers, Angers **Neurospin, I2BM, DRF, CEA, Gif-sur-Yvette, France.

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http://dx.doi.org/10.1097/WAD.0000000000000163DOI Listing
November 2017

Acute Morphine Exposure Increases the Brain Distribution of [18F]DPA-714, a PET Biomarker of Glial Activation in Nonhuman Primates.

Int J Neuropsychopharmacol 2017 01;20(1):67-71

Imagerie Moléculaire In Vivo, IMIV, CEA, Inserm, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay, France; Variabilité de réponse aux psychotropes, Inserm, Université Paris Descartes, Faculté de pharmacie, Université Paris Diderot, UMR-S 1144, Paris,France.

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http://dx.doi.org/10.1093/ijnp/pyw077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737475PMC
January 2017

Distinct tau PET imaging patterns in typical and atypical Alzheimer's disease.

Brain 2016 05;139(Pt 5):1321-4

UNIACT, NeuroSpin, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à l'Energie Atomique; Laboratoire Imagerie Moléculaire in Vivo, UMR 1023, Service Hospitalier Frédéric Joliot, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à l'Energie Atomique, France.

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http://dx.doi.org/10.1093/brain/aww041DOI Listing
May 2016

Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

Brain 2016 Apr 15;139(Pt 4):1252-64. Epub 2016 Mar 15.

Unit of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France

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http://dx.doi.org/10.1093/brain/aww017DOI Listing
April 2016

Sulcal morphology as a new imaging marker for the diagnosis of early onset Alzheimer's disease.

Neurobiol Aging 2015 Nov 15;36(11):2932-2939. Epub 2015 Jul 15.

Department of Neurology of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.04.019DOI Listing
November 2015

Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.

J Nucl Med 2015 Jul 29;56(7):1048-54. Epub 2015 May 29.

CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.

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http://dx.doi.org/10.2967/jnumed.115.156083DOI Listing
July 2015

FID navigator-based MR thermometry method to monitor small temperature changes in the brain of ventilated animals.

NMR Biomed 2015 Jan 11;28(1):101-7. Epub 2014 Nov 11.

CEA/DSV/I2BM/NeuroSpin/UNIRS, CEA Saclay, 91191, Gif sur Yvette, France.

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http://dx.doi.org/10.1002/nbm.3232DOI Listing
January 2015

Imaging of monoamine oxidase-A in the human brain with [11C]befloxatone: quantification strategies and correlation with mRNA transcription maps.

Nucl Med Commun 2014 Dec;35(12):1254-61

aUniversity of Bordeaux, CNRS, INCIA, UMR 5287, Talence bCEA, DSV, I2BM, SHFJ, Orsay cINSERM, CEA, University Paris sud, University Paris Descartes, Research Unit 1000 'NeuroImagery & Psychiatry', Orsay dCEA, DSV, I2BM, Neurospin, Gif-sur-Yvette, France eDepartment of Information Engineering, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1097/MNM.0000000000000196DOI Listing
December 2014

[11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain.

J Cereb Blood Flow Metab 2014 Dec 17;34(12):1951-2. Epub 2014 Sep 17.

CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette, France.

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http://dx.doi.org/10.1038/jcbfm.2014.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269741PMC
December 2014

Two distinct amnesic profiles in behavioral variant frontotemporal dementia.

Biol Psychiatry 2014 Apr 3;75(7):582-8. Epub 2013 Oct 3.

Alzheimer Institute, Department of Neurology, Hôpital Pitié-Salpêtrière (Assistance Publique - Hôpitaux de Paris), Paris; Centre Psychiatrie et Neurosciences, INSERM UMR S894, Université Paris Descartes, Paris V, and Department of Neurology, Centre Hospitalier Saint Anne, Paris, France.

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http://dx.doi.org/10.1016/j.biopsych.2013.08.017DOI Listing
April 2014

High density of nicotinic receptors in the cingulo-insular network.

Neuroimage 2013 Oct 28;79:42-51. Epub 2013 Apr 28.

Department of Neurology, University Hospital and Medical School of Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.neuroimage.2013.04.074DOI Listing
October 2013

Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand.

Drug Metab Dispos 2013 Jan 12;41(1):122-31. Epub 2012 Oct 12.

CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, 91406 Orsay, France.

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http://dx.doi.org/10.1124/dmd.112.046342DOI Listing
January 2013

Minimally invasive input function for 2-18F-fluoro-A-85380 brain PET studies.

Eur J Nucl Med Mol Imaging 2012 Apr 10;39(4):651-9. Epub 2012 Jan 10.

Molecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, MSC-1026, Bethesda, MD, 20892-2035, USA,

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http://dx.doi.org/10.1007/s00259-011-2004-9DOI Listing
April 2012

Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling Part I: PET studies.

Nucl Med Biol 2012 Feb 26;39(2):227-33. Epub 2011 Oct 26.

CEA, I2BM, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, F-91401 Orsay, France.

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http://dx.doi.org/10.1016/j.nucmedbio.2011.08.003DOI Listing
February 2012

Similar amyloid-β burden in posterior cortical atrophy and Alzheimer's disease.

Brain 2011 Jul;134(Pt 7):2036-43

Fédération des Maladies du Système Nerveux, Research and Resource Memory Centre, Pavillon Jean Lhermitte, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France.

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http://dx.doi.org/10.1093/brain/awr130DOI Listing
July 2011

[18F]ZW-104, a new radioligand for imaging alpha2-alpha3-alpha4/beta2 central nicotinic acetylcholine receptors: Evaluation in mutant mice.

Synapse 2010 Jul;64(7):570-2

Atomic Energy Commission, I2BM, Service Hospitalier Frédéric Joliot, Orsay F-91401, France.

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http://dx.doi.org/10.1002/syn.20776DOI Listing
July 2010

In vivo quantification of monoamine oxidase A in baboon brain: a PET study using [(11)C]befloxatone and the multi-injection approach.

J Cereb Blood Flow Metab 2010 Apr 18;30(4):792-800. Epub 2009 Nov 18.

CEA, DSV, I2BM, Service Hospitalier Frédéric Joliot, 4, place du Général Leclerc, F-91401 Orsay, France.

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http://dx.doi.org/10.1038/jcbfm.2009.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949159PMC
April 2010

ADDME--Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective.

BMC Neurol 2009 Jun 12;9 Suppl 1:S1. Epub 2009 Jun 12.

Apredica, 313 Pleasant Street, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1186/1471-2377-9-S1-S1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697629PMC
June 2009

[18F]FPhEP and [18F]F2PhEP, two new epibatidine-based radioligands: evaluation for imaging nicotinic acetylcholine receptors in baboon brain.

Synapse 2007 Sep;61(9):764-70

CEA, Institut d'Imagerie Biomédicale, Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, F-91406 Orsay, France.

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http://dx.doi.org/10.1002/syn.20426DOI Listing
September 2007

Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task.

Cereb Cortex 2007 Apr 17;17(4):749-59. Epub 2006 May 17.

INSERM 562, Cognitive Neuroimaging, Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique/Département de Recherche Médicale/Direction des Sciences du Vivant, Orsay Cedex, and Collège de France, Paris, France.

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http://dx.doi.org/10.1093/cercor/bhk028DOI Listing
April 2007

Synthesis and radiosynthesis of [(18)F]FPhEP, a novel alpha(4)beta(2)-selective, epibatidine-based antagonist for PET imaging of nicotinic acetylcholine receptors.

Bioorg Med Chem 2006 Jun 7;14(11):3848-58. Epub 2006 Feb 7.

Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, CEA/DSV, 4 Place du Général Leclerc, F-91401 Orsay, France.

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http://dx.doi.org/10.1016/j.bmc.2006.01.032DOI Listing
June 2006

Imaging of CNS myelin by positron-emission tomography.

Proc Natl Acad Sci U S A 2006 Jun 5;103(24):9304-9. Epub 2006 Jun 5.

Institut National de la Santé et de la Recherche Médicale, U711, Hôpital de la Salpêtrière, F-75013 Paris, France.

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http://dx.doi.org/10.1073/pnas.0600769103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482605PMC
June 2006

Radiosynthesis of (E)-N-(2-[11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist.

Appl Radiat Isot 2006 Mar 22;64(3):348-54. Epub 2005 Nov 22.

Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, CEA/DSV, 4 place du Général Leclerc, F-91401 Orsay, France.

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http://linkinghub.elsevier.com/retrieve/pii/S096980430500313
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http://dx.doi.org/10.1016/j.apradiso.2005.08.005DOI Listing
March 2006

Biodistribution and radiation dosimetry of [11C]raclopride in healthy volunteers.

Eur J Nucl Med Mol Imaging 2005 Aug 20;32(8):952-8. Epub 2005 Apr 20.

Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique, Orsay Cedex, France.

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http://dx.doi.org/10.1007/s00259-005-1783-2DOI Listing
August 2005

Acute inhibition of cardiac monoamine oxidase A after tobacco smoke inhalation: validation study of [11C]befloxatone in rats followed by a positron emission tomography application in baboons.

J Pharmacol Exp Ther 2005 Jul 15;314(1):431-6. Epub 2005 Apr 15.

Service Hospitalier Frédéric Joliot, DSV/DRM-CEA, French Atomic Agency, F-91406 Orsay, France.

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http://dx.doi.org/10.1124/jpet.105.085704DOI Listing
July 2005

Acute effects of physostigmine and galantamine on the binding of [18F]fluoro-A-85380: a PET study in monkeys.

Synapse 2005 Jun;56(4):217-21

Service Hospitalier Frédéric Joliot, Direction of Life Sciences, Department of Medical Research, French Atomic Agency, Orsay, France.

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http://dx.doi.org/10.1002/syn.20145DOI Listing
June 2005

In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET.

J Nucl Med 2005 Feb;46(2):240-7

Service Hospitalier Frédéric Joliot, Departement de Recherche Medicale/Direction des Sciences du Vivant, Commissariat à l'Energie Atomique, F-91406 Orsay, France.

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February 2005

Mapping the cerebral monoamine oxidase type A: positron emission tomography characterization of the reversible selective inhibitor [11C]befloxatone.

J Pharmacol Exp Ther 2003 May 11;305(2):467-73. Epub 2003 Feb 11.

Commissariat à l'Energie Atomique, Service Hospitalier Frédéric Joliot, Département de Recherche Médicale/Direction des Sciences du Vivant, Orsay, France.

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http://dx.doi.org/10.1124/jpet.102.046953DOI Listing
May 2003

Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers.

J Nucl Med 2003 Apr;44(4):596-601

Department of Medical Research, Division of Life Sciences, Service Hospitalier Frédéric Joliot, French Atomic Agency, 4 Place du Général Leclerc, F-91406 Orsay, France.

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April 2003

Fluoro-A-85380 demonstrated no mutagenic properties in in vivo rat micronucleus and Ames tests.

Nucl Med Biol 2002 Nov;29(8):849-53

Service Hospitalier Frédéric Joliot, CEA, DSV/DRM, 4 Place du Général Leclerc, F-91406, Orsay, France.

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http://dx.doi.org/10.1016/s0969-8051(02)00331-1DOI Listing
November 2002

Anesthesia affects the disposition of [18F]fluoro-A-85380: a PET study in monkeys.

Synapse 2002 Apr;44(1):58-9

Service Hospitalier Frédéric Joliot, Department of Medical Research-French Atomic Agency, Orsay, France.

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http://dx.doi.org/10.1002/syn.10047DOI Listing
April 2002

(+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET.

Nucl Med Biol 2002 Apr;29(3):295-302

Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, NSW 2050, Camperdown, Australia.

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http://dx.doi.org/10.1016/s0969-8051(01)00306-7DOI Listing
April 2002

In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density.

J Nucl Med 2002 Feb;43(2):215-26

Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique/Direction des Sciences du Vivant, Orsay, France.

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February 2002