Michel Arock

Michel Arock

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Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells.

Pharmacol Res 2020 Feb 5:104682. Epub 2020 Feb 5.

Pharmacology & Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.104682DOI Listing
February 2020

New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019.

Leuk Lymphoma 2019 Dec 26:1-9. Epub 2019 Dec 26.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1080/10428194.2019.1703974DOI Listing
December 2019

Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches.

Int J Mol Sci 2019 Jun 18;20(12). Epub 2019 Jun 18.

Division of Allergy and Clinical Immunology, University of Salerno, 84131 Salerno, Italy.

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http://dx.doi.org/10.3390/ijms20122976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627900PMC
June 2019

Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions.

Front Immunol 2019 19;10:1361. Epub 2019 Jun 19.

Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.3389/fimmu.2019.01361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593472PMC
June 2019

Omalizumab Therapy for Mast Cell-Mediator Symptoms in Patients with ISM, CM, MMAS, and MCAS.

J Allergy Clin Immunol Pract 2019 Sep - Oct;7(7):2387-2395.e3. Epub 2019 Apr 5.

Imagine Institute, INSERM U1163 and CNRS ERL 8654, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Department of Hematology, Necker Children's Hospital, APHP, Paris, France; French Reference Center for Mastocytosis (CEREMAST), Necker Children's Hospital, APHP, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193032
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http://dx.doi.org/10.1016/j.jaip.2019.03.039DOI Listing
April 2019

The underestimated role of basophils in Ph chronic myeloid leukaemia.

Eur J Clin Invest 2018 Oct 6;48(10):e13000. Epub 2018 Aug 6.

LBPA CNRS UMR8113, Ecole Normale Supérieure de Paris Saclay, Cachan, France.

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http://dx.doi.org/10.1111/eci.13000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175372PMC
October 2018

Tyrosine Kinase Inhibition in Mastocytosis: KIT and Beyond KIT.

Immunol Allergy Clin North Am 2018 08;38(3):527-543

Cellular and Molecular Oncology, LBPA CNRS UMR8113, Ecole Normale Supérieure de Paris Saclay, 61, Avenue du Président Wilson, Cachan Cedex 94235, France; Laboratory of Hematology, Pitié-Salpêtrière Hospital, 83, Boulevard de l'Hôpital, Paris 75013, France. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2018.04.007DOI Listing
August 2018

Acute mast cell leukemia: A rare but highly aggressive hematopoietic neoplasm.

Diagn Cytopathol 2018 Jul 7;46(7):639-641. Epub 2018 May 7.

Biological Haematology Department, Pitié-Salpêtrière Hospital, Paris.

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http://dx.doi.org/10.1002/dc.23965DOI Listing
July 2018

MYB-GATA1 fusion promotes basophilic leukaemia: involvement of interleukin-33 and nerve growth factor receptors.

J Pathol 2017 07 29;242(3):347-357. Epub 2017 May 29.

Equipe thérapie génique, INSERM U 1035 Biothérapie des maladies génétiques et cancers, University of Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.1002/path.4908DOI Listing
July 2017

Allogeneic NK cells eradicate myeloblasts but not neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia.

Am J Hematol 2017 May 24;92(5):E66-E68. Epub 2017 Feb 24.

Division of Hematology-Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/ajh.24673DOI Listing
May 2017

A new therapeutic advance for symptomatic systemic mastocytosis?

Authors:
Michel Arock

Lancet 2017 02 7;389(10069):576-578. Epub 2017 Jan 7.

Molecular and Cellular Oncology, LBPA CNRS UMR 8113, Ecole Normale Supérieure de Cachan, 94235-Cachan CEDEX, and Clinical Hematology Laboratory, Pitié-Salpêtrière Hospital, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)31655-5DOI Listing
February 2017

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.

Haematologica 2016 10;101(10):1133-1143

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.3324/haematol.2016.146563DOI Listing
October 2016

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.

PLoS One 2015 30;10(12):e0145142. Epub 2015 Dec 30.

Centre de Mathématiques et de Leurs applications, Ecole Normale Supérieure de Cachan, CNRS, Université Paris-Saclay, Cachan, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145142PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696835PMC
June 2016

Mastocytosis among elderly patients: A multicenter retrospective French study on 53 patients.

Medicine (Baltimore) 2016 Jun;95(24):e3901

aService de médecine interne, Hôpital Tenon, Université Pierre et Marie Curie, Paris, France bService de Médecine Interne, CHU de Caen, Université Basse Normandie, Caen, France cInstitut d'Hématologie de Basse Normandie, Centre Hospitalier Universitaire, Université de Caen-Basse Normandie, Caen, France dFaculté de Médecine et AP-HP Necker-Enfants Malades, Centre de Référence des Mastocytoses, Paris Cedex 15, France eInserm, U1068, CRCM [Signaling, Hematopoiesis and Mechanism of Oncogenesis], Institut Paoli-Calmettes,Marseille, Aix-Marseille Univ, CNRS, UMR7258, Marseille, France fMastocytosis Competence Center of Midi-Pyrénées, Department of Dermatology, Toulouse University Hospital, Toulouse, France gService de Médecine Interne, Université Claude Bernard Lyon1, Groupe Hospitalier Lyon-Sud. Chemin du Grand Revoyet, Pierre Bénite, France hService de Dermatologie, Hôpital Tenon, Université Pierre et Marie Curie-Paris 6, Paris, France iService d'Hématologie Adultes, Université Paris Descartes, Paris Sorbonne Cité, Faculté de Médecine et AP-HP Necker-Enfants Malades, Institut Imagine, Université Paris Descartes, Paris Cedex 15, France jService de Médecine interne, Hôpital St Antoine, Université Pierre et Marie Curie-Paris 6, Paris, France kService de Médecine interne, Université de Rennes 1, Hôpital Sud CHU Rennes, Rennes, France lService de Médecine interne, Hôpital Pitié Salpêtrière, Université Pierre et Marie Curie-Paris 6, Paris, France mService de Médecine interne, CHU, Nantes, France nService de Médecine interne, Hôpital Européen Georges Pompidou, Université Paris 5, Paris, France oUniversité de Lille, UFR Médecine, Lille, France; CHRU Lille, Pôle Spécialités Médicales et Gérontologie, Département de Médecine Interne et Immunologie Clinique, Lille Cedex, France; Centre National de Référence Maladies Systémiques et Auto-immunes Rares (Sclérodermie Systémique), Lille Cedex, France; LIRIC UMR 995, EA2686, France

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http://dx.doi.org/10.1097/MD.0000000000003901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998476PMC
June 2016

Expression of programmed cell death ligand-1 in mastocytosis correlates with disease severity.

J Allergy Clin Immunol 2016 Jan 20;137(1):314-318.e5. Epub 2015 Aug 20.

Department of Dermatology, University of Cologne, Cologne, Germany; Department of Dermatology, University of Luebeck, Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.07.006DOI Listing
January 2016

Mast cell differentiation: still open questions?

Authors:
Michel Arock

Blood 2016 Jan;127(4):373-4

ECOLE NORMALE SUPERIEURE DE CACHAN.

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http://dx.doi.org/10.1182/blood-2015-12-686592DOI Listing
January 2016

The increasing roles of epigenetics in breast cancer: Implications for pathogenicity, biomarkers, prevention and treatment.

Int J Cancer 2015 Dec 1;137(12):2785-94. Epub 2014 Dec 1.

Molecular Oncology and Pharmacology, LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France.

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http://dx.doi.org/10.1002/ijc.29347DOI Listing
December 2015

Current treatment options in patients with mastocytosis: status in 2015 and future perspectives.

Eur J Haematol 2015 Jun 26;94(6):474-90. Epub 2015 Mar 26.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/ejh.12544DOI Listing
June 2015

Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features.

Leuk Res 2015 Jan 30;39(1):1-5. Epub 2014 Sep 30.

Institute of Pathology, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1016/j.leukres.2014.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896385PMC
January 2015

ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases.

PLoS One 2014 21;9(1):e85362. Epub 2014 Jan 21.

Centre de Référence des Mastocytoses, Faculté de Médecine et AP-HP Necker-Enfants Malades, Paris, France ; CNRS UMR 8147 and Institut Imagine, AP-HP, Hôpital Necker-Enfants Malades, Paris, France ; Service d'Hématologie Adulte, Université Paris Descartes, Paris Sorbonne Cité, Faculté de Médecine et AP-HP Necker-Enfants Malades, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085362PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897447PMC
October 2014

The serum tryptase test: an emerging robust biomarker in clinical hematology.

Expert Rev Hematol 2014 Oct 28;7(5):683-90. Epub 2014 Aug 28.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1586/17474086.2014.955008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603354PMC
October 2014

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection.

Blood 2014 Jul 27;124(1):111-20. Epub 2014 Mar 27.

Laboratoire de Biologie et Pharmacologie Appliquée, Centre Nationale de la Recherche, Unité Mixte de Recherche 8113, Ecole Normale Supérieure de Cachan, Cachan, France; Laboratoire Central d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;

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http://dx.doi.org/10.1182/blood-2013-10-534685DOI Listing
July 2014

Molecular defects in mastocytosis: KIT and beyond KIT.

Immunol Allergy Clin North Am 2014 May;34(2):239-62

Molecular Oncology and Pharmacology, LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, 61, Avenue du Président Wilson, Cachan 94235, France. Electronic address:

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http://dx.doi.org/10.1016/j.iac.2014.01.009DOI Listing
May 2014

Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis.

J Am Acad Dermatol 2014 Apr 9;70(4):683-690.e1. Epub 2014 Feb 9.

Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.jaad.2013.12.002DOI Listing
April 2014

Relocalization of KIT D816V to cell surface after dasatinib treatment: potential clinical implications.

Clin Lymphoma Myeloma Leuk 2013 Feb 3;13(1):62-9. Epub 2012 Nov 3.

CNRS UMR 8113, Laboratoire de Biologie et Pharmacologie Appliquée, École Normale Supérieure de Cachan, Cachan, France.

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http://dx.doi.org/10.1016/j.clml.2012.08.004DOI Listing
February 2013

ICON: Eosinophil Disorders.

World Allergy Organ J 2012 Dec;5(12):174-81

1Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria 2Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, NIH/NIAID, Bethesda, MD 3Children's Mercy Hospital, Kansas City, MO 4LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France 5Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 6Division of Allergic Diseases, Mayo Clinic, Rochester, MN 7Division of Hematology, Stanford Cancer Center, Stanford, CA 8MLL Münchner Leukämielabor, Munich, Germany 9Department of Hematology, Medical University School of Gdansk, Gdańsk, Poland 10Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany 11Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 12III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany 13Department of Allergy and Immunology, National Research Institute for Children's Health and Development, Tokyo, Japan 14Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 15Division of Allergy and Immunology, Cincinnati Children's Hospital, Medical Center, Cincinnati, OH 16Institute of Pharmacology, University of Bern, Bern, Switzerland 17Center for Human Genetics, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium 18Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 19Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.

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http://dx.doi.org/10.1097/WOX.0b013e31827f4192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651188PMC
December 2012

Cancer stem cell definitions and terminology: the devil is in the details.

Nat Rev Cancer 2012 11 11;12(11):767-75. Epub 2012 Oct 11.

The Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna & Ludwig-Boltzmann Cluster Oncology, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1038/nrc3368DOI Listing
November 2012

Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes.

J Clin Endocrinol Metab 2012 Sep 28;97(9):E1677-85. Epub 2012 Jun 28.

Institut National de la Santé et de la Recherche Médicale Unité 872, Nutriomique, and Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers, Unité Mixte de Recherche (UMR) S872, F-75006 Paris, France.

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http://dx.doi.org/10.1210/jc.2012-1532DOI Listing
September 2012

Clinical and laboratory parameters of mast cell activation as basis for the formulation of diagnostic criteria.

Int Arch Allergy Immunol 2011 16;156(2):119-27. Epub 2011 May 16.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1159/000323763DOI Listing
November 2011

Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.

Expert Rev Hematol 2010 Aug;3(4):497-516

Laboratoire de Biologie et Pharmacologie Appliquée, CNRS UMR 8113, Ecole Normale Supérieure de Cachan, 61, Ave du Président Wilson, 94235 Cachan Cedex, France.

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http://dx.doi.org/10.1586/ehm.10.42DOI Listing
August 2010

Ex vivo and in vitro primary mast cells.

Methods Mol Biol 2008 ;415:241-54

Ecole Normale Supérieure de Cachan, Laboratoire de Biotechnologies et Pharmacologie Génétique Appliquées, Cachan, France.

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http://dx.doi.org/10.1007/978-1-59745-570-1_14DOI Listing
June 2008

H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12.

J Allergy Clin Immunol 2007 Oct 6;120(4):827-34. Epub 2007 Aug 6.

Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud 11, Faculté de Médecine Paris Sud, Institut Fédératif de Recherche 13, Clamart, France.

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http://dx.doi.org/10.1016/j.jaci.2007.05.046DOI Listing
October 2007

Peritoneal cell-derived mast cells: an in vitro model of mature serosal-type mouse mast cells.

J Immunol 2007 May;178(10):6465-75

Unité d'Allergologie Moléculaire et Cellulaire, Département d'Immunologie, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.178.10.6465DOI Listing
May 2007

Referent d-dimer enzyme-linked immunosorbent assay testing is of limited value in the exclusion of thromboembolic disease: result of a practical study in an ED.

Am J Emerg Med 2006 May;24(3):313-8

Department of Emergency Medicine, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, 75013 Paris, France.

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http://dx.doi.org/10.1016/j.ajem.2005.11.012DOI Listing
May 2006

Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation.

J Exp Med 2005 Dec 13;202(12):1635-41. Epub 2005 Dec 13.

Institut National de la Santé et de la Recherche Médicale U563, Centre de Physiopathologie de Toulouse Purpan, Purpan Hospital, 31000 Toulouse, France.

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http://dx.doi.org/10.1084/jem.20050807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212965PMC
December 2005

A new model of pre-B acute lymphoblastic leukemia chemically induced in rats.

Exp Hematol 2005 Oct;33(10):1130-9

Laboratoire d'Hématologie Cellulaire et Moléculaire, Faculté de Pharmacie, Paris, France.

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http://dx.doi.org/10.1016/j.exphem.2005.06.018DOI Listing
October 2005

Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway.

J Biol Chem 2004 Dec 22;279(49):50700-9. Epub 2004 Sep 22.

Institute of Biochemistry and Molecular Biology, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.

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http://dx.doi.org/10.1074/jbc.M410800200DOI Listing
December 2004

Establishment and characterization of a new human erythroleukemic cell line, ERY-1.

Leuk Res 2004 Dec;28(12):1329-39

Unité CNRS UMR 8147, Faculté de Pharmacie et Hôpital Necker 4, Avenue de l'Observatoire 75006, Paris, France.

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http://dx.doi.org/10.1016/j.leukres.2004.04.013DOI Listing
December 2004

Diagnosis and treatment of systemic mastocytosis: state of the art.

Br J Haematol 2003 Sep;122(5):695-717

Department of Internal Medicine I, Division of Haematology, University of Vienna, Austria.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04575.xDOI Listing
September 2003

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria.

Leuk Res 2003 Jul;27(7):635-41

Department of Internal Medicine I, Division of Hematology & Hemostaseology, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.

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http://dx.doi.org/10.1016/s0145-2126(02)00168-6DOI Listing
July 2003

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells.

Eur J Immunol 2003 Apr;33(4):899-906

CNRS FRE 2444, Faculty of Pharmacy, Paris V University, Paris, France.

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http://dx.doi.org/10.1002/eji.200323830DOI Listing
April 2003

Mast cells: new targets for multiple sclerosis therapy?

J Neuroimmunol 2002 Oct;131(1-2):5-20

INSERM U546, Pitié Salpêtrière Hospital, 105 Boulevard de l'Hôpital, 75634 Cedex 13, Paris, France.

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http://dx.doi.org/10.1016/s0165-5728(02)00250-3DOI Listing
October 2002

Signal transduction-associated and cell activation-linked antigens expressed in human mast cells.

Int J Hematol 2002 May;75(4):357-62

Department of Internal Medicine I, University of Vienna, Austria.

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http://dx.doi.org/10.1007/bf02982124DOI Listing
May 2002

Trends in histamine research: new functions during immune responses and hematopoiesis.

Trends Immunol 2002 May;23(5):255-63

CNRS UMR 8603 - Université René Descartes - Paris V, Hôpital Necker, 161 rue de Sèvres, 75743 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/s1471-4906(02)02215-9DOI Listing
May 2002

Differentiation of human basophils: an overview of recent advances and pending questions.

J Leukoc Biol 2002 Apr;71(4):557-64

Department of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmacy, Paris, France.

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April 2002

The role of mast cells in host defense and their subversion by bacterial pathogens.

Trends Immunol 2002 Mar;23(3):151-8

Dept of Cellular and Molecular Hematology, UPRES-EA 2509, Faculty of Pharmacy, 4 Avenue de l'Observatoire, 75006, Paris, France.

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http://dx.doi.org/10.1016/s1471-4906(01)02156-1DOI Listing
March 2002

Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts.

Int Arch Allergy Immunol 2002 Feb;127(2):110-4

Cellular and Molecular Hematology Unit, Faculty of Pharmacy, Paris, France.

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http://dx.doi.org/10.1159/000048179DOI Listing
February 2002