Publications by authors named "Michal Minczuk"

77Publications

Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective.

Trends Mol Med 2020 Jul 26;26(7):698-709. Epub 2020 Mar 26.

CRUK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2020.02.006DOI Listing
July 2020

TRMT2B is responsible for both tRNA and rRNA mU-methylation in human mitochondria.

RNA Biol 2020 04 17;17(4):451-462. Epub 2020 Jan 17.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1080/15476286.2020.1712544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237155PMC
April 2020

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.

PLoS Comput Biol 2019 06 26;15(6):e1007023. Epub 2019 Jun 26.

Department of Mathematics, Imperial College London, London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1007023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615642PMC
June 2019

The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.

Nucleic Acids Res 2019 07;47(13):7078-7093

Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, 50 UNIST-gil, Ulsan 44919, Republic of Korea.

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http://dx.doi.org/10.1093/nar/gkz454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648332PMC
July 2019

Mechanisms of Mitochondrial DNA Deletion Formation.

Trends Genet 2019 03 25;35(3):235-244. Epub 2019 Jan 25.

Department of Neurology, University of Miami, Miller School of Medicine, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2019.01.001DOI Listing
March 2019

The mammalian mitochondrial epitranscriptome.

Biochim Biophys Acta Gene Regul Mech 2019 03 4;1862(3):429-446. Epub 2018 Dec 4.

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414753PMC
March 2019

Delivery of mtZFNs into Early Mouse Embryos.

Methods Mol Biol 2018 ;1867:215-228

Mitochondrial Genetics Group, MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

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http://link.springer.com/10.1007/978-1-4939-8799-3_16
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http://dx.doi.org/10.1007/978-1-4939-8799-3_16DOI Listing
July 2019

Enhanced Manipulation of Human Mitochondrial DNA Heteroplasmy In Vitro Using Tunable mtZFN Technology.

Methods Mol Biol 2018 ;1867:43-56

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

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http://link.springer.com/10.1007/978-1-4939-8799-3_4
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http://dx.doi.org/10.1007/978-1-4939-8799-3_4DOI Listing
July 2019

Mitochondrial transcription and translation: overview.

Essays Biochem 2018 07 20;62(3):309-320. Epub 2018 Jul 20.

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.1042/EBC20170102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056719PMC
July 2018

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.

Nat Commun 2018 04 30;9(1):1727. Epub 2018 Apr 30.

Institute of Experimental Epileptology and Cognition Research, University of Bonn, Sigmund-Freud-Str. 25, D-53105, Bonn, Germany.

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http://dx.doi.org/10.1038/s41467-018-04131-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928156PMC
April 2018

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.

Mol Cell 2018 02;69(4):581-593.e7

Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823973PMC
February 2018

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.

Dev Cell 2018 02 1;44(4):484-499.e6. Epub 2018 Feb 1.

Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932465PMC
February 2018

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.

Trends Genet 2018 02 24;34(2):101-110. Epub 2017 Nov 24.

Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01689525173019
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http://dx.doi.org/10.1016/j.tig.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783712PMC
February 2018

New insights into the phenotype of FARS2 deficiency.

Mol Genet Metab 2017 12 12;122(4):172-181. Epub 2017 Oct 12.

Department of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734183PMC
December 2017

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Sci Rep 2017 10 10;7(1):12886. Epub 2017 Oct 10.

MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/s41598-017-13227-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634993PMC
October 2017

Human mitochondrial ribosomes can switch structural tRNAs - but when and why?

RNA Biol 2017 12 13;14(12):1668-1671. Epub 2017 Sep 13.

c MRC Mitochondrial Biology Unit , Wellcome Trust/MRC Building, Hills Road, Cambridge, England , UK.

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https://www.tandfonline.com/doi/full/10.1080/15476286.2017.1
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http://dx.doi.org/10.1080/15476286.2017.1356551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731804PMC
December 2017

Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.

Trends Biochem Sci 2017 08 9;42(8):625-639. Epub 2017 Mar 9.

Mitochondrial Genetics, Medical Research Council (MRC) Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538620PMC
August 2017

Dealing with an Unconventional Genetic Code in  Mitochondria: The Biogenesis and Pathogenic  Defects of the 5-Formylcytosine Modification in  Mitochondrial tRNA.

Biomolecules 2017 03 2;7(1). Epub 2017 Mar 2.

Mitochondrial Genetics, Medical Research Council Mitochondrial Biology Unit, University of Cambridge,  Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.3390/biom7010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372736PMC
March 2017

Human mitochondrial ribosomes can switch their structural RNA composition.

Proc Natl Acad Sci U S A 2016 10 11;113(43):12198-12201. Epub 2016 Oct 11.

The Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom; The Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom

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http://dx.doi.org/10.1073/pnas.1609338113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087001PMC
October 2016

Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy.

Methods Mol Biol 2016 ;1351:145-62

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1007/978-1-4939-3040-1_11DOI Listing
September 2016

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome.

Nucleic Acids Res 2016 Jan 19;44(2):992. Epub 2015 Oct 19.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkv1125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737142PMC
January 2016

Mitochondrial transcript maturation and its disorders.

J Inherit Metab Dis 2015 Jul 28;38(4):655-80. Epub 2015 May 28.

MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1007/s10545-015-9859-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493943PMC
July 2015

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease.

Front Genet 2015 10;6:79. Epub 2015 Mar 10.

Mitochondrial Genetics, Mitochondrial Biology Unit, Medical Research Council, Cambridge, UK.

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http://dx.doi.org/10.3389/fgene.2015.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354410PMC
March 2015

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder.

J Med Genet 2015 Aug 18;52(8):532-40. Epub 2015 Mar 18.

Department of Pediatrics, Section of Genetics, University of Colorado School of Medicine, Aurora, Colorado, USA Intellectual and Developmental Disabilities Research Center, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1136/jmedgenet-2015-103049DOI Listing
August 2015

In D-loop: 40 years of mitochondrial 7S DNA.

Exp Gerontol 2014 Aug 4;56:175-81. Epub 2014 Apr 4.

MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2014.03.027DOI Listing
August 2014

Polyadenylation in bacteria and organelles.

Methods Mol Biol 2014 ;1125:211-27

Mitochondrial Genetics Group, MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK,

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http://dx.doi.org/10.1007/978-1-62703-971-0_18DOI Listing
November 2014

ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.

Am J Hum Genet 2013 Aug 11;93(2):211-23. Epub 2013 Jul 11.

Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.ajhg.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738821PMC
August 2013

Mitochondria: mitochondrial RNA metabolism and human disease.

Int J Biochem Cell Biol 2013 Apr 17;45(4):845-9. Epub 2013 Jan 17.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.biocel.2013.01.005DOI Listing
April 2013

Alternative translation initiation augments the human mitochondrial proteome.

Nucleic Acids Res 2013 Feb 28;41(4):2354-69. Epub 2012 Dec 28.

MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gks1347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575844PMC
February 2013

The post-transcriptional life of mammalian mitochondrial RNA.

Biochem J 2012 Jun;444(3):357-73

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, U.K.

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http://dx.doi.org/10.1042/BJ20112208DOI Listing
June 2012

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome.

Nucleic Acids Res 2012 May 11;40(9):4097-109. Epub 2012 Jan 11.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gkr1282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351152PMC
May 2012

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria.

Nucleic Acids Res 2011 Sep 11;39(17):7750-63. Epub 2011 Jun 11.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gkr470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177208PMC
September 2011

TEFM (c17orf42) is necessary for transcription of human mtDNA.

Nucleic Acids Res 2011 May 28;39(10):4284-99. Epub 2011 Jan 28.

MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/nar/gkq1224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105396PMC
May 2011

An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1.

Mol Cell Biol 2010 Nov 7;30(21):5123-34. Epub 2010 Sep 7.

Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/MCB.00619-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953059PMC
November 2010

Engineered zinc finger proteins for manipulation of the human mitochondrial genome.

Authors:
Michal Minczuk

Methods Mol Biol 2010 ;649:257-70

Medical Research Council Mitochondrial Biology Unit, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-60761-753-2_16DOI Listing
December 2010

Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA.

Nat Protoc 2010 Feb 4;5(2):342-56. Epub 2010 Feb 4.

Mitochondrial Biology Unit, MRC, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2009.245DOI Listing
February 2010

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

Nucleic Acids Res 2008 Jul 29;36(12):3926-38. Epub 2008 May 29.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1093/nar/gkn313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475635PMC
July 2008

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase.

Proc Natl Acad Sci U S A 2006 Dec 14;103(52):19689-94. Epub 2006 Dec 14.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0609502103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1750892PMC
December 2006

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.

Nucleic Acids Res 2007 6;35(1):100-12. Epub 2006 Dec 6.

Institut für Biochemie, FB 08, Heinrich-Buff-Ring 58, Justus-Liebig-Universität Giessen, 35392 Giessen, Germany.

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http://dx.doi.org/10.1093/nar/gkl1035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761428PMC
February 2007

Designer zinc-finger proteins and their applications.

Gene 2006 Jan 17;366(1):27-38. Epub 2005 Nov 17.

MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.gene.2005.09.011DOI Listing
January 2006

Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.

FEBS J 2005 Oct;272(19):5008-19

Department of Genetics, University of Warsaw, Poland.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04910.xDOI Listing
October 2005

The 5' region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: promoter characterization and alternative pre-mRNA splicing.

Biochim Biophys Acta 2005 Jun;1729(2):81-7

Department of Genetics, University of Warsaw, Pawinskiego 5A, 02-106 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbaexp.2005.04.005DOI Listing
June 2005

RNA degradation in yeast and human mitochondria.

Toxicol Mech Methods 2004 ;14(1-2):53-7

Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

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http://dx.doi.org/10.1080/15376520490257473DOI Listing
October 2012

Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues.

J Med Chem 2003 Oct;46(22):4776-89

Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA.

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http://dx.doi.org/10.1021/jm030277kDOI Listing
October 2003

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria.

J Mol Biol 2003 Jun;329(5):853-7

Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5A, 02-106 Warsaw, Poland.

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http://dx.doi.org/10.1016/s0022-2836(03)00528-xDOI Listing
June 2003

Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors.

Proc Natl Acad Sci U S A 2003 Feb 6;100(4):1621-6. Epub 2003 Feb 6.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.252773399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149882PMC
February 2003

The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism.

J Biol Chem 2003 Jan 7;278(3):1603-11. Epub 2002 Nov 7.

Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland.

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http://dx.doi.org/10.1074/jbc.M208287200DOI Listing
January 2003

Overexpressed yeast mitochondrial putative RNA helicase Mss116 partially restores proper mtRNA metabolism in strains lacking the Suv3 mtRNA helicase.

Yeast 2002 Nov;19(15):1285-93

Department of Genetics, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland.

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http://dx.doi.org/10.1002/yea.906DOI Listing
November 2002