Publications by authors named "Michal Beran"

7 Publications

  • Page 1 of 1

KCNQ2 Mutation Explains the Etiology of Chloral Hydrate-Responsive Ohtahara Syndrome.

Pediatr Neurol 2017 02 8;67:e3-e4. Epub 2016 Dec 8.

DNA Laboratory, Department of Child Neurology, 2nd Faculty of Medicine, Charles University and Motol Hospital, Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.11.007DOI Listing
February 2017

[Arytmogenic ventricular cardiomyopathy].

Soud Lek 2015 ;60(4):51-6

Arrhythmogenic ventricular cardiomyopathy is considered to be a primary cardiomyopathy. Over the last few decades, although being a relatively rare disease with its prevalence 1:2000 - 1:5000, there were numerous studies performed with the aim to elucidate the underlaying causes, pathogenesis, diagnostical aspects and possible treatment options of the disease. Arrhythmogenic ventricular cardiomyopathy is genetically conditioned disease where proteins of the cell-cell junctions are involved. Mutations of the myocardial intercalated dics proteins, mainly desmosomal proteins (e.g.plakoglobin), are held to be responsible for electromechanical instability of the myocardium which causes regressive changes in cardiomyocytes in most cases of arrhythmogenic ventricular cardiomyopathy. Subsequent morphological changes include fibrofatty replacement and inflammation of the myocardium. The condition results in structural changes of the heart hence arrhytmias and other signs of heart disease. There are 3 variants of this cardiomyopathy: 'classical variant with predominant right ventricular involvement, biventricular and variant with left ventricular predominance. Clinical findings in patients with arrhythmogenic ventricular cardiomyopathy suggested the most appropriate means of the diagnostics and helped to create Task Force Criteria for in vivo diagnosis of the disease. The major pitfall and significance of arrhythmogenic ventricular cardiomyopathy lies in its common presentation as sudden cardiac death affecting mostly young adults.
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April 2016

Pathomorphology of inflammatory response following traumatic brain injury, serum values of interleukins, and gene polymorphisms.

Soud Lek Fall 2014;59(4):40-7

Unlabelled: Our present study was aimed to investigate time-profile kinetics of interleukins, vascular endothelial growth factor (VEGF) in acute inflammatory response following traumatic brain injury, and the influence of activated microglial cells in patients who developed severe space occupying lesion (SOL) of secondary traumatic brain injury. Interleukins IL-6, monocyte chemo attractant protein (MCP-1), and VEGF had a significant different time-profile kinetics (p<0.05) in patient with, and without expansive traumatic brain contusions (SOL). The serum VEGF was significantly higher in trauma patients with uncomplicated brain contusions, and lower in patients with SOL. The patients with septic complications developed the sudden increase of TNF alpha and IL-8 within the first 72 hours. Our data suggested PSGL and CD68 immunopositivity of microglial cells in both focal and diffuse TBI, predominantly in perivascular space correlated with telolysosome formation in cytoplasma. Polymorphism of PAI-1, MTHFR, eNOS, VEGF, and Apo E genes in TBI were in patients with SOL were bound to show up leucocyte plugging in capillaries.

Keywords: traumatic brain injury - acute inflammatory response - microglial cells - interleukins - vascular endothelial growth factor - monocyte chemoattractant protein - gene polymorphisms.
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November 2014

A concise history of forensic medicine in Czech Republic.

Acta Med Hist Adriat 2013 ;11(2):349-58

Institute of Forensic Medicine, Faculty of Medicine Masaryk University and St. Anne's University Hospital Brno, Brno, Czech Republic.

This paper presents the most important historical facts about all forensic medicine workplaces in the Czech Republic since the beginning till present day, including a perspective on how to establish a new one. Each of the University Forensic Medicine Institutes or district Departments is covered by at least one author. The oldest institute is in Prague and in Brno, the youngest is in Pardubice.
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March 2014

[Insect and a dead man in his flat. Case report].

Soud Lek 2013 Jan;58(1):2-5

Unlabelled: The case report illustrates a cooperation of the specialists in forensic medicine and forensic entomology using insect in estimation of the post mortem interval. It simultaneously presents less frequent consequence of the necrophagous fauna effect on the dead body condition, generally encountered in the Czech Republic only on corpses exposed for a long time in enclosed spaces.

Keywords: post mortem interval - forensic - medicine - entomology - frass.
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January 2013

The temperature of cremation and its effect on the microstructure of the human rib compact bone.

Anthropol Anz 2012 ;69(4):439-60

Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Praha, Czech Republic.

The presented study deals with the effect of the cremation temperature on the microstructure and morphology of the human compact bone. The biological material consisted of samples from ribs of recent Central European origin belonging to individuals of known age, sex and cause of death. Each bone sample was divided into several sections. One section remained unburned and the rest were burned at 700, 800 and 1000 degrees C. A few samples were burned also at the temperature of 600 degrees C. The undecalcified unstained ground cross-sections were made from burned and unburned bones; photographed and analysed using the SigmaScan Pro 5 programme. During burning, both the macroscopic and microscopic dimensions of the bone shrink, including the measures of the individual microstructures. The percentual representation of the area of individual microstructures on the area of the cross-section decreases. The number of individual microstructures per mm2 of the compact bone cross-section increases. Most microstructural variables demonstrated statistically significant differences at the individual temperatures of cremation. The burned bones showed a large scale of the colours, especially at 700 degrees C.
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http://dx.doi.org/10.1127/0003-5548/2012/0213DOI Listing
February 2013

Histological estimation of age at death from the compact bone of burned and unburned human ribs.

J Forensic Sci 2013 Jan;58 Suppl 1:S135-45

Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Vinicna 7, 128 00, Prague 2, Czech Republic.

This study describes the estimation of age at death from the compact bone of burned and unburned human ribs. Bone samples came from individuals of known age, sex, and cause of death. Each bone was divided into four sections; three sections were burned at 700, 800, and 1000°C. Undecalcified, unstained ground cross sections were photographed, and 28 variables were analyzed in the bones using SigmaScan Pro 5. Age-related as well as heat-induced microstructural changes were found. These changes were often very similar and made estimating the age at death difficult in the burned bones. Differences between the sexes were found in some variables, caused by both aging and also by the different behavior of some variables during burning. Regression equations were developed to estimate age at death for unburned bones (r² = 0.579 and 0.707), bones burned at 700°C (r² = 0.453 and 0.501), and 800°C (r² = 0.334 and 0.340).
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http://dx.doi.org/10.1111/j.1556-4029.2012.02303.xDOI Listing
January 2013