Publications by authors named "Michail Brovko"

8 Publications

  • Page 1 of 1

Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial.

Probiotics Antimicrob Proteins 2021 Oct 13. Epub 2021 Oct 13.

Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow, Russian Federation.

The treatment of coronavirus disease (COVID-19) and COVID-19-associated diarrhea remains challenging. This study aimed to evaluate the efficacy of a multi-strain probiotic in the treatment of COVID-19. This was a randomized, controlled, single-center, open-label trial (NCT04854941). Inpatients with confirmed COVID-19 and pneumonia were randomly assigned to a group that received a multi-strain probiotic (PRO group) or to the control group (CON group). There were 99 and 101 patients in the PRO and CON groups, respectively. No significant differences in mortality, total duration of disease and hospital stay, incidence of intensive care unit admission, need for mechanical ventilation or oxygen support, liver injury development, and changes in inflammatory biomarker levels were observed between the PRO and CON groups among all included patients as well as among subgroups delineated based on age younger or older than 65 years, and subgroups with chronic cardiovascular diseases and diabetes. Diarrhea on admission was observed in 11.5% of patients; it resolved earlier in the PRO group than in the CON group (2 [1-4] vs. 4 [3-6] days; p = 0.049). Hospital-acquired diarrhea developed less frequently in the PRO group than in the CON group among patients who received a single antibiotic (0% vs. 12.5%; p = 0.023) unlike among those who received > 1 antibiotic (10.5% vs. 13.3%; p = 0.696). The studied probiotic had no significant effect on mortality and changes in most biomarkers in COVID-19. However, it was effective in treating diarrhea associated with COVID-19 and in preventing hospital-acquired diarrhea in patients who received a single antibiotic.
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http://dx.doi.org/10.1007/s12602-021-09858-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512595PMC
October 2021

Sex differences in mortality in the intensive care unit patients with severe COVID-19.

J Infect 2021 02 28;82(2):282-327. Epub 2020 Sep 28.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, 11/5 Rossolimo, Moscow 119435, Russia.

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http://dx.doi.org/10.1016/j.jinf.2020.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521429PMC
February 2021

Virtual Care for Critically Ill Patients with COVID-19.

Telemed J E Health 2020 11 16;26(11):1326-1327. Epub 2020 Jun 16.

Clinic of Pulmonology, Sechenov First Moscow State, Medical University, Moscow, Russia.

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http://dx.doi.org/10.1089/tmj.2020.0214DOI Listing
November 2020

Cancer in intensive care unit patients with COVID-19.

J Infect 2020 08 28;81(2):e124-e125. Epub 2020 May 28.

Sechenov First Moscow State Medical University, 119882 Moscow, Russia.

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http://dx.doi.org/10.1016/j.jinf.2020.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255725PMC
August 2020

Rheumatic diseases in intensive care unit patients with COVID-19.

Ann Rheum Dis 2021 02 20;80(2):e16. Epub 2020 May 20.

Vinogradov Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russian Federation.

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http://dx.doi.org/10.1136/annrheumdis-2020-217676DOI Listing
February 2021

Is there a future for hydroxychloroquine/chloroquine in prevention of SARS-CoV-2 infection (COVID-19)?

Ann Rheum Dis 2021 02 21;80(2):e19. Epub 2020 Apr 21.

Vinogradov Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.

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http://dx.doi.org/10.1136/annrheumdis-2020-217570DOI Listing
February 2021
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